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National Human Genome Research Institute (NHGRI)
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Mission Statement
The NHGRI Mission is to accelerate scientific and medical breakthroughs that improve human health. NHGRI does this by driving cutting-edge research, developing new technologies, and studying the impact of genomics on society.
Interest Areas
General Topics
NHGRI funds grants that develop generalizable and broadly applicable resources, approaches, and technologies that accelerate and support studies focused on the structure and biology of genomes, identify the genomic underpinnings of human health and disease, and ensure that genomics is applied responsibly to improve patient care and benefit society. Research topics supported by NHGRI include, but are not limited to, the following:
- Genome Biology, Functional Genomics, and Technology Development
- Development of novel genomic technologies for measurement, sequencing, synthesis, and spatial biology.
- Functional genomics, gene regulation, epigenetics, chromatin, and transcriptomics, and multi-omic approaches.
- Comparative and population genomics to infer genome function and evolution.
- Genomic Variation, Disease Mechanisms, and Clinical Interpretation
- Identifying and interpreting variants linked to Mendelian, rare, and complex diseases.
- Understanding molecular mechanisms connecting variants to biological function.
- Pharmacogenomics and other clinically relevant genomic analyses.
- Clinical Genomics and Implementation in Healthcare
- Development and evaluation of clinical sequencing methods and workflows.
- Integration of genomic data into care delivery and electronic health systems.
- Studies of clinical utility, impact, equitable implementation, and return of genomic results.
- Computational Genomics, Data Science, and Genomic Infrastructure
- Computational tools for sequence analysis, variant interpretation, and functional genomics, and multi-omic analysis.
- Statistical genomics, population-scale analyses, and data privacy/security.
- Standards, databases, and platforms supporting large-scale genomic and phenotype data sharing.
- Ethical, Legal, and Social Implications
- Ethical and policy questions in genomic healthcare and research.
- Institutional, legal, and regulatory frameworks shaping genomic research and clinical practice.
Assistance Listing
Assistance listings are detailed public descriptions of federal programs used across government agencies that provide grants, loans, scholarships, insurance, and other types of assistance awards. They are maintained in the System for Award Management (SAM) and can be used to search for opportunities in Grants.gov.
View NHGRI Assistance Listing Numbers
- 93.172 - Human Genome Research
Highlighted Topics
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Funding Opportunities and Notices
Search for NHGRI’s funding opportunities and notices
- NHGRI Grant Funding Opportunity Participation
- NHGRI Notices in the NIH Guide for Grants and Contracts
Additional Information by Funding Category
Administrative Supplements
- Program Directors/Principal Investigators (PDs/PIs) with an active NHGRI grant may request an administrative supplement to support unanticipated costs not included in the most recent competitive or non-competitive application.
PDs/PIs are strongly encouraged to consult with their NHGRI Program Officer (PO) to confirm eligibility, discuss the scope and justification of the proposed supplement, and obtain technical guidance.
- Requests may be submitted at any time during the fiscal year but should be made at least 90 days before the anticipated need and no later than March 15.
- Due to fiscal and system constraints, supplements are not awarded in October or November.
NHGRI Research Funding
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