decorative image
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
decorative image
Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

n/a Warning! This browser is not supported - Some features might not work. Try using a different browser such as Chrome, Edge, Firefox, or Safari.

Select Agent Information


On This Page:



This page provides the NIH awards process for research involving infectious agents and select agents, including submissions, awards, monitoring and oversight. This page also clarifies the processes and responsibilities for investigations of laboratory accidents, research-related illnesses and potential Biosafety violations.

Laws and Policies

  • HR 3448: Public Health Security and Bioterrorism Preparedness and Response Act, January 23, 2002 (PDF - 971 KB)
  • USA Patriot Act of 2001, October 26, 2001 (PDF - 908 KB)
  • Code of Federal Regulations: 

    7 CFR Part 331 and 9 CFR Part 121
    USDA Possession Use and Transfer of Select Agents and Toxins
    PDF - 333 KB Link to External Site
    29 CFR Part 1910-1030Bloodborne PathogensHTML Link to External Site
    PDF - 808 KB
    29 CFR Part 1910-1450Occupational Exposure to Hazardous Chemicals in LaboratoriesHTML
    42 CFR Part 72Additional Requirements for Facilities Transferring or Receiving Select AgentsPDF - 200 KB
    42 CFR Part 73 and 42 CFR Part 1003HHS Possession Use and Transfer of Select Agents and ToxinsPDF - 255 KB Link to External Site
    49 CFR Part 171DOT Hazardous Materials – Revision to Standards for Infectious SubstancesHTML Link to External Site
    49 CFR Part 171.15Immediate Notice of Certain Hazardous Materials IncidentsPDF - 78 KB
  • U.S. Code

    18 USC Part 175Prohibitions with respect to Biological WeaponsHTML Link to External Site
    18 USC Part 175aRequests for Military Assistance to Enforce Prohibition in Certain EmergenciesHTML Link to External Site
    18 USC Part 175bPossession by Restricted PersonsHTML Link to External Site
    18 USC Part 2332aUse of Weapons of Mass DestructionHTML Link to External Site
    42 USC Part 262aEnhanced Control of Dangerous Biological Agents and ToxinsHTML Link to External Site
    42 USC Part 4321-4347National Environmental Policy ActHTML Link to External Site
  • HHS Select Agents and Toxins Page (including the list of select agents and toxins and information about additions or deletions to the list) Link to External Site
  • NIH Grants Policy Statement: Select Agent Requirements

Guidelines and Resources

Monitoring and Oversight for NIH Awards


Select Agent Programs