Notice of Special Interest: Development and Implementation of Clinical Informatics Tools to Enhance Patients’ Use of Genomic Information
Notice Number:
NOT-HG-22-011

Key Dates

Release Date:

January 6, 2022

First Available Due Date:
February 10, 2022
Expiration Date:
September 25, 2025

Related Announcements

PA-20-183 - NIH Research Project Grant (Parent R01 Clinical Trial Required)

PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-20-194 - Parent R21 Exploratory/Developmental Grant, Clinical Trial Required

PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

PAR-20-100 - Genomic Community Resources (U24 Clinical Trial Not Allowed)

PAR-21-254 - Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)

PAR-21-255 - Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)

RFA-HG-20-036 - Advancing Genomic Medicine Research (R01 Clinical Trial Optional)

RFA-HG-20-037 - Advancing Genomic Medicine Research (R21 Clinical Trial Optional)

PA-21-259 - PHS 2021-2 - Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

PA-21-261 - PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

Issued by

National Human Genome Research Institute (NHGRI)

Purpose

Purpose:

The National Human Genome Research Institute (NHGRI) is issuing a Notice of Special Interest (NOSI) to encourage applications to develop and implement patient-facing genomic-based clinical informatics tools that facilitate or enhance patient-provider electronic communication, patient tracking and registry functions, patient self-management and support, provider electronic prescribing, test tracking, referral tracking, and health care decision-making.

Background:

A critical gap in genomic medicine is the availability of clinical informatics tools that employ computational and electronic approaches to facilitate patient understanding of genomic information and assist in using that information for health care decisions. Recognizing this gap, NHGRI is interested in receiving applications that propose the development and implementation of patient-facing clinical informatics tools that incorporate genomic information. Applicants should describe how their proposed tool(s) will: 1) adapt to healthcare systems varying in size and resources, 2) be useable by a clinically and socio-demographically diverse array of patients, 3) present genomic information in a customizable and patient-friendly manner, 4) improve providers’ ability to engage in shared decision-making with patients about care and treatment, and 5) address barriers that limit the development and implementation of genomic information in patient care. Applications should also include plans for using the latest evidence-based recommendations and guidelines across relevant fields (e.g., genomic science, health service delivery, patient education, informatics). Areas of interest include but are not limited to genomic based computational and electronic tools that allow patients to:

  • Securely share their genomic results and associated health data
  • Participate in population health management services related to their genomic results
  • Remain engaged with their genomic information over their lifetime
  • Self-monitor their genomic information, particularly as its interpretation evolves with accruing knowledge
  • Learn about their genomic health
  • Engage with their genomic information across multiple platforms
  • Improve shared decision making with their providers

Applications should describe how approaches will mitigate bias, health disparities, and other factors that threaten the meaningful, equitable, and beneficial use of genomics in patient care. These factors may be tied to the availability, accessibility, quality, use and/or interpretation of data and clinical algorithms, information systems, and health care providers and services. Applications should also describe how they will involve and integrate feedback from future users.

Application and Submission Information

This notice applies to due dates on or after February 10, 2022 and subsequent receipt dates through September 24, 2025.

Applications submitted in response to this NOSI must reference one of the following funding opportunities announcements or any reissues of the following announcements through the expiration date of this notice:

PA-20-183 - NIH Research Project Grant (Parent R01 Clinical Trial Required)

PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-20-194 - Parent R21 Exploratory/Developmental Grant, Clinical Trial Required

PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

PAR-20-100 - Genomic Community Resources (U24 Clinical Trial Not Allowed)

PAR-21-254 - Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)

PAR-21-255 - Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)

RFA-HG-20-036 - Advancing Genomic Medicine Research (R01 Clinical Trial Optional)

RFA-HG-20-037 - Advancing Genomic Medicine Research (R21 Clinical Trial Optional)

PA-21-259 - PHS 2021-2 - Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

PA-21-261 - PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:

  • For funding consideration, applicants must include “NOT-HG-22-011” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.

Applications nonresponsive to terms of this NOSI will be withdrawn from consideration for this initiative.

Inquiries

Please direct all inquiries to the contacts in Section VII of the listed funding opportunity announcements with the following additions/substitutions:

Scientific/Research Contact

Ken Wiley, Jr., Ph.D.
National Human Genome Research Institute (NHGRI)
Division of Genomic Medicine
Telephone: 301-435-5540
Email: ken.wiley@nih.gov

Peer Review Contact(s)

Examine your eRA Commons account for review assignment and contact information (information appears two weeks after the submission due date).