NIH Guide to Grants and Contracts

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Results: 11389 to 11413 of 11975

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Temporal Dynamics of Neurophysiological Patterns as Potential Targets for Treating Cognitive Deficits in Brain Disorders (R01) - PAR-14-153

Organization: NIMH 

Posting Date: 03-14-2014 

Expiration Date: 05-08-2017 

Activity Code: R01 

Summary: A rich body of evidence suggests that cognitive processes are associated with particular patterns of neural activity. These data indicate that oscillatory rhythms, their co-modulation across frequency bands, spike-phase correlations, spike population dynamics, and other patterns might be useful drivers of therapeutic development for cognitive improvement in neuropsychiatric disorders. This initiative encourages applications to test whether modifying electrophysiological patterns during behavior can improve cognitive abilities. Applications should use experimental designs that incorporate active manipulations to address at least one, and ideally more, of the following topics: (1) in behaving animals, determine which parameters of neural coordination, when manipulated in isolation, improve particular aspects of cognition; (2) in animals or humans, determine how particular abnormalities at the cellular or molecular level, such as specific receptor dysfunction, affect the coordination of electrophysiological patterns during behavior; (3) determine whether in vivo, systems-level electrophysiological changes in behaving animals predict analogous electrophysiological and cognitive improvements in normal humans or clinical populations; and (4) use systems-level computational modeling to develop a principled understanding of the function and mechanisms by which oscillatory and other electrophysiological temporal dynamic patterns unfold across the brain (cortically and subcortically) to impact cognition.  

Temporal Dynamics of Neurophysiological Patterns as Potential Targets for Treating Cognitive Deficits in Brain Disorders (R21) - PAR-14-158

Organization: NIMH 

Posting Date: 03-14-2014 

Expiration Date: 05-08-2017 

Activity Code: R21 

Summary: A rich body of evidence suggests that cognitive processes are associated with particular patterns of neural activity. These data indicate that oscillatory rhythms, their co-modulation across frequency bands, spike-phase correlations, spike population dynamics, and other patterns might be useful drivers of therapeutic development for cognitive improvement in neuropsychiatric disorders. This initiative encourages applications to test whether modifying electrophysiological patterns during behavior can improve cognitive abilities. Applications should use experimental designs that incorporate active manipulations to address at least one, and ideally more, of the following topics: (1) in behaving animals, determine which parameters of neural coordination, when manipulated in isolation, improve particular aspects of cognition; (2) in animals or humans, determine how particular abnormalities at the cellular or molecular level, such as specific receptor dysfunction, affect the coordination of electrophysiological patterns during behavior; (3) determine whether in vivo, systems-level electrophysiological changes in behaving animals predict analogous electrophysiological and cognitive improvements in normal humans or clinical populations; and (4) use systems-level computational modeling to develop a principled understanding of the function and mechanisms by which oscillatory and other electrophysiological temporal dynamic patterns unfold across the brain (cortically and subcortically) to impact cognition.  

Temporomandibular Joint and Muscle Disorders: Pathophysiological Mechanisms Linking Comorbid Conditions (R01) - PA-06-188

Organization: NIDCR 

Posting Date: 03-01-2006 

Expiration Date: 01-03-2007 

Activity Code: R01 

Summary: The purpose of this program announcement is to stimulate research on discovering etiological and pathophysiological mechanisms underlying a set of chronic, comorbid conditions associated with temporomandibular joint and muscle disorders (TMJMDs). TMJMDs are a complex collection of diseases involving one or more tissues of the TMJ and facial musculature. Primary symptoms include chronic pain in facial muscles and limited and painful movement of the jaw. In addition, these and other symptoms of TMJMD can occur together with other chronic illnesses such as fibromyalgia, atypical face pain, trigeminal neuralgia, chronic fatigue syndrome, multiple chemical sensitivity, irritable bowel syndrome, complex regional pain syndrome, migraine headache, speech hearing, swallowing, balance, smell, and taste disorders, and certain cardiovascular diseases. This program announcement seeks research applications that use state-of-the-art, multidisciplinary and interdisciplinary approaches to discover molecular, physiological, and behavioral mechanisms responsible for the overlapping symptoms manifested in the set of disorders that may co-exist with TMJMD. These applications may have as their research focus the chronic, comorbid conditions themselves or TMJMDs, provided that the aims and goals of the project are to discover biological mechanisms linking the comorbidities. While the overarching goal of this announcement is to arrive at a better understanding of potential mechanisms underlying TMJMDs as related to the variety of comorbidities associated with them, it is expected that no single research project will be able to accomplish this. Applicants are, therefore, encouraged to focus their attention on a particular pathway and a specific disease that is comorbid with TMJMD.  

Temporomandibular Joint and Muscle Disorders: Pathophysiological Mechanisms Linking Comorbid Conditions (R01) - PA-07-150

Organization: NIDCR 

Posting Date: 12-13-2006 

Expiration Date: 05-08-2009 

Activity Code: R01 

Summary: -Purpose. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research on discovering etiological and pathophysiological mechanisms underlying a set of chronic, comorbid conditions associated with temporomandibular joint and muscle disorders (TMJMDs). TMJMDs are a complex collection of diseases involving one or more tissues of the TMJ and facial musculature. Primary symptoms include chronic pain in facial muscles and limited and painful movement of the jaw. In addition, these and other symptoms of TMJMD can occur together with other chronic illnesses such as fibromyalgia, atypical face pain, trigeminal neuralgia, chronic fatigue syndrome, multiple chemical sensitivity, irritable bowel syndrome, complex regional pain syndrome, migraine headache, speech hearing, swallowing, balance, smell, and taste disorders, and certain cardiovascular diseases. This program announcement seeks research applications that use state-of-the-art, multidisciplinary and interdisciplinary approaches to discover molecular, physiological, and behavioral mechanisms responsible for the overlapping symptoms manifested in the set of disorders that may co-exist with TMJMD. These applications may have as their research focus the chronic, comorbid conditions themselves or TMJMDs, provided that the aims and goals of the project are to discover biological mechanisms linking the comorbidities. While the overarching goal of this announcement is to arrive at a better understanding of potential mechanisms underlying TMJMDs as related to the variety of comorbidities associated with them, it is expected that no single research project will be able to accomplish this. Applicants are, therefore, encouraged to focus their attention on a particular pathway and a specific disease that is comorbid with TMJMD. -Mechanism of Support. This FOA will utilize the Research Project Grant (R01) award mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-267 and PA-06-268, that solicit applications under the Small Research (R03) and the Exploratory/Developmental (R21) grant mechanisms, respectively. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. 

Temporomandibular Joint and Muscle Disorders: Pathophysiological Mechanisms Linking Comorbid Conditions (R03) - PA-06-267

Organization: NIDCR 

Posting Date: 03-24-2006 

Expiration Date: 05-08-2009 

Activity Code: R03 

Summary: -The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research on discovering etiological and pathophysiological mechanisms underlying a set of chronic, comorbid conditions associated with temporomandibular joint and muscle disorders (TMJMDs). TMJMDs are a complex collection of diseases involving one or more tissues of the TMJ and facial musculature. Primary symptoms include chronic pain in facial muscles and limited and painful movement of the jaw. In addition, these and other symptoms of TMJMD can occur together with other chronic illnesses such as fibromyalgia, atypical face pain, trigeminal neuralgia, chronic fatigue syndrome, multiple chemical sensitivity, irritable bowel syndrome, complex regional pain syndrome, migraine headache, speech hearing, swallowing, balance, smell, and taste disorders, and certain cardiovascular diseases. This program announcement seeks research applications that use state-of-the-art, multidisciplinary and interdisciplinary approaches to discover molecular, physiological, and behavioral mechanisms responsible for the overlapping symptoms manifested in the set of disorders that may co-exist with TMJMD. These applications may have as their research focus the chronic, comorbid conditions themselves or TMJMDs, provided that the aims and goals of the project are to discover biological mechanisms linking the comorbidities. While the overarching goal of this announcement is to arrive at a better understanding of potential mechanisms underlying TMJMDs as related to the variety of comorbidities associated with them, it is expected that no single research project will be able to accomplish this. Applicants are, therefore, encouraged to focus their attention on a particular pathway and a specific disease that is comorbid with TMJMD. - The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. -The R03 is intended to support small research projects that can be carried out in a short period of time with limited resources. The R03 is not renewable. -The total amount to be awarded and the anticipated number of awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. -Budgets for direct costs of up to $50,000 per year and a project duration of up to two years may be requested for a maximum of $100,000 direct costs over a two-year project period. -The types of mechanisms: This FOA will utilize the Small Research Grant (R03) mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-188 that solicits applications under the R01 grant mechanism and PA-06-268 that solicits applications under the R21 mechanism. -Eligible organizations: For-profit organizations; non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of State government; units of local government; eligible institutions of the Federal government; domestic institutions; foreign institutions; faith-based or community-based organizations; units of State Tribal government; and units of Local Tribal government. -Eligible Project Director/Principal Investigators (PD/PIs): Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. -Applicants may submit more than one application, provided each application is scientifically distinct.  

Temporomandibular Joint and Muscle Disorders: Pathophysiological Mechanisms Linking Comorbid Conditions (R21) - PA-06-268

Organization: NIDCR 

Posting Date: 03-24-2006 

Expiration Date: 05-08-2009 

Activity Code: R21 

Summary: -The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research on discovering etiological and pathophysiological mechanisms underlying a set of chronic, comorbid conditions associated with temporomandibular joint and muscle disorders (TMJMDs). TMJMDs are a complex collection of diseases involving one or more tissues of the TMJ and facial musculature. Primary symptoms include chronic pain in facial muscles and limited and painful movement of the jaw. In addition, these and other symptoms of TMJMD can occur together with other chronic illnesses such as fibromyalgia, atypical face pain, trigeminal neuralgia, chronic fatigue syndrome, multiple chemical sensitivity, irritable bowel syndrome, complex regional pain syndrome, migraine headache, speech hearing, swallowing, balance, smell, and taste disorders, and certain cardiovascular diseases. This program announcement seeks research applications that use state-of-the-art, multidisciplinary and interdisciplinary approaches to discover molecular, physiological, and behavioral mechanisms responsible for the overlapping symptoms manifested in the set of disorders that may co-exist with TMJMD. These applications may have as their research focus the chronic, comorbid conditions themselves or TMJMDs, provided that the aims and goals of the project are to discover biological mechanisms linking the comorbidities. While the overarching goal of this announcement is to arrive at a better understanding of potential mechanisms underlying TMJMDs as related to the variety of comorbidities associated with them, it is expected that no single research project will be able to accomplish this. Applicants are, therefore, encouraged to focus their attention on a particular pathway and a specific disease that is comorbid with TMJMD. -The types of mechanisms: This FOA will utilize the Exploratory/Developmental (R21) grant mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-188, that solicits applications under the R01 mechanism and PA-06-267 that solicits applications under the R03 mechanism. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. -Eligible organizations: For profit organizations; Non-profit organizations; Public or private institutions, such as universities, colleges, hospitals and laboratories; Units of State government; Units of local government; Eligible institutions of the Federal government; Domestic institutions; Foreign institutions; Faith-based or community-based organizations; Units of State Tribal government; and Units of Local Tribal government.  -Eligible Project Directors/Principal Investigators (PD/PIs): Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. -Applicants may submit more than one application, provided each application is scientifically distinct.  

Test & Evaluation Grant for Integrated Advanced Information Management Systems (IAIMS) - PAR-05-077

Organization: NLM 

Posting Date: 03-25-2005 

Expiration Date: 05-08-2008 

Activity Code: R24 

Summary: - Integrated advanced information systems (IAIMS) are comprehensive trans-organizational information management structures. In an IAIMS environment, organizations apply proven management practices and appropriate expertise about informatics and information services in order to link and relate the published biomedical knowledge base with clinical, research, educational and administrative, information, using computers and networks. - The National Library of Medicine (NLM) provides IAIMS grants to health-related institutions and organizations that seek assistance for projects to plan, deploy, evaluate and sustain a comprehensive information environment that supports organizational mission activities. Implementing an IAIMS information environment that crosses organizational and disciplinary boundaries is a complex task. Professionals and consumers need ready access to usable, useful, reliable information to guide their decisions and learning. For this reason, NLM's IAIMS grant program has a fundamental area of interest, context-appropriate information. - There are three different IAIMS grants: Planning, Test & Evaluation, and Operations. This program announcement describes the IAIMS Test & Evaluation (T&E) grant. The purpose of the IAIMS T&E grant is to support small-scale implementations and feasibility tests of approaches for delivering context appropriate information on a larger scale. - IAIMS is not a grant program for the selection and installation of an electronic health record system or laboratory reporting system or other single-purpose information tool. IAIMS work usually involves integrating an array of commercial products (which may include electronic health record systems or electronic full-text journals) with local systems, resources and services and Internet-based information to create a single point of access. - Because the nature and scope of the proposed work will vary from application to application, it is anticipated that the size and duration of each award will vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. - The IAIMS T&E grant uses the R24 grant mechanism. Applicants may request up to $100,000 per year in direct costs for one or two years. - U.S. public and private, non-profit institutions engaged in health administration and education, biomedical research, or clinical care are eligible to apply. - Individuals with the skills, knowledge, and resources necessary to carry out the proposed project are invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - An applicant may submit more than one IAIMS T&E grant application, but applications received in the same grant cycle must be distinctly different from one another. Applications received in the same grant cycle will compete against one another for funds. - Application materials, including special instructions and a link to the downloadable application form, are available on the NLM Extramural Programs Division web site at http://www.nlm.nih.gov/ep/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088 

Testing Interventions for Health-Enhancing Physical Activity (R01 - Clinical Trial Optional) - PAR-17-306

Organization: ODP 

Posting Date: 10-10-2017 

Expiration Date: 10-17-2017 

Activity Code: R01 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to fund highly innovative and promising research that tests multi-level physical activity intervention programs acting on at least two levels of the socio-ecological model and designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. This FOA provides support for up to 5 years for research planning, intervention delivery, and follow-up activities. 

Testing Interventions for Health-Enhancing Physical Activity (R01) - PAR-14-315

Organization: ODP 

Posting Date: 08-13-2014 

Expiration Date: 09-08-2017 

Activity Code: R01 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to fund highly innovative and promising research that tests multi-level intervention programs of 1 to 2 years in length that are designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. This FOA provides support for up to 5 years for research planning, intervention delivery, and follow-up activities. 

Testing Multi-Level Interventions to Improve Blood Pressure Control in Minority Racial/Ethnic, Low Socioeconomic Status, and/or Rural Populations (UH2/UH3) - RFA-HL-15-021

Organization: NHLBI 

Posting Date: 12-08-2014 

Expiration Date: 02-20-2015 

Activity Code: UH2/UH3 

Summary: This funding opportunity announcement (FOA) solicits applications to fund up to two patient-centered comparative effectiveness clinical trials using a UH2/UH3 cooperative agreement mechanism. This initiative is supported by the Hypertension Disparities Reduction Program Partnership (HDRPP), a research partnership between NHLBI, NINDS, and the Patient-Centered Outcomes Research Institute (PCORI), with funds provided by PCORI to the NIH. The research initiative aims to reduce disparities in hypertension, a leading cause of cardiovascular disease that disproportionately affects certain populations including racial and ethnic minorities, individuals with low socioeconomic status, and rural communities. Approximately 30% of adults in the U.S. have hypertension, and of these, more than half have uncontrolled hypertension. The purpose of the FOA is to compare alternative, evidence-based approaches to reduce inadequate control of hypertension among high risk populations, including racial/ethnic minority groups, patients with low socioeconomic status (SES), and individuals residing in rural geographical areas with an above average lifetime risk of cardiovascular disease (CVD).  

Testing Stem Cell Therapy in Mouse Models of Premature Aging - PA-05-136

Organization: NIA 

Posting Date: 07-13-2005 

Expiration Date: 11-02-2006 

Activity Code: R01 R21 

Summary: - Through this PA, the NIA is encouraging applications to test stem cell therapies in mouse models of accelerated aging. - Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary , with the exception of R21 awards, whose duration is fixed at 2 years . The total amount awarded and the number of awards will depend upon the mechanism, quality, duration, and costs of the applications received. - This PA will use NIH research project grant (R01) and exploratory/developmental research grant (R21) award mechanism(s). - Eligible organizations include: - For-profit organizations - Non-profit organizations - Public or private institutions, such as universities, colleges, hospitals, and laboratories - Units of State government - Units of local government - Eligible agencies of the Federal government - Foreign Institutions - Domestic Institutions - Eligible principal investigators include any individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - Applicants may submit more than one application, provided they are scientifically distinct. - Application materials may be obtained from the NIH web site at http://grants.nih.gov/grants/funding/phs398/phs398.html - Telecommunications for the hearing impaired is available at: TTY 301-451-0088  

Testing Stem Cell Therapy in Mouse Models of Premature Aging (R21) - PA-06-137

Organization: NIA 

Posting Date: 03-10-2006 

Expiration Date: 09-08-2008 

Activity Code: R21 

Summary: Through this Funding Opportunity Announcement (FOA), the NIA is encouraging applications to test stem cell therapies in mouse models of accelerated aging. 

Testing Tobacco Products Promoted to Reduce Harm (R01) - PA-07-174

Organization: NCI 

Posting Date: 12-15-2006 

Expiration Date: 05-08-2009 

Activity Code: R01 

Summary: -Purpose. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate multidisciplinary research on potential reduced-exposure tobacco products, both smoked and smokeless, through the interplay of basic, biological, and behavioral research, surveillance, and epidemiology. The tobacco industry is currently promoting some new products with claims that they are less harmful or less addictive because these products purportedly deliver lower amounts of toxic, carcinogenic, and/or addictive agents to the user compared with conventional products. However, to date, the scientific evidence is insufficient to evaluate whether these new products actually reduce the users exposure or risk for tobacco-related diseases. The key research question of this FOA is, Do potential reduced-exposure tobacco products provide a truly, less-harmful alternative to conventional tobacco products, both on the individual and population level? -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-06-361, that solicits applications under the NIH Exploratory/Developmental Grant (R21) grant mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. 

Testing Tobacco Products Promoted to Reduce Harm (R01) - PA-09-046

Organization: NCI 

Posting Date: 02-19-2009 

Expiration Date: 05-08-2012 

Activity Code: R01 

Summary: Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI) and the National Institute on Drug Abuse (NIDA),invites applications that propose multidisciplinary research on potential reduced-exposure tobacco products, both smoked and smokeless. The multidisciplinary studies can span basic, biological, behavioral, surveillance, and epidemiology research. The tobacco industry is currently promoting several new products with claims that they: a) are less either harmful or less addictive; and b) purportedly deliver lower amounts of toxic, carcinogenic, and/or addictive agents to the user compared with conventional products. However, to date, the scientific evidence is insufficient to evaluate whether these new products actually reduce the users exposure or risk for tobacco-related diseases. The overarching goal of this FOA is to determine whether potential reduced-exposure tobacco products provide a truly, less-harmful alternative to conventional tobacco products, both at the individual and population level. Mechanism of Support. This FOA uses the NIH research project R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-09-047 that encourages applications under the NIH Exploratory/Developmental (R21) Grant mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period. The total project period for an application submitted in response to this funding opportunity may not exceed 5 years.Applicants for an R01 award are not limited in dollars but need to reflect the actual needs of the proposed project. Application Research Plan Component Length: The R01 application Research Plan component of the PHS398 (Items 2-5) may not exceed 25 pages, including tables, graphs, figures, diagrams, and charts (see also http://grants.nih.gov/grants/funding/funding_program.htm). Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A. are eligible to apply. Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/ organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of PDs/PIs. More than one PD/PI (i.e., multiple PDs/PIs) may be designated on the application. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Resubmissions. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement).See new NIH policy on resubmission (amended) applications (NOT-OD-09-003, NOT-OD-09-016). 

Testing Tobacco Products Promoted to Reduce Harm (R21) - PA-06-361

Organization: NCI 

Posting Date: 04-18-2006 

Expiration Date: 05-08-2009 

Activity Code: R21 

Summary: The purpose of this funding opportunity announcement (FOA) is to stimulate multidisciplinary research on potential reduced-exposure tobacco products, both smoked and smokeless, through the interplay of basic, biological, behavioral, surveillance, and epidemiology research. The tobacco industry is currently promoting some new products with claims that they are less harmful or less addictive because these products purportedly deliver lower amounts of toxic, carcinogenic, and/or addictive agents to the user compared with conventional products. However, to date, the scientific evidence is insufficient to evaluate whether these new products actually reduce the users exposure or risk for tobacco-related diseases. The key research question of this FOA is, Do potential reduced-exposure tobacco products provide a truly, less-harmful alternative to conventional tobacco products, both on the individual and population level? -Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications; therefore, the anticipated number of awards is not known. -This FOA utilizes the NIH exploratory/developmental (R21) grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-04-103, which is now a solicitation for applications using the NIH Research Project Grant (R01) mechanism only. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -The total project period for an application submitted in response to this funding opportunity may not exceed 2 years. Direct costs are limited to $275,000 over an R21 2-year period, with no more than $200,000 in direct costs allowed in any single year. -Eligible organizations include: for-profit organizations; non-profit organizations; public or private institutions, such as universities, colleges, hospitals and laboratories; units of State governments; units of local governments; eligible institutions of the Federal government; domestic institutions; foreign institutions; and faith-based or community-based organizations; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); and Indian/Native American Tribally Designated Organization. -Eligible Project Directors/Principal Investigators (PDs/PIs) include any individual from the institution with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -Applicants may submit more than one application, provided each application is scientifically distinct.  

Testing Tobacco Products Promoted to Reduce Harm (R21) - PA-09-047

Organization: NCI 

Posting Date: 02-19-2009 

Expiration Date: 05-08-2012 

Activity Code: R21 

Summary: Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI) and the National Institute on Drug Abuse (NIDA), invites applications that propose multidisciplinary research on potential reduced-exposure tobacco products, both smoked and smokeless. The multidisciplinary studies can span basic, biological, behavioral, surveillance, and epidemiology research. The tobacco industry is currently promoting several new products with claims that they: a) are less either harmful or less addictive; and b) purportedly deliver lower amounts of toxic, carcinogenic, and/or addictive agents to the user compared with conventional products. However, to date, the scientific evidence is insufficient to evaluate whether these new products actually reduce the users exposure or risk for tobacco-related diseases. The overarching goal of this FOA is to determine whether potential reduced-exposure tobacco products provide a truly, less-harmful alternative to conventional tobacco products, both at the individual and population level. Mechanism of Support. This FOA utilizes the NIH exploratory/developmental (R21) grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-09-046, which uses the NIH Research Project Grant (R01) mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications; therefore, the anticipated number of awards is not known Budget and Project Period. The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. Research Plan Component Length: Items 2-5 of the PHS398 Research Plan component of the R21 application may not exceed 15 pages, including tables, graphs, figures, diagrams, and charts. For information on NIH Exploratory/Developmental Research Grant Award (R21). Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A. are eligible to apply. Eligible Project Directors/Principal Investigators (PDs/PIs). Include Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of PDs/PIs. More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application. Number of Applications. Applicants may submit more than one application, provided that each application is scientifically distinct. Resubmissions. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement).See new NIH policy on resubmission (amended) applications (NOT-OD-09-003, NOT-OD-09-016). 

The Adipogenic Phenotype in Aging Musculoskeletal Tissues - RFA-AG-06-003

Organization: NIA 

Posting Date: 09-01-2005 

Expiration Date: 11-16-2005 

Activity Code: R01 

Summary: This RFA invites grant applications for basic research on aging-related mechanisms of formation and function of adipocytes within tissues of the aging musculoskeletal system, as well as effects of those adipocytes on the function of aging bone, muscle and cartilage. Studies that lead to understanding of the mechanism(s) by which adipocytes, and parenchymal cells that exhibit storage of fat, increase in tissues of the musculoskeletal system as a result of aging, and also determine the properties and effects of adipose and adipose-like cells in these tissues are specifically requested. Projects envisioned for support should investigate mechanisms and sources of cells involved in adipogenesis localized to aged musculoskeletal tissues and, as well, the properties of the increased adipose tissue and effects of increased adipogenesis on the surrounding aged musculoskeletal tissues. Multidisciplinary collaborations are likely to be necessary and are encouraged.  

The American College of Radiology Imaging Network (ACRIN) (Limited Competition U01) - RFA-CA-07-505

Organization: NCI 

Posting Date: 02-09-2007 

Expiration Date: 04-11-2007 

Activity Code: U01 

Summary: -The Cancer Imaging Program, Division of Cancer Diagnosis and Treatment, the National Cancer Institute (NCI), invites applications for a limited competition Request for Applications (RFA) for the continued support of a unique, multi-center imaging network -- the American College of Radiology Imaging Network (ACRIN; hereafter referred to as the “Network”). -The overall objective of this limited competition RFA is to improve the use of imaging in cancer research and cancer care management through further support for the activities of the Network. The Network should continue to focus on investigator-initiated research involving key aspects of imaging technology assessment in oncology. Specific goals for the Network include: 

The Application of Big Data Analytics to Drug Abuse Research (R01) - PA-16-119

Organization: NIDA 

Posting Date: 03-09-2016 

Expiration Date: 01-25-2018 

Activity Code: R01 

Summary: The purpose of this FOA is to encourage the application of Big Data analytics to reveal deeper or novel insights into the biological and behavioral processes associated with substance abuse and addiction.NIDA recognizes that to accelerate progress toward understanding how the human brain and behavior is altered by chronic drug use and addiction, it is vital to develop more powerful analytical methods and visualization tools that can help capture the richness of data being generated from genetic, epigenetic, molecular, proteomic, metabolomic, brain-imaging, micro-electrode, behavioral, clinical, social, services, environmental studies as well as data generated from electronic health records.Applications for this FOA should develop and/or utilize computational approaches for analyzing large, complex datasets acquired from drug addiction research.The rapid increase of technologies to acquire unprecedented amounts of neurobiological and behavioral data, and an expanding capacity to store those data, results in great opportunity to bring to bear the power of the computational methods of Big Data analytics on drug abuse and addiction.  

The Bernard Osher Foundation/NCCAM CAM Practitioner Research Career Development Award (K01) - PAR-07-003

Organization: NCCIH  (formerly NCCAM)

Posting Date: 10-05-2006 

Expiration Date: 01-08-2009 

Activity Code: K01 

Summary: -The goals of the NIH-supported career development programs are to help ensure that diverse pools of highly trained scientists are available in adequate numbers and in appropriate research areas to address the Nations biomedical, behavioral, and clinical research needs.For this specific announcement the research area of interest is complementary and alternative medicine (CAM). -The specific purpose ofthis research career development Award (K01) is to provide research training support for CAM Practitioners with clinical doctorates, who have had limited opportunities for research training, but a strong desire to pursue a career in CAM research. The long term goal is to encourage more CAM practitioners to enter research careers, thus enriching CAM research through their experience and knowledge of CAM practice. This award will provide support and protected time (three, four, or five years) for intensive, supervised career development research experience in the biomedical, behavioral, or clinical sciences related to complementary and alternative medicine (CAM). Awards are not renewable, nor are they transferable from one principal investigator to another. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the numbers, quality, duration, and costs of the applications received.  

The Bernard Osher Foundation/NCCAM CAM Practitioner Research Career Development Award (K01) - PAR-09-072

Organization: NCCIH  (formerly NCCAM)

Posting Date: 01-07-2009 

Expiration Date: 01-08-2010 

Activity Code: K01 

Summary: Purpose: The specific purpose ofthis research career development Award (K01) is to provide research training support for CAM Practitioners with clinical doctorates, who have had limited opportunities for research training, but a strong desire to pursue a career in CAM research. The long term goal is to encourage more CAM practitioners to enter research careers, thus enriching CAM research through their experience and knowledge of CAM practice. This award will provide support and protected time (three, four, or five years) for intensive, supervised career development research experience in the biomedical, behavioral, or clinical sciences related to complementary and alternative medicine (CAM). Mechanism of Support: This Funding Opportunity Announcement (FOA) will utilize the NIH Mentored Research Scientist Development Award (K01) mechanism. Funds Available and Anticipated Number of Awards: The total amount to be awarded by NCCAM and the number of awards will depend upon the quality and merit of applications received and the availability of funds. 

The BioSense Initiative to Improve Early Event Detection - RFA-PH-05-126

Organization: NCPHI 

Posting Date: 06-14-2005 

Expiration Date: 07-16-2005 

Activity Code: R01 

Summary: The Centers for Disease Control and Prevention (CDC) invites applications for research in support of the BioSense Initiative to improve early detection of disease outbreaks of public health importance . This project will award approximately $1.8 million in total costs to fund 3 - 5 grants. The BioSense Initiative seeks to develop the science of early event detection and situational awareness through the secondary use of existing information in electronic, health-related databases. This field is still early in its development and this Program seeks to support research to make it as useful and efficient as possible for public health purposes. The Program focuses on three broad areas: (1) increasing the sensitivity and specificity of detection algorithms, (2) establishing the efficacy of different data sources, and (3) developing software methods and components compatible with the Public Health Information Network Preparedness Initiative functional and technical specifications (http://www.cdc.gov/phin). Responders should focus on one key question or problem . Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. CDC encourages individuals from all racial and ethnic groups as well as individuals with disabilities to apply for this program. Only one application per Principal Investigator will be funded under this announcement.  

The Biology of Estrogen Receptor-Negative Breast Cancer in Various Racial and Ethnic Groups (U01) - RFA-CA-09-026

Organization: NCI 

Posting Date: 08-13-2009 

Expiration Date: 01-06-2010 

Activity Code: U01 

Summary: Purpose.The purpose of this funding opportunity announcement (FOA) is to promote the systematic study of the biology of estrogen receptor (ER)-negative human breast cancers, the characterization of their molecular features, the signaling pathways and networks that support their growth, as well as to identify differences in the biology of ER-negative breast tumors among racial and ethnic groups. The information will be crucial in developing early detection and intervention strategies. This initiative will support studies on: the basic biology of ER-negative breast cancers and delineation of differences that exist between ER-positive and ER-negative breast cancers; the identification of the subtypes or heterogeneity that exist within ER-negative breast cancers; and the determination of whether the biology of ER-negative breast tumors differs across racial and ethnic groups. In order to address these goals, the National Cancer Institute (NCI) solicits applications from collaborative teams of interdisciplinary investigators focused on characterizing the biologic drivers, including genetic, epigenetic, molecular, and cellular factors, of ER-negative human breast cancer development and progression. Mechanism of Support. This FOA will utilize the NIH U01 cooperative agreement mechanism. Funds Available and Anticipated Number of Awards. The NCI expects to commit approximately $10 million for 5 years to fund up to three awards.  

The Centers for Education and Research on Therapeutics (CERTs) - RFA-HS-05-014

Organization: AHRQ 

Posting Date: 10-26-2004 

Expiration Date: 03-12-2005 

Activity Code: U18 

Summary: The Centers for Education and Research on Therapeutics (CERTs) program is a merit-based, peer-reviewed program created in response to a legislative mandate to “conduct state-of-the-art research to increase awareness of: (1) new uses of drugs, biological products, and devices; (2) ways to improve the effective use of drugs, biological products, and devices; and (3) risks of new uses and risks of combinations of drugs and biological products.” Further, the legislation directs “CERTs to provide objective clinical information to the following individuals and entities: (1) health care practitioners and other providers of health care goods or services; (2) pharmacists, pharmacy benefit managers and purchasers; (3) health maintenance organizations and other managed health care organizations; (4) health care insurers and governmental agencies; and (5) patients and consumers.” Additionally the centers are to “investigate various ways to improve the quality of health care while reducing the cost of health care through an increase in the appropriate use of drugs, biological products, and devices and the prevention of adverse effects of drugs, biological products, and devices and the consequences of such effects, such as unnecessary hospitalizations.” Finally, the CERTs will “conduct research on the comparative effectiveness, cost-effectiveness, and safety of drugs, biological products, and devices.” The purpose of these awards is to expand the work of the existing CERTs program and address existing gaps to develop and implement research and create educational strategies for translating those research findings into improved clinical practices.  

The Central Processing of Taste Information (R01) - PA-07-094

Organization: NIDCD 

Posting Date: 11-27-2006 

Expiration Date: 05-08-2010 

Activity Code: R01 

Summary: -Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, solicits Research Project Grant (R01) applications from institutions/organizations studying the role of the central nervous system in the processing of taste information and the perception of taste quality.The purpose of this FOA is to foster basic and clinical research on the central mechanisms underlying the perception of taste quality.A broad range of experimental approaches is encouraged. The NIDCD encourages applications from investigators who are conducting research outside the field of gustation and who are using methodological approaches that have not been typically applied to but which would greatly promote scientific progress within the field. The NIDCD also encourages applications from new investigators in the early stages of establishing an independent research program. -Mechanism of Support. This FOA will utilize the Research Project Grant (R01) award mechanism -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. 

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