National Center for Complementary and Integrative Health (NCCIH)

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Mission Statement

The NCCIH Mission is to determine, through rigorous scientific investigation, the fundamental science, usefulness, and safety of complementary and integrative health approaches and their roles in improving health and health care.

Interest Areas

General Topics

Geneal Research topics of interest include:

Whole Person Health

  • Examining how biological, behavioral, psychological, social, and environmental factors interact to influence health, resilience, and recovery.
  • Studying complementary and integrative health interventions including multicomponent interventions targeting multisystem outcomes for disease treatment and prevention, and for health restoration and promotion.
  • Using AI and multiscale modeling to understand whole person health dynamics.

Fundamental Science and Translational Research

  • Probing neural, biological, biomechanical, physiological and behavioral mechanisms underlying complementary and integrative health approaches.
  • Advancing translational research to inform intervention development and optimization.

Clinical Research and Implementation:

  • Supporting feasibility studies, rigorous explanatory clinical trials, pragmatic studies to evaluate effectiveness, safety, and real-world applicability,
  • Improving uptake of evidence-based integrative approaches into clinical care, public health, and self-care.

Pain & Pain Management

  • Advancing evidence on integrative, non-drug strategies (e.g., mind–body, manual therapies, movement-based approaches) for acute and chronic pain.

Mind & Body Connection

  • Studying mechanisms, effectiveness, and implementation of practices.
  • Refining mind and body interventions to treat and prevent disease and promote health. 

Health Promotion and Disease Prevention 

  • Studying integrative approaches and their mechanisms that support healthy behaviors, resilience, prevent disease, and promote well-being across the lifespan. 

Nutrition & Natural Products

  • Studying effects of natural products, phytochemicals, and probiotics on health and disease including inter-individual differences
  • Investigating the mechanisms and potential therapeutic effects of cannabis and minor cannabinoids.

Highlighted Topics

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Funding Opportunities and Notices

Search for NCCIH’s funding opportunities and notices

Additional Information by Funding Category

Administrative Supplements
In addition to our Administrative Supplements overview, consider the following NCCIH-specific information.
Administrative Supplement Interest Areas:

NCCIH has prioritized funding investigator-initiated grants at the highest possible level, so the number of successful administrative supplement applications will be low. Investigators are strongly encouraged to contact their NCCIH Program Officer before submission to confirm eligibility and ensure alignment with NCCIH scientific priorities.

Administrative Supplement Due Dates:

Requests are reviewed on a rolling basis. Investigators should apply well in advance of the desired start date. 

Administrative Supplement Contact:

Contact the program officer listed on the Notice of Award for the most recent parent award.

Direct general questions to: [email protected]

See Also

National Center for Complementary and Integrative Health (NCCIH)

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