Investigator-Focused Awards

Purpose

These programs aim to accelerate transformative biomedical discoveries by funding exceptionally creative scientists and bold ideas.

Goals

• Support high-risk, high-reward research with potential for transformative impact
• Empower exceptionally creative investigators to pursue bold, unconventional ideas
• Shift focus from specific projects to investigator-driven innovation
• Foster new scientific directions and interdisciplinary approaches
• Enable innovation across career stages, from early-career to established leaders
• Accelerate breakthrough discoveries that might not emerge through traditional funding mechanisms

Benefits

• Provide substantial, multi-year funding stability
• Offer greater flexibility in how research is conducted and evolves over time
• Reduce administrative burden compared to standard NIH grants
• Encourage scientific creativity and exploration without strict predefined aims
• Enhance speed and agility of research progress
• Deliver prestige and visibility, helping attract and retain top talent

Programs

Investigator award programs support innovation across career stages, from early independence to established investigators, while encouraging new research directions and unconventional approaches

• Investigator-Focused Award (R35)
• NIH Director's Pioneer Award (DP1)
• NIH Director's New Innovator Awards (DP2)
• NIH Director's Pathfinder Award - Multi-Yr Funding (DP4)
• Early Independence Award (DP5)