PA-20-196 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) is used for the submission of applications to the following Notices of Special Interest (NOSIs)

Active NOSIs

Title Notice Number Organization Release
Date
Expiration
Date
Activity
Code(s)
Notice of Special Interest (NOSI): Understanding Exposure and Health Effects of Micro and/or Nanoplastics NOT-ES-23-002 NIEHS Oct 3, 2022 Nov 17, 2027 R21, R01
Notice of Special Interest (NOSI): Research on the Impact of Policy Changes and Emerging and Evolving Public Health Crises on NICHD Populations of Interest NOT-HD-22-038 NICHD , NIDA Sep 14, 2022 Jan 8, 2025 R15, R03, R01, R21
Notice of Special Interest (NOSI): Development and Preliminary Testing of Health-related Behavioral Interventions NOT-OD-22-203 OBSSR , NCCIH , NCI , NIA , NIDA , NIDCR , NINR Sep 9, 2022 Sep 27, 2024 R01, R34, R21, UG3/UH3, R61/R33, U54, U01, R21/R33
Notice of Special Interest (NOSI): Research on the Health of Bisexual and Bisexual+ People NOT-OD-22-166 OD , NCCIH , NIA , NIAAA , NIAID , NICHD , NIDA , NIDCR , NIMH , NIMHD , NINDS , ODP Aug 11, 2022 Sep 8, 2023 K24, U01, R01, K01, R15, R03, K76, R34, K99/R00, T32, F32, UG3/UH3, R21, K23, F31
Notice of Special Interest (NOSI): Community-Based Participatory Research (CBPR) Initiative in Reducing and Eliminating Health Disparities with a focus on addressing diverse representation in research on Down syndrome (R21 Clinical Trial Optional) NOT-OD-22-142 OD , NCI , NEI , NHLBI , NIA , NIAMS , NICHD , NIDCD , NIDCR , NIMHD , NINDS Aug 5, 2022 Mar 17, 2025 R21
Notice of Special Interest (NOSI): Promoting Mechanistic Research on Therapeutic and Other Biological Properties of Minor Cannabinoids and Terpenes NOT-AT-22-027 NCCIH , NCI , NEI , NIA , NIAAA , NIDA , NIDCR , NINDS , ODS , ORWH Jul 27, 2022 Jul 1, 2025 R21, R01, UG3/UH3
Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening NOT-OD-22-179 ODP , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO Jul 14, 2022 May 8, 2025 R21, R01, R61/R33, UG3/UH3, R34, U01
Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan NOT-OD-22-178 ODP , NCI , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO Jul 14, 2022 May 8, 2025 R21, R01, UG3/UH3, R61/R33, R34, R03
Notice of Special Interest (NOSI): Climate Change and Health NOT-ES-22-006 NIEHS , FIC , NCI , NHGRI , NHLBI , NIA , NIAID , NIAMS , NICHD , NIDCR , NIMH , NIMHD , NINDS , NINR , NLM , ODP Jun 1, 2022 May 8, 2025 R21, F31, D43, K01, R03, K43, K99/R00, U01, U19, R01, F32, K23, F30, R21/R33
Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan NOT-OD-22-106 ODP , NCI , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO May 12, 2022 May 8, 2025 R03, R01, R34, R21, UG3/UH3, R61/R33, 333
Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening NOT-OD-22-107 ODP , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO May 12, 2022 May 8, 2025 333, R01, R34, R21, R61/R33, U01, UG3/UH3
Notice of Special Interest: Research on Alcohol and Coronavirus Disease (COVID-19) within the Mission of NIAAA NOT-AA-22-012 NIAAA Apr 29, 2022 Mar 6, 2024 R01, R03, R21, K99/R00
Notice of Special Interest: Achieving Tissue Robustness Through Harnessing Immune System Plasticity NOT-DE-22-005 NIDCR Apr 26, 2022 Sep 9, 2025 R21, R01
Notice of Special Interest (NOSI) - Emerging and Existing Issues of Coronavirus Disease 2019 (COVID-19) Research Related to the Health and Well-Being of Women, Children and Individuals with Physical and/or Intellectual Disabilities NOT-HD-22-002 NICHD , NIDA , NIEHS , NINDS , OBSSR , ORWH Mar 28, 2022 Jun 6, 2024 R01, R21
Notice of Special Interest (NOSI): Public Health Research on Cannabis NOT-DA-22-003 NIDA Feb 18, 2022 May 5, 2025 R21, R01, 333, R03
Notice of Special Interest (NOSI): Addressing Accessibility Inequities with COVID Home-Based Testing for Individuals with Visual Impairment NOT-EY-22-010 NEI Feb 4, 2022 Mar 9, 2024 R41/R42, R15, 333, R01, R43/R44, R21
Notice of Special Interest: NIMH Priorities on Research on Aggression and Violence Against Others NOT-MH-22-095 NIMH Feb 3, 2022 Jan 8, 2025 R36, R01, R34, R21, F32, R21/R33, R03, R61/R33, U01, K08, R15, K23, P50, F30, K99/R00, F31, K22, K01
Notice of Special Interest: Neuro-Glia Mechanisms Governing Complex Behaviors (R01 Clinical Trial Optional) NOT-MH-22-090 NIMH Feb 3, 2022 May 8, 2025 R21, R01
Notice of Special Interest (NOSI): Research to Prevent Drug Use, Misuse and Addiction NOT-DA-23-001 NIDA , ODP Jan 21, 2022 May 8, 2025 R01, R21, R34, R03
Notice of Special Interest (NOSI): COVID-19 Pandemic Mental Health Research NOT-MH-22-100 NIMH Jan 19, 2022 Jan 8, 2025 R21, R34, R01
Notice of Special Interest: Research on Pain, Pain Management, and Opioids in Aging NOT-AG-22-004 NIA Dec 22, 2021 Jan 8, 2025 F31, P01, K99/R00, K08, R01, K01, R43/R44, F32, 332, F33, F99/K00, R15, K24, R21, K02, K25, R25, F30, K23, R36, R41/R42, SB1, K76, K22, K07, R13, R21/R33, U19
Notice of Special Interest (NOSI) Pediatric COVID-19 and Respiratory Viral Co-infection NOT-HL-22-004 NHLBI , NICHD , NIAID Dec 21, 2021 Sep 8, 2025 R01, R21
Notice of Special Interest (NOSI): Electronic Nicotine Delivery Systems (ENDS) and Alternative Nicotine and Tobacco Delivery Systems: Basic Mechanisms of Health Effects NOT-OD-22-022 ODP , NIDCR , NCI , NIEHS , NIDA Dec 9, 2021 May 9, 2023 R01, R61/R33, R21, 333, R03
Notice of Special Interest (NOSI): Electronic Nicotine Delivery Systems (ENDS) and Alternative Nicotine and Tobacco Delivery Systems: Population, Clinical and Applied Prevention Mechanisms of Health Effects NOT-OD-22-023 ODP , NCI , NIDA , NIMHD , NIDCR Dec 8, 2021 May 9, 2024 R21, R01, 333, R34, R03, R61/R33
Notice of Special Interest: Expanding the Otitis Media Research Workforce: Focus on Early Stage Investigators NOT-DC-22-001 NIDCD Nov 23, 2021 Sep 8, 2025 R21, R01, U01
Notice of Special Interest (NOSI): Mechanistic studies on the impact of substance use in sex and gender differences in HIV-associated neurocognitive disorders NOT-DA-22-047 NIDA , ORWH Nov 19, 2021 Jan 8, 2025 R21, R01
Notice of Special Interest (NOSI): Secondary Analysis of Posttraumatic Psychopathology Data NOT-MH-22-045 NIMH Nov 18, 2021 Jan 8, 2025 R01, R21, K08, F30, K01, K23, K22, F32, F31, R03, R36, K99/R00, R15, F99/K00
Notice of Special Interest (NOSI): Biologic Factors Underlying Dental, Oral, and Craniofacial Health Disparities NOT-DE-21-013 NIDCR , NCI , NIMHD Oct 7, 2021 Jan 8, 2025 R21, R01
Notice of Special Interest (NOSI): Electronic Nicotine Delivery Systems (ENDS) and Alternative Nicotine and Tobacco Delivery Systems: Basic Mechanisms of Health Effects NOT-OD-21-127 ODP , NIEHS , NIDCR , NIDA , NCI Jun 28, 2021 May 8, 2023 333, R03, R01, R21
Notice of Special Interest (NOSI): Advancing HIV/AIDS Research through Computational Neuroscience NOT-DA-21-030 NIDA Jun 22, 2021 Jan 8, 2025 R01, R21, R03, DP2, DP1, K99/R00, K01, R36, P01, R15, K24
Notice of Special Interest: NIDCD Health Disparities and Inequities Research NOT-DC-21-003 NIDCD , SGMRO Jun 11, 2021 May 8, 2024 R01, R21, P50, F30, F31, F32, F99/K00, K01, K08, K18, K23, K24, K25, K99/R00, 333, R41/R42, R43/R44
Notice of Special Interest (NOSI): Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence NOT-DA-21-012 NIDA , NIAAA , ORWH , SGMRO Apr 23, 2021 Sep 8, 2024 R01, R03, R21
Notice of Special Interest (NOSI): Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health NOT-OD-21-100 OBSSR , NIMHD , NIDA , NIMH , ORWH , NIDCD , SGMRO , ODP , NIA , NHLBI , NCI , NINR , NCCIH , NEI , NICHD Apr 8, 2021 Jun 8, 2024 R01, R21, R03, R41/R42, R43/R44, R21/R33, UG3/UH3, R34
Notice of Special Interest (NOSI): Developing and Testing Multilevel Physical Activity Interventions to Improve Health and Well-Being NOT-OD-21-087 ODP , NCCIH , NCI , NIA , NIAAA , NIAMS , NICHD , NIDCD , NIMH , NIMHD , NINR , OBSSR , ORWH Apr 6, 2021 Feb 16, 2024 R01, R21, 333, R03
Notice of Special Interest (NOSI): Identification of Biomarkers of HIV Pathogenesis and Substance Use Disorder Comorbidity NOT-DA-21-014 NIDA Mar 31, 2021 Sep 8, 2024 R01, R21, DP2, DP1, K99/R00, K01, R36, P01, R15, K24
Notice of Special Interest (NOSI): Deciphering the Mosaic of Glia in the Addicted Brain NOT-DA-21-001 NIDA Mar 29, 2021 Sep 10, 2024 R21, R01, R15
Notice of Special Interest (NOSI): Fundamental Science Research on Complementary and Integrative Health Approaches, Including Natural Products or Mind and Body Interventions NOT-AT-21-006 NCCIH Mar 19, 2021 Sep 8, 2024 R01, R21
Notice of Special Interest (NOSI): Neurological and Neurocognitive Sequelae from SARS-CoV-2 Infection and COVID-19 in Aging and Age-Related Neurodegeneration NOT-AG-21-016 NIA Feb 26, 2021 May 8, 2023 R01, R21, R03
Notice of Special Interest (NOSI): Telehealth Strategies for Individuals with HIV and Substance Use Disorders NOT-DA-21-019 NIDA Feb 10, 2021 Sep 8, 2024 R01, R03, R21
Notice of Special Interest (NOSI): Medical Consequences of Smoking and Vaping Drugs of Abuse in Individuals with HIV and COVID-19 NOT-DA-21-017 NIDA Feb 4, 2021 Sep 8, 2024 R01, R03, R21
Notice of Special Interest (NOSI): Long-Term Neurocognitive Consequences of COVID-19 in Individuals Living with HIV and Substance Use Disorders NOT-DA-21-018 NIDA Feb 3, 2021 Sep 8, 2024 R01, R03, R21
Notice of Special Interest (NOSI): Understanding the effects of cancer and cancer treatment on aging trajectories and aging outcomes NOT-CA-21-031 NCI , NIA Jan 27, 2021 Jan 8, 2024 R21, R03, R01, U01, P01, K99/R00, K08, R43/R44, R41/R42, R13, R21/R33, K01, K23
Notice of Special Interest (NOSI): Effects of smoking and vaping on the risk and outcome of COVID-19 infection NOT-DA-21-011 NIDA Jan 26, 2021 Sep 8, 2024 R01, R03, R21
Notice of Special Interest (NOSI): Promoting Research on Interoception and Its Impact on Health and Disease NOT-AT-21-002 NCCIH , NIDA , ORWH , NIMH , NIDCR , OBSSR , NIA , NIEHS , NCI Jan 22, 2021 May 7, 2024 R01, R21
Notice of Special Interest: Alcohol-induced Tissue-specific and Organ System Diseases (R01/R21/R03) NOT-AA-20-024 NIAAA Jan 4, 2021 May 8, 2024 R01, R21, R03
Notice of Special Interest (NOSI): Adopting Techniques and Tools Developed from the BRAIN Initiative Toward NIMH Strategic Research Priorities NOT-MH-21-115 NIMH Dec 28, 2020 May 8, 2023 R01, R21, R15, P50
Notice of Special Interest (NOSI) regarding the Use of Human Connectome Data for Secondary Analysis NOT-MH-21-175 NIMH , NEI , NIA , NIDA Dec 23, 2020 May 8, 2024 R01, R21
Notice of Special Interest (NOSI) for the NEI Anterior Segment Initiative (ASI): Identification and Development of New Biomarkers and Effective methods to Diagnose Dry Eye Disease. NOT-EY-21-007 NEI Dec 21, 2020 May 8, 2023 R01, R21, R43/R44, R41/R42
Notice of Special Interest (NOSI) regarding the Use of Human Connectome Data for Secondary Analysis NOT-MH-21-075 NIMH , NEI , NIDA , NIA Dec 18, 2020 May 8, 2024 R01, R21
Notice of Special Interest: Advances in Research for the Treatment, Services, and Recovery of Alcohol Use Disorder NOT-AA-20-022 NIAAA Nov 27, 2020 Sep 8, 2023 R01, R03, R21
Notice of Special Interest: Advancing the Science of Geriatric Palliative Care NOT-AG-20-041 NIA , ORWH , NINR , NCI , NHLBI , NIMHD Sep 3, 2020 Sep 8, 2023 R01, R21
Notice of Special Interest: Alcohol and Aging NOT-AA-20-019 NIAAA Aug 19, 2020 Sep 8, 2023 R01, R03, R21
Notice of Special Interest: Epidemiology and Prevention in Alcohol Research NOT-AA-20-017 NIAAA Jul 13, 2020 Sep 8, 2023 R01, R21, R03
Notice of Special Interest (NOSI): Role of Astrocytes and Astrocytic Networks in Drug Abuse NOT-DA-20-060 NIDA Jun 8, 2020 Sep 8, 2023 R01, R21
Notice of Special Interest (NOSI): Research on Co-morbid Substance Use, Substance Use Disorders, and Other Psychiatric Disorders NOT-DA-20-004 NIDA , ORWH Jun 4, 2020 May 8, 2023 R34, R21, R03, R01
Notice of Special Interest: Promoting Fundamental and Applied Research in Inflammation Resolution NOT-ES-20-018 NIEHS , NHLBI , NIAMS May 27, 2020 May 31, 2024 R21, R01
Notice of Special Interest (NOSI): Advancing Research on SUD through Computational Neuroscience NOT-DA-20-022 NIDA May 5, 2020 Sep 8, 2023 R01, R21
Notice of Special Interest (NOSI): Cannabis, Prescription Opioid, or Prescription Benzodiazepine Drug Use Among Older Adults NOT-DA-20-014 NIDA Apr 22, 2020 Sep 8, 2023 R01, R03, R21
Notice of Special Interest (NOSI): Neuroimmune Signaling and Function in Substance Use Disorders NOT-DA-20-046 NIDA Apr 7, 2020 Sep 8, 2023 R01, R21, R15, 333
Notice of Special Interest (NOSI): Effects of Cannabis Use and Cannabinoids on the Developing Brain NOT-DA-20-039 NIDA Mar 5, 2020 Sep 8, 2023 R01, R03, R21
Notice of Special Interest (NOSI): Harnessing computational tools for sophisticated analyses of Substance Use Disorder-related behaviors NOT-DA-20-017 NIDA Mar 5, 2020 Sep 8, 2023 R01, R03, R21, 333
Notice of Special Interest (NOSI): Preclinical and Clinical Studies of the Interactions of Opioids and Stimulants NOT-DA-20-007 NIDA Jan 6, 2020 Jun 5, 2023 R03, R21, R01
Notice of Special Interest (NOSI): Modeling Social Contagion of Substance Use Epidemics NOT-DA-20-009 NIDA Jan 2, 2020 Jan 8, 2023 R01, R03, R21

Expired NOSIs

Title Notice Number Organization Release
Date
Expiration
Date
Activity
Code(s)
Notice of Special Interest (NOSI): Advancing Research on Early Pregnancy Loss NOT-HD-22-026 NICHD ORWH Jul 5, 2022 n/a R01, R21
Notice of NIDA's Participation in NOT-MD-22-006 "Notice of Special Interest (NOSI): Research to Address Vaccine Hesitancy, Uptake, and Implementation among Populations that Experience Health Disparities" NOT-DA-22-002 NIDA Jan 20, 2022 n/a R01, 333, R21
Notice of Special Interest (NOSI): Electronic Nicotine Delivery Systems (ENDS) and Alternative Nicotine and Tobacco Delivery Systems: Population, Clinical and Applied Prevention Mechanisms of Health Effects NOT-OD-21-137 ODP NIMHD NCI NIDA NIDCR Jun 28, 2021 Dec 8, 2021 333, R34, R01, R21, R03
Notice of Special Interest (NOSI): Aging-Relevant Behavioral and Social Research on Coronavirus Disease 2019 (COVID-19) NOT-AG-21-015 NIA Jan 26, 2021 Sep 10, 2021 R01, R03, R21, U19, P01, R21/R33
Notice of Special Interest (NOSI): Research in the Emergency Setting NOT-NS-20-005 NINDS NCI NIDA NHLBI NIDCD NIAAA NICHD NIA NIGMS NEI NIMHD NIMH Sep 8, 2020 Sep 8, 2022 R01, R21, R03, K01, K99/R00, K08, K23, R13, R43/R44, R41/R42, P01, U01, R34, R35, RM1
Notice of Special Interest: Basic and Translational Research on Affective, Motivational, and Social Function in Normative Aging and/or Alzheimers Disease and Related Dementias (AD/ADRD) NOT-AG-20-040 NIA Aug 3, 2020 Jan 8, 2022 R01, R21
Notice of Special Interest: Fundamental and Translational Research on Decision Making in Aging and/or Alzheimers Disease and Alzheimers Disease Related Dementias (AD/ADRD) NOT-AG-20-039 NIA Jul 21, 2020 Jan 8, 2022 R01, R21
Notice of Special Interest (NOSI): NIDCD is Interested in Supporting Research on the Impact of COVID-19 on Mission Specific Sensory and Communication Disorders NOT-DC-20-008 NIDCD Jun 4, 2020 Sep 8, 2022 R01, R21, R41/R42, R43/R44
Notice of Special Interest (NOSI): NIDCD is Interested in Supporting Research on the Impact of COVID-19 on Mission Specific Sensory and Communication Disorders NOT-DC-20-008 NIDCD Jun 4, 2020 Sep 8, 2022 R01, R21, R41/R42, R43/R44
Notice of Special Interest (NOSI): Development and Preliminary Testing of Health-related Behavioral Interventions NOT-OD-20-106 OBSSR NIAMS NIMH NCCIH NIDA NIA NCI NIDCR NINR May 19, 2020 Sep 26, 2022 R01, R21, 333
Notice of Special Interest (NOSI): Competitive Revisions for Firearms Injury and Mortality Prevention Research NOT-OD-20-089 OBSSR NIA NICHD NIMH NCCIH ODP NIMHD ORWH NIAAA Mar 20, 2020 May 16, 2020 R01, R21
Notice of Special Interest (NOSI): Drug-drug interactions among substances of abuse, medications to treat HIV infection, and pharmacotherapies to treat substance use disorders NOT-DA-20-013 NIDA Feb 6, 2020 May 8, 2022 R01, R03, R21
Notice of Special Interest: Exploring the Mechanisms Underlying Analgesic Properties of Minor Cannabinoids and Terpenes NOT-AT-20-002 NCCIH Dec 13, 2019 Jan 8, 2022 R01, R21
Notice of Special Interest: NIMHs Interest in Early Stage Clinical and/or Mechanistic Trials in Posttraumatic Psychopathology, Directed at Testing FAAH Inhibitors NOT-MH-19-055 NIMH Oct 17, 2019 Jan 8, 2022 U01, R61/R33, R21, R01
Notice of Special Interest in High Priority Research Areas for Sex and Gender Influences on the Adolescent Brain and the Mental Health of Girls and Young Women (Ages 12-24) NOT-MH-19-039 NIMH Sep 9, 2019 May 18, 2022 R21, R01, P50
Notice of Special Interest (NOSI): Public Health Research on Cannabis NOT-DA-19-065 NIDA Aug 14, 2019 Jan 8, 2022 R01, R21, R03, 333
Notice of Special Interest (NOSI): The Application of Big Data Analytics to Drug Abuse Research NOT-DA-19-041 NIDA Jul 12, 2019 Jan 8, 2022 R01, R21, R03
Notice of Special Interest (NOSI): Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R01, R21, R03) NOT-DA-19-037 NIDA Jul 11, 2019 Sep 8, 2022 R01, R21, R03
Notice of Special Interest (NOSI): Gene-Environment Interplay in Substance Use Disorders (R01, R21) NOT-DA-19-038 NIDA Jul 10, 2019 Jan 8, 2022 R01, R21


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