Notice Number: NOT-DA-19-038
Release Date: July 11, 2019
First Available Due Date: October 5, 2019
Expiration Date: January 8, 2022
PA-19-056 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
PA-19-055 - Research Project Grant (Parent R01 Clinical Trial Required)
PA-19-091 - NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
PA-19-092 -NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)
PA-19-053 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
PA-19-054 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
National Institute on Drug Abuse (NIDA)
The purpose of this Notice is to inform potential applicants to the National Institute on Drug Abuse (NIDA) of special interest in research project applications studying the interplay of genetic and environmental factors in the onset, developmental trajectories, comorbidity, and outcomes of substance use disorders (SUDs). These interests include studies to elucidate phenotypes and develop methodologic approaches that will enhance translation to treatment, prevention, gene-finding and molecular studies.
Research applying genetic epidemiologic and molecular genetic approaches has contributed increasingly significant advances to understanding the causes of use, misuse, and disorders of addictive substances, including alcohol, illicit drugs, nicotine, and prescription medications [Substance Use Disorders (SUDs)]. These studies have established that SUDs are complex developmental disorders, with high heritability, and strong shared environmental effects, particularly early in adolescence and at drug use initiation. Genetic epidemiologic approaches have highlighted the roles of gene-environment interactions and correlations in understanding SUD risk and trajectories and to apply methodologies to explicate etiological mechanisms, often in combination with molecular approaches. New studies continue to be needed to elucidate the complex interplay of genetic and environmental (GxE) factors in developmental trajectories of SUDs and comorbid conditions, deepen and refine phenotypic definitions of SUDs, and meet methodologic challenges.
NIDA welcomes applications studying the interplay of genetic and environmental factors to elucidate risk trajectories and underlying mechanisms of risk and progression of substance use disorders. Applicants are strongly encouraged to explain how their work can enhance opportunities for translation to treatment, prevention, gene-finding and molecular studies. A report by an outside panel of experts on future directions for NIDA's gene-environment program can be found at https://www.drugabuse.gov/about-nida/strategic-plan/strategic-planning-workgroup-genes-x-environment-x-development-interplay-gedi.
Examples of approaches that are encouraged include, but are not limited to:
Cost effective approaches that take advantage of existing data or research infrastructure are also encouraged, including:
Application and Submission Information:
This notice applies to due dates on or after October 5, 2019 and subsequent receipt dates through January 8, 2022.
Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.
All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:
Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.
Please direct all inquiries to: