Small Business Innovation Research Grants (SBIR) - Phase II (R44)

To support in - depth development of R&D ideas whose feasibility has been established in Phase I and which are likely to result in commercial products or services. SBIR Phase II are considered “Fast-Track” and do not require National Council Review.

Organization Eligibility

Only United States small business concerns are eligible to submit applications to SBIR and STTR funding opportunities. Collaborating research institutions (e.g., universities) are subcontractors to the small businesses and may not apply as applicants. See SEED: Eligibility Criteria.

Carefully read the Eligibility section of the funding opportunity for opportunity-specific organization eligibility requirements.

Project Director/ Principal Investigator (PD/PI) Eligibility

PD/PI primary employment (> 50%) should be with the small business.

Carefully read the Eligibility section of the funding opportunity for opportunity-specific PD/PI eligibility requirements.

Award Information

  • Funding Instrument: Grant
  • Funding Category: Small Business
  • Budget Mechanism Code: SB - Small Business

Total funding support (direct costs, indirect costs, fee) normally may not exceed the SBA budget guidelines found at to SEED: Understanding SBIR and STTR.

Application and Submission Information

Parent Announcements

R44 Parent Announcements are available.

  • Parent announcements are broad funding opportunities that applicants can use to submit investigator-initiated applications for a range of popular programs. They do not specify any particular area of scientific interest. They simply provide the standard forms and instructions needed to apply. 

  • Not all NIH institutes and centers participate on all parent announcements. Check the participating organization in the funding opportunity before applying.

After identifying a funding opportunity, follow guidance in the How to Apply – Application Guide including any SBIR/STTR (B) instruction call-outs, except where instructed to do otherwise in the funding opportunity or related notices.

Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Active Funding Opportunities
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Due Dates

The Key Dates section of funding opportunities lists specific due dates. Many opportunities indicate Standard Due Dates apply.

Standard Application Due Dates (when applicable) Review and Award Cycles
New Renewal, Resubmission,
Revision as Allowed		 AIDS and AIDS Related
Grant Applications		 Scientific Merit Review Advisory Council
Review		 Earliest Start Date

Participating Funding Organizations

Each funding opportunity specifies the participating organizations. Applications must fit within the mission of at least one participating funding organization and meet all opportunity-specific requirements.

The following funding organizations participate on at least one active funding opportunity.

  • Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  • National Cancer Institute (NCI)
  • National Center for Advancing Translational Sciences (NCATS)
  • National Center for Complementary and Integrative Health (NCCIH)
  • National Eye Institute (NEI)
  • National Heart, Lung, and Blood Institute (NHLBI)
  • National Human Genome Research Institute (NHGRI)
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  • National Institute of Biomedical Imaging and Bioengineering (NIBIB)
  • National Institute of Dental and Craniofacial Research (NIDCR)
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  • National Institute of Environmental Health Sciences (NIEHS)
  • National Institute of General Medical Sciences (NIGMS)
  • National Institute of Mental Health (NIMH)
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • National Institute of Nursing Research (NINR)
  • National Institute on Aging (NIA)
  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  • National Institute on Deafness and Other Communication Disorders (NIDCD)
  • National Institute on Drug Abuse (NIDA)
  • National Institute on Minority Health and Health Disparities (NIMHD)
  • National Library of Medicine (NLM)
  • Office of Research on Women's Health (ORWH)
  • Sexual and Gender Minority Research Office (SGMRO)

Related Resources

Contact

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This page last updated on: October 28, 2024
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