PA-22-176 - PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) is used for the submission of applications to the following Notices of Special Interest (NOSIs)

Active NOSIs

Title Notice Number Organization Release
Date
Expiration
Date
Activity
Code(s)
Notice of Special Interest (NOSI): Applications of Data Science in Translational Dental, Oral, and Craniofacial Research NOT-DE-24-003 NIDCR Oct 23, 2023 May 8, 2026 UE5, R41/R42, U01, K02, K25, F30, R13, D43, F99/K00, F33, F31, K99/R00, R16, D71, R15, R43/R44, K18, K43, K08, R01, R21, K23, K01, F32, R03, G11, K22
Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access NOT-DK-23-015 NIDDK , NCATS , NIBIB Aug 14, 2023 Apr 7, 2025 R41/R42, R43/R44
Notice of Special Interest (NOSI): Advancing Biomedical Research in Pulmonary Non-Tuberculous Mycobacterial (NTM) Infections NOT-AI-23-050 NIAID Jun 27, 2023 Jul 17, 2026 R21, R41/R42, R43/R44, R01, U44
Notice of Special Interest (NOSI): Using Targeted Degradation of Protein and non-Protein Targets for the Development of Novel Anti-Infectives NOT-AI-23-049 NIAID Jun 23, 2023 Jul 17, 2026 R03, R01, R41/R42, R43/R44, R21
Notice of Special Interest (NOSI): Promoting Research and Development of Vaccines Against Enteric Viruses NOT-AI-23-048 NIAID Jun 15, 2023 Jul 17, 2026 R01, R43/R44, U44, R41/R42, R21
Notice of Special Interest (NOSI): Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults NOT-MH-23-250 NIMH May 19, 2023 Sep 8, 2026 K43, R41/R42, R21, K08, R25, K99/R00, T32, K01, F30, R34, R03, F31, R15, R43/R44, K24, K23, F32, R01
Notice of Special Interest (NOSI): Synthetic Biology for Biomedical Applications. NOT-EB-23-002 NIBIB , NCCIH , NCI , NHLBI , NIA , NIAID , NICHD , NIGMS Apr 14, 2023 May 17, 2026 R01, R21, R35, R41/R42, R43/R44
Notice of Special Interest (NOSI): Development of Innovative Informatics and Data Science Technologies, Tools, and Methods for Vision Research NOT-EY-23-005 NEI Apr 3, 2023 Feb 16, 2026 R41/R42, R43/R44, R21
Notice of Special Interest (NOSI): Promoting Language and Communication in Minimally Verbal/Non-Speaking Individuals with Autism NOT-DC-23-009 NIDCD Apr 3, 2023 Jun 6, 2026 R13, R15, R01, U01, R21, R43/R44, R41/R42, R03
Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine NOT-AI-23-031 NIAID Feb 23, 2023 Jan 15, 2026 R01, R41/R42, R43/R44, R21, U44
Notice of Special Interest (NOSI): Small Business Digital Technologies for Early Detection, Characterization and Monitoring of Senescence-Related Changes NOT-AG-23-004 NIA Feb 7, 2023 Jan 6, 2026 R43/R44, R41/R42
Notice of Special Interest (NOSI): Advancing Research for Amyotrophic Lateral Sclerosis (ALS) NOT-NS-23-062 NINDS Feb 6, 2023 Jun 24, 2024 R61/R33, R41/R42, R43/R44
Notice of Special Interest (NOSI): Development of Functional Assay Sites to Evaluate Candidate -Omics Variants Associated with Heart, Lung, Blood, or Sleep Disease (R01, R41, R42, R43, R44) NOT-HL-23-066 NHLBI Jan 31, 2023 Sep 8, 2026 R41/R42, R43/R44, R01
Notice of Special Interest (NOSI): Optimization of Data Storage and Utilization for the Sequence Read Archive (SRA) NOT-GM-23-015 NIGMS , NLM , ODSS Dec 14, 2022 Dec 19, 2025 R41/R42, R43/R44, R01, K08, RM1, R21, K25, K99/R00, K23, F30, F32, F33, F31, R16, R35, R15
Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine NOT-AI-23-007 NIAID Nov 25, 2022 Jan 8, 2026 R21, R41/R42, R43/R44, R01
Notice of Special Interest (NOSI): Advancing Research for Tickborne Diseases (TBDs) NOT-AI-23-013 NIAID , NIAMS , NIMH , NINDS Nov 25, 2022 Jan 8, 2026 R43/R44, R15, R01, R21, R03, R41/R42
Notice of Special Interest (NOSI): Advancing Development of Rapid Point-of-Care Hepatitis C Virus Diagnostics NOT-AI-23-001 NIAID , NCI , NIBIB Nov 23, 2022 Jan 8, 2026 R01, R41/R42, R43/R44, R21
Notice of Special Interest (NOSI): Utilization of Cohorts and Prospective Study Designs for Liquid Biopsy Assay Validation for Early Detection of Cancers NOT-CA-23-004 NCI Oct 17, 2022 Jul 2, 2025 R43/R44, R21, R01, UH2/UH3, R41/R42, U01
Notice of Special Interest (NOSI): Towards Developing a Cure for HBV in HIV/HBV Co-Infection NOT-AI-22-043 NIAID Apr 29, 2022 May 8, 2025 R01, R41/R42, R21, R43/R44
Notice of Special Interest (NOSI): Technological Innovations for Advancing Clinical SPECT Imaging NOT-EB-22-006 NIBIB Mar 21, 2022 May 8, 2024 R21, F30, K01, R13, K23, K25, R43/R44, K08, R01, K99/R00, R41/R42, F32, R03, F31
Notice of Special Interest (NOSI): Research Addressing Eye and Vision Health Equity/Health Disparities NOT-EY-22-004 NEI , NIMHD Feb 14, 2022 Jan 25, 2025 R01, UG1, F31, R21, 333, K99/R00, K08, F30, K23, R43/R44, R34, R41/R42, F32
Notice of Special Interest (NOSI): Advancing NEI AGI Research on newly Identified Factors Into Models of Visual System Regeneration NOT-EY-22-002 NEI Jan 10, 2022 Feb 10, 2025 R43/R44, R21, R15, R41/R42, R01, R24
Notice of Special Interest: Development and Implementation of Clinical Informatics Tools to Enhance Patients Use of Genomic Information NOT-HG-22-011 NHGRI Jan 6, 2022 Dec 31, 2025 R01, R21, U24, R43/R44, R41/R42
Notice of Special Interest (NOSI): Advancing Innovative Non-invasive Physiologic Monitoring To Improve Fetal Assessment NOT-HD-21-053 NICHD Dec 28, 2021 May 8, 2024 R03, R01, R41/R42, R43/R44, R21
Notice of Special Interest: Research on Pain, Pain Management, and Opioids in Aging NOT-AG-22-004 NIA Dec 22, 2021 Jan 8, 2025 F31, P01, K99/R00, K08, R01, K01, R43/R44, F32, 332, F33, F99/K00, R15, K24, R21, K02, K25, R25, F30, K23, R36, R41/R42, SB1, K76, K22, K07, R13, R21/R33, U19
Notice of Special Interest (NOSI): Methods Development for Genomic Studies of Genetic Variation, Function, and Disease NOT-HG-22-007 NHGRI Dec 9, 2021 Nov 5, 2024 R41/R42, R01, R43/R44, R21
Notice of Special Interest (NOSI): Epidemiology and Prevention of Alcohol Misuse in Understudied Young Adult Populations; Military, Workforce, and Community College NOT-AA-22-001 NIAAA Dec 9, 2021 Sep 9, 2025 R21, R03, R01, R43/R44, R41/R42
Notice of Special Interest: SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed) NOT-NS-22-017 NINDS , NIDCR , NEI , NCI , NIA Nov 12, 2021 Jan 8, 2025 R43/R44
Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed) NOT-DE-21-012 NIDCR Sep 1, 2021 Sep 5, 2025 R43/R44, R41/R42
Notice of Special Interest (NOSI): Genomics Education Interactive Digital Media Resources (SBIR/STTR) NOT-HG-21-038 NHGRI Aug 26, 2021 Dec 31, 2024 R43/R44, R41/R42
Notice of Special Interest (NOSI): National Cancer Institute SBIR/STTR Program Announcement Regarding Cancer Prevention, Diagnosis, and Treatment Technologies for Low-Resource Settings NOT-CA-21-062 NCI Jul 23, 2021 Sep 7, 2024 R43/R44, R41/R42
Notice of Special Interest (NOSI): HIV Drug Resistance Assays and Actionable Data Dissemination Strategies NOT-AI-21-056 NIAID , NIDA Jun 17, 2021 May 8, 2024 R01, R21, U01, U24, R41/R42, R43/R44
Notice of Special Interest: NIDCD Health Disparities and Inequities Research NOT-DC-21-003 NIDCD , SGMRO Jun 11, 2021 May 8, 2024 R01, R21, P50, F30, F31, F32, F99/K00, K01, K08, K18, K23, K24, K25, K99/R00, 333, R41/R42, R43/R44
Notice of Special Interest (NOSI): Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health NOT-OD-21-100 OBSSR , NIMHD , NIDA , NIMH , ORWH , NIDCD , SGMRO , ODP , NIA , NHLBI , NCI , NINR , NCCIH , NEI , NICHD Apr 8, 2021 Jun 8, 2024 R01, R21, R03, R41/R42, R43/R44, R21/R33, UG3/UH3, R34

Expired NOSIs

Title Notice Number Organization Release
Date
Expiration
Date
Activity
Code(s)
Notice of Special Interest (NOSI): Research to Support Regulatory Science on Infant Formula NOT-HD-22-016 NICHD OD ODS Jun 13, 2022 May 8, 2023 R03, R41/R42, R43/R44, R01, 333, R21
Notice of Special Interest (NOSI): Innovative Technologies to Improve Assessments, Interventions, and Outcomes for Individuals with Intellectual and Developmental Disabilities (R43/R44) NOT-HD-22-009 NICHD Jun 7, 2022 Apr 6, 2023 R41/R42, R43/R44
Notice of Special Interest (NOSI): Innovative Technologies for Research on Climate Change and Human Health (R43/R44 Small Business Innovation Research (R43/R44 Clinical Trial Optional) NOT-ES-22-010 NIEHS NCATS NEI NHLBI NIA NIAID NIAMS NICHD NIMH NIMHD NINR NLM Jun 3, 2022 Apr 6, 2023 R43/R44
Notice of Special Interest (NOSI): Addressing Accessibility Inequities with COVID Home-Based Testing for Individuals with Visual Impairment NOT-EY-22-010 NEI Feb 4, 2022 Mar 9, 2024 R41/R42, R15, 333, R01, R43/R44, R21
Notice of Special Interest (NOSI): Validation of Digital Health and Artificial Intelligence Tools for Improved Assessment in Epidemiological, Clinical, and Intervention Research NOT-CA-22-037 NCI NHLBI NIA NIDA NIMH NINR OBSSR Jan 27, 2022 Mar 9, 2024 R01, R03, R21, R43/R44, R41/R42, R33, R34, R61/R33
Notice of Special Interest (NOSI): Navigating Pediatric to Adult Health Care: Lost in Transition NOT-HD-21-027 NICHD NIAAA NCI NIMH NIAMS OBSSR NIBIB NIDCR Jun 22, 2021 Jan 8, 2024 R01, R21, R43/R44, R41/R42
Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace NOT-MH-21-125 NIMH NIA NIAAA NIBIB NINDS NIDA NEI NCCIH NICHD NIDCD Mar 3, 2021 Jan 6, 2024 R43/R44, R41/R42
Notice of Special Interest (NOSI): Small Business Initiatives for Innovative Diagnostic Technology for Improving Outcomes for Maternal Health NOT-EB-21-001 NIBIB NIAID ORWH NICHD NIMHD NIMH NINDS OD NCATS NHLBI NHGRI Feb 22, 2021 Apr 6, 2023 R41/R42, R43/R44, 333
Notice of Special Interest (NOSI): Hearing Healthcare for Adults: Improving Access and Affordability NOT-DC-21-001 NIDCD Feb 16, 2021 Jan 8, 2024 R01, R21, U01, R43/R44, R41/R42
Notice of Special Interest (NOSI): Understanding the effects of cancer and cancer treatment on aging trajectories and aging outcomes NOT-CA-21-031 NCI NIA Jan 27, 2021 Jan 8, 2024 R21, R03, R01, U01, P01, K99/R00, K08, R43/R44, R41/R42, R13, R21/R33, K01, K23
Notice of Special Interest (NOSI) for the NEI Anterior Segment Initiative (ASI): Identification and Development of New Biomarkers and Effective methods to Diagnose Dry Eye Disease. NOT-EY-21-007 NEI Dec 21, 2020 May 8, 2023 R01, R21, R43/R44, R41/R42
Notice of Special Interest (NOSI): Advancing Genomic Technology Development for Research and Clinical Application NOT-HG-21-018 NHGRI Dec 4, 2020 Jan 10, 2024 R01, R21, R43/R44, R41/R42
Notice of Special Interest: Kidney Precision Medicine Technology Development and Translation NOT-DK-21-007 NIDDK Dec 2, 2020 Sep 6, 2023 R43/R44, R41/R42
Notice of Special Interest (NOSI): Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (SBIR/STTR) NOT-AT-21-001 NCCIH Oct 23, 2020 Jan 5, 2024 R41/R42, R43/R44
Notice of Special Interest (NOSI): Research in the Emergency Setting NOT-NS-20-005 NINDS NCI NIDA NHLBI NIDCD NIAAA NICHD NIA NIGMS NEI NIMHD NIMH Sep 8, 2020 Sep 8, 2022 R01, R21, R03, K01, K99/R00, K08, K23, R13, R43/R44, R41/R42, P01, U01, R34, R35, RM1
Notice of Special Interest (NOSI): Methods Development in Natural Products Research (SBIR/STTR) NOT-AT-20-015 NCCIH Jul 16, 2020 Sep 6, 2023 R41/R42, R43/R44
Notice of Special Interest (NOSI) of NIDCR in Supporting Dental, Oral, and Craniofacial Research Using Bioinformatic, Computational, and Data Science Approaches NOT-DE-20-006 NIDCR Jun 5, 2020 Aug 8, 2023 R01, R21, R03, R41/R42, F99/K00, F30, F31, F32, F33, K01, K08, K23, K25, K22, K99/R00, K43, K18, R15, R43/R44
Notice of Special Interest: NIGMS Priorities for Small Business Development of Sepsis Diagnostics and Therapeutics NOT-GM-20-028 NIGMS Jun 2, 2020 Sep 12, 2023 R41/R42, R43/R44, SB1


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