National Heart, Lung, and Blood Institute (NHLBI)

Mission Statement

The NHLBI Mission is to provide global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives.


Interest Areas

General Topics

The National Heart Lung and Blood Institute (NHLBI) supports heart, lung, blood, and sleep disorder research while also promoting training and career development to ensure a pipeline of HLBS researchers. 

NHLBI’s Extramural Divisions and Centers:

  • Center for Translation Research and Implementation Science
  • Division of Blood Diseases and Resources
  • Division of Cardiovascular Sciences
  • Division of Extramural Research Activities
  • Division of Lung Diseases
  • National Center on Sleep Disorders Research

NHLBI priority areas include, but not limited to, the following categories:

  • Behavioral Issues Impacting heart, lung, blood and sleep diseases and disorders (diet/nutrition, physical activity, tobacco use, etc.)
  • Blood Diseases and Disorders
  • Clinical Trials Optimization
  • Community Engaged Research & Health Disparities Reduction
  • Heart Disease and Disorders (Cardiovascular Science)
  • HIV/AIDS
  • Implementation Science
  • Long COVID (PASC)
  • Lung Diseases and Disorders (Respiratory)
  • Precision Medicine
  • Sleep Disorders
  • Small Business Innovations

Assistance Listing

Assistance listings are detailed public descriptions of federal programs used across government agencies that provide grants, loans, scholarships, insurance, and other types of assistance awards. They are maintained in the System for Award Management (SAM) and can be used to search for opportunities in Grants.gov.

View NHLBI Assistance Listing Numbers

  • 93.233 - National Center on Sleep Disorders Research
  • 93.837 - Cardiovascular Diseases Research
  • 93.838 - Lung Diseases Research
  • 93.839 - Blood Diseases and Resources Research
  • 93.840 - Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

Highlighted Topics

Title Lead ICO Participating ICOs Posted Date Expiration Date

Funding Opportunities and Notices

Search for NHLBI’s funding opportunities and notices


Additional Information by Funding Category

Small Business
In addition to our Small Business overview, consider the following NHLBI-specific information.
Small Business Interest Areas:

The National Heart Lung and Blood Institute (NHLBI) is interested in supporting the development of novel therapeutics, devices, diagnostics, digital health technologies, research tools, and other innovative solutions for advancing the prevention, diagnosis, and treatment of heart, lung, blood, and sleep (HLBS) diseases and disorders. 

Topics of particular interest for the NHLBI SBIR/STTR program include, but are not limited to, the following topics: 

  • Technologies addressing HLBS complications relevant to maternal health and women’s health  
  • Artificial Intelligence/Machine Learning technologies to improve the diagnosis, treatment, and prevention of HLBS diseases and disorders 
  • Precision medicine approaches to treating HLBS diseases and disorders 
  • New approach methodologies, tools, and point-of-care technologies to improve detection and therapeutic development for HLBS diseases and disorders 
Phase IIB & Commercialization Readiness Pilot (CRP):
  • NHLBI accepts Phase IIB SBIR projects
  • NHLBI accepts Commercialization Readiness Pilot (CRP) projects
Clinical Trials:
  • NHLBI accepts clinical trials through the SBIR programs
  • NHLBI accepts clinical trials through the STTR programs
  • NHLBI accepts clinical trials through the Phase IIB SBIR program
Centers Contact:

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