National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Mission Statement

The NIDDK Mission is to conduct and support medical research and research training and to disseminate science-based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases, to improve people's health and quality of life.


Interest Areas

General Topics

NIDDK supports basic, translational, and clinical research across diabetes, endocrine, metabolic, digestive, kidney, urologic, hematologic, and obesity-related diseases. The institute also supports training and career development for academic and clinical researchers within these general areas.

NIDDK has three extramural programmatic divisions and one office, each with its own scope.  While the divisions each have scientific boundaries, some topics are crosscutting and may fit within more than one division.

Division of Digestive Diseases and Nutrition (DDN)

  • Supports research on digestive diseases affecting the alimentary tract, liver, and pancreas, as well as nutrition and obesity.

Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)

  • Supports research on type 1 and type 2 diabetes, metabolic disorders (including cystic fibrosis), endocrinology, obesity, neuroendocrinology, energy balance, and liver, fat, and endocrine tissue biology.

Division of Kidney, Urologic, and Hematologic Diseases (KUH)

  • Supports research on non-cancerous kidney, urinary tract conditions, and disorders of blood and blood-forming organs.

Office of Obesity Research (OOR)

  • Coordination of obesity-related research across NIDDK.

NIDDK also oversees the statutory Special Diabetes Program for Type 1 Diabetes on behalf of HHS, in collaboration with NIH Institutes and Centers, CDC, and the Diabetes Mellitus Interagency Coordinating Committee.

At a very high level, NIDDK seeks to:

  • Sustain strong funding for investigator-initiated research.
  • Invest in cross-cutting science applicable to multiple diseases.
  • Advance understanding of biological pathways and environmental factors in health and disease.
  • Support key clinical studies and trials for prevention, treatment, and cures.
  • Promote stakeholder engagement, including patients as research partners.
  • Encourage and support new investigators entering biomedical research careers.

Assistance Listing

Assistance listings are detailed public descriptions of federal programs used across government agencies that provide grants, loans, scholarships, insurance, and other types of assistance awards. They are maintained in the System for Award Management (SAM) and can be used to search for opportunities in Grants.gov.

View NIDDK Assistance Listing Numbers

  • 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research
  • 93.KRC - Diabetes, Digestive, Kidney Extramural Research - Research Centers
  • 93.KRP - Diabetes, Digestive, Kidney Extramural Research - Research Projects
  • 93.KRR - Diabetes, Digestive, Kidney Extramural Research - Other Research
  • 93.KSB - Diabetes, Digestive, Kidney Extramural Research - SBIR-STTR
  • 93.KT1 - Diabetes, Digestive, Kidney Extramural Research - Special Diabetes Program
  • 93.KTR - Diabetes, Digestive, Kidney Extramural Research - Training, Individual
  • 93.KTS - Diabetes, Digestive, Kidney Extramural Research - Training, Institutional

Highlighted Topics

Title Lead ICO Participating ICOs Posted Date Expiration Date

Funding Opportunities and Notices

Search for NIDDK’s funding opportunities and notices


ICO Funding Policies and Considerations

Visit NIH Fiscal Policies for NIH-wide information on appropriations and other budgetary information (salary limits, stipends, tuition/fees) and Funding Decisions to learn about NIH's consistent and unified approach for making funding decisions.

NIDDK Funding Policies and Considerations builds on that general information.


Additional Information by Funding Category

Administrative Supplements
In addition to our Administrative Supplements overview, consider the following NIDDK-specific information.
Administrative Supplement Interest Areas:

NIDDK has prioritized funding investigator-initiated grants at the highest possible level. 

  • The institute has little flexibility to support administrative supplements.
  • Given this prioritization, the number of successful administrative supplement applications will be low.
Administrative Supplement Due Dates:

NIDDK will accept and consider administrative supplement requests at any time. Requests received late in the fiscal year may be considered the following fiscal year.

Administrative Supplement Contact:

Program Contacts:

Grants Management Contact

Conferences and Meetings
In addition to our Conferences and Meetings overview, consider the following NIDDK-specific information.
Conferences and Meetings Interest Areas:

NIDDK R13 Conference Grants:

  • Primarily provide travel support for junior investigators and trainees to scientific meetings, conferences, and workshops.
  • Must address a critical need not met by societies or industry.
  • NIDDK does NOT support multi-year meetings.
  • Meeting theme must focus on cutting-edge NIDDK-relevant research topics.
  • Topic should not have been substantially covered by other conferences within the past year. Should foster cross-disciplinary engagement among investigators who do not typically interact.
  • Must provide strong training environment for NIDDK junior investigators/trainees.
  • For virtual meetings, applicants may request registration (full or partial) for junior investigators/trainees.
  • May consider partial support for virtual platform/packages if clearly tied to enhancing junior investigator/trainee access and experience.
Conferences and Meetings Budget Considerations:
  • NIDDK funding primarily supports travel and access for junior investigators/trainees to attend meetings within the mission interests of the NIDDK.
  • Meetings held outside of North America are not eligible for funding.
  • Indirect costs are generally not allowed.
Conferences and Meetings Key Date Considerations:

NIDDK will accept conference grant applications for all standard R13 due dates. Applicants are strongly encouraged to submit their application for the due date that is closest to one year prior to the planned meeting or conference.

Conferences and Meetings Project Period Considerations:

Multi-year requests are rarely considered and allowed only under special circumstances.

Conferences and Meetings Contacts:

Conference Grant Program Contacts

Grants Management Contact

Individual Career Development
In addition to our Individual Career Development, consider the following NIDDK-specific information.
Individual Career Development Interest Areas:
  • NIDDK supports applications from postdoctoral and non-tenured junior faculty conducting research in basic, translational, and/or patient-oriented research within the mission areas of the NIDDK.
  • NIDDK supports candidates for the following programs
    • Research Scientist Development Award (K01)
    • Clinical Investigator Award (K08)
    • Mentored Patient-Oriented Research Career Development Award (K23)
    • Mentored Quantitative Research Career Development Award (K25)
    • Career Transition Award (K99/R00)
  • Applicants are strongly encouraged to contact the appropriate NIDDK program staff well in advance of applying.
Individual Career Development Project Period Considerations:
NIDDK may limit project periods as follows:

NIDDK supports project periods up to 5 years.

Individual Career Development Salary Fringe Benefits:
  • NIDDK will support up to $90,000 in salary per year, plus fringe benefits for K01 and K25 applicants
  • NIDDK will support up to $100,000 in salary per year, plus fringe benefits for K08 and K23 applicants
  • NIDDK will provide support up to $90,000 total costs for the K99 phase and up to $249,000 total costs for the R00 phase for K99/R00 applicants.
    • During the K99 phase, NIDDK will provide:
      • up to $75,000 per year for salary
      • appropriate fringe benefits
Individual Career Development Other Program Related Expenses:
  • NIDDK will provide up to $25,000 per year in research support for K01 and K99 applicants.
  • NIDDK will provide up to $25,000 per year in research support for K08 applicants and up to $50,000 per year for K23 applicants.
  • NIDDK will provide up to $40,000 per year for K25 applicants

In addition to the above, NIDDK will provide up to an additional $1,500 to support travel to the NIDDK K Awardees’ Workshop during the award project period. 

Individual Career Development Research Effort Considerations:
  • In general, NIDDK expects candidates to commit a minimum of 75% of full-time professional effort (i.e., a minimum of 9 person-months) to their program of career development. 
  • Candidates who are surgeon-scientists in sub-specialties recognized by the American College of Surgeons, as well as transplant surgeons, may request a minimum of 50% full-time professional effort (6 person-months).
Individual Career Development Contacts:

Scientific Program Contacts

Division of Diabetes, Endocrinology and Metabolic Diseases 
Email: [email protected] 

Division of Digestive Diseases and Nutrition 
Email: [email protected]   

Division of Kidney, Urologic, and Hematologic Diseases 
Email: [email protected] 

Office of Obesity Research 
Email: [email protected]   

Grants Management Contact: 

Email: [email protected]

Individual Fellowship
In addition to our Individual Fellowships Overview, consider the following NIDDK-specific information.
Individual Fellowships Interest Areas:
  • NIDDK participates in the following Ruth L. Kirschstein National Research Service Award (NRSA) Fellowships
    • Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (F30)
    • Predoctoral Individual National Research Service Award (F31)
    • Postdoctoral Individual National Research Service Award (F32)
  • NIDDK will support students who have identified a dissertation project and an appropriate dissertation director, and training of postdoctoral M.D., Ph.D., or equivalent fellows, in an area of research supported by the Institute: diabetes, endocrinology, metabolic diseases; gastroenterology, hepatology, obesity, nutrition; and kidney, urologic, and hematologic disorders.
  • Ph.D. postdoctoral fellows with more than three years of research postdoctoral experience may wish to consider applying for the NIH Parent K01 Award.
  • Applicants are strongly encouraged to contact the appropriate NIDDK program director before beginning the process of applying for a fellowship.  
Individual Fellowships Budget Considerations:
Individual Fellowships Contacts:

Scientific Program Contact:

Division of Diabetes, Endocrinology and Metabolic Diseases 
Email: [email protected]   

Division of Digestive Diseases and Nutrition 
Email: [email protected]    

Division of Kidney, Urologic, and Hematologic Diseases 
Email: [email protected]   

Office of Obesity Research 
Email: [email protected]    

Grants Management Contact: 

Email: [email protected] 

Institutional Career Development
In addition to our Institutional Career Development, consider the following NIDDK-specific information.
Institutional Career Development Interest Areas:

NIDDK prioritizes institutional career development programs in two programmatic areas:

  • Non-malignant urology (KURe program): through institutional awards, to promote the career development of individuals with doctorate degrees (e.g. MD, DO, MD/PhD, or PhD) to prepare them for careers in basic, translational, and/or patient-oriented urologic research within the mission areas of NIDDK
  • Diabetes (DiabDOCS program): through a single national award, to promote the career development of clinician scientists to prepare them for careers in conducting innovative research into the causes and consequences of type 1 diabetes. The program will also support the career development of physicians whose research focuses on innovative projects in type 2 or other forms of diabetes, as co-funding permits.   

Applications focused on other NIDDK mission areas will not be supported.

Institutional Career Development Key Date Considerations:

KURe applications will be considered for funding for the May 2027 and May 2028 Council rounds.

DiabDOCS applications will be considered for funding for the May 2027 Council round.

Institutional Career Development Project Period Considerations:
NIDDK may limit project periods as follows:

Support can be requested for up to 5 years.

Institutional Career Development Salary Fringe Benefits:

For both programs:

NIDDK will provide up to $100,000 plus fringe per year for appointed scholars.

Institutional Career Development Other Program Related Expenses:

KURe

  • NIDDK will provide up to $50,000 in direct costs per year per scholar to support research development costs.  

    Allowable expenses include:

    • Research supplies and small equipment
    • Technical personnel
    • Tuition and fees
    • Travel
    • Statistical services
  • Travel funds should include travel to the annual CAIRIBU Meeting.
  • Effort for the PI/PD and faculty with significant program responsibilities is limited to 1.2 person months.  Administrative services are limited to 6.0 CM combined total effort.

DiabDOCS

  • NIDDK will provide up to $50,000 in direct costs per year per scholar to support research development costs.  
    • Allowable expenses are the same as listed above for KURe.
  • Up to $3,000 per year may be used for career development tuition and books
  • NIDDK may provide up to $70,000 to support an annual retreat for the scholars. Effort for the PD/PI and faculty with significant program responsibilities is limited to 4.5 person months. Administrative services are limited to 6.0 CM combined total effort
Institutional Career Development Research Effort Considerations:
  • Scholars are expected to devote a minimum of 9 person-months (75% of full-time professional effort) during the appointment on the K12 award.
  • Scholars who are urologic surgeons may request between 6 and 9 person-months (50% to 75%) of full-time professional effort.
Institutional Career Development Contacts:

Scientific Program Contacts:

Division of Diabetes, Endocrinology and Metabolic Diseases 
Email: [email protected] 

Division of Kidney, Urologic, and Hematologic Diseases 
Email: [email protected]  

Grants Management Contact: 

Email: [email protected]

Institutional Training
In addition to our Institutional Training, consider the following NIDDK-specific information.
Institutional Training Interest Areas:

NIDDK supports the following institutional training programs:

  • Institutional National Research Service Award (T32)  
    • Division of Diabetes, Endocrinology and Metabolic Diseases (DEM) and Division of Digestive Diseases and Nutrition (DDN) encourage institutions to propose programs designed to support the training of predoctoral students, postdoctoral fellows, or both, in the following research areas: diabetes, endocrinology, metabolic diseases; gastroenterology, hepatology, obesity, and nutrition.
  • Institutional Network Award for Promoting Kidney, Urologic, & Hematologic Research Training (U2C-TL1) 
    • Division of Kidney, Urologic and Hematologic Diseases (KUH) encourages institutions to propose programs designed to recruittrain, and retain the next generation of researchers and provide them with the coordinated support, resources, and networks they need to succeed and lead. The U2C cooperative component will provide administrative, networking, professional development resources, while the TL1 training component will allow the institution(s) to recruit and fund at least five highly competitive pre- and/or post-doctoral trainees engaged in KUH research. 
Institutional Training Participants:
NIDDK prioritizes funding for the following trainees:

For both the T32 and U2C-TL1 programs, NIDDK prioritizes appointments for predoctoral and postdoctoral trainees.

Institutional Training Key Date Considerations:
  • T32 applications will be considered during January Councils 
  • U2C-TL1 applications will be accepted for consideration as described in the Notice of Funding Opportunity.
Institutional Training Contacts:

Scientific Program Contacts:

Grants Management Contacts: 

Research Education
In addition to our Research Education overview, consider the following NIDDK-specific information.
Research Education Interest Areas:

NIDDK sponsors education grants for research experiences, short courses for skills development and mentoring activities and networks. 

Research Experiences: 

NIDDK supports research experiences for

  • high school students, undergraduates, and post baccalaureates to provide hands-on exposure to research, to reinforce their intent to graduate with a science degree, and/or to prepare them for graduate school admissions and/or careers in research;
  • graduate and medical, dental, nursing and other health professional students: to provide research experiences and related training not available through formal NIH training mechanisms
  • postdoctorates and medical residents: to extend their skills, experiences, and knowledge base. 

Courses for Skills Development: 

NIDDK supports advanced courses involving participants in a specific discipline or research area, clinical procedures for research, or specialized research techniques. NIDDK will not prioritize programs for syllabus and methods development.

Mentoring Activities & Networks: 

NIDDK supports programs that will equip individuals and cohorts of scholars with professional skills and networks that will allow them to transition to and succeed in independent research careers.     

Research Education Key Date Considerations:

Research Experiences applications are considered for funding during October Council. 

Research Education Participants:
NIDDK prioritizes funding for participants in the following areas:
  • Undergraduate
  • Predoctoral
  • Postdoctoral/Residency
  • Other
    • High school (for research experiences only)
    • Postbaccalaureates
Research Education Project Period Considerations:
NIDDK may limit project periods for specific education activities, as follows:

Maximum project period is 5 years.

Research Education Budget Considerations:
NIDDK may limit budgets for specific education activities, as follows:
  • Research Experiences: up to $150,000 direct costs per year
  • Courses, Curriculum & Methods: up to $100,000 direct costs per year
  • Mentoring Activities & Networks: up to $100,000 direct costs per year
Research Education Personnel, Participant, and Other Program-Related Costs:
NIDDK may limit awarded budgets for personnel, participant, and other costs, as follows:

Research Experiences:

  • Total allowable personnel (including consultants) cost is proportional to the number of participants in the program. For each participant, up to $4,500 (Direct Costs) is allowed for personnel (including consultant) costs per year. All personnel and consultant costs must be adequately justified and take into consideration yearly fluctuations in required effort.
  • Participant cost allowed: Round-trip travel to and from the R25 research experience site for non-local participants; Subsistence: up to $9,000 for 15-week, 40hrs per week program; Housing: up to $1,000, Research Expenses: up to $1,000.

Courses, Curriculum & Methods: 

  • Up to $100,000 direct costs per year

Mentoring Activities & Networks: 

NIDDK will contribute up to $10,000 per year for the following expenses: 

  • Mentor training courses for the PD/PI.
  • PD/PI and mentee travel to research meetings or mentorship training and networking events.
  • Registration fees for workshops, courses, or didactic training focused on career development activities for mentees.
  • Other relevant opportunities proposed by the applicant/awardee if well justified and approved by NIDDK officials.

Salary for secretarial and administrative assistants, etc. is not allowed.

Research Education Funding Instruments:
NIDDK does not award Research Education Cooperative Agreements (UE5)
NIDDK awards Research Education Grant Projects (R25)
Research Education Contacts:

Program Contacts:

Grants Management Contacts: 

Small Business
In addition to our Small Business overview, consider the following NIDDK-specific information.
Small Business Interest Areas:

NIDDK is interested in projects that include robust timelines for commercialization, requisite fundraising, and all required regulatory milestones.

For those projects intended to support completion of research needed for an Investigational New Drug (IND) application, Investigational Device Exemption (IDE), or other regulatory clearance or approval, NIDDK is interested in projects that demonstrate how formal consultation with the U.S. Food and Drug Administration (FDA) has informed the research strategy.

NIDDK is interested in Phase IIB and Commercialization Readiness Pilot projects that propose to continue the process of developing products that ultimately require clinical evaluation and approval by a Federal regulatory agency, and that position the projects for independence from NIH support after the project period. 

Approved Topics for Awards Over Statutory Budget Guidelines:

A. Development or evaluation of pharmacological agents (i.e., drugs, therapeutics), gene therapies, novel formulations, cell-based or other biological technologies for intervention in or prevention of diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
B. Development or evaluation of biomedical devices, tools, techniques, or instrumentation for intervention in or prevention of diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
C. Development of biomarkers, assays, techniques, diagnostic technologies or associated reagents for assessing state or function in normal, developing, or diseased cells or tissues affected by diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
D. Development or evaluation of imaging, screening, or evaluation techniques or technologies for assessing state or function in normal, developing, or diseased cells or tissues affected by diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
E. Development or evaluation of animal or cell models for studying diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
F. Development or evaluation of novel materials or material treatments (e.g., sterilization, coating, etc.) for use in devices or other tools or methods used to prevent, diagnose, or treat diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
G. Development of cell- or data-banks for the biomedical research community for studying diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
H. Development or evaluation of technologies, including software applications, for improving patient adherence in diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
I. Development or evaluation of technologies for improving clinical research in diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases, including technologies for improving data collection and reporting of patient outcomes.  
J. Development or evaluation of –omics, informatics, or internet-based technologies for biomedical research or clinical applications in diagnosing or managing diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases.  
K. Development or evaluation of technologies to prevent or avert cell or tissue injury germane to diseases and disorders within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases during other disease states or surgical procedures.  
 

Phase IIB & Commercialization Readiness Pilot (CRP):
NIDDK accepts Phase IIB SBIR projects
NIDDK accepts Commercialization Readiness Pilot (CRP) projects
Clinical Trials:
NIDDK accepts clinical trials through the SBIR programs
NIDDK does not accept clinical trials through the STTR programs
NIDDK accepts clinical trials through the Phase IIB SBIR program
NIDDK does not accept clinical trials through the Commercialization Readiness Pilot (CRP)
Small Business Contact:

Program Contacts:

Grants Management Contact


For technical issues E-mail OER Webmaster