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PA-22-176 - PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) is used for the submission of applications to the following Notices of Special Interest (NOSIs)

On This Page: 56

Active NOSIs

Title Notice Number Organization Release
Date		 Expiration
Date		 Activity
Code(s)
Notice of Special Interest (NOSI): Discovery and Development of Oral Small-molecule Direct-acting Antivirals Targeting Viruses of Pandemic Potential NOT-AI-24-053 NIAID Jun 27, 2024 Jul 17, 2027 R21, R41/R42, R43/R44, R01
Notice of Special Interest (NOSI): Applications of Data Science in Translational Dental, Oral, and Craniofacial Research NOT-DE-24-003 NIDCR Oct 23, 2023 May 8, 2026 UE5, R41/R42, U01, K02, K25, F30, R13, D43, F99/K00, F33, F31, K99/R00, R16, D71, R15, R43/R44, K18, K43, K08, R01, R21, K23, K01, F32, R03, G11, K22
Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access NOT-DK-23-015 NIDDK , NCATS , NIBIB Aug 14, 2023 Apr 7, 2025 R41/R42, R43/R44
Notice of Special Interest (NOSI): Advancing Biomedical Research in Pulmonary Non-Tuberculous Mycobacterial (NTM) Infections NOT-AI-23-050 NIAID Jun 27, 2023 Jul 17, 2026 R21, R41/R42, R43/R44, R01, U44
Notice of Special Interest (NOSI): Using Targeted Degradation of Protein and non-Protein Targets for the Development of Novel Anti-Infectives NOT-AI-23-049 NIAID Jun 23, 2023 Jul 17, 2026 R03, R01, R41/R42, R43/R44, R21
Notice of Special Interest (NOSI): Promoting Research and Development of Vaccines Against Enteric Viruses NOT-AI-23-048 NIAID Jun 15, 2023 Jul 17, 2026 R01, R43/R44, U44, R41/R42, R21
Notice of Special Interest (NOSI): Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults NOT-MH-23-250 NIMH May 19, 2023 Sep 8, 2026 K43, R41/R42, R21, K08, R25, K99/R00, T32, K01, F30, R34, R03, F31, R15, R43/R44, K24, K23, F32, R01
Notice of Special Interest (NOSI): Synthetic Biology for Biomedical Applications. NOT-EB-23-002 NIBIB , NCCIH , NCI , NHLBI , NIA , NIAID , NICHD , NIGMS Apr 14, 2023 May 17, 2026 R01, R21, R35, R41/R42, R43/R44
Notice of Special Interest (NOSI): Development of Innovative Informatics and Data Science Technologies, Tools, and Methods for Vision Research NOT-EY-23-005 NEI Apr 3, 2023 Feb 16, 2026 R41/R42, R43/R44, R21
Notice of Special Interest (NOSI): Promoting Language and Communication in Minimally Verbal/Non-Speaking Individuals with Autism NOT-DC-23-009 NIDCD Apr 3, 2023 Jun 6, 2026 R13, R15, R01, U01, R21, R43/R44, R41/R42, R03
Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine NOT-AI-23-031 NIAID Feb 23, 2023 Jan 15, 2026 R01, R41/R42, R43/R44, R21, U44
Notice of Special Interest (NOSI): Small Business Digital Technologies for Early Detection, Characterization and Monitoring of Senescence-Related Changes NOT-AG-23-004 NIA Feb 7, 2023 Jan 6, 2026 R43/R44, R41/R42
Notice of Special Interest (NOSI): Development of Functional Assay Sites to Evaluate Candidate -Omics Variants Associated with Heart, Lung, Blood, or Sleep Disease (R01, R41, R42, R43, R44) NOT-HL-23-066 NHLBI Jan 31, 2023 Sep 8, 2026 R41/R42, R43/R44, R01
Notice of Special Interest (NOSI): Optimization of Data Storage and Utilization for the Sequence Read Archive (SRA) NOT-GM-23-015 NIGMS , NLM , ODSS Dec 14, 2022 Dec 19, 2025 R41/R42, R43/R44, R01, K08, RM1, R21, K25, K99/R00, K23, F30, F32, F33, F31, R16, R35, R15
Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine NOT-AI-23-007 NIAID Nov 25, 2022 Jan 8, 2026 R21, R41/R42, R43/R44, R01
Notice of Special Interest (NOSI): Advancing Research for Tickborne Diseases (TBDs) NOT-AI-23-013 NIAID , NIAMS , NIMH , NINDS Nov 25, 2022 Jan 8, 2026 R43/R44, R15, R01, R21, R03, R41/R42
Notice of Special Interest (NOSI): Advancing Development of Rapid Point-of-Care Hepatitis C Virus Diagnostics NOT-AI-23-001 NIAID , NCI , NIBIB Nov 23, 2022 Jan 8, 2026 R01, R41/R42, R43/R44, R21
Notice of Special Interest (NOSI): Utilization of Cohorts and Prospective Study Designs for Liquid Biopsy Assay Validation for Early Detection of Cancers NOT-CA-23-004 NCI Oct 17, 2022 Jul 2, 2025 R43/R44, R21, R01, UH2/UH3, R41/R42, U01
Notice of Special Interest (NOSI): Towards Developing a Cure for HBV in HIV/HBV Co-Infection NOT-AI-22-043 NIAID Apr 29, 2022 May 8, 2025 R01, R41/R42, R21, R43/R44
Notice of Special Interest (NOSI): Research Addressing Eye and Vision Health Equity/Health Disparities NOT-EY-22-004 NEI , NIMHD Feb 14, 2022 Jan 25, 2025 R01, UG1, F31, R21, 333, K99/R00, K08, F30, K23, R43/R44, R34, R41/R42, F32
Notice of Special Interest (NOSI): Advancing NEI AGI Research on newly Identified Factors Into Models of Visual System Regeneration NOT-EY-22-002 NEI Jan 10, 2022 Feb 10, 2025 R43/R44, R21, R15, R41/R42, R01, R24
Notice of Special Interest: Development and Implementation of Clinical Informatics Tools to Enhance Patients Use of Genomic Information NOT-HG-22-011 NHGRI Jan 6, 2022 Dec 31, 2025 R01, R21, U24, R43/R44, R41/R42
Notice of Special Interest: Research on Pain, Pain Management, and Opioids in Aging NOT-AG-22-004 NIA Dec 22, 2021 Jan 8, 2025 F31, P01, K99/R00, K08, R01, K01, R43/R44, F32, 332, F33, F99/K00, R15, K24, R21, K02, K25, R25, F30, K23, R36, R41/R42, SB1, K76, K22, K07, R13, R21/R33, U19
Notice of Special Interest (NOSI): Methods Development for Genomic Studies of Genetic Variation, Function, and Disease NOT-HG-22-007 NHGRI Dec 9, 2021 Nov 5, 2024 R41/R42, R01, R43/R44, R21
Notice of Special Interest (NOSI): Epidemiology and Prevention of Alcohol Misuse in Understudied Young Adult Populations; Military, Workforce, and Community College NOT-AA-22-001 NIAAA Dec 9, 2021 Sep 9, 2025 R21, R03, R01, R43/R44, R41/R42
Notice of Special Interest: SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed) NOT-NS-22-017 NINDS , NIDCR , NEI , NCI , NIA Nov 12, 2021 Jan 8, 2025 R43/R44
Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed) NOT-DE-21-012 NIDCR Sep 1, 2021 Sep 5, 2025 R43/R44, R41/R42
Notice of Special Interest (NOSI): Genomics Education Interactive Digital Media Resources (SBIR/STTR) NOT-HG-21-038 NHGRI Aug 26, 2021 Dec 31, 2024 R43/R44, R41/R42

Expired NOSIs

Title Notice Number Organization Release
Date		 Expiration
Date		 Activity
Code(s)
Notice of Special Interest (NOSI): Advancing Research for Amyotrophic Lateral Sclerosis (ALS) NOT-NS-23-062 NINDS Feb 6, 2023 Jun 24, 2024 R61/R33, R41/R42, R43/R44
Notice of Special Interest (NOSI): Research to Support Regulatory Science on Infant Formula NOT-HD-22-016 NICHD OD ODS Jun 13, 2022 May 8, 2023 R03, R41/R42, R43/R44, R01, 333, R21
Notice of Special Interest (NOSI): Innovative Technologies to Improve Assessments, Interventions, and Outcomes for Individuals with Intellectual and Developmental Disabilities (R43/R44) NOT-HD-22-009 NICHD Jun 7, 2022 Apr 6, 2023 R41/R42, R43/R44
Notice of Special Interest (NOSI): Innovative Technologies for Research on Climate Change and Human Health (R43/R44 Small Business Innovation Research (R43/R44 Clinical Trial Optional) NOT-ES-22-010 NIEHS NCATS NEI NHLBI NIA NIAID NIAMS NICHD NIMH NIMHD NINR NLM Jun 3, 2022 Apr 6, 2023 R43/R44
Notice of Special Interest (NOSI): Technological Innovations for Advancing Clinical SPECT Imaging NOT-EB-22-006 NIBIB Mar 21, 2022 May 8, 2024 R21, F30, K01, R13, K23, K25, R43/R44, K08, R01, K99/R00, R41/R42, F32, R03, F31
Notice of Special Interest (NOSI): Addressing Accessibility Inequities with COVID Home-Based Testing for Individuals with Visual Impairment NOT-EY-22-010 NEI Feb 4, 2022 Mar 9, 2024 R41/R42, R15, 333, R01, R43/R44, R21
Notice of Special Interest (NOSI): Validation of Digital Health and Artificial Intelligence Tools for Improved Assessment in Epidemiological, Clinical, and Intervention Research NOT-CA-22-037 NCI NHLBI NIA NIDA NIMH NINR OBSSR Jan 27, 2022 Mar 9, 2024 R01, R03, R21, R43/R44, R41/R42, R33, R34, R61/R33
Notice of Special Interest (NOSI): Advancing Innovative Non-invasive Physiologic Monitoring To Improve Fetal Assessment NOT-HD-21-053 NICHD Dec 28, 2021 May 8, 2024 R03, R01, R41/R42, R43/R44, R21
Notice of Special Interest (NOSI): National Cancer Institute SBIR/STTR Program Announcement Regarding Cancer Prevention, Diagnosis, and Treatment Technologies for Low-Resource Settings NOT-CA-21-062 NCI Jul 23, 2021 Sep 7, 2024 R43/R44, R41/R42
Notice of Special Interest (NOSI): Navigating Pediatric to Adult Health Care: Lost in Transition NOT-HD-21-027 NICHD NIAAA NCI NIMH NIAMS OBSSR NIBIB NIDCR Jun 22, 2021 Jan 8, 2024 R01, R21, R43/R44, R41/R42
Notice of Special Interest (NOSI): HIV Drug Resistance Assays and Actionable Data Dissemination Strategies NOT-AI-21-056 NIAID NIDA Jun 17, 2021 May 8, 2024 R01, R21, U01, U24, R41/R42, R43/R44
Notice of Special Interest: NIDCD Health Disparities and Inequities Research NOT-DC-21-003 NIDCD SGMRO Jun 11, 2021 May 8, 2024 R01, R21, P50, F30, F31, F32, F99/K00, K01, K08, K18, K23, K24, K25, K99/R00, 333, R41/R42, R43/R44
Notice of Special Interest (NOSI): Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health NOT-OD-21-100 OBSSR NIMHD NIDA NIMH ORWH NIDCD SGMRO ODP NIA NHLBI NCI NINR NCCIH NEI NICHD Apr 8, 2021 Jun 8, 2024 R01, R21, R03, R41/R42, R43/R44, R21/R33, UG3/UH3, R34
Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace NOT-MH-21-125 NIMH NIA NIAAA NIBIB NINDS NIDA NEI NCCIH NICHD NIDCD Mar 3, 2021 Jan 6, 2024 R43/R44, R41/R42
Notice of Special Interest (NOSI): Small Business Initiatives for Innovative Diagnostic Technology for Improving Outcomes for Maternal Health NOT-EB-21-001 NIBIB NIAID ORWH NICHD NIMHD NIMH NINDS OD NCATS NHLBI NHGRI Feb 22, 2021 Apr 6, 2023 R41/R42, R43/R44, 333
Notice of Special Interest (NOSI): Hearing Healthcare for Adults: Improving Access and Affordability NOT-DC-21-001 NIDCD Feb 16, 2021 Jan 8, 2024 R01, R21, U01, R43/R44, R41/R42
Notice of Special Interest (NOSI): Understanding the effects of cancer and cancer treatment on aging trajectories and aging outcomes NOT-CA-21-031 NCI NIA Jan 27, 2021 Jan 8, 2024 R21, R03, R01, U01, P01, K99/R00, K08, R43/R44, R41/R42, R13, R21/R33, K01, K23
Notice of Special Interest (NOSI) for the NEI Anterior Segment Initiative (ASI): Identification and Development of New Biomarkers and Effective methods to Diagnose Dry Eye Disease. NOT-EY-21-007 NEI Dec 21, 2020 May 8, 2023 R01, R21, R43/R44, R41/R42
Notice of Special Interest (NOSI): Advancing Genomic Technology Development for Research and Clinical Application NOT-HG-21-018 NHGRI Dec 4, 2020 Jan 10, 2024 R01, R21, R43/R44, R41/R42
Notice of Special Interest: Kidney Precision Medicine Technology Development and Translation NOT-DK-21-007 NIDDK Dec 2, 2020 Sep 6, 2023 R43/R44, R41/R42
Notice of Special Interest (NOSI): Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (SBIR/STTR) NOT-AT-21-001 NCCIH Oct 23, 2020 Jan 5, 2024 R41/R42, R43/R44
Notice of Special Interest (NOSI): Research in the Emergency Setting NOT-NS-20-005 NINDS NCI NIDA NHLBI NIDCD NIAAA NICHD NIA NIGMS NEI NIMHD NIMH Sep 8, 2020 Sep 8, 2022 R01, R21, R03, K01, K99/R00, K08, K23, R13, R43/R44, R41/R42, P01, U01, R34, R35, RM1
Notice of Special Interest (NOSI): Methods Development in Natural Products Research (SBIR/STTR) NOT-AT-20-015 NCCIH Jul 16, 2020 Sep 6, 2023 R41/R42, R43/R44
Notice of Special Interest (NOSI) of NIDCR in Supporting Dental, Oral, and Craniofacial Research Using Bioinformatic, Computational, and Data Science Approaches NOT-DE-20-006 NIDCR Jun 5, 2020 Aug 8, 2023 R01, R21, R03, R41/R42, F99/K00, F30, F31, F32, F33, K01, K08, K23, K25, K22, K99/R00, K43, K18, R15, R43/R44
Notice of Special Interest: NIGMS Priorities for Small Business Development of Sepsis Diagnostics and Therapeutics NOT-GM-20-028 NIGMS Jun 2, 2020 Sep 12, 2023 R41/R42, R43/R44, SB1


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