The NIH is committed to promoting rigorous and transparent research in all areas of science supported by a variety of grant programs. Grant application instructions and the criteria by which reviewers are asked to evaluate the scientific merit of the application include components that address reproducibility, rigor, and transparency. Learn how to address rigor and reproducibility in your grant application and discover what reviewers are looking for as they evaluate the application for scientific merit.
Overview of Guidelines for Rigor in Your Application
Infographics on grant guidelines, including information on the four key areas of rigor, and details the updates to research strategy guidance, authentication, and new reviewer guidelines.
NIH Enhancing Reproducibility Guidelines
Infographic courtesy of Ms. Nichole Swan, Dr. Shana Spindler, and Dr. Yvette Pittman of the unice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Download PDFEnhancing Reproducibility in NIH Applications: Resource Chart
Infographic courtesy of OER
Download PDFResearch Grants and Mentored Career Development Awards
NIH research grant and career development award application instructions and review language focus on four key areas
The rigor of the prior research | |
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Rigorous experimental design for robust and unbiased results | |
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Consideration of relevant biological variables | |
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Authentication of key biological and/or chemical resources |
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Institutional Training Grants, Institutional Career Development, Individual Career Development, and Individual Fellowships
The NIH plans to require formal instruction in rigorous experimental design and transparency to enhance reproducibility for institutional training, institutional career development, individual career development, and individual fellowship applications with due dates on or after May 25, 2020. In addition, the requirements for rigor and transparency already in place for other research grants will be extended to fellowship research grants.
When implemented, applications will be expected to provide the following:
Institutional research training and institutional career development applications
- The Program Plan section of the application will be expected to include a description of how the program and faculty will provide training in rigorous research design and relevant data science and quantitative approaches.
- The requirement to include a Plan for Instruction in Methods for Enhancing Reproducibility attachment will be expanded to all applicants.
Individual career development applications
- In describing their career development plans in the Program Plan attachment, candidates for career development awards will be expected to address, as applicable, any new research skills they plan to acquire in the areas of rigorous research design, experimental methods, quantitative approaches, and data analysis and interpretation.
Individual fellowship applications
- In describing their training goals and objectives in the Program Plan attachment, fellowship candidates will be expected to address, as applicable, any new research skills they plan to acquire in the areas of rigorous research design, experimental methods, quantitative approaches, and data analysis and interpretation.
- In the Research Strategy section of the Program Plan attachment, fellowship candidates will be expected to describe (a) the strengths and weaknesses in the rigor of the prior research that serves as the key support for the proposed project, (b) plans to address any weaknesses in the rigor of the prior research, (c) how the experimental objectives proposed will achieve robust and unbiased results, and (d) how relevant biological variables are factored into research designs and analyses.
- If applicable, fellowship candidates will be required to include the Authentication of Key Biological and/or Chemical Resources attachment.