Activity Codes

NIH uses three-character activity codes to differentiate the wide variety of research-related programs NIH supports. The first character typically identifies the major funding category or program type. For example, activity codes for research and development often start with "R," training with "T," fellowship with "F," and career development with "K." Each institute and center (IC) participates in a subset of activity codes. Although each activity code has a broadly defined purpose, there may be differences in their use from one IC to another. Applicants should always refer to the funding opportunity for the specific requirements and details of an initiative.

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Activity Code â–Ľ Funding Category Title Description
C06 Construction and Modernization Research Facilities Construction Grant To provide matching Federal funds, up to 75%, for construction or major remodeling, to create new research facilities. In addition to basic research laboratories this may include, under certain circumstances, animal facilities and/or limited clinical facilities where they are an integral part of an overall research effort.
DP4 Research and Development NIH Director’s Pathfinder Award - Multi-Yr Funding

To support multi-year funded research with unique, high impact ideas for addressing biomedical research including assuring a balanced and effective workforce. This research grant program will encourage exceptionally creative scientists to develop potentially transforming approaches for supported research. The proposed research must reflect ideas that are substantially different from those already being pursued or they must apply existing research designs in new and innovative ways. 
E11 Grants for Public Health Special Projects To provide grants to public or nonprofit organizations for planning, development, demonstration, research, training, public information projects for preventive medicine, health promotion and disease prevention to improve the health of targeted populations.
F30 Research Training and Career Development Individual Predoctoral NRSA for M.D./Ph.D. Fellowships Individual fellowships for predoctoral training which leads to the combined M.D./Ph.D. degrees.
F31 Research Training and Career Development Predoctoral Individual National Research Service Award To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.).
F32 Research Training and Career Development Postdoctoral Individual National Research Service Award To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas.
FI2 Research Training and Career Development Intramural Postdoctoral Research Associate To provide postdoctoral research training to individuals in the NIH or FDA intramural research programs to broaden their scientific background and extend their potential for research in specified health-related areas.
FM1 Research Training and Career Development Fellowship for Intramural Dual-Degree Scientists (FIDDS) To provide predoctoral individuals with training which leads to the combined degrees (e.g., MD/PhD) for trainees completing PhD dissertation research in NIH intramural labs.
G07 Research and Development Resources Improvement Grant A non-renewable grant available to health related organizations to establish, expand or improve Internet connectivity and improve access to digital information resources.
G08 Research and Development Resources Project Grant (NLM) A grant available to health-related institutions to improve the organization and management of health related information using computers and networks.
G11 Research and Development Extramural Associate Research Development Award (EARDA) To provide funds to institutions eligible to participate in the NIH Extramural Associates Program for establishing or enhancing an office of sponsored research and for other research infrastructure needs.
G12 Research Centers in Minority Institutions Award

To assist resource-limited institutions that offer the doctorate in the health professions and/or health-related sciences in strengthening and augmenting their human and physical resources for the conduct of biomedical research.
G13 Research and Development Health Sciences Publication Support Awards (NLM) To provide short-term assistance for the preparation of book-length manuscripts about important scientific information needed by U.S. health professionals. Grants are awarded for major critical reviews and analyses of historical studies and current developments in informatics, technology, librarianship, and secondary reference materials in the biomedical field. Publication in formats other than print-on-paper (e.g., electronic, film, etc.) are encouraged, as are new and innovative ways of organizing and presenting information. Publication grants do not support journals or other serials and are not suitable for operation of established databases. Work judged to have significant commercial viability will not be supported by these grants.
G20 Construction and Modernization Grants for Repair, Renovation and Modernization of Existing Research Facilities To provide funds for major repair, renovation, and modernization of existing research facilities. These facilities may be the clinical research facilities, animal research facilities, and other related research facilities.
G94 Administrative Support for Public Health Service Agency Foundations Provides financial assistance, as specified by legislation or other authority, for administration of an agency foundation which supports and carries out research, educational, health services, or other activities related to the mission of that PHS agency.
H23 Immunization Program Provides financial assistance to public agencies for the purposes of planning, developing, implementing, and studying immunization programs to control serious diseases for which effective immunizing agents are available.
H28 State and Community-Based Injury Control Programs Provides financial assistance to health agencies serving populations of over 1 million for them to develop, expand, or improve injury control programs to reduce morbidity, mortality, severity, disability, and cost from injuries.
H50 Maternal and Child Health Services Project, RB Funds Active (Definition not available)
H62 Services or Education on AIDS Provides financial assistance to public and non-profit private entities for information and education programs on the Acquired Immune Deficiency Syndrome, and for diagnostic, prevention, and control services of AIDS.
H64 State and Community-Based Childhood Lead Poisoning Prevention Program Provides financial assistance to State agencies and city/country agencies, based on need, to enable them to develop, expand, or improve childhood lead poisoning prevention programs.
H79 Mental Health and/or Substance Abuse Services Grants To support services and other activities for the prevention and/or treatment of mental illness and/or substance abuse disorders and/or for the promotion of health.
HD4 Drug Use/Alcohol Abuse Prevention Demo: Community Partnership Study Provides financial assistance to local governments and/or local private non-profit organizations, designated to act on behalf of larger coalitions, to demonstrate models for elimination of alcohol and other drug abuse, especially by development of partnerships to encourage various individuals and groups in a community to more effectively coordinate prevention programs and to develop prevention initiatives; and to demonstrate the effectiveness of such community-based groups in prevention and early intervention. The Community Prevention Coalitions Demonstration (CPCD) program is included in this activity code.
IK3 Research Training and Career Development Non-DHHS Nursing Research Initiative To provide research and salary support for a supervised/mentored career development experience for nurses. Awards are not renewable, nor are they transferable from one principal investigator to another.
K14 Research Training and Career Development Resource-Limited Institution Faculty Development Awards

To encourage the development of faculty investigators at resource-limited institutions and to enhance their research capabilities in specified health and health related areas.
K25 Research Training and Career Development Mentored Quantitative Research Career Development Award To engender and foster such activities by supporting the career development of investigators with quantitative scientific and engineering backgrounds outside of biology or medicine who have made a commitment to focus their research endeavors on behavioral and biomedical research (basic or clinical). This mechanism is aimed at research-oriented scientists with experience at the level of junior faculty (e.g., early to mid-levels of assistant professor or research assistant professor ranks). This award provides support for a period of mentored study and research for professionals with such backgrounds who have the potential to integrate their expertise with biomedicine and develop into productive investigators. Examples of quantitative scientific and technical backgrounds outside of biology or medicine considered appropriate for this award include, but are not limited to: mathematics, statistics, computer science, informatics, physics, chemistry, and engineering.
K30 Research Training and Career Development Clinical Research Curriculum Award (CRCA) The CRCA is an award to institutions and is intended to stimulate the inclusion of high-quality, multi-disciplinary didactic training as part of the career development of clinical investigators. This award is intended to support the development of new didactic programs in clinical research at institutions that do not currently offer such programs or, in institutions with existing didactic programs in clinical research to support or expand their programs or to improve the quality of instruction.
KD1 Research Training and Career Development Mental Health and/or Substance Abuse KD&A Grants To provide support to develop new knowledge about ways to improve the prevention and/or treatment of substance abuse and/or mental illness, and to work with State and local governments as well as providers, families, and consumers to apply that knowledge effectively in everyday practice. Outcome measures are the heart and core of the KD&A program. KD&As do not provide operating funds for service programs, except as required by the knowledge development activity.
KM1 Research Training and Career Development Institutional Career Enhancement Awards - Multi-Yr Funding

Provides for part time (minimum 25% effort) up to full-time support for medical, scientific, statistics and health care professionals with post-doctoral or equivalent experience selected by an institution, to broaden their research capabilities by acquiring new research skills or knowledge. Further it provides for curriculum development of new programs to support these same types of individuals. This is an institutional mentored career program, not an individual program.
L32 Loan Repayment Programs Loan Repayment Program for Clinical Researchers from Disadvantaged Backgrounds To provide for the repayment of the educational loan debt of qualified health professionals from disadvantaged backgrounds involved in clinical research. Qualified health professionals from disadvantaged backgrounds who contractually agree to conduct qualified clinical research are eligible to apply for this program.
L70 Loan Repayment Programs Loan Repayment Program for Research in Emerging Areas Critical to Human Health

For investigators pursuing major opportunities or gaps in emerging high-priority research areas, as defined by NIH Institutes and Centers.
P2C Research and Development Resource-Related Research Multi-Component Projects and Centers To support multi-component research resource projects and centers that will enhance the capability of resources to serve biomedical research.
P40 Research and Development Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants To develop and support animal (mammalian and nonmammalian) models, or animal or biological materials resources available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program. Nonmammalian resources include nonmammalian vertebrates, invertebrates, cell systems, and nonbiological systems.
P41 Research and Development Biotechnology Resource Grants To support biotechnology resources available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program area.
P42 Research and Development Hazardous Substances Basic Research Grants Program (NIEHS) To support basic research directed towards understanding and attenuating the public health effects resulting from exposure to hazardous substances, including 1) advanced techniques for detection, assessment and evaluation of the effects on human health of hazardous substances; 2) methods to assess risks to human health presented by hazardous substances; 3) methods and technologies to detect hazardous substances in the environment and 4) basic biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances. This special program, authorized under Superfund legislation, is for a broadly based, multi-disciplinary research effort which must include biomedical research components and which may include research components related to engineering, hydrogeology, ecology and epidemiology so long as they are linked to basic biomedical science. Each research project is generally under the leadership of an established investigator. The grant can provide support for certain basic resources used by the groups in the program (cores), including an administrative structure for effective coordination.
PM1 Research and Development Program Project or Center with Complex Structure

To support a complex research program or center with complicated structures.
R24 Research and Development Resource-Related Research Projects To support research projects that will enhance the capability of resources to serve biomedical research.
R25 Research Training and Career Development Education Projects For support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.
R28 Research and Development Resource-Related Research Projects To support research projects contributing to improvement of the capability of resources to serve clinical research.
R2F Research and Development Food Safety Capacity and Infrastructure Building To build food safety capacity and infrastructure by assisting State, locality, territory, Indian tribe, or nonprofit food safety training entity that collaborates with 1 or more institutions of higher education to undertake food safety inspections, investigations, and examinations; train to the standards established by the HHS Secretary; build lab capacity; and respond to notifications received under Section 1008 and recalls.
R30 Research and Development Preventive Health Service - Venereal Disease Research, Demonstration, and Public Information and Education Grants (Definition not available)
R35 Research and Development Outstanding Investigator Award To provide long term support to an experienced investigator with an outstanding record of research productivity. This support is intended to encourage investigators to embark on long-term projects of unusual potential.
R41 Small Business Small Business Technology Transfer (STTR) Grants - Phase I To support cooperative R&D projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization. Awards are made to small business concerns only.
R42 Small Business Small Business Technology Transfer (STTR) Grants - Phase II To support in - depth development of cooperative R&D projects between small business concerns and research institutions, limited in time and amount, whose feasibility has been established in Phase I and that have potential for commercialization. Awards are made to small business concerns only.
R43 Small Business Small Business Innovation Research Grants (SBIR) - Phase I To support projects, limited in time and amount, to establish the technical merit and feasibility of R&D ideas which may ultimately lead to a commercial product(s) or service(s).
R44 Small Business Small Business Innovation Research Grants (SBIR) - Phase II To support in - depth development of R&D ideas whose feasibility has been established in Phase I and which are likely to result in commercial products or services. SBIR Phase II are considered “Fast-Track” and do not require National Council Review.
R49 Injury Control Research and Demonstration Projects and Injury Prevention Research Centers Provides financial assistance to non-profit and for-profit organizations to conduct research and demonstration projects as well as training programs to develop a comprehensive and integrated approach to injury control. These projects will integrate aspects of the disciplines of engineering, public health, behavioral sciences, medicine, and others in order to prevent and control injuries.
R90 Research Training and Career Development Interdisciplinary Regular Research Training Award To support comprehensive interdisciplinary research training programs at the undergraduate, predoctoral and/or postdoctoral levels, by capitalizing on the infrastructure of existing multidisciplinary and interdisciplinary research programs. This Activity Code is for trainees who do not meet the qualifications for NRSA authority.
RC2 Research and Development High Impact Research and Research Infrastructure Programs

To support high impact ideas through cooperative agreements that that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code could support either a specific research question or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future.
RC3 Research and Development Biomedical Research, Development, and Growth to Spur the Acceleration of New Technologies (BRDG-SPAN) Program To accelerate the transition of NIH-supported research innovations and technologies toward the development of products or services that will improve human health, through grants that may advance the mission of NIH and its Institutes and Centers (ICs), and create significant value and economic stimulus or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code is intended to support research and development (R&D) specifically targeted at activities that can help address the funding gap between promising R&D and transitioning to the market, often called the “Valley of Death” by contributing the critical funding needed by applicants to pursue the next appropriate milestone(s) toward ultimate commercialization; i.e., to carry out later stage research activities necessary to that end; to foster partnerships among a variety of research and development (R&D) collaborators working toward these aims. Awards are made only to U.S.-owned, for-profit enterprises doing a majority of its business in the United States. RC3 applications may be given funding priority if the applicant organization is associated with an enterprise that is of small size (e.g., 500 or fewer employees), and/or of limited resources, such as an early-stage company, and/or one positioned for receiving funding or in-kind support from a third-party investor and/or strategic partner. The RC3 SPAN program is not intended to support “upstream” R&D for doing feasibility testing of an innovative idea or to conduct early-stage R&D as an extension of such ideas. (Projects such as these should be submitted under the NIH SBIR/STTR programs.)
RC4 Research and Development High Impact Research and Research Infrastructure Programs—Multi-Yr Funding

To support multi-year funded research with high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code could support either a specific research question or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future.
RF1 Research and Development Multi-Year Funded Research Project Grant

To support a discrete, specific, circumscribed project to be performed by the named investigator(s) in an area representing specific interest and competencies based on the mission of the agency.
RL5 Research Training and Career Development Linked Education Project For support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation. The grant is administratively linked to another project or projects. A RL5 award may only be disaggregated from a U54 application and organizations may not apply for an RL5, Linked Education Project. The RL5 is used in lieu of the R25 for those programs that offer linked awards.
RM1 Research and Development Research Project with Complex Structure

To support a large-scale research project with a complex structure.
RS1 Research and Development Programs to Prevent the Emergence and Spread of Antimicrobial Resistance in the United States Develop, implement, and evaluate an antimicrobial project to prevent and control the emergence, prevalence, and spread of antimicrobial resistance in rural areas, and microbiologic mechanisms of dissemination of antimicrobial resistance genes and the relationship to antimicrobial drug use.
S06 Research and Development Tribal Biomedical Research Support

To strengthen the biomedical research and research training capabilities of federally recognized Tribes and Tribal Entities. 
S07 Research and Development Biomedical Research Support Grants To strengthen, balance, and stabilize Public Health Service supported biomedical and behavioral research programs at qualifying institutions through flexible funds, awarded on a formula basis, that permit recipient institutions to respond quickly and effectively to emerging needs and opportunities, to enhance creativity and innovation, to support pilot studies, and to improve research resources, both physical and human.
S10 Research and Development Biomedical Research Support Shared Instrumentation Grants To make available to institutions with a high concentration of NIH extramural research awards, research instruments which will be used on a shared basis.
S11 Research and Development Biomedical Research Support Thematic Project Grants for Developing Institutions

To promote increased faculty and interdepartmental collaboration through programs that focus on specific research themes or scientific disciplines at developing institutions. 
S15 Research and Development Small Instrumentation Grants Program

An institutional award to support the purchase of equipment costing no less than $5,000 and no more than $60,000, to be used by one or more recipients of active NIH research grants.
S21 Research and Development Research and Institutional Resources Health Disparities Endowment Grants -Capacity Building To strengthen the research and training infrastructure of the institution, while addressing current and emerging needs in other health disparities research.
S22 Research Training and Career Development Research and Student Resources Health Disparities Endowment Grants - Educational Programs

To increase the investment in student-centered programs: to improve the academic success students in biomedical and bio-behavioral fields of study.
SB1 Small Business Commercialization Readiness Program To support follow-on awards to small businesses for technology development, testing, evaluation, and commercialization assistance for SBIR or STTR Phase II technologies or for awards to small businesses to support the progress of research, research and development, and commercialization conducted under the SBIR or STTR programs to Phase III.
SC3 Research and Development Research Continuance Award Individual investigator-initiated research projects for faculty at MSIs to conduct research of limited scope in environments with limited research infrastructure/facilities.
SI2 Research and Development Intramural Clinical Scholar Research Award

This program will encourage exceptionally talented clinical researchers to conduct research in the Intramural Research Program for a specified period of time who will then be able to work with an extramural institution to develop an independent research grant application for follow-on support. This code can only be used as phase 1 (intramural) of a 2-phase intramural/extramural program. No extramural award can be issued using this activity code.
T01 Research Training and Career Development Graduate Training Program To assist and extend training of individuals preparing for research and academic careers in fundamental, preclinical, clinical, public health, and other disciplines related to the area of interest of the awarding Institute/Division.
T02 Research Training and Career Development Undergraduate Training Program

To assist qualified institutions to improve and expand the training of undergraduate students in disciplines related to an area of interest of the awarding Institute/Division.
T09 Research Training and Career Development Scientific Evaluation

To provide the chairman of the training committee funds for operation of the review group.
T15 Research Training and Career Development Continuing Education Training Grants To assist professional schools and other public and nonprofit institutions to establish, expand, or improve programs of continuing professional education, especially for programs of extensive continuation, extension, or refresher education dealing with new developments in the science of technology of the profession.
T32 Research Training and Career Development Institutional National Research Service Award To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas.
T34 Research Training and Career Development Undergraduate NRSA Institutional Research Training Grants

To enhance undergraduate research training in biomedical, behavioral, clinical and social sciences through Organizational National Research Service Award Training Grants, in preparation for research doctorate degree programs.
T42 Research Training and Career Development Educational Resource Center Training Grants To provide assistance to regional centers in developing specialized personnel in the occupational safety and health field with academic training, research training, and continuing education and outreach in industrial hygiene, occupational health nursing, occupational medicine, and occupational safety.
TL4 Research Training and Career Development Undergraduate NRSA Institutional Research Training Grants

To enhance undergraduate research training in biomedical, behavioral, clinical and social sciences through Organizational National Research Service Award Training Grants, in preparation for research doctorate degree programs. This is the linked equivalent of the T34.
TU2 Research Training and Career Development Institutional National Research Service Award with Involvement of NIH Intramural Faculty The cooperative agreement counterpart to the T32, this award enables institutions to provide research-training experiences for graduate students and postdoctoral scientists in specified shortage areas. In addition, these awards involve identified NIH Intramural Staff who serve as a part of the training faculty and participate in the operation of the training program.
U01 Research and Development Research Project--Cooperative Agreements To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.
U09 Scientific Review and Evaluation--Cooperative Agreements To provide the chairman of an initial review group funds for operation of the review group.
U10 Cooperative Clinical Research--Cooperative Agreements To support clinical evaluation of various methods of therapy and/or prevention in specific disease areas. These represent cooperative programs between sponsoring institutions and participating principal investigators, and are usually conducted under established protocols.
U11 Study (in China) of Periconceptional Vitamin Supplements to Prevent Spina Bifida and Anencephaly Cooperative Agreements In cooperation with the Beijing Medical University (BMU) of the People’s Republic of China, to support a project undertaken by BMU to conduct a randomized controlled trial in china to determine whether vitamins, taken before pregnancy begins and through the first trimester, prevent spina bifida and anencephaly. The project will consist of an initial preparation stage and a 1-2 year pilot study which will document the potential for a full-scale randomized controlled trial.
U13 Research and Development Conference--Cooperative Agreements To support international, national or regional meetings, conferences and workshops where substantial programmatic involvement is planned to assist the recipient.
U17 Applied Methods in Violence-Related or Accidental Injury Surveillance Cooperative Agreements Provides financial assistance to State and territorial health agencies to develop, implement, and/or evaluate new or existing methods and techniques used in accidental-injury and violence-related injury surveillance and /or prevention. Such injuries include violence against women; alcohol or firearm-related injury; bicycle or automobile-occupant injury; fire-related burns; head and spinal cord injury, and others. These methods and techniques are applicable to statewide injury surveillance systems and are replicable in other public health jurisdictions.
U18 Research Demonstration--Cooperative Agreements To provide support for testing, by means of a research design, the effectiveness of the transfer and application of techniques or interventions derived from a research base for the control of diseases or disorders or for the promotion of health. The project should be capable of making conclusions which are generalizable to other sites. These are usually cooperative programs between participating principal investigators, institutions, and the sponsoring Institute(s).
U19 Research and Development Research Program--Cooperative Agreements To support a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach. A cooperative agreement research program generally involves the organized efforts of large groups, members of which are conducting research projects designed to elucidate the various aspects of a specific objective. Substantial Federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of award. The investigators have primary authorities and responsibilities to define research objectives and approaches, and to plan, conduct, analyze, and publish results, interpretations and conclusions of their studies. Each research project is usually under the leadership of an established investigator in an area representing his/her special interest and competencies. Each project supported through this mechanism should contribute to or be directly related to the common theme of the total research effort. The award can provide support for certain basic shared resources, including clinical components, which facilitate the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence.
U1A Capacity Building for Core Components of Tobacco Prevention and Control Programs Cooperative Agreements

In cooperation with State health agencies, to 1) supplement existing tobacco control efforts and provide assistance in the development of the essential components of a comprehensive public health tobacco control program, or 2) develop the infrastructure in preparation for carrying out a tobacco control program.
U1B Cooperative Agreement for Research and Surveillance Activities to Reduce the Incidence of HIV/AIDS In cooperation with State and local public health authorities and other non-profit organizations, to assist in detecting and preventing the further spread of AIDS/HIV through research and active surveillance.
U1Q Emergency Disaster Relief Relating to CDC Programs Cooperative Agreement In cooperation with eligible State health departments, to provide assistance to States impacted by designated natural disasters to assess the health threats and address health issues associated with the disaster, and to restore CDC-related public health programs that were impacted by the disaster.
U1V Capacity Building for Core Components of Tobacco Prevention and Control Programs Cooperative Agreements

In cooperation with State health agencies, to 1) supplement existing tobacco control efforts and provide assistance in the development of the essential components of a comprehensive public health tobacco control program, or 2) develop the infrastructure in preparation for carrying out a tobacco control program.
U21 Immunization Service Cooperative Agreements (Definition not available)
U22 HIV/STD Preventive Services (Definition not available)
U23 TB Prevention and Control Services Cooperative Agreements

n cooperation with national and regional nonprofit organizations, to strengthen and increase the effectiveness of tuberculosis prevention and treatment services for racial and ethnic minority populations (especially the 25-44 years old age group); to improve organizational capabilities, programmatic efforts, and coordination of tuberculosis awareness; and to promote tuberculosis prevention and control, information dissemination, and training and education.
U24 Resource-Related Research Projects--Cooperative Agreements To support research projects contributing to improvement of the capability of resources to serve biomedical research.
U27 Surveillance of Complications of Hemophilia Cooperative Agreements In cooperation with State public health agencies, to characterize the epidemiology of hemophilia and its complications by using surveillance methodologies such as data collection, interviews, and progress reports. The data collected through this program can assist hemophilia treatment providers and States in developing, implementing, and evaluating education and prevention programs designed to reduce the morbidity, mortality, and costs of hemophilia and its complications.
U2C Resource-Related Research Multi-Component Projects and Centers Cooperative Agreements To support multi-component research resource projects and centers that will enhance the capability of resources to serve biomedical research. Substantial federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of the award.
U2F Research and Development Food Safety Capacity and Infrastructure Building To build food safety capacity and infrastructure by assisting State, locality, territory, Indian tribe, or nonprofit food safety training entity that collaborates with 1 or more institutions of higher education to undertake food safety inspections, investigations, and examinations; train to the standards established by the HHS Secretary; build lab capacity; and respond to notifications received under Section 1008 and recalls.
U2G Global HIV/AIDS Non-Research Cooperative Agreements In cooperation with other countries, international organizations, and other partners to conduct HIV/AIDS prevention, care and treatment of non-research activities in international countries most heavily affected by the HIV/AIDS epidemic.
U2R Research Training and Career Development International Research Training Cooperative Agreements Cooperative agreement mechanism for D43 to support research training programs for US and foreign professionals and students to strengthen global health research and international research collaboration.
U30 Prev. Health Services: Venereal Disease Research, Demonstration, and Public Information and Education Projects Cooperative Agreements to provide assistance to programs designed for the conduct of research, demonstration, and public information and education for the prevention and control of venereal disease.
U32 State-based Diabetes Control Programs In cooperation with State health agencies: To reduce the effect of preventable problems in service delivery to diabetics (such as excess days of hospitalization, high amputation rates, and the effect of insurance policy on securing care), to define the preventable service delivery problems, and to demonstrate improved service delivery to diabetics.
U34 Research and Development Planning Cooperative Agreement This cooperative agreement would provide support, substantial Federal programmatic involvement, and technical assistance for the initial development of a clinical trial or research project. Also, it would include the establishment of the research team; the development of tools for data management and oversight of the research; the development of a trial design or experimental research designs and other essential elements of the study or project, such as the protocol, recruitment strategies, and procedure manuals; and to collect feasibility data.
U36 Program Improvements for Schools of Public Health In cooperation with the Associated Schools of Public Health, to stimulate improvements in the educational programs of schools of public health.
U38 Uniform National Health Program Reporting System In cooperation with the States to operate a uniform national health program reporting system, which is to provide data for analytical purposes to assist health planners and health program managers in their decision-making processes.
U3R Research and Development NIH Small Research Grant Program (Cooperative Agreement) This grant mechanism will support small research projects that can be carried out in a short period of time with limited resources and will be used as the companion cooperative agreement activity code to the R03.
U41 Biotechnology Resource Cooperative Agreements To support biotechnology resources available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program area.
U42 Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements To develop and support animal (mammalian and nonmammalian) model, or animal or biological materials resources available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program. Nonmammalian resources include nonmammalian vertebrates, invertebrates, cell systems, and nonbiological systems.
U43 Small Business Small Business Innovation Research (SBIR) Cooperative Agreements - Phase I To support projects, limited in time and amount, to establish the technical merit and feasibility of R&D ideas that may ultimately lead to commercial products or services.
U44 Small Business Small Business Innovation Research (SBIR) Cooperative Agreements - Phase II To support in-depth development of R&D ideas whose feasibility has been established in Phase I and that are likely to result in commercial products or services.
U45 Hazardous Waste Worker Health and Safety Training Cooperative Agreements (NIEHS) To develop, implement, and evaluate programs to train workers who are or may be engaged in activities related to hazardous waste removal, containment, or emergency response.
U47 Laboratory/Other Diagnostic Medical Quality Improvement Cooperative Agreements In cooperation with public or private health-related organizations, to establish data collection networks or other methods to increase the effectiveness of primary care physicians in determining the level and impact of problems in laboratory testing, or in other services for diagnosis of health problems, by determining what problems exist; how often problems occur; what impact these problems have on patient care, and what interventions can be developed to improve the disease testing or control process.
U48 Health Promotion and Disease Prevention Research Centers In cooperation with schools of public health, medicine, or osteopathy, to establish and maintain interdisciplinary academic centers focused on health issues or themes of national importance and to promote translation of the results of the school’s research into improved public health practice.
U49 Coop: Injury Control Res. and Demo and Injury Prevention

In cooperation with public and private nonprofit and for-profit organizations to conduct research and demonstration projects as well as training programs to develop a comprehensive and integrated approach to injury control. This is to include those directed toward violence toward women, intimate partners, and youth. These projects will integrate aspects of the disciplines of engineering, public health, behavioral sciences, medicine, and others in order to prevent and control injuries.
U50 Special Cooperative Investigations/Assessment of Control/Prevention Methods In cooperation with State or local government or other health-related organization, to perform special investigations of communicable diseases and other preventable health conditions, or to evaluate special methods of preventing disease or controlling health conditions.
U51 Health Planning Strategies/National Academy of Sciences Activities Financial support for activities of interest to the Public Health Service, primarily, support for a series of Boards to oversee a variety of health and health administration topics.
U52 Cooperative Agreement for Tuberculosis Control In cooperation with State and local health departments, to reduce the number of tuberculosis cases by case finding and follow-up of patient compliance with treatment.
U53 Capacity Bldg: Occupational Safety/Community Environmental Health In cooperation with State and local health departments to expand State capacities in the area of occupational safety and community environmental public health.
U54 Specialized Center--Cooperative Agreements To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These differ from program project in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes, with funding component staff helping to identify appropriate priority needs.
U55 Core Support For American Council on Transplantation Active (Definition not available)
U56 Exploratory Grants--Cooperative Agreements To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers. Substantial Federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of award.
U57 State-Based Comprehensive Breast/Cervical Cancer Control Program Cooperative Agreements In cooperation with State and territorial health agencies, to develop comprehensive breast and cervical cancer control programs, increasing screening and follow-up among all groups of women in the State or territory, with special efforts to reach women who are of low income, uninsured, underinsured, minority, or Native American.
U58 Chronic Disease Control Cooperative Agreement In cooperation with State and local public health agencies and other public or private organizations to assist in controlling and preventing chronic diseases. Efforts are directed at the integrated application of surveillance; applied epidemiology; laboratory sciences; evaluation; health education; dynamic and productive relationships; training; and extensive applied management of effective disease control programs.
U59 Disabilities Prevention Cooperative Agreement Program In cooperation with State and local agencies or private organizations, to conduct and evaluate interventions to prevent disabilities and to support demonstration and epidemiology programs for States in building capacity to coordinate disability prevention activities.
U60 Cooperative Agreements in Occupational Safety and Health Research, Demonstrations, Evaluation and Education Research, Demonstrations, Evaluation and Education In cooperation with universities or other eligible recipients, to investigate the underlying characteristics and causes of occupational safety and health problems; to eliminate or control factors in the work environment which are harmful to the health and/or safety of workers, or to demonstrate effective solutions for occupational safety and health problems.
U61 Preventive Health Activities Regarding Hazardous Substances In cooperation with State and local health authorities, to provide programs and activities designed to protect the public from exposure to hazardous substances, and to protect the worker from hazards associated with hazardous waste removal or other remedial response actions.
U62 Prevention/Surveillance Activities/Studies of AIDS In cooperation with the State and local public health authorities and other non-profit organizations, to assist in detecting and preventing the further spread of AIDS through active surveillance and epidemiologic investigation, sero-prevalence surveys, laboratory services, public information campaigns, health education and risk reduction activities, and counseling, testing and partner notification.
U65 Minority/Other Community-based HIV Prevention Project, Cooperative Agreements In cooperation with non-profit organizations based in communities most heavily affected by the HIV epidemic, to assist in achieving a reduction of the risk of HIV transmission through education programs.
U66 Immunization Demonstration Projects Cooperative Agreements Provides financial assistance to State and local health agencies and other public and non-profit entities for (1) assessment of projects to develop methods/strategies to effectively assess preschool-age immunization protection at the State or county level and/or (2) intervention projects to develop innovative ways to successfully identify and vaccinate preschool-age children living in inner-city, high-disease morbidity areas.
U75 National Cancer Registries Cooperative Agreements In cooperation with State health agencies or eligible academic or other nonprofit organizations, to establish a national program of cancer registries by supporting and enhancing existing State cancer registries so that they are statewide and population-based, and by planning, implementing, and supporting statewide population-based cancer registries where State registries do not currently exist.
U79 Mental Health and/or Substance Abuse Services Cooperative Agreements To support the provision of mental health and/or substance abuse prevention and treatment services. These are cooperative programs between participating principal investigators. Organizations and sponsoring Centers and where substantial programmatic involvement is planned to assist the recipient.
U81 Injury Community Demonstration Projects: Evaluation of Youth Violence Prevention Program In cooperation with qualified recipients to design, implement, and determine the effectiveness of multifaceted, community-based youth violence prevention programs in reducing the incidence of interpersonal violent behavior and associated injuries and deaths.
U82 Enhancement of State and Local Capacity to Assess the Progress toward Healthy People 2010 Objectives In cooperation with State and local health agencies and Federally-recognized Indian Tribes, to increase the assessment capacity of State and local health agencies and to develop new surveillance models to measure currently underassessed conditions or populations.
U83 Research to Advance the Understanding of the Health of Racial and Ethnic Populations or Subpopulations Cooperative Agreements In cooperation with public and private non-profit organizations, to advance the understanding of the health of racial and ethnic populations or subpopulations through 1) special studies and analyses to improve existing knowledge, and 2) improvements in existing research methodological techniques used to gather information on these groups.
U84 Cooperative Agreements for Fetal Alcohol Syndrome Prevention Research Programs In cooperation with qualified recipients, to develop methods for identifying women at high risk for having children with Fetal Alcohol Syndrome or other adverse alcohol effects, to design primary prevention strategies for these women, and to rigorously evaluate the effectiveness of these strategies.
U86 State Demonstration: Comprehensive School Health Programs to Prevent Important Health Problems and Improve Educational Outcome In cooperation with State education agencies of the States with specified high total mortality rates, to strengthen the capacity of those States to plan, implement, and evaluate effective comprehensive school health programs to prevent important health-risk behavior among youth, including: tobacco use; dietary patterns that contribute to disease; sedentary lifestyle; STDs and unintended pregnancy; alcohol and other drug use; behaviors that result unintentional and intentional injuries, and other behaviors or conditions that are leading causes of death and disability. The U87 code is to be used for aspects of the demonstration project that deal with HIV infection. (PHS Act, S.301a, 311b, and 317K0)
U87 State Demonstration: Comprehensive School Health Program to Prevent Sexual Behaviors that Result in HIV Infection and to Improve Educational Outcome In cooperation with State education agencies of the States with specified high total mortality rates, to strengthen the capacity of those States to plan, implement, and evaluate effective comprehensive school health programs to prevent sexual behaviors that result in HIV infection. This program is a companion to U86
U90 Cooperative Agreements for Special Projects of National Significance (SPNS) In cooperation with State and local public health agencies and other public or private nonprofit entities, to conduct HIV service-related projects which meet the criteria for funding and target one of the specified priority areas. The primary purpose of the SPNS program is to contribute to the advancement of knowledge and skill in the delivery of health and support services to persons with HIV disease.
UA1 AIDS Research Project Cooperative Agreement In cooperation with a named investigator, to support a discrete, specified, circumscribed project on Acquired Immune Deficiency Syndrome in an area representing the investigator's specific interest and competencies.
UA5 Research and Development Academic Research Enhancement Award (AREA) Cooperative Agreements

Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation's research scientists but that have not been major recipients of NIH support. 
UB1 Small Business Commercialization Readiness Program – Cooperative Agreement To support follow-on awards to small businesses for technology development, testing, evaluation, and commercialization assistance for SBIR or STTR Phase II technologies or for awards to small businesses to support the progress of research, research and development, and commercialization conducted under the SBIR or STTR programs to Phase III.
UC1 NIH Challenge Grants and Partnerships Program - Phase II-Coop.Agreement To promote the implementation of joint ventures between the NIH and both domestic and global entities to facilitate rapid implementation of R&D in biomedical or biotechnology projects for infectious diseases that benefit public health and have a commercial potential that otherwise could not have been attained without matching funds. <br><br> Essential elements of recipient responsibility would include: 1) interim research and development of target goals upon whose achievement funds would be incrementally released to the awardee; 2) a single principle investigator who would be scientifically and administratively responsible for the project's research and development, and 3) a single applicant organization that would be legally and financially responsible for the funds awarded.
UC2 Research and Development High Impact Research and Research Infrastructure Cooperative Agreement Programs To support high impact ideas through cooperative agreements that that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code could support either a specific research question or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future. This is the cooperative agreement companion to the RC2.
UC3 Biomedical Research, Development, and Growth to Spur the Acceleration of New Technologies (BRDG-SPAN) Cooperative Agreement Program To accelerate the transition of NIH-supported research innovations and technologies toward the development of products or services that will improve human health, through cooperative agreements that may advance the mission of NIH and its Institutes and Centers (ICs), and create significant value and economic stimulus or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code is intended to support research and development (R&D) specifically targeted at activities that can help address the funding gap between promising R&D and transitioning to the market, often called the “Valley of Death” by contributing the critical funding needed by applicants to pursue the next appropriate milestone(s) toward ultimate commercialization; i.e., to carry out later stage cooperative agreement activities necessary to that end; to foster partnerships among a variety of research and development (R&D) collaborators working toward these aims. The UC3 SPAN program is not intended to support “upstream” R&D for doing feasibility testing of an innovative idea or to conduct early-stage R&D as an extension of such ideas. (Projects such as these should be submitted under the NIH SBIR/STTR programs.)
UC4 High Impact Research and Research Infrastructure Cooperative Agreement Programs—Multi-Yr Funding

To support multi-year funded cooperative agreement research with high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery. This activity code could support either a specific research question or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future.
UC6 Construction and Modernization Construction Cooperative Agreement To provide financial support, substantial programmatic involvement and technical assistance for designing, constructing and commissioning of laboratories to be used as extramural facilities for bio-defense and emerging infectious diseases research.
UC7 Biocontainment Laboratory Operation Cooperative Agreement To support core and shared resources for biocontainment laboratories enabling them to develop and maintain the research resources and facilities needed to meet national, regional and local biodefense and emerging infectious diseases research needs. This support, by providing more accessible resources, is expected to assure greater productivity at biocontainment laboratories.
UD1 Mental Health and/or Substance Abuse KD&A Cooperative Agreements To provide support to develop new knowledge about ways to improve the prevention and/or treatment of substance abuse and/or mental illness, and to work with State and local governments as well as providers, families, and consumers to apply that knowledge effectively in everyday practice. Outcome measures are the heart and core of the KD&As, do not provide operating funds for service programs, except as required by the knowledge development activity.
UE1 Studies of Environmental Hazards and Health Effects Studies ways to prevent or control health problems associated with exposure to air pollution, radiation, and other toxicants, as well as health problems resulting from natural, technological or terrorist disasters.
UE2 Emergency and Environmental Health Services Provide national and international leadership for coordinating, delivering, and evaluating emergency and environmental public health services.
UE5 Research Training and Career Development Education Projects - Cooperative Agreements For support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.
UF1 Research and Development Multi-Year Funded Research Project Cooperative Agreement

To support a discrete, specific, circumscribed project to be performed by the named investigator(s) in an area representing specific interest and competencies based on the mission of the agency.
UF2 Rape Prevention and Education Cooperative Agreement To provide financial assistance to States for rape prevention and education programs conducted by rape crisis centers, State sexual assault coalitions, and other public and private nonprofit entities for: educational seminars, operation of hotlines, training for professionals, preparation of informational material; education and training for college and university students and personnel to reduce sexual assault; and awareness programs. The awards are based on a formula.
UG1 Clinical Research Cooperative Agreements - Single Project

To support single project applications conducting clinical evaluation of various methods of therapy and/or prevention (in specific disease areas). Substantial federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of the award.
UG3 Research and Development Phase 1 Exploratory/Developmental Cooperative Agreement As part of a bi-phasic approach to funding exploratory and/or developmental research, the UG3 provides support for the first phase of the award. This activity code is used in lieu of the UH2 activity code when larger budgets and/or project periods are required to establish feasibility for the project.
UG4 National Network of Libraries of Medicine Multicomponent cooperative agreements are awarded to medical libraries to enable them to serve as regional medical libraries for their geographical areas. The purpose of the program is to develop a national system of regional medical libraries, each of which would have sufficient facilities to supplement the services of other medical libraries in its region.
UH1 HBCU Research Scientist Award To assist HBCUs in strengthening and augmenting their human resources by recruiting an established research scientist; to enhance the career of the recruited research scientist; and to strengthen other HBCU resources for the conduct of biomedical and/or behavioral research. The recruited research scientist must have received competitive and independent research support.
UH2 Research and Development Exploratory/Developmental Cooperative Agreement Phase I To support the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.)
UH3 Research and Development Exploratory/Developmental Cooperative Agreement Phase II The UH3 award is to provide a second phase for the support for innovative exploratory and development research activities initiated under the UH2 mechanism. Although only UH2 awardees are generally eligible to apply for UH3 support, specific program initiatives may establish eligibility criteria under which applications could be accepted from applicants demonstrating progress equivalent to that expected under UH2.
UH4 Hazmat Training at DOE Nuclear Weapons Complex To develop, implement, and evaluate programs to train workers who are or may be engaged in activities related to hazardous waste removal, containment, or emergency response at the DOE Nuclear Weapons Complex. This is the single project equivalent to the U45
UL1 Linked Specialized Center Cooperative Agreement To support clinical and translational research. The UL1 administratively linked to another project or projects. AUL1 award may only be disaggregated from a U54 application and organizations may not apply for a UL1, Linked Specialized Center Cooperative Agreement. The UL 1 activity code is used in lieu of the U54 for those programs that offer linked awards.
UM1 Research and Development Research Project with Complex Structure Cooperative Agreement

To support cooperative agreements involving large-scale research activities with complicated structures, e.g. clinical networks, research programs or consortium. The components represent a variety of supporting functions and are not independent of each component. Substantial federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of the award. 
UM2 Research and Development Program Project or Center with Complex Structure Cooperative Agreement To support cooperative agreements involving program projects or centers with complicated structures that cannot be appropriately categorized into an available multicomponent activity code, e.g. clinical networks, research programs or consortiums. At least one component must be UM1-like, supporting a variety of functions that are dependent on each other and cannot be separated into distinct components. Substantial federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of the award. The performance period may extend up to seven years but only through the established deviation request process.
UP5 Research Training and Career Development Early Independence Award Cooperative Agreement To support the independent research project of a recent doctoral degree recipient. This research grant program will encourage exceptionally creative scientists to bypass the typical post-doc research training period in order to move rapidly to research independence. It will encourage institutions to develop independent career tracks for recent graduates in order to demonstrate the benefits of early transition to independence both in terms of career productivity for the candidate and research capability for the institution.
UR6 Prevention Intervention Research on Substance Abuse in Children Cooperative Agreements In cooperation with public and private nonprofit and for-profit organizations, to support research to determine the most effective interventions to change the developmental course of early predictor markers for substance abuse in children at several defined developmental stages.
UR8 Applied Research in Emerging Infections-(including Tick-borne Diseases) Cooperative Agreements In cooperation with eligible organizations, to research emerging infections, such as tick borne diseases, through epidemiological studies and development and evaluation of diagnostic tests. Associated grant program under Activity Code RR8.
US3 Hantaviral Reservoir Studies Cooperative Agreements In cooperation with eligible organizations, to study the behavior, movement, reproductive biology, population
US4 Community-Based Primary Prevention Programs: Intimate Partner Violence Cooperative Agreements In cooperation with non-profit community-based organizations, to develop, implement, expand the capacity of, and evaluate the process and outcomes of, programs for preventing intimate partner violence.
UT1 Small Business Small Business Technology Transfer (STTR) – Cooperative Agreements - Phase I To support cooperative research and development projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization.
UT2 Small Business Small Business Technology Transfer (STTR) – Cooperative Agreements - Phase II To support in-depth development of cooperative research and development projects between small business concerns and research institutions, limited in time and amount, whose feasibility has been established in Phase I and that have potential for commercialization.
VF1 Rape Prevention and Education Grants Provides financial assistance to States for rape prevention and education programs conducted by rape crisis centers, State sexual assault coalitions, and other public and private nonprofit entities for: educational seminars, operation of hotlines, training for professionals, preparation of informational material; education and training for college and university students and personnel to reduce sexual assault; and awareness programs. The awards are based on a formula.
X01 Resource Access Program A Program to invite eligible institutions to seek access to NIH research resources. This includes programs where institutions will request access to submit to the resource, e.g., high throughput screening assays. It also includes programs where access to a specific NIH research resource is needed to conduct certain research.
X98 Protection and Advocacy for Mentally Ill Individuals Provides financial assistance to State and local government agencies and public and private organizations, to establish systems to protect and advocate the rights of the mentally ill. This program is to ensure that the rights of mentally ill individuals are protected and advocated in conformance with constitutional, Federal and State mandates.
X99 National All Schedules Prescription Electronic Reporting (NASPER) Provides financial assistance to States and the District of Columbia who by July 10, 2009, have enacted legislation or regulations that permit the implementation of a State controlled substance monitoring program as well as the imposition of appropriate penalties for the unauthorized use and disclosure of information maintained in the program.
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