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Notice of Special Interest (NOSI) of NIDCR in Supporting Dental, Oral, and Craniofacial Research Using Bioinformatic, Computational, and Data Science Approaches
Notice Number:
NOT-DE-20-006

Key Dates

Release Date:

June 5, 2020

First Available Due Date:
August 11, 2020
Expiration Date:
August 08, 2023

Related Announcements

PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-19-053 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

PAR-19-370 - NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)

PA-20-260 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

PA-19-270 - Re-issued as PA-20-265 - PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications

PAR-20-069 - NIDCR Predoctoral to Postdoctoral Transition Award for a Diverse Dental, Oral and Craniofacial Research Workforce (F99/K00 Independent Clinical Trial Not Allowed)

PA-19-191 - Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship for Students at Institutions With NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)

PA-19-192 - Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)

PA-19-196 - Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (F31- Diversity)

PA-20-195 - Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (F31)

PA-19-188 - Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32)

PA-19-187 - Individual NRSA Senior Fellowship (F33)

PA-20-190 - NIH Mentored Research Scientist Development Award (K01 - Independent Clinical Trial Not Allowed)

PA-20-203 - Mentored Clinical Scientist Research Career Development Award (K08 - Independent Clinical Trial Not Allowed)

PA-20-205 - Mentored Patient-Oriented Research Career Development Award (K23 - Independent Clinical Trial Not Allowed)

PA-20-188 - NIH Pathway to Independence Award (K99/R00 - Independent Clinical Trial Not Allowed)

PA-20-199 - Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed)

PAR-19-152 - NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Independent Clinical Trial Not Allowed)

PAR-19-144 - NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 - Clinical Trial Not Allowed)

PAR-19-098 - Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)

PAR-19-238 - Short-term Mentored Career Enhancement Award in Dental, Oral and Craniofacial Research for Mid-Career and Senior Investigators (K18 Independent Clinical Trial Not Allowed)

PAR-19-134 - Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)

Issued by

National Institute of Dental and Craniofacial Research (NIDCR)

Purpose

The volume, dimension, and complexity of biomedical and behavioral research data are expanding rapidly, requiring bioinformatic, computational, and data science approaches to manage and analyze the data, address new questions, and obtain deeper insight from the data. This Notice of Special Interest (NOSI) calls for research and research training projects that focus on dental, oral, and craniofacial biology and diseases using bioinformatic, computational, and data science approaches.

Specific Areas of Research Interest

Projects may address, but are not limited to the following themes:

  • Development of ontological systems, knowledge representation approaches, and other tools and approaches to facilitate findability, accessibility, interoperability and reusability (FAIR) of information from diverse sources relevant to NIDCR’s mission of improving dental, oral, and craniofacial health;
  • Integration and analysis of available molecular, omic, genetic, phenotypic, behavioral, environmental, and socioeconomic data, and electronic health records, to identify novel association of genetic variants with dental, oral, or craniofacial diseases, traits or health disparities, or to reconstruct signaling and regulatory pathways underlying dental, oral, and craniofacial development and abnormalities;
  • Development of bioinformatic and computational methods and approaches, including machine learning (ML)/artificial intelligence (AI), to aid in validation and further refinement of dental, oral and craniofacial disease mechanisms, thereby improving research rigor and reproducibility;
  • Development of robust bioinformatic and computational methods, including ML/AI methods, for prognoses and diagnoses of diseases with dental, oral, or craniofacial abnormalities;
  • Development of novel and robust data analysis algorithms to tackle causal mechanisms of action for onset and progression of disease for identified candidate causal genetic variants, or biological sex as a scientific variable;
  • ML/AI based optimization of clinical procedures for precision dental care; and
  • Computational modeling for treatment planning and assessment of treatment outcomes.

Application and Submission Information

This notice applies to due dates on or after August 11, 2020 and subsequent receipt dates through August 8, 2023.

Submit applications for this initiative using one of the following FOAs or any reissues of these announcements through the expiration date of this notice.

  • PA-19-056 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed )
  • PA-19-056 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  • PA-18-489 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  • PAR-19-370 - NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)
  • PA-20-260 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  • PA-19-270 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  • PAR-20-069 - NIDCR Predoctoral to Postdoctoral Transition Award for a Diverse Dental, Oral and Craniofacial Research Workforce (F99/K00 Independent Clinical Trial Not Allowed)
  • PA-19-191 - Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship for Students at Institutions With NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)
  • PA-19-192 - Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)
  • PA-19-196 - Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (F31- Diversity)
  • PA-19-195 - Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (F31)
  • PA-19-188 - Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32)
  • PA-19-187 - Individual NRSA Senior Fellowship (F33)
  • PA-19-126 - NIH Mentored Research Scientist Development Award (K01 - Independent Clinical Trial Not Allowed)
  • PA-19-117 - Mentored Clinical Scientist Research Career Development Award (K08 - Independent Clinical Trial Not Allowed)
  • PA-19-119 - Mentored Patient-Oriented Research Career Development Award (K23 - Independent Clinical Trial Not Allowed)
  • PA-19-130 - NIH Pathway to Independence Award (K99/R00 - Independent Clinical Trial Not Allowed)
  • PA-19-124 - Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed)
  • PAR-19-152 - NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Independent Clinical Trial Not Allowed)
  • PAR-19-144 - NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 - Clinical Trial Not Allowed)
  • PAR-19-098 - Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)
  • PAR-19-238 - Short-term Mentored Career Enhancement Award in Dental, Oral and Craniofacial Research for Mid-Career and Senior Investigators (K18 Independent Clinical Trial Not Allowed)
  • PAR-19-134 - Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed

All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:

For funding consideration, applicants must include NOT-DE-20-006" (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered.

Applications nonresponsive to terms of this NOSI will be not be considered for the NOSI initiative.

Inquiries

Please direct all inquiries to the Scientific/Research, Peer Review, and Financial/Grants Management contacts in Section VII of the listed funding opportunity announcements.

Scientific/Research Contact

Lu Wang, Ph.D.
National Institute of Dental and Craniofacial Research
Telephone: 301-594-4846
Email: wanglu@nidcr.nih.gov

Financial/Grants Management Contact

Diana Rutberg, MBA
National Institute of Dental and Craniofacial Research (NIDCR)
Telephone: 301-594-4798
Email: rutbergd@mail.nih.gov

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