Notice Number: NOT-MH-19-039
Release Date: September 9, 2019
First Available Due Date: October 5, 2019
Expiration Date: May 18, 2022
National Institute of Mental Health (NIMH)
The purpose of this Notice of Special Interest (NOSI) is to outline NIMH priorities for potential applications in the field of women’s mental health research, specifically during the adolescent and young adult period. This notice does not in any diminish the importance of NIMH sponsored women’s mental health research across the lifespan.
The NIMH encourages multidisciplinary research projects to examine biological, social, cultural and behavioral contributions of sex and gender influences on mental health and illness (e.g., anxiety, depression, suicide, psychosis, schizophrenia, bipolar disorder, trauma related disorders, eating disorders, etc.) in adolescent girls and young women. Research is needed to identify biomarkers and behavioral indicators that predict risk trajectories of mental illness. Additionally, translational research is needed that applies recent basic research discoveries and identifies opportunities to advance clinical research and mental health services research. Prevention and intervention projects that consider the impact of biological as well as social, cultural, and gender-based target mechanisms on mental health outcomes are also encouraged.
Global epidemiological data consistently reports up to 20% of children and adolescents suffer from a disabling mental illness; suicide is the third leading cause of death among adolescents and up to 50% of all adult mental illnesses have their onset in adolescence. Recent global trends show rising rates of depressive disorders among adolescent girls and young women when compared to adolescent boys and young men. Research findings indicate that early adverse experiences may compromise brain and behavioral development and the mental health and well-being of adolescents and young adults. Relevant gender specific research findings indicate “(1) that gender differences in adults emerge at young ages; (2) the influence of gender roles and expectations on the expression and interpretation of behavioral and emotional symptoms, are different for boys and girls; and (3) gender is a modifier of the (mental) illness risks and protective factors that can be identified at the genetic, neurobiological and psychosocial levels.” Equally important is research that incorporates sex as a significant biological variable, for preclinical research and clinical research, that recognizes that sex, defined as being XY or XX, is a construct derived from chromosomal complement. As such, sex is an important biologic variable in preclinical research that informs the premise and design of clinical research. Current findings demonstrate that sex affects health status, including disease presentation, pathophysiology, and therapeutic response. Together, the combination of both sex and gender influences not only strengthen study design but also advance human health.
Given the biological, social and cultural changes that impact adolescents and young adults, the NIMH seeks studies that explore sex and gender influences on the development of the adolescent brain and adolescent mental health of girls and young women.
Research areas of interest include but are not limited to:
Basic and Behavioral Neuroscience
Interventions Development and Services Research
Research Areas of interest shared across the NIMH
Application and Submission Information:
This notice applies to due dates on or after October 5, 2019 and subsequent receipt dates through May 18, 2022. The following funding opportunity announcements (FOAs) or their reissued equivalents must be used for submissions for this initiative. Although NIMH is not listed as a Participating Organization in all the FOAs listed below, applications for this initiative will be accepted.
|Activity Code||FOA||First Available Due Date|
|R21||PA-19-092, NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)||October 16, 2019|
|R21||PA-18-350, NIMH Exploratory/ Development Research Grant (R21 Clinical Trial Not Allowed)||October 16, 2019|
|R01||PA-19-091, NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)||October 5, 2019|
|R01||PA-19-055, Research Project Grant (Parent R01 Clinical Trial Required)||October 5, 2019|
|P50||PAR-18-701, Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional)||May 18, 2020|
All instructions in the SF424 (R&R) Application Guide and the listed funding opportunity announcements must be followed, with the following additions:
For funding consideration, applicants must include “NOT-MH-19-039” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative. Applications nonresponsive to the terms of this notice will not be considered for this initiative.
The NIMH encourages multidisciplinary collaborations that interweave basic science and translational research to identify actionable targets for mechanisms that spur the development of innovative mental health interventions for girls and young women. In addition, NIMH encourages investigators to draw on existing large scale comprehensive multidomain research such as the Adolescent Brain and Cognitive Development (ABCD) Project and the Human Connectome Project in Development (HCP-D), other longitudinal studies, existing research cores, CTSAs, or other institutional assets in the design of their projects.
Please direct all inquiries to:
Tamara Lewis Johnson, MPH, MBA
National Institute of Mental Health (NIMH)