How to Apply – Application Guide

Scope Note

Use the application instructions found on this page along with the guidance in the funding opportunity to submit grant applications to NIH, the Centers for Disease Control and Prevention, the Food and Drug Administration, and the Agency for Healthcare Research and Quality.

Policy Quick Links

 

Form-by-Form, Field-by-Field Application Instructions


Determine the Correct Application Instructions for Your Activity Code

Application InstructionsDescriptionSF424 (R&R) - Version H
(Applications to Fellowship Parent Opportunities for April 8 and May 7, 2025 due dates)
SF424 (R&R) - Version I
(Due dates ON/AFTER Jan. 25, 2025)
G

General Instructions

Comprehensive guidance, including standard instructions that apply to all applications and all program-specific instruction call-out boxes (research, training, fellowship, career development, multi-project, and small business)

HTML / PDF

Alert
Limited use. See Fellowship Instructions below.

 

HTML / PDF

Alert
Updated March 18, 2025. See Significant Changes.

Filtered Application Instructions
R

Research Instructions

Standard instructions that apply to all applications plus research instruction call-out boxes.
Activity Codes: Research (R), including Research Education (R25), and equivalent Cooperative Agreements (U)
 PDF
K

Career Development Instructions

Standard instructions that apply to all applications plus career development instruction call-out boxes.
Activity Codes: Individual Career Development (K), excluding Institutional Career Development (K12, KL2, KM1)
 PDF
T

Training Instructions

Standard instructions that apply to all applications plus training instruction call-out boxes.
Activity Codes: Institutional Training (T), including International Training (D43, D71, U2R) and Institutional Career Development (K12, KL2, KM1)
 PDF
F

Fellowship Instructions

Standard instructions that apply to all applications plus fellowship instruction call-out boxes.
Activity codes: Fellowship (F)
PDF

Alert
Use FORMS-H for parent fellowship opportunities (PA-23-260, PA-23-261, PA-23-262, PA-23-263, PA-23-272) with April 8 & May 7 due dates.
PDF

Alert
Use FORMS-I for non-parent fellowship opportunities (e.g., PAR-25-234, PAR-25-250, PAR-23-109, RFA-OD-24-007, or PAR-25-021).
M

Multi-Project Instructions

Standard instructions that apply to all applications plus multi-project instruction call-out boxes.
Activity Codes: Program Project Grants and Center Grants (P) and equivalent Cooperative Agreements (U)
 PDF
B

SBIR/STTR Instructions

Standard instructions that apply to all applications plus small business instruction call-out boxes.
Activity Codes: R41-R44, SB1, U43, U44, UB1, UT1, UT2
 PDF

Resources

General

Quick Links
Systems
  • ASSIST—NIH system used to access, prepare, and submit application forms
  • eRA Commons—NIH system used to securely exchange information between agency staff and applicants/recipients
  • Grants.gov—central portal used by all federal grant-making agencies and their applicants to find and apply for federal grant funding

See Also

  • eRA—general information, tutorials, user guides, and other resources for eRA systems
    • eRA News—announcements of system features and system health

Contact

Section VII. Agency Contacts in each funding opportunity provides application submission, scientific/research, peer review, and financial/grants management contacts.

Check online guidance and direct your questions to staff in your organization's sponsored programs office. If you still need assistance, find NIH contacts at Need Help?


This page last updated on: March 18, 2025
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