Office of Research Infrastructure Programs (ORIP)

Mission Statement

ORIP advances the NIH mission to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.


Interest Areas

General Topics

The Office of Research Infrastructure Programs (ORIP) advances the NIH mission by supporting infrastructure for innovation. General Topics of Interest for ORIP include: 

  • Models and related biomaterials for human diseases
  • Cutting-edge scientific instrumentation and equipment
  • Construction and modernization of shared use biomedical research or resource facilities
  • Development of biomedical models, biomaterials, and related methods and technologies under the NIH SEED funding program
  • Research training opportunities for scientists 

Highlighted Topics

Title Lead ICO Participating ICOs Posted Date Expiration Date

Funding Opportunities and Notices

Search for ORIP’s funding opportunities and notices


ICO Funding Policies and Considerations

Visit NIH Fiscal Policies for NIH-wide information on appropriations and other budgetary information (salary limits, stipends, tuition/fees) and Funding Decisions to learn about NIH's consistent and unified approach for making funding decisions.

ORIP Funding Policies and Considerations builds on that general information.


Additional Information by Funding Category

Administrative Supplements
In addition to our Administrative Supplements overview, consider the following ORIP-specific information.
Administrative Supplement Interest Areas:

Examples of interest areas that ORIP may consider include:

  • Support of alterations and renovations (A&R) of research facilities
  • Purchase of instrument(s)/equipment critical for biomedical research
  • Importation costs of a special collection to an ORIP supported repository
Administrative Supplement Contact:

Principal Investigators are encouraged to speak to their eRA assigned Program Official before applying to discuss eligibility, need for the supplement, availability of funds, and application procedures.

General Inquiries:

Division of Comparative Medicine

[email protected]

Conferences and Meetings
In addition to our Conferences and Meetings overview, consider the following ORIP-specific information.
Conferences and Meetings Interest Areas:
  • ORIP’s high-priority thematic areas for conferences and meetings are: 
    • Developing model resources to advance the study of human diseases 
    • Innovating cross-disciplinary research training in model systems 
  • ORIP will only support research meetings that are held at domestic sites.
  • For models-oriented conferences and meetings, proposals must be applicable to the research interests of two or more categorical NIH Institutes/Centers (ICs). 
    • Applications focused on a specific disease or category of research will not be accepted and should be proposed to the appropriate categorical IC of the NIH. 
    • Applications proposing conferences or scientific meetings that are predominantly of interest to one NIH IC and only peripherally of interest to other NIH ICs are not acceptable.
  • For training-oriented conferences and meetings, applications with a primary focus on cross-disciplinary research training in model systems for early-career scientists will receive priority for consideration.
Conferences and Meetings Budget Considerations:
  • Grants awarded by ORIP generally support only a portion of the entire cost of a conference or meeting. 
  • ORIP typically provides nominal support between $5K and $10K for conferences or meetings.
  • ORIP will consider support up to $75K only in highly compelling cases.
  • Other ICOs may co-fund awards by ORIP for conferences or meetings above the support provided by ORIP.
Conferences and Meetings Key Date Considerations:
  • Applications can be submitted for any of the NIH standard due dates for R13 applications.
Conferences and Meetings Project Period Considerations:
  • ORIP typically accepts applications for up to 2 years of support across all areas of ORIP’s mission.
  • ORIP will consider applications for up to 5 years of support only in highly compelling cases.
Conferences and Meetings Contacts:

Office of Research Infrastructure Programs (ORIP)
Email: [email protected]

Small Business
In addition to our Small Business overview, consider the following ORIP-specific information.
Small Business Interest Areas:

ORIP supports research projects to develop technology including, but not limited to, the following: 

  • Create, characterize, or improve models of human disease; and develop new approach methodologies (NAMs) to complement or reduce the use of animal models in research. 
  • Preservation, revival and monitoring of cells, tissue, organs or gametes from model systems. 
  • Validate research models to enhance the rigor and reproducibility of pre-clinical studies. 
  • Devices and technologies required for development and maintenance of conventional and NAM biological model systems, including those for advancing the care, welfare, housing, and management of these models; or sensor and monitoring technologies for the surveillance of models or environmental factors that lead to improved rigor and reproducibility for studies using these models.
Phase IIB & Commercialization Readiness Pilot (CRP):
ORIP accepts Phase IIB SBIR projects
ORIP does not accept Commercialization Readiness Pilot (CRP) projects
Clinical Trials:
ORIP does not accept clinical trials through the SBIR programs
ORIP does not accept clinical trials through the STTR programs
ORIP does not accept clinical trials through the Phase IIB SBIR program
ORIP does not accept clinical trials through the Commercialization Readiness Pilot (CRP)
Small Business Contact:

General Inquiries:

ORIP Small Business

[email protected]


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