National Heart, Lung, and Blood Institute (NHLBI)

Mission Statement

The NHLBI Mission is to provide global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives.


Interest Areas

General Topics

The National Heart Lung and Blood Institute (NHLBI) supports heart, lung, blood, and sleep disorder research while also promoting training and career development to ensure a pipeline of HLBS researchers. 

NHLBI’s Extramural Divisions and Centers:

  • Center for Translation Research and Implementation Science
  • Division of Blood Diseases and Resources
  • Division of Cardiovascular Sciences
  • Division of Extramural Research Activities
  • Division of Lung Diseases
  • National Center on Sleep Disorders Research

NHLBI priority areas include, but not limited to, the following categories:

  • Behavioral Issues Impacting heart, lung, blood and sleep diseases and disorders (diet/nutrition, physical activity, tobacco use, etc.)
  • Blood Diseases and Disorders
  • Clinical Trials Optimization
  • Community Engaged Research & Health Disparities Reduction
  • Heart Disease and Disorders (Cardiovascular Science)
  • HIV/AIDS
  • Implementation Science
  • Long COVID (PASC)
  • Lung Diseases and Disorders (Respiratory)
  • Precision Medicine
  • Sleep Disorders
  • Small Business Innovations

Assistance Listing

Assistance listings are detailed public descriptions of federal programs used across government agencies that provide grants, loans, scholarships, insurance, and other types of assistance awards. They are maintained in the System for Award Management (SAM) and can be used to search for opportunities in Grants.gov.

View NHLBI Assistance Listing Numbers

  • 93.233 - National Center on Sleep Disorders Research
  • 93.837 - Cardiovascular Diseases Research
  • 93.838 - Lung Diseases Research
  • 93.839 - Blood Diseases and Resources Research
  • 93.840 - Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

Highlighted Topics

Title Lead ICO Participating ICOs Posted Date Expiration Date

Funding Opportunities and Notices

Search for NHLBI’s funding opportunities and notices


Additional Information by Funding Category

Administrative Supplements
In addition to our Administrative Supplements overview, consider the following NHLBI-specific information.
Administrative Supplement Interest Areas:

NHLBI may award administrative supplements under rare circumstances and contingent upon the availability of funds; consideration will be given for the following:

Research Project Grants (RPG):

  • Preservation of a unique research material or resource that may otherwise be lost
  • Provision for an orderly termination or temporary continuation of support
  • Replacement of equipment, supplies, and/or time lost

Career Related:

  • Full or part-time mentored research training experiences to Reenter, Reintegrate, or Retrain (RRR) in an active research career
  • Research continuity and retention of investigators facing critical life events who are either transitioning from mentored career development awards to research independence or are first-time RPG awardees preparing for a renewal of their current award or a second NIH RPG award, with the goal to minimize departures from biomedical research workforce.
Administrative Supplement Due Dates:

Research Project Grants (RPG) - 60 days before requested start date 

Career Related 

  • RRR - 90 days before requested start date (awards not issued October and November)
  • Research Continuity and Retention - February 1, June 1, and October 1
Administrative Supplement Contact:

RPG:

Contact the Program Officer listed on the Notice of Award for the most recent parent award and/or the NHLBI Office of Grants Management [email protected] 

Career Related:

Research Re-entry, Re-integrate, or Re-train

[email protected]

Research Continuity and Retention

[email protected]

 

Conferences and Meetings
In addition to our Conferences and Meetings overview, consider the following NHLBI-specific information.
Conferences and Meetings Interest Areas:

The NHLBI supports conferences that are critical to the mission of the NIH and NHLBI (i.e., meetings directly related to heart, lung, non-plastic blood, and/or sleep disorders and conditions), including advancing the science of solution-focused health disparities research, implementation science, community-engaged research, and global health reciprocal innovation or any combination of these. Meetings for the sole purpose of professional development (e.g., continuing medical education) fall outside of NHLBI priorities. Supported meetings generally explore and identify: (a) critical gaps in knowledge; (b) research challenges and opportunities; and/or (c) promising strategies for advancing prevention, diagnosis and/or treatment modalities for science related to the NHLBI mission.

Conferences and Meetings Budget Considerations:

The NHLBI accepts primary and secondary assignments on applications for the support of meetings directly related to heart, lung, blood, and sleep disorders and conditions. Typically, NHLBI provides nominal support for conferences between $5K and $10K.

Conferences and Meetings Key Date Considerations:

Applicants should select a submission date that allows sufficient time for NHLBI to make a potential award prior to the conference/meeting event.

Conferences and Meetings Project Period Considerations:

NHLBI will consider support requests for a series of annual or biannual conferences for up to 5 years.

Conferences and Meetings Contacts:

Scientific Program Contact:  
NHLBI Conferences and Meetings
Email: [email protected]

Grants Management Contact:
NHLBI Office of Grants Management
Email: [email protected]

Small Business
In addition to our Small Business overview, consider the following NHLBI-specific information.
Small Business Interest Areas:

The National Heart Lung and Blood Institute (NHLBI) is interested in supporting the development of novel therapeutics, devices, diagnostics, digital health technologies, research tools, and other innovative solutions for advancing the prevention, diagnosis, and treatment of heart, lung, blood, and sleep (HLBS) diseases and disorders. 

Topics of particular interest for the NHLBI SBIR/STTR program include, but are not limited to, the following topics: 

  • Technologies addressing HLBS complications relevant to maternal health and women’s health  
  • Artificial Intelligence/Machine Learning technologies to improve the diagnosis, treatment, and prevention of HLBS diseases and disorders 
  • Precision medicine approaches to treating HLBS diseases and disorders 
  • New approach methodologies, tools, and point-of-care technologies to improve detection and therapeutic development for HLBS diseases and disorders 
Phase IIB & Commercialization Readiness Pilot (CRP):
  • NHLBI accepts Phase IIB SBIR projects
  • NHLBI accepts Commercialization Readiness Pilot (CRP) projects
Clinical Trials:
  • NHLBI accepts clinical trials through the SBIR programs
  • NHLBI accepts clinical trials through the STTR programs
  • NHLBI accepts clinical trials through the Phase IIB SBIR program
Small Business Contact:

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