PA-25-306 - NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required) is used for the submission of applications to the following Notices of Special Interest (NOSIs)

On This Page: 64

Active NOSIs

Title Notice Number Organization Release
Date		 Expiration
Date		 Activity
Code(s)
Notice of Special Interest (NOSI): Discovery and Development of Natural Products to Treat Substance Use Disorders (SUDs) NOT-DA-25-032 NIDA , NCCIH Nov 25, 2024 Jan 8, 2029 R01, UG3/UH3, U01, R21
Notice of Special Interest (NOSI): Effectiveness of Mobile Health Clinics to Advance Health Equity NOT-MD-24-022 NIMHD , NICHD , ODP , SGMRO , THRO Sep 26, 2024 Nov 17, 2027 R01, K01, R21, K08, K99/R00, K23
Notice of Special Interest (NOSI): Consequences of Prenatal Fentanyl Exposure NOT-DA-26-003 NIDA Sep 13, 2024 Sep 8, 2028 R21, R01, R03
Notice of Special Interest (NOSI): Application of Artificial Intelligence in Treatment Development for Substance Use Disorders NOT-DA-26-005 NIDA Sep 13, 2024 Sep 8, 2028 R03, R01, R21
Notice of Special Interest (NOSI): Model-informed Drug Development (MIDD) Approaches to Facilitate the Development of Therapeutics for Substance Use Disorders NOT-DA-26-002 NIDA Aug 27, 2024 Sep 8, 2028 R01, R21, R03
Notice of Special Interest (NOSI): Fundamental Science Research on Complementary and Integrative Health Approaches, Including Natural Products or Mind and Body Interventions NOT-AT-24-041 NCCIH Aug 13, 2024 Oct 18, 2027 R21, R01
Notice of Special Interest (NOSI): Supporting Research Using the Resources from the Osteoarthritis Initiative (OAI) NOT-AR-24-019 NIAMS , NIA Aug 8, 2024 Sep 8, 2027 R01, R21
Notice of Special Interest (NOSI): Ending the HIV Epidemic (EHE) NOT-AI-24-059 NIAID , NHLBI , NIA , NIAAA , NICHD , NIDA , NIMH , NIMHD , NINR , OAR Aug 6, 2024 Jan 10, 2026 R01, R34, R21
Notice of Special Interest (NOSI): Impact of Financing and Payment Mechanisms to Improve Behavioral Health Access, Utilization and Outcomes NOT-MH-24-270 NIMH , NIDA Jul 25, 2024 Oct 15, 2027 K01, K08, K99/R00, K23, R01, R03, R21, R34
Notice of Special Interest (NOSI): Advancing Research on SUD with brain-based computational models NOT-DA-26-001 NIDA Jul 2, 2024 Sep 8, 2027 R01, R21, R61/R33, K01, R15, R03, K99/R00
Notice of Special Interest (NOSI): Improving Adherence to Treatment and Prevention Regimens and Maintenance of Health Behaviors to Promote Health NOT-OD-24-146 OBSSR , NCCIH , NCI , NEI , NHLBI , NIA , NIDA , NIMH , NIMHD , NINR , OAR , ODP , ORWH , SGMRO Jun 24, 2024 Jul 14, 2027 P01, P30, R01, R03, UG3/UH3, R34, U24, R41/R42, R21, R43/R44, R21/R33, R61
Notice of Special Interest (NOSI): Research Opportunities Centering the Health of Women Across the HIV Research Continuum NOT-OD-24-119 ORWH , FIC , NCCIH , NCI , NIA , NIAAA , NIAID , NIAMS , NICHD , NIDA , NIDDK , NIMH , NIMHD , NINDS , OAR , OBSSR , SGMRO May 21, 2024 Jan 8, 2026 K99/R00, R01, R34, F32, K23, K25, K02, R15, K01, K43, R21, K24, R61/R33, K08, F30, R03, DP1, U34, F31, T32, R36
Notice of Special Interest (NOSI): Exploring the Effects of Endocannabinoids and Exogenous Cannabinoids on Brain Development NOT-DA-25-030 NIDA Apr 30, 2024 May 8, 2028 R01, K01, K25, R21, R03, K08, K99/R00
Notice of Special Interest: Womens Health Research NOT-OD-24-079 ORWH , FIC , NCATS , NCCIH , NCI , NEI , NHGRI , NHLBI , NIA , NIAAA , NIAID , NIAMS , NIBIB , NICHD , NIDA , NIDCD , NIDCR , NIDDK , NIEHS , NIGMS , NIMH , NIMHD , NINDS , NINR , NLM , OAR , OBSSR , ODP , ODS , ODSS , SGMRO Mar 26, 2024 Nov 5, 2027 R15, R01, K01, R16, K08, R21, K43, F31, R43/R44, R41/R42, F30, R03, K23, F32, R34
Notice of Special Interest (NOSI): Developing and Testing Multi-level Physical Activity Interventions to Improve Health and Well-Being NOT-OD-24-058 ODP , NCCIH , NCI , NIA , NIAMS , NICHD , NIMHD , NINR , OBSSR , ODS , ORWH Feb 20, 2024 Jan 8, 2027 U24, R01, R21, R34, UG3/UH3, R03
Notice of Special Interest (NOSI): Validation of Digital Health and Artificial Intelligence/Machine Learning Tools for Improved Assessment in Biomedical and Behavioral Research NOT-CA-24-031 NCI , NHLBI , NIA , NIDA , NIMH , NINR , OBSSR , ODSS Feb 15, 2024 Jul 6, 2025 R61/R33, R01, R21, R43/R44, R34, R41/R42
Notice of Special Interest (NOSI): NIDCD is Interested in Supporting Research on the Impact of Post-Acute Sequelae of SARS-CoV-2 Infection on Mission Specific Sensory and Communication Disorders NOT-DC-24-001 NIDCD Dec 14, 2023 Jan 30, 2027 R41/R42, R43/R44, R01, R21
Notice of Special Interest (NOSI): Quantum Sensing Technologies in Biomedical Applications NOT-EB-23-022 NIBIB , NCATS , NCI , NEI , NHLBI , NIGMS Dec 13, 2023 Jan 27, 2027 R35, RM1, R21, R01, U01, R15, R13, K99/R00
Notice of Special Interest (NOSI): Data Informed, Place-Based Community-Engaged Research to Advance Health Equity NOT-HL-23-110 NHLBI , NCI , NIDCR , NIEHS , NIMH , NIMHD , NINR , OBSSR , ODP , ORWH Nov 28, 2023 Jan 8, 2027 R01, R34, R21, UG3/UH3, K01, R03, P01, P50, K08, K23
Notice of Special Interest (NOSI): Interventions to promote mental well-being in populations that experience health disparities through social, cultural, and environmental connectedness NOT-OD-23-194 ODP , NCCIH , NIA , NIBIB , NIDCR , NIMH , NIMHD , OAR , ORWH , SGMRO Nov 6, 2023 Sep 8, 2026 R21, R01, R34, UG3/UH3
Notice of Special Interest (NOSI): The Road to Prevention of Stillbirth NOT-HD-23-021 NICHD Oct 3, 2023 Nov 17, 2026 F31, R03, R15, K08, R01, R21, F30, U24, R43/R44, K23, R41/R42, R25, S06, F32, U01
Notice of Special Interest (NOSI): Xylazine: Understanding Its Use and the Consequences NOT-DA-24-012 NIDA Aug 28, 2023 Jan 8, 2025 R21, R03
Notice of Special Interest in Research on Family Support and Rejection in the Health and Well-Being of SGM Populations NOT-OD-23-166 OD , NCI , NIA , NIAMS , NICHD , NIDDK , NIMH , NIMHD , OBSSR , ODP , ORWH , THRO Aug 28, 2023 May 8, 2026 R21, R15, R01, R34, K25, K99/R00, K01, R03, P01, K08, K23
Notice of Special Interest (NOSI): Epidemiology and Prevention in Alcohol Research NOT-AA-23-018 NIAAA , NCI Aug 24, 2023 Sep 6, 2026 R03, R21, R01, UG3/UH3, R61/R33
Notice of Special Interest (NOSI): Role of social function on SUD treatment and outcomes NOT-DA-25-026 NIDA Aug 1, 2023 Sep 8, 2026 R01, R21
Notice of Special Interest (NOSI): Accelerating Research in Understudied Skin Types NOT-AR-24-009 NIAMS Jul 31, 2023 Jul 17, 2026 R21, R01, R34
Notice of Special Interest (NOSI): Advancing Biomedical Research in Pulmonary Non-Tuberculous Mycobacterial (NTM) Infections NOT-AI-23-050 NIAID Jun 27, 2023 Jul 17, 2026 R21, R41/R42, R43/R44, R01, U44
Notice of Special Interest (NOSI): Promoting Research and Development of Vaccines Against Enteric Viruses NOT-AI-23-048 NIAID Jun 15, 2023 Jul 17, 2026 R01, R43/R44, U44, R41/R42, R21
Notice of Special Interest (NOSI): Impacts of Psychedelic and Dissociative Drug Policy Changes on Public Health Outcomes NOT-DA-24-010 NIDA Jun 13, 2023 Sep 8, 2026 R03, 333, R01, R15, R21
Notice of Special Interest (NOSI): Supporting Exploratory/Developmental Research Focused on NIAMS Core Mission Areas NOT-AR-23-006 NIAMS Apr 17, 2023 Jan 8, 2027 R21
Notice of Special Interest (NOSI): Synthetic Biology for Biomedical Applications. NOT-EB-23-002 NIBIB , NCCIH , NCI , NHLBI , NIA , NIAID , NICHD , NIGMS Apr 14, 2023 May 17, 2026 R01, R21, R35, R41/R42, R43/R44
Notice of Special Interest (NOSI): Encouraging Womens Health Research within the NIDCD Mission Areas NOT-DC-23-006 NIDCD Mar 28, 2023 May 6, 2026 R15, R21, R01
Notice of Special Interest: Advancing mHealth Interventions for Understanding and Preventing Alcohol-Related Domestic Violence NOT-AA-23-003 NIAAA Mar 6, 2023 Sep 8, 2026 R01, R21, R34, K99/R00
Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine NOT-AI-23-031 NIAID Feb 23, 2023 Jan 15, 2026 R01, R41/R42, R43/R44, R21, U44
Notice of Special Interest (NOSI): Priority Research Opportunities in Crisis Response Services NOT-MH-23-140 NIMH , NIDA , ORWH Jan 18, 2023 May 8, 2025 R21, R01, R34
Notice of Special Interest (NOSI): Targeting the Endocannabinoid System for Brain Health and Acute and Chronic Diseases NOT-DA-22-048 NIDA , NCI , NIDCR Jan 9, 2023 Jan 8, 2026 R01, R21, DP2, DP1, K99/R00, K01, R36, K08, R15, K24
Notice of Special Interest (NOSI): Firearm Injury and Mortality Prevention Research NOT-OD-23-039 OBSSR , NCCIH , NIA , NIAAA , NICHD , NIDA , NIMH , NIMHD , NINR , ODP , ORWH , SGMRO Dec 16, 2022 Feb 5, 2026 R01, R34, R21, U24, R61/R33, UG3/UH3
Notice of Special Interest (NOSI): The Neural Mechanisms of Multi-Dimensional Emotional and Social Representation NOT-MH-23-120 NIMH Dec 7, 2022 Jan 8, 2025 R21, R01, R03, R15
Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine NOT-AI-23-007 NIAID Nov 25, 2022 Jan 8, 2026 R21, R41/R42, R43/R44, R01
Notice of Special Interest (NOSI): Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R01, R21, R03) NOT-DA-23-012 NIDA Nov 2, 2022 Feb 8, 2026 R01, R03, R21
Notice of Special Interest (NOSI): Research on the Impact of Policy Changes and Emerging and Evolving Public Health Crises on NIDA Populations of Interest NOT-DA-22-084 NIDA Oct 20, 2022 Jan 8, 2026 R15, R21, R01, R03
Notice of Special Interest (NOSI): Research on the Impact of Policy Changes and Emerging and Evolving Public Health Crises on NICHD Populations of Interest NOT-HD-22-038 NICHD , NIDA Sep 14, 2022 Jan 8, 2025 R15, R03, R01, R21
Notice of Special Interest (NOSI): Research on the Health of Bisexual and Bisexual+ People NOT-OD-22-166 OD , NCCIH , NIA , NIAAA , NIAID , NICHD , NIDA , NIDCR , NIMH , NIMHD , NINDS , ODP Aug 11, 2022 May 8, 2025 K24, U01, R01, K01, R15, R03, K76, R34, K99/R00, T32, F32, UG3/UH3, R21, K23, F31
Notice of Special Interest (NOSI): Community-Based Participatory Research (CBPR) Initiative in Reducing and Eliminating Health Disparities with a focus on addressing diverse representation in research on Down syndrome (R21 Clinical Trial Optional) NOT-OD-22-142 OD , NCI , NEI , NHLBI , NIA , NIAMS , NICHD , NIDCD , NIDCR , NIMHD , NINDS Aug 5, 2022 Mar 17, 2025 R21
Notice of Special Interest (NOSI): Promoting Mechanistic Research on Therapeutic and Other Biological Properties of Minor Cannabinoids and Terpenes NOT-AT-22-027 NCCIH , NCI , NEI , NIA , NIAAA , NIDA , NIDCR , NINDS , ODS , ORWH Jul 27, 2022 Jul 1, 2025 R21, R01, UG3/UH3
Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening NOT-OD-22-179 ODP , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO Jul 14, 2022 May 8, 2025 R21, R01, R61/R33, UG3/UH3, R34, U01
Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan NOT-OD-22-178 ODP , NCI , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO Jul 14, 2022 May 8, 2025 R21, R01, UG3/UH3, R61/R33, R34, R03
Notice of Special Interest (NOSI): Research on Addressing Violence to Improve Health Outcomes NOT-OD-22-167 OBSSR , NIA , NIAAA , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINR , ODP , ORWH , SGMRO Jul 8, 2022 Oct 5, 2025 R21, R01, R34, UG3/UH3
Notice of Special Interest (NOSI): Preventive Interventions to Address Cardiometabolic Risk Factors in Populations that Experience Health Disparities NOT-OD-22-154 ODP , NCI , NHLBI , NIAAA , NIAMS , NIDCR , NIEHS , NIMHD , NINDS , OBSSR , ORWH Jun 14, 2022 Oct 6, 2025 R01, R21, R34, R03, UG3/UH3
Notice of Special Interest (NOSI): Climate Change and Health NOT-ES-22-006 NIEHS , FIC , NCI , NHGRI , NHLBI , NIA , NIAID , NIAMS , NICHD , NIDCR , NIMH , NIMHD , NINDS , NINR , NLM , ODP Jun 1, 2022 May 8, 2025 R21, F31, D43, K01, R03, K43, K99/R00, U01, U19, R01, F32, K23, F30, R21/R33
Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan NOT-OD-22-106 ODP , NCI , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO May 12, 2022 May 8, 2025 R03, R01, R34, R21, UG3/UH3, R61/R33, 333
Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening NOT-OD-22-107 ODP , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO May 12, 2022 May 8, 2025 333, R01, R34, R21, R61/R33, U01, UG3/UH3
Notice of Special Interest (NOSI): Research using implementation science to support the delivery of evidence-based practices in community-based mental or general medical healthcare settings NOT-MH-22-170 NIMH , NIDA Mar 25, 2022 May 8, 2025 R21, R01, R34
Notice of Special Interest (NOSI): Leveraging Data Science to Bring Actionable Insights for Substance Use Prevention and Treatment NOT-DA-23-006 NIDA Mar 1, 2022 Sep 8, 2025 R21, R01, R03, 333
Notice of Special Interest (NOSI): Public Health Research on Cannabis NOT-DA-22-003 NIDA Feb 18, 2022 May 5, 2025 R21, R01, 333, R03
Notice of Special Interest (NOSI): Priority Research Opportunities in Crisis Response Services NOT-MH-22-110 NIMH , NIDA , ORWH Feb 8, 2022 May 8, 2025 R21, R01, R34, R43/R44
Notice of Special Interest: NIMH Priorities on Research on Aggression and Violence Against Others NOT-MH-22-095 NIMH Feb 3, 2022 Jan 8, 2025 R36, R01, R34, R21, F32, R21/R33, R03, R61/R33, U01, K08, R15, K23, P50, F30, K99/R00, F31, K22, K01
Notice of Special Interest (NOSI): Research to Prevent Drug Use, Misuse and Addiction NOT-DA-23-001 NIDA , ODP Jan 21, 2022 May 8, 2025 R01, R21, R34, R03
Notice of Special Interest (NOSI): COVID-19 Pandemic Mental Health Research NOT-MH-22-100 NIMH Jan 19, 2022 Jan 8, 2025 R21, R34, R01
Notice of Special Interest: Development and Implementation of Clinical Informatics Tools to Enhance Patients Use of Genomic Information NOT-HG-22-011 NHGRI Jan 6, 2022 Dec 31, 2025 R01, R21, U24, R43/R44, R41/R42
Notice of Special Interest: Research on Pain, Pain Management, and Opioids in Aging NOT-AG-22-004 NIA Dec 22, 2021 Jan 8, 2025 F31, P01, K99/R00, K08, R01, K01, R43/R44, F32, 332, F33, F99/K00, R15, K24, R21, K02, K25, R25, F30, K23, R36, R41/R42, SB1, K76, K22, K07, R13, R21/R33, U19
Notice of Special Interest (NOSI): Epidemiology and Prevention of Alcohol Misuse in Understudied Young Adult Populations; Military, Workforce, and Community College NOT-AA-22-001 NIAAA Dec 9, 2021 Sep 9, 2025 R21, R03, R01, R43/R44, R41/R42
Notice of Special Interest (NOSI): Accelerating Progress in Celiac Disease Research NOT-AI-22-004 NIAID , NIAMS , NCCIH , NCI Nov 23, 2021 Jan 8, 2025 R03, R21, U01, U44, R01, R34, P01, R61/R33
Notice of Special Interest (NOSI): Advancing HIV/AIDS Research through Computational Neuroscience NOT-DA-21-030 NIDA Jun 22, 2021 Jan 8, 2025 R01, R21, R03, DP2, DP1, K99/R00, K01, R36, P01, R15, K24

Expired NOSIs

Title Notice Number Organization Release
Date		 Expiration
Date		 Activity
Code(s)
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