National Institute of Environmental Health Sciences (NIEHS)

Mission Statement

The NIEHS Mission is to research how the environment affects biological systems across the lifespan and to translate this knowledge to reduce disease and promote human health.


Interest Areas

General Topics

The NIEHS supports research, training and career development programs on the biological response and human health impacts of exposures from environmental sources (see NIEHS Strategic Plan 2025-2029).  

  • Environmental exposures include chemical, physical, and biologically derived (non-pathogenic) factors that humans can be exposed to via inhalation, ingestion, or ocular/dermal contact, individually or as mixtures.
  • Research supported includes:
    • the development of technologies to assess human environmental exposures and biological impacts of exposure;
    • mechanistic understanding of exposures on biological systems including the use of environmentally derived analytes as probes of fundamental biological mechanisms;
    • epidemiological studies of the health effects of environmental exposures including the interactions between environmental and genetic factors;
    • community engaged research; and
    • the development of strategies to reduce the burden of exposure and mitigate the impacts of exposures to improve human health at the individual and population levels.
  • Research  must be anchored in human health relevant outcomes
    • Outcomes may be at the molecular, cellular, organ, system, organism or population level.
    • Use of computation and non-human models is allowed, provided relevance to human health is justified
  • Through the Superfund Research Program, NIEHS also supports research on environmental science and engineering, including the development and validation of remediation technologies and studies of the environmental fate and transport of chemicals.  This work can be removed from a direct relevance on human health and biomedical research efforts.
  • Through the Worker Training Program, NIEHS supports the training of workers engaged in activities related to hazardous or radioactive materials and waste generation, removal, containment, transportation, and emergency response.  This includes the development of training curricula and materials.
     

Assistance Listing

Assistance listings are detailed public descriptions of federal programs used across government agencies that provide grants, loans, scholarships, insurance, and other types of assistance awards. They are maintained in the System for Award Management (SAM) and can be used to search for opportunities in Grants.gov.

View NIEHS Assistance Listing Numbers

  • 93.113 - Environmental Health
  • 93.142 - NIEHS Hazardous Waste Worker Health and Safety Training
  • 93.143 - NIEHS Superfund Hazardous Substances_Basic Research and Education

Highlighted Topics

Title Lead ICO Participating ICOs Posted Date Expiration Date

Funding Opportunities and Notices

Search for NIEHS’s funding opportunities and notices


ICO Funding Policies and Considerations

Visit NIH Fiscal Policies for NIH-wide information on appropriations and other budgetary information (salary limits, stipends, tuition/fees) and Funding Decisions to learn about NIH's consistent and unified approach for making funding decisions.

NIEHS Funding Policies and Considerations builds on that general information.


Additional Information by Funding Category

Administrative Supplements
In addition to our Administrative Supplements overview, consider the following NIEHS-specific information.
Administrative Supplement Due Dates:

Annual due dates by application purpose:

  • Support of mentored research training: 2/1, 4/1, 6/1, 9/1, 10/1 and 12/1
  • Retention of investigators: 2/1, 4/1, 6/1, 9/1, 10/1 and 12/1
  • All other areas: 4/1, 9/1, and 12/1

Note: 

  • The earliest possible award date for all NIEHS administrative supplements is 3-4 months after the due date.
Administrative Supplement Contact:
Conferences and Meetings
In addition to our Conferences and Meetings overview, consider the following NIEHS-specific information.
Conferences and Meetings Interest Areas:

The NIEHS Conference Grant Program supports investigator-initiated scientific meetings —such as conferences, workshops, symposia, and seminars— that directly advance the institute’s mission, particularly research on how environmental factors and gene–environment interactions influence disease or dysfunction. Relevant topics include environmental toxicology, chemical exposure, mechanistic toxicology, environmental epidemiology, exposure science, detection of hazardous substances, and scientific methods to reduce environmental hazards. Support is available for events of all sizes. For larger conferences, NIEHS prioritizes multidisciplinary or interdisciplinary events that foster collaboration among researchers. Applications are encouraged to include graduate students, postdoctoral fellows, junior investigators, and community members with funding allowed for their participation. 

The NIEHS Superfund Research Program also supports meetings relevant to their interest areas.

Conferences and Meetings Budget Considerations:

NIEHS limits conference grant awards to no more than $25,000 in direct costs per year for new (had no previous NIEHS support) and $50,000 in direct costs per year for returning (had previous NIEHS support) conferences. Typical support is less than the outlined limits. NIEHS will consider providing co-funding for conference applications administered by other ICOs (usually less than $10,000).

Conferences and Meetings Key Date Considerations:

NIEHS considers applications submitted to all conference standard due dates.

It is highly suggested that applicants reach out to the NIEHS Conference Grant Coordinator no later than 6 weeks prior to the receipt date with any questions.

Conferences and Meetings Project Period Considerations:

NIEHS considers requests for a single conference or a series up to 3 years.

Conferences and Meetings Contacts:
Small Business
In addition to our Small Business overview, consider the following NIEHS-specific information.
Small Business Interest Areas:

NIEHS SBIR/STTR grants help small businesses transform cutting-edge research into developing innovative and commercially viable products such as tools, technologies, assays, or services to translate and communicate environmental health research into improvements in human health. NIEHS SBIR/STTR program uses a combination of research & development, technology transfer, and communication strategies to aid the mission of NIEHS. 
The institute’s scientific areas of emphasis include, but are not limited to, the following: 
•    Tools/technologies such as sensors, computational methods, and exposomics approaches  for detecting and assessing human exposures to environmental hazards 
•    Innovative and/or alternative high-throughput or high-content assays/model systems,  computational toxicology approaches, and other related new approach methodologies (NAMs) for toxicity testing and understanding effects on human health and disease
•    Tools/methods/applications for evaluating environmental health and safety of engineered nanomaterials and micro/nanoplastics
•    Biomonitoring technologies   such as point-of-care approaches for personal exposure assessment and exposure mediated biological response biomarkers.
•    Intervention technologies and precision environmental health approaches to prevent or reduce human exposures or adverse health effects related to environmental stressors
•    Educational materials to promote or support understanding of environmental health science
The NIEHS Superfund Research Program (accepting SBIR applications only) focused on detection and remediation technologies for hazardous substances with relevance to Superfund and/or other contaminated sites

The NIEHS Worker Training Program (accepting SBIR applications only) also participates

Phase IIB & Commercialization Readiness Pilot (CRP):
NIEHS does not accept Phase IIB SBIR projects
NIEHS accepts Commercialization Readiness Pilot (CRP) projects
Clinical Trials:
NIEHS accepts clinical trials through the SBIR programs
NIEHS accepts clinical trials through the STTR programs
NIEHS does not accept clinical trials through the Phase IIB SBIR program
NIEHS does not accept clinical trials through the Commercialization Readiness Pilot (CRP)
Small Business Contact:

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