National Human Genome Research Institute (NHGRI)

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Mission Statement

The NHGRI Mission is to accelerate scientific and medical breakthroughs that improve human health. NHGRI does this by driving cutting-edge research, developing new technologies, and studying the impact of genomics on society.

Interest Areas

General Topics

NHGRI funds grants that develop generalizable and broadly applicable resources, approaches, and technologies that accelerate and support studies focused on the structure and biology of genomes, identify the genomic underpinnings of human health and disease, and ensure that genomics is applied responsibly to improve patient care and benefit society. Research topics supported by NHGRI include, but are not limited to, the following:

  • Genome Biology, Functional Genomics, and Technology Development
    • Development of novel genomic technologies for measurement, sequencing, synthesis, and spatial biology.
    • Functional genomics, gene regulation, epigenetics, chromatin, and transcriptomics, and multi-omic approaches.
    • Comparative and population genomics to infer genome function and evolution.
  • Genomic Variation, Disease Mechanisms, and Clinical Interpretation
    • Identifying and interpreting variants linked to Mendelian, rare, and complex diseases.
    • Understanding molecular mechanisms connecting variants to biological function.
    • Pharmacogenomics and other clinically relevant genomic analyses.
  • Clinical Genomics and Implementation in Healthcare
    • Development and evaluation of clinical sequencing methods and workflows.
    • Integration of genomic data into care delivery and electronic health systems.
    • Studies of clinical utility, impact, equitable implementation, and return of genomic results.
  • Computational Genomics, Data Science, and Genomic Infrastructure
    • Computational tools for sequence analysis, variant interpretation, and functional genomics, and multi-omic analysis.
    • Statistical genomics, population-scale analyses, and data privacy/security.
    • Standards, databases, and platforms supporting large-scale genomic and phenotype data sharing.
  • Ethical, Legal, and Social Implications
    • Ethical and policy questions in genomic healthcare and research.
    • Institutional, legal, and regulatory frameworks shaping genomic research and clinical practice.

Assistance Listing

Assistance listings are detailed public descriptions of federal programs used across government agencies that provide grants, loans, scholarships, insurance, and other types of assistance awards. They are maintained in the System for Award Management (SAM) and can be used to search for opportunities in Grants.gov.

View NHGRI Assistance Listing Numbers

  • 93.172 - Human Genome Research

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Funding Opportunities and Notices

Search for NHGRI’s funding opportunities and notices

ICO Funding Policies and Considerations

Visit NIH Fiscal Policies for NIH-wide information on appropriations and other budgetary information (salary limits, stipends, tuition/fees) and Funding Decisions to learn about NIH's consistent and unified approach for making funding decisions.

NHGRI Funding Policies and Considerations builds on that general information.

Additional Information by Funding Category

Administrative Supplements
In addition to our Administrative Supplements overview, consider the following NHGRI-specific information.
Administrative Supplement Interest Areas:
  • Program Directors/Principal Investigators (PDs/PIs) with an active NHGRI grant may request an administrative supplement to support unanticipated costs not included in the most recent competitive or non-competitive application.

  • PDs/PIs are strongly encouraged to consult with their NHGRI Program Officer (PO) to confirm eligibility, discuss the scope and justification of the proposed supplement, and obtain technical guidance.

     

Administrative Supplement Due Dates:
  • Requests may be submitted at any time during the fiscal year but should be made at least 90 days before the anticipated need and no later than March 15.
  • Due to fiscal and system constraints, supplements are not awarded in October or November. 
Administrative Supplement Contact:

NHGRI Research Funding

[email protected]

Small Business
In addition to our Small Business overview, consider the following NHGRI-specific information.
Small Business Interest Areas:
  • Significant innovations in genomic methods or technology development. This includes, but is not limited to, advancements in nucleic acid sequencing, synthetic nucleic acid synthesis, functional genomics, single cell genomic analysis, transcriptomics, multi-omics, instrumentation, or molecular kits. 
  • Tools and techniques that use genomics to improve patient health, such as approaches to incorporate genomic results into electronic medical records, clinical decision support tools, or genomic directed health care. 
  • Strategies to enhance ethical, legal, and social aspects of genomics research or translation of genomics into health care. 
  • Bioinformatics software or platforms for genomic, genetic, or sequence data processing or analysis, functional genomics, associations between genomic data and diseases or phenotypes, interpretation of variants, or genomic data integration into clinical decision making. 
  • Databases and data management platforms for genomics research and application including platforms for sequence, functional, or phenotypic data or annotation of variants. 
  • Development and application of methods for machine learning, pattern detection, or knowledge networks for genomics science or translation into health care. 
  • Informatics methods and platforms that adopt data standards, enhance data sharing with privacy, and improve data exchange in genomics science or translation of genomics into health care. 
  • Use of cloud and other computing models to improve scale, reproducibility, interoperability, cost-effectiveness, and utility of genomic and clinical data in genomics or translation into health care. 
  • Development of curriculum and educational opportunities that increase the genomics knowledge of participants at the undergraduate, postbaccalaureate, graduate, postdoctoral, or professional levels. 
Phase IIB & Commercialization Readiness Pilot (CRP):
  • NHGRI accepts Commercialization Readiness Pilot (CRP) projects
Clinical Trials:
  • NHGRI accepts clinical trials through the SBIR programs
  • NHGRI accepts clinical trials through the STTR programs
Centers Contact:

NHGRI Small Business

[email protected]

See Also

National Human Genome Research Institute (NHGRI)

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