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Investigator Initiated Research Project Grant Applications

Purpose of the Award

  • Provides funding to support investigator-initiated research on a discrete, specified, circumscribed project
  • Investigator-initiated research, also known as unsolicited research, is research funded as a result of an investigator submitting a research grant application to NIH in an investigator’s area of interest and competency


  • NIH's most commonly used grant program
  • No specific dollar limit unless specified in funding opportunity
  • Advance permission required for $500,000 or more (direct costs) in any year
  • Generally awarded for 3 to 5 years
  • Utilized by all NIH Institutes and Centers


  • The R01 research plan proposed by the applicant institution/organization must be related to the stated program interests of one or more of the NIH Institutes and Centers (ICs) based on descriptions of their programs

More Information