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Activity Code	Category	Title	Description	Resources
R00	Research Projects	Research Transition Award	To support the second phase of a Career/Research Transition award program that provides 1 -3 years of independent research support (R00) contingent on securing an independent research position. Award recipients will be expected to compete successfully for independent R01 support from the NIH during the R00 research transition award period.	More Information
R01	Research Projects	Research Project	To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.	More Information
R03	Research Projects	Small Research Grants	To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable.	More Information
R13	Research Projects	Conference	To support recipient sponsored and directed international, national or regional meetings, conferences and workshops.	More Information
R15	Research Projects	Research Enhancement Awards	Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code.	More Information
R16	Research Projects	Research Excellence Award	Supports small-scale research projects at educational institutions that that enroll significant numbers of students from backgrounds nationally underrepresented in biomedical research, award baccalaureate and graduate degrees in biomedical sciences, and receive limited NIH funding.
R18	Research Projects	Research Demonstration and Dissemination Projects	To provide support designed to develop, test, and evaluate health service activities, and to foster the application of existing knowledge for the control of categorical diseases.
R21	Research Projects	Exploratory/Developmental Grants	To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.)	More Information
R24	Research Projects	Resource-Related Research Projects	To support research projects that will enhance the capability of resources to serve biomedical research.	More Information
R25	Research Projects	Education Projects	For support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.	More Information
R28	Research Projects	Resource-Related Research Projects	To support research projects contributing to improvement of the capability of resources to serve clinical research.
R2F	Research Projects	Food Safety Capacity and Infrastructure Building	To build food safety capacity and infrastructure by assisting State, locality, territory, Indian tribe, or nonprofit food safety training entity that collaborates with 1 or more institutions of higher education to undertake food safety inspections, investigations, and examinations; train to the standards established by the HHS Secretary; build lab capacity; and respond to notifications received under Section 1008 and recalls.
R30	Research Projects	Preventive Health Service - Venereal Disease Research, Demonstration, and Public Information and Education Grants	(Definition not available)
R33	Research Projects	Exploratory/Developmental Grants Phase II	The R33 award is to provide a second phase for the support for innovative exploratory and development research activities initiated under the R21 mechanism. Although only R21 awardees are generally eligible to apply for R33 support, specific program initiatives may establish eligibility criteria under which applications could be accepted from applicants demonstrating progress equivalent to that expected under R33.
R34	Research Projects	Planning Grant	To provide support for the initial development of a clinical trial or research project, including the establishment of the research team; the development of tools for data management and oversight of the research; the development of a trial design or experimental research designs and other essential elements of the study or project, such as the protocol, recruitment strategies, procedure manuals and collection of feasibility data.	More Information
R35	Research Projects	Outstanding Investigator Award	To provide long term support to an experienced investigator with an outstanding record of research productivity. This support is intended to encourage investigators to embark on long-term projects of unusual potential.
R36	Research Projects	Dissertation Award	To support dissertation research costs of students in accredited research doctoral programs in the United States (including Puerto Rico and other U.S. territories or possessions). Dissertation awards are not renewable.	More Information
R37	Research Projects	Method to Extend Research in Time (MERIT) Award	To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements.
R38	Research Projects	Mentored Research Pathway in Residency	For support to develop and/or implement an institutional program offering mentored research in residency.
R41	Research Projects	Small Business Technology Transfer (STTR) Grants - Phase I	To support cooperative R&D projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization. Awards are made to small business concerns only.	More Information
R42	Research Projects	Small Business Technology Transfer (STTR) Grants - Phase II	To support in - depth development of cooperative R&D projects between small business concerns and research institutions, limited in time and amount, whose feasibility has been established in Phase I and that have potential for commercialization. Awards are made to small business concerns only.	More Information
R43	Research Projects	Small Business Innovation Research Grants (SBIR) - Phase I	To support projects, limited in time and amount, to establish the technical merit and feasibility of R&D ideas which may ultimately lead to a commercial product(s) or service(s).	More Information
R44	Research Projects	Small Business Innovation Research Grants (SBIR) - Phase II	To support in - depth development of R&D ideas whose feasibility has been established in Phase I and which are likely to result in commercial products or services. SBIR Phase II are considered “Fast-Track” and do not require National Council Review.	More Information
R49	Research Projects	Injury Control Research and Demonstration Projects and Injury Prevention Research Centers	Provides financial assistance to non-profit and for-profit organizations to conduct research and demonstration projects as well as training programs to develop a comprehensive and integrated approach to injury control. These projects will integrate aspects of the disciplines of engineering, public health, behavioral sciences, medicine, and others in order to prevent and control injuries.
R50	Research Projects	Research Specialist Award	The Research Specialist Award is designed to encourage the development of stable research career opportunities for exceptional scientists who want to pursue research within the context of an existing research program, but not serve as Principal Investigators. The Award is intended to provide desirable salaries and sufficient autonomy so that individuals are not solely dependent on grants held by Principal Investigators for career continuity.
R55	Research Projects	James A. Shannon Director's Award	To provide a limited award to investigators to further develop, test, and refine research techniques; perform secondary analysis of available data sets; test the feasibility of innovative and creative approaches; and conduct other discrete projects that can demonstrate their research capabilities and lend additional weight to their already meritorious applications.
R56	Research Projects	High Priority, Short Term Project Award	To provide limited interim research support based on the merit of a pending R01 application while applicant gathers additional data to revise a new or competing renewal application. This grant will underwrite highly meritorious applications that if given the opportunity to revise their application could meet IC recommended standards and would be missed opportunities if not funded. Interim funded ends when the applicant succeeds in obtaining an R01 or other competing award built on the R56 grant. These awards are not renewable.	More Information
R61	Research Projects	Phase 1 Exploratory/Developmental Grant	As part of a bi-phasic approach to funding exploratory and/or developmental research, the R61 provides support for the first phase of the award. This activity code is used in lieu of the R21 activity code when larger budgets and/or project periods are required to establish feasibility for the project.
R90	Research Projects	Interdisciplinary Regular Research Training Award	To support comprehensive interdisciplinary research training programs at the undergraduate, predoctoral and/or postdoctoral levels, by capitalizing on the infrastructure of existing multidisciplinary and interdisciplinary research programs. This Activity Code is for trainees who do not meet the qualifications for NRSA authority.	More Information
RC1	Research Projects	NIH Challenge Grants and Partnerships Program	NIH Challenge Grants in Health and Science Research
RC2	Research Projects	High Impact Research and Research Infrastructure Programs	To support high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code could support either a specific research question or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future.
RC3	Research Projects	Biomedical Research, Development, and Growth to Spur the Acceleration of New Technologies (BRDG-SPAN) Program	To accelerate the transition of NIH-supported research innovations and technologies toward the development of products or services that will improve human health, through grants that may advance the mission of NIH and its Institutes and Centers (ICs), and create significant value and economic stimulus or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code is intended to support research and development (R&D) specifically targeted at activities that can help address the funding gap between promising R&D and transitioning to the market, often called the “Valley of Death” by contributing the critical funding needed by applicants to pursue the next appropriate milestone(s) toward ultimate commercialization; i.e., to carry out later stage research activities necessary to that end; to foster partnerships among a variety of research and development (R&D) collaborators working toward these aims. Awards are made only to U.S.-owned, for-profit enterprises doing a majority of its business in the United States. RC3 applications may be given funding priority if the applicant organization is associated with an enterprise that is of small size (e.g., 500 or fewer employees), and/or of limited resources, such as an early-stage company, and/or one positioned for receiving funding or in-kind support from a third-party investor and/or strategic partner. The RC3 SPAN program is not intended to support “upstream” R&D for doing feasibility testing of an innovative idea or to conduct early-stage R&D as an extension of such ideas. (Projects such as these should be submitted under the NIH SBIR/STTR programs.)
RC4	Research Projects	High Impact Research and Research Infrastructure Programs—Multi-Yr Funding	To support multi-year funded research with high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code could support either a specific research question or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future. It is the multi-year funded companion activity code to the existing RC2; thus ICs need OER prior approval to use the RC4.
RF1	Research Projects	Multi-Year Funded Research Project Grant	To support a discrete, specific, circumscribed project to be performed by the named investigator(s) in an area representing specific interest and competencies based on the mission of the agency, using standard peer review criteria. This is the multi-year funded equivalent of the R01 but can be used also for multi-year funding of other research project grants such as R03, R21 as appropriate.
RL1	Research Projects	Linked Research project Grant	To support a discrete, specified, circumscribed project that is administratively linked to another project or projects, and to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. An RL1 award may only be disaggregated from U54 application and organizations may not apply for an RL1, Linked Research Project Grant. The RL1 activity code is used in Lieu of the R01 for those programs that offer linked awards.
RL2	Research Projects	Linked Exploratory/Development Grant	To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time). The grant is administratively linked to another project or projects. An RL2 award may only be disaggregated from a U54 application and organizations may not apply for an RL2, Linked Exploratory/Development Grant. The RL2 activity code is used in lieu of the R21 for those programs that offer linked awards.
RL5	Research Projects	Linked Education Project	For support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation. The grant is administratively linked to another project or projects. A RL5 award may only be disaggregated from a U54 application and organizations may not apply for an RL5, Linked Education Project. The RL5 is used in lieu of the R25 for those programs that offer linked awards.
RL9	Research Projects	Linked Research Training Award	To support comprehensive interdisciplinary research training programs at the undergraduate, pre-doctoral and/or postdoctoral levels, by capitalizing on the infrastructure of existing multidisciplinary and interdisciplinary research programs. The RL9 is for trainees who do not meet the qualifications for NRSA authority. The training program is administratively linked to another project or projects. An RL9 award may only be disaggregated from a U54 application and organizations may not apply for an RL9, Linked Research Training Award. The RL9 is used in lieu of the R90 for those programs that offer linked awards.
RM1	Research Projects	Research Project with Complex Structure	To support a large-scale research project with a complex structure that cannot be appropriately categorized into an available single component activity code. The performance period may extend up to seven years but only through the established deviation request process. ICs desiring to use this activity code for programs greater than 5 years must receive OPERA prior approval through the deviation request process.
RS1	Research Projects	Programs to Prevent the Emergence and Spread of Antimicrobial Resistance in the United States	Develop, implement, and evaluate an antimicrobial project to prevent and control the emergence, prevalence, and spread of antimicrobial resistance in rural areas, and microbiologic mechanisms of dissemination of antimicrobial resistance genes and the relationship to antimicrobial drug use.
U2R	Cooperative Agreements	International Research Training Cooperative Agreements	Cooperative agreement mechanism for D43 to support research training programs for US and foreign professionals and students to strengthen global health research and international research collaboration.
U3R	Research Projects	NIH Small Research Grant Program (Cooperative Agreement)	This grant mechanism will support small research projects that can be carried out in a short period of time with limited resources and will be used as the companion cooperative agreement activity code to the R03.
UR6	Cooperative Agreements	Prevention Intervention Research on Substance Abuse in Children Cooperative Agreements	In cooperation with public and private nonprofit and for-profit organizations, to support research to determine the most effective interventions to change the developmental course of early predictor markers for substance abuse in children at several defined developmental stages.
UR8	Cooperative Agreements	Applied Research in Emerging Infections-(including Tick-borne Diseases) Cooperative Agreements	In cooperation with eligible organizations, to research emerging infections, such as tick borne diseases, through epidemiological studies and development and evaluation of diagnostic tests. Associated grant program under Activity Code RR8.

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