Human Subjects Research

According to 45 CFR 46 Link to Non-U.S. Government Site - Click for Disclaimer, a human subject is "a living individual about whom an investigator (whether professional or student) conducting research:

  • Obtains information or biospecimens through intervention or interaction with the individual, and uses, studies, or analyzes the information or biospecimens; or
  • Obtains, uses, studies, analyzes, or generates identifiable private information or identifiable biospecimens."
Are you planning on conducting human subjects research? Learn more about research that meets the definition human subjects research, Federal regulation requirements, and whether your project may be considered exempt. Also, learn about NIH specific considerations and become more familiar with NIH policies, and other regulations as it relates to human subjects research protections. 
 
 

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Decision Tool: Am I Doing Human Subjects Research? 

The questionnaire is a tool to assist you with determining whether your project involves non-exempt human subjects research, meets the criteria for exempt human subjects research, or does not involve human subjects research. 

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Human Subjects Research Infographic

This resource summarizes the definition of human subjects research and provides examples of human subjects research projects. It also describes what you will need when you are preparing your NIH application and what is required if you are funded.

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Exempt Human Subjects Research Infographic

This resource is a guide to simplify the understanding of the exemptions from the federal regulations for the protection of human subjects research. It summarizes Exemptions 1, 2, 3, 4, 5, 6, 7 and 8, providing basic definitions, examples of studies that meet and do not meet the criteria of the exemption, and aspects one must consider when engaged in exempt or non-exempt human subjects research. 

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Assistance Preparing the PHS Human Subjects and Clinical Trials Information Form

Find useful resources for filling out the PHS Human Subjects and Clinical Trials Information form including a summary of form changes, a video walk-through of the form, annotated form sets, and more.

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PHS Human Subjects and Clinical Trials Information Form

Find detailed instructions for completing the PHS Human Subjects and Clinical Trials Information form from the application guide.