Notice of Special Interest (NOSI): Research on Addressing Violence to Improve Health Outcomes
Notice Number:
NOT-OD-22-167

Key Dates

Release Date:

July 8, 2022

First Available Due Date:
September 07, 2022
Expiration Date:
October 05, 2025

Related Announcements

PA-20-183 NIH Research Project Grant (Parent R01 Clinical Trial Required)

PA-20-185 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-20-194 NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)

PA-20-195 NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

PA-20-144 Innovations in HIV Prevention, Testing, Adherence and Retention to Optimize HIV Prevention and Care Continuum Outcomes (R01 Clinical Trial Optional)

PA-20-141 Formative and Pilot Intervention Research for Prevention and Treatment of HIV/AIDS (R34 Clinical Trial Optional)

PA-20-145 Innovations in HIV Prevention, Testing, Adherence and Retention to Optimize HIV Prevention and Care Continuum Outcomes (R21 Clinical Trial Optional)

PAR-22-156 Alcohol Health Services Research (R01 Clinical Trial Optional)

PAR-22-158 Alcohol Treatment and Recovery Research (R01 Clinical Trial Required)

PA-21-110 Pilot and Feasibility Studies in Preparation for Substance Use Prevention Trials (R34 Clinical Trial Optional)

PA-21-180 Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

PAR-21-317 NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

PAR-21-063 NIDCD low risk Clinical Trials in Communication Disorders (R01 Clinical Trial Required)

PAR-21-358 Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

PAR-22-145 Leveraging Health Information Technology to Address and Reduce Health Care Disparities (R01 Clinical Trial Optional)

PAR-21-081 Addressing Health Disparities Among Immigrant Populations through Effective Interventions (R01 Clinical Trial Optional)

PAR-20-310 Health Services Research on Minority Health and Health Disparities (R01- Clinical Trial Optional)

PA-20-184 Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

PAR-22-094 Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R21 Clinical Trial Optional)

PAR-22-093 Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)

PAR-20-150 NIMHD Exploratory/Developmental Research Grant Program (R21 - Clinical Trial Optional)

PAR-22-105 Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

PAR-22-109 Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Issued by

Office of Behavioral and Social Sciences Research (OBSSR)

National Institute on Aging (NIA)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute on Deafness and Other Communication Disorders (NIDCD)

National Institute of Dental and Craniofacial Research (NIDCR)

National Institute on Drug Abuse (NIDA)

National Institute of Mental Health (NIMH)

National Institute of Nursing Research (NINR)

National Institute on Minority Health and Health Disparities (NIMHD)

Sexual and Gender Minority Research Office (SGMRO)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

Office of Research on Women's Health (ORWH)

Purpose

Purpose

The purpose of this Notice is to highlight interest in addressing the role of violence in health outcomes and integrating violence-related screening and interventions into health care settings. This Notice is to encourage intervention research focused on addressing exposure to violence - including but not limited to child maltreatment, intimate partner violence/teen dating violence, elder mistreatment, peer violence/bullying, and community violence – to improve individual-level health processes and outcomes.

Background

Violence is defined by the World Health Organization as: “the intentional use of physical force or power, threatened or actual, against oneself, another person, or against a group or community, that either results in or has a high likelihood of resulting in injury, death, psychological harm, maldevelopment, or deprivation.” Violence affects people of all ages, and its impact is far-reaching. Violent victimization events are associated with not only physical injury or mortality, but also a range of acute and chronic physical and behavioral health conditions, such as obesity, cardiovascular disease, asthma, substance use disorders, depression and anxiety, sleep disturbance, impairments in cognitive development and executive functioning, and adverse birth outcomes. Findings from prior research suggest that indirect (witnessing) exposures to violence have adverse effects on behavioral and physical health that are similar to the effects of direct exposures.

Despite recognition that violence is a serious public health issue, most behavioral and medical health care settings do not adequately screen and assess for experiences of violence as a part of routine care. There are some notable exceptions. For example, the Veterans Administration (VA) and the Department of Defense (DoD) health care systems have a history of integrating screening for intimate partner violence and treatment for post-traumatic stress disorder (PTSD) into their health care system, routine screenings for intimate partner violence and child maltreatment are conducted in some primary care settings, and some emergency departments have integrated violence intervention programs to reduce the recurrence of violence-related injury. However, the integration of screening for exposure to violence and for subsequent trauma symptomatology, along with the integration of treatment when appropriate, into a broader range of health care settings, has the potential to improve a wide range of health conditions for people of all ages. Likewise, strategies to reduce and prevent violence perpetration and victimization that can be linked to, facilitated by, or delivered in the health care context, may have beneficial effects on physical and behavioral health conditions.

Furthermore, recent events including the COVID-19 pandemic and racial and social justice issues have brought an increased recognition that social determinants of health and the often-intersecting burden of poverty and structural racism are drivers of population-level health disparities. Reducing the disproportionate impact of violence and victimization on women, children, older adults, racial/ethnic minorities, sexual and gender minorities, and other populations that are disproportionally impacted by violence , requires attention to the sociocultural environment.

This Notice highlights NIH’s interest in addressing the role of violence in health outcomes and encouraging intervention research in health care settings focused on addressing exposure to violence to improve individual-level health processes and outcomes. For the purposes of this Notice, health care settings are broadly defined to include any organization where patients get physical or behavioral health care, including but not limited to Federally Qualified Health Centers (FQHCs), community or school-based health clinics, primary care or urgent care facilities, mobile clinics, HIV clinics, VA facilities, correctional health care providers, assisted living, skilled nursing, or substance use treatment providers.

Research Objectives

This Notice encourages novel intervention research aimed at developing, refining, adapting, and testing interventions focused on preventing violence or addressing acute and chronic effects of violence on physical and behavioral health. Interventions for the treatment and prevention of violence victimization and perpetration across different populations in settings where other health conditions are treated are encouraged. In addition, interventions that seek to translate basic behavioral and social science research findings into innovative treatment approaches are encouraged. Implementation research can elucidate effective strategies for moving evidence-based prevention and treatment approaches into practice. As such, effectiveness, implementation, and hybrid effectiveness-implementation designs are encouraged, as appropriate to the research questions proposed.

The targets for the intervention/s being developed and tested in response to this Notice should be based on research identifying a link between the health outcome and experiences of violence. Interventions may be delivered at the individual, dyadic, family, group, or organizational level, in-person, virtually, or via e-Health platforms, as appropriate. Interventions to screen for violence exposure, prevent violence, or treat symptoms associated with exposure to violence should occur in coordination with prevention or treatment for other physical or behavioral health conditions.

The primary outcomes should be the physical or behavioral health indicators relevant to the health care setting that have been linked to violence exposure. Outcomes may include clinical indicators or health-related measures assessed at the individual level or shifts in behavior or health indicators that are measured at an aggregate level (e.g., clinic, community, or population). It is expected that violence perpetration, exposure, and trauma symptomatology would be measured as appropriate to the intervention targets.

Applicants are encouraged to employ innovative study designs for building, adapting, and optimizing behavioral interventions. Intervention creation and refinement require iterative and systematic testing of intervention features and components. Study timelines should include clear research steps, goals and milestones (go/no-go decision points). Interdisciplinary project teams are encouraged, as are cost-effectiveness components or studies. Finally, NIH is committed to supporting research to enhance diversity, equity, inclusion and accessibility (DEIA) in biomedical and behavioral sciences research. Applicants are encouraged to discuss how they will foster these principles in their proposed research activities.

The Office of Behavioral and Social Sciences Research (OBSSR) does not have grant-making authority and can only support grants deemed grants deemed meritorious after review by one of the ICs participating in this announcement and after a co-funding request is initiated through the IC. Please contact the relevant IC Scientific/Research Contact(s) listed for questions regarding IC research priorities and funding. For additional information about OBSSR’s research priorities and interests, please refer to the OBSSR Strategic Plan.

National Institute of Mental Health (NIMH)
NIMH will only accept AIDS applications for this Notice.The NIMH Division of AIDS Research (DAR) is interested in the impact of violence on HIV testing, prevention, and treatment outcomes, with a focus on intervention and implementation research.For non-AIDS applications to NIMH on aggression and violence research, see NOT-MH 22-095.

Research studies may include but are not limited to:

  • Studies to understand (outer and inner setting) barriers and facilitators to implementing routine screening for violence and linkage to services in HIV testing, prevention, and treatment settings, and to develop and test strategies to implement violence screening and linkage as standard of care in these settings
  • Studies of interventions delivered in HIV testing, prevention, or treatment settings that address the sequelae of exposure to violence to improve HIV-related outcomes
  • Studies of interventions to prevent violence, delivered in HIV testing, prevention, or treatment settings, to improve HIV-related outcomes
  • Implementation science approaches to integrate evidence-based interventions addressing violence as part of standard of care in HIV testing, prevention, or treatment settings
  • Studies that test the implementation and/or effectiveness of collaborative care or other evidence-based models of integrated mental and physical health care to address mental health needs around trauma and violence as well as HIV prevention and treatment needs
  • Studies to assess relevant policies and the economic costs and benefits of addressing violence in HIV testing, prevention, and treatment settings

National Institute on Drug Abuse (NIDA)

NIDA is interested in research on violence-focused treatment and prevention interventions (both new and adapted) for individuals exposed to violence and perpetrators of violence in harm reduction, substance use prevention, treatment, and recovery settings. Key individual-level outcomes of interest include any of the following: substance use initiation, escalation, substance use disorder (SUD) diagnosis, connection to treatment, and engagement or retention in treatment or address issues relevant to maintaining sustained recovery from substance use disorders over the long term. Ultimately, the goal is to develop user-centered interventions addressing violence in the context of substance use that are effective, practical, cost-effective, scalable, and sustainable. Therefore, applicants are strongly encouraged to consider issues of feasibility, scalability, sustainability, and translation to practice in their study designs and dissemination plans. As such, applicants should consider input from clients, patients, and stakeholders, as appropriate, to assess the feasibility of the proposed intervention in the targeted setting as appropriate to the design.

Research areas of interest include, but are not limited to, the following:

  • The added benefit of including evidence-based screening protocols and interventions to address trauma and PTSD for individuals exposed to violence in the context of SUD treatment and recovery, including harm reduction settings
  • The added benefit of including evidence-based violence prevention interventions in the context of SUD prevention
  • Implementation research focused on how providers and organizations can best incorporate evidence-based violence prevention interventions and treatment for PTSD into standard substance use care
  • For individuals on MOUDs, research that addresses how exposure to violence impacts MOUD adherence and whether there is any difference by type of medication
  • Policy relevant research that addresses issues of cost-effective and scalability of violence-focused interventions
  • How health clinics or SUD prevention and treatment providers who serve homeless populations can best address the intersection of homelessness, violence, and substance use
  • Intervention research in substance use treatment settings that targets reductions in violence related to acquiring illegal drugs

Eunice Kennedy Shriver Institute of Child Health and Human Development (NICHD)

NICHD is interested in basic, translational, and clinical research in pediatric trauma including exposure to and direct experiences of all forms of violence as well as violence-related injuries.

Research studies may include but not be limited to the following areas:

  • Evidence-based interventions in clinical settings for children and families experiencing grief and loss due to direct and indirect exposure to violence. This may also include studies focused on coping, resilience, and post-traumatic growth in the recovery process.
  • Studies to improve screening, treatment, and follow-up of child abuse or neglect and youth violence through programs implemented in emergency departments or in pre-hospital care.
  • Studies to improve screening, treatment and care of IPV victimization during pregnancy and follow-up studies addressing pregnancy outcomes, psychological health status, and child health outcomes.
  • Studies that address the treatment of pain, traumatic stress, and other outcomes of violence exposures that may have an impact on recovery and well-being.
  • Studies to determine the most effective therapeutic and management strategies for injured children due to such forms of violence as abusive head trauma and the necessary medical services to enhance survival and minimize disability.
  • Hospital-based interventions for victims of violence that are trauma-informed and that have the potential to address retaliation and adjudication in the criminal justice system.
  • Interventions in clinical settings that address the health and well-being of the whole child taking into consideration the pediatric patient’s trauma history including exposure to political violence and war; adverse childhood experiences (ACEs), and domestic violence.
  • Testing of interventions in clinical settings intended to treat one type of violence that might have the benefit of screening for and addressing other types of violence, recognizing the interaction of multiple forms of violence.

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIAA supports research projects focused on violence prevention that are conducted in health care settings. The use and misuse of alcohol often is a factor in various forms of other- and self-directed violence, including intimate partner violence, dating violence, elder abuse, child maltreatment, bullying, sexual assault, homicide, and suicide. Proposed interventions may focus on the perpetrators of the violence, the victims, or potential bystanders.

National Institute of Dental and Craniofacial Research (NIDCR)

NIDCR is interested in research on violence related to dental, oral, or craniofacial health. Relevant research may identify or evaluate opportunities for dental healthcare providers to optimally contribute to violence-related screening or intervention efforts.

National Institute of Deafness and other Communication Disorders (NIDCD)

NIDCD encourages translational and interventional studies in health care settings that address the role of violence in health outcomes affecting individuals with communication disorders, specifically those disorders that cover the mission areas of hearing, balance, taste, smell, voice, speech, and language. We encourage responsive studies from across the lifespan, as children and adults with communication disorders may be vulnerable to various forms of maltreatment.

Meritorious studies emphasizing engagement of underrepresented minorities, including sexual and gender minorities, will be prioritized. Areas of scientific interest include but are not limited to:

  • Studies of interventions in health care settings that address intimate partner violence in the Deaf community, and among women and sexual and gender minorities with communication disorders
  • Studies of interventions in health care settings addressing violence toward those with communication disorders, such as post-stroke aphasia or severe autism, who may be unable to self-report or communicate mistreatment
  • Studies that focus on efforts in the health care setting to address bullying toward children with communication disorders, including hearing loss and expressive voice, speech, and language disorders

National Institute on Minority Health and Health Disparities (NIMHD)

The mission of NIMHD is to lead scientific research to improve minority health and reduce health disparities. Populations that experience health disparities include African Americans/Blacks, Hispanic/Latinos, American Indians/Alaska Natives, Asians, Native Hawaiians, and other Pacific islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minority (SGM) populations. In the context of this NOSI, NIMHD is especially interested in how best to prevent or mitigate the impact of violence in these populations. NIMHD is especially focused on the innovative application of community-engaged approaches and utilization of the NIMHD Research Framework to implement violence-related screening and interventions integrated in health care settings among populations that experience health disparities and individuals with intersecting health disparity population membership, across multiple levels of influence (i.e., individual, community, societal).

Examples of potential topic areas include but are not limited to:

  • Rigorous studies of community-based, multilevel interventions that includes diverse health care settings to prevent, screen for, and/or addresses violence victimization and/or perpetration in populations that experience health disparities.
  • Development and evaluation of interventions that addresses violence prevention, screening, treatment and/or case management that can be linked to, facilitated by, or delivered in the health care setting and in partnership with community organizations, social services, public health, law enforcement, and other relevant partners.
  • Intervention studies that leverage Health Information Technology to address violence-related screening, prevention, treatment, and/or case management along with appropriate referrals and linkages to services, resources, and support within the community.

National Institute of Nursing Research (NINR)

NINR supports research to solve pressing health challenges and inform practice and policy - optimizing health and advancing health equity into the future. NINR discovers solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care. Drawing on the strengths of nursing’s holistic, contextualized perspective, core values, and broad reach, NINR funds multilevel and cross-sectoral research that examines the factors that impact health across the many settings in which nurses work, including homes, schools, workplaces, clinics, justice settings, and the community.

Areas of programmatic interest to NINR include but are not limited to

  • Studies that address the social determinants of violence, both victimization and perpetration through health care screening and service linkage.
  • Clinic-based studies that address multilevel factors (i.e., individual, interpersonal, community, and societal) that increase risk of violence exposure.
  • Organizational level interventions that implement innovative systems and models of care, especially those that are nurse-led, to detect, prevent, and address violence and related health impacts.
  • Interventions that bridge clinical and community care to address social factors that increase the risk of exposure to violence.
  • Person-centered interventions that equally involve the priority population in addressing violence and its impacts on health.
  • Violence prevention interventions implemented in justice and school health care settings, especially those that are nurse-led.
  • Interventions in health care settings that are developed using an intersectionality lens to understand and intervene upon factors that create and produce overlapping risks of violence exposure (e.g., intersectionality of race, gender, and socioeconomic status).
  • Studies focused on violence prevention among pregnant and mothering people.
  • Interventions that incorporate multisectoral partners (e.g., health, justice, and community to prevent violence and improve related health outcomes.

National Institute on Aging (NIA)

NIA welcomes research applications for the development of aging-relevant violence interventions for mid-life and older adults. NIA is especially interested in interventions that can address multiple and interconnected forms of violence.

  • NIA encourages research that can address the priority research needs and gaps highlighted in the U.S. Preventive Services Task Force’s 2018 final recommendation statement on Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: Screening in areas where there is currently insufficient evidence to make a recommendation for or against routine screening for Elder Mistreatment (EM) and the provision of preventive interventions that can be provided in or referred from primary care settings.
  • NIA strongly encourages applicants to propose intervention research in and with NIA-designated priority populations, as specified in the NIA Health Disparities Research Framework.
  • Participants may be community-dwelling or living in a residential care facility or nursing home. Interventions may be focused on individuals, dyads, families, communities, organizations, and/or systems.
  • Research projects proposed to NIA are encouraged to take into account individual differences in participants’ housing and living conditions, household composition, health and disability status, self-reported race and ethnicity, and sexual and gender identity.
  • Applications are expected to integrate diversity, equity, inclusion, and accessibility (DEIA) into the composition of the investigative team, the inclusion criteria of participants, and the study approach. Applications are also encouraged to include a management plan for mitigating cognitive bias in the detection, prevention, and intervention of EM. NIA is particularly interested in intervention research that assesses and examines the impact of racial/ethnic and gender concordance between patients and clinicians.
  • NIA encourages applicants to propose integrated care interventions that develop clinical and community linkages or leverage and build on existing programs.
  • NIA is especially interested in behavioral intervention studies guided by the NIH Stage Model Framework . Research encouraged includes, but is not limited to, that focused on intervention development, refinement, modification, and adaptation and pilot testing (Stage I); traditional efficacy testing (Stage II); and efficacy testing with real-world providers (Stage III). Research can also focus on improving the effectiveness of promising community- and societal-level strategies for the prevention or reduction of violence and other violence-related interventions.
  • NIA is especially interested in EM intervention research in the context of chronic disease, and in particular, in Alzheimer's Disease-Related Dementias (AD/ADRD). Research that includes participants with AD/ADRD is expected to align with the Alzheimer's Disease-Related Dementias Research Implementation Milestones.

Research of priority to NIA includes, but is not limited to the following topic areas:

Intervention Development:

  • Point-of-care screening tools for the early detection of both direct (as a victim) and indirect (as a witness to a violence act) exposure to violence.
  • Family history screening tools to identify individuals and families at risk of exposure to violence and to violent behaviors.
  • Strategies to promote disclosure experiences of violence and the perpetration of violent behaviors.
  • Primary interventions for the prevention of EM and for secondary prevention to prevent revictimization.
  • Treatment strategies to promote recovery and resilience in victims and their families and in those who inflicted harm.
  • Behavioral interventions to mitigate the risks of adverse effects in older age of early-life exposure to violence and to reduce the perpetration of violence by midlife or in older age.
  • The development and testing of components of personalized preventive care programs that incorporate EM screening and EM multidisciplinary teams assembled across various healthcare and community settings.
  • Interventions that address health inequities and health disparities related to EM.
  • Applications proposing tailored interventions are expected to provide justification for such need and evidence for the proposed approach.

Office of Research on Women's Health (ORWH)

The Office of Research on Women’s Health (ORWH) is part of the Office of the Director of NIH and works in partnership with the NIH Institutes and Centers to ensure that women's health research is part of the scientific framework at the NIH, and throughout the scientific community. ORWH is interested in co funding applications that include adequate plans to address sex as a biological variable (SABV), including plans to disaggregate data by sex/gender with a focus on examining sex and gender influences.

Applicants are encouraged to discuss applications with the ORWH contact listed under Agency Contacts. The 2019 – 2023 Trans-NIH strategic plan for women's health research: "Advancing Science for the Health of Women” highlights research priorities to improve the health of women. The overarching themes of the Strategic Plan include but are not limited to sex determinants, evidence-based interventions, advancing women in biomedical research, and innovative approaches. Information on the strategic plan can be reviewed at Trans NIH Strategic Plan for Women's Health Research.

Sexual & Gender Minority Research Office (SGMRO)

The SGMRO coordinates research and activities related to the health and well-being of sexual and gender minorities (SGM; defined for NIH research in NOT-OD-19-139) by working directly with the NIH ICOs and serves as a liaison for the research community to ensure SGM populations are considered and represented in research activities across the agency.

Violence is a major concern for members of the SGM community. In an effort to increase SGM-focused research and knowledge related to violence and health, the SGMRO sponsored and coordinated the 2021 Scientific Workshop on Violence & Related Health Outcomes in Sexual & Gender Minority Communities. The workshop focused on five research areas (demographics and epidemiology; risk factors and pathways; preventive interventions; treatment-focused interventions; and ethics and logistical challenges) across four domains of violence (family of origin abuse, peer/friend victimization, romantic/sexual partner violence, and community violence). Key findings and opportunities are summarized and discussed in the Final Workshop Summary Document for consideration by investigators submitting SGM-related applications to this Notice.

The SGMRO does not have grant-making authority and can only support grants deemed meritorious after review by one of the ICs participating in this announcement and after a co-funding request is initiated through the IC. Please reach out to the relevant Scientific/Research Contact(s) identified in this announcement with any questions about IC-specific research priorities and funding. More SGM- and SGMRO-specific information is available in the NIH Strategic Plan to Advance Research on the Health and Well-being of Sexual and Gender Minorities FYs 2021-2025 and on the Office’s Research Resources webpage.

Office of Disease Prevention (ODP)

The ODP is the lead office at the NIH responsible for assessing, facilitating, and stimulating research in disease prevention. In partnership with the 27 NIH Institutes and Centers, the ODP strives to increase the scope, quality, dissemination, and impact of NIH-supported prevention research. The ODP co-funds research that has strong implications for disease, injury, health equity, and violence prevention, and that includes innovative and appropriate research design, measurement, and analysis methods. The ODP has a specific interest in projects that develop and/or test preventive interventions. Of particular interest is prevention research addressing leading causes and risk factors for premature morbidity and mortality, dissemination and implementation, and health disparities. For this NOSI, the ODP is interested in research that addresses evidence gaps identified by the U.S. Preventive Services Task Force (e.g., gaps related to child maltreatment or the abuse and neglect of older or vulnerable adults) and other clinical guideline developers and systematic review organizations.

The ODP does not award grants; therefore, applications must be relevant to the objectives of at least one of the participating NIH Institutes and Centers (IC) listed in this announcement. Please contact the relevant IC Scientific/Research Contact(s) listed for questions regarding IC research priorities and funding. The ODP only accepts co-funding requests from NIH Institutes and Centers. For additional information about ODP’s research priorities and interests, please refer to the ODP Strategic Plan for Fiscal Years 2019–2023.

Application and Submission Information

Applicants must select the IC and associated FOA to use for submission of an application in response to this NOSI. The selection must align with the IC requirements listed in order to be considered responsive to that FOA. Non-responsive applications will be withdrawn from consideration for this initiative.

In addition, applicants using NIH Parent Announcements (listed below) will be assigned to those ICs on this NOSI that have indicated those FOAs are acceptable and based on usual application-IC assignment practices.

This notice applies to due dates on or after September 7, 2022 and subsequent receipt dates through October 5, 2025.

Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.

FOA

FOA Title

First Available Due Date

Expiration Date

Participating IC(s)

PA-20-183

NIH Research Project Grant (Parent R01 Clinical Trial Required)

June 5, 2020

(AIDS: Sept. 7, 2020)

May 8, 2023

NIMH, NIDA, NIAAA, NIMHD, NICHD, NINR, NIA

PA-20-185

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

June 5, 2020

(AIDS: Sept. 7, 2020)

May 8, 2023

NIMH, NIDA, NIDCD, NIAAA, NIDCR, NIMHD, NICHD, NINR, NIA

PA-20-194

NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)

June 16, 2020

(AIDS: Sept. 7, 2020)

May 8, 2023

NIMH, NIDA, NIDCD, NIAAA, NICHD, NINR, NIA

PA-20-195

NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

June 16, 2020

(AIDS: Sept. 7, 2020)

May 8, 2023

NIDA, NIDCD, NIAAA, NIDCR, NICHD, NINR, NIA

PA-20-144

Innovations in HIV Prevention, Testing, Adherence and Retention to Optimize HIV Prevention and Care Continuum Outcomes (R01 Clinical Trial Optional)

May 7, 2020

January 8, 2023

NIMH

PA-20-141

Formative and Pilot Intervention Research for Prevention and Treatment of HIV/AIDS (R34 Clinical Trial Optional)

May 7, 2020

January 8, 2023

NIMH

PA-20-145

Innovations in HIV Prevention, Testing, Adherence and Retention to Optimize HIV Prevention and Care Continuum Outcomes (R21 Clinical Trial Optional)

May 7, 2020

January 8, 2023

NIMH


PAR-22-156

Alcohol Health Services Research (R01 Clinical Trial Optional)

June 5, 2022

May 8, 2023

NIAAA

PAR-22-158

Alcohol Treatment and Recovery Research (R01 Clinical Trial Required)

June 5, 2022

May 8, 2023

NIAAA

PA-21-110

Pilot and Feasibility Studies in Preparation for Substance Use Prevention Trials (R34 Clinical Trial Optional)

February 16, 2021

(AIDS: May 7, 2021)

May 8, 2024

NIDA

PA-21-180

Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

June 16, 2021

(AIDS: Sept. 7, 2021)

May 8, 2024

NIDA

PAR-21-317

NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

October 6, 2021

(AIDS: January 7, 2022)

May 8, 2024

NIDCR

PAR-21-063

NIDCD low risk Clinical Trials in Communication Disorders (R01 Clinical Trial Required)

February 5, 2021

(AIDS: May 7, 2021)

January 8, 2024

NIDCD

PAR-21-358

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

June 5, 2022

(AIDS: September 7, 2022)

May 8, 2025

NIMHD, NINR

PAR-22-145

Leveraging Health Information Technology to Address and Reduce Health Care Disparities (R01 Clinical Trial Optional)

June 5, 2022

(AIDS: September 7, 2022)

May 8, 2025

NIMHD, NIA

PAR-21-081

Addressing Health Disparities Among Immigrant Populations through Effective Interventions (R01 Clinical Trial Optional)

February 5, 2021

January 8, 2023

NIMHD, NINR

PAR-20-310

Health Services Research on Minority Health and Health Disparities (R01- Clinical Trial Optional)

November 27, 2020

March 28, 2023

NIMHD

PA-20-184

Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

June 5, 2022

May 8, 2023

NIA

PAR-22-094

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R21 Clinical Trial Optional)

July 8, 2022

November 13, 2024

NIA

PAR-22-093

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)

July 8, 2022

November 13, 2024

NIA

PAR-20-150

NIMHD Exploratory/Developmental Research Grant Program (R21 - Clinical Trial Optional)

June 16, 2020

May 8, 2023

NIMHD

PAR-22-105

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

June 15, 2022

(AIDS: September 7, 2022)

May 8, 2025

NINR, NIDA, NIDCD, NIA NIAAA, NIDCR NICHD, NIMHD

PAR-22-109

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

June 15, 2022

(AIDS: September 7, 2022)

May 8, 2025

NINR, NIDA, NIDCD, NIAAA, NICHD, NIA

All instructions in theSF424 (R&R) Application Guide must be followed, with the following additions:

  • For funding consideration, applicants must include “NOT-OD-22-167” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.

Applicants planning to submit an application in response to this NOSI are strongly encouraged to contact and discuss their proposed research/aims with the NIH Program Officer listed on this NOSI well in advance of the grant receipt date.

Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.

Inquiries

Please direct all inquiries to the Scientific/Research, Peer Review, and Financial/Grants Management contacts in Section VII of the listed funding opportunity announcements.

Scientific/Research Contact(s)

Dara R. Blachman, Ph.D.
Office of Behavioral and Social Sciences Research (OBSSR)
Phone: 301-496-8522

Email: Dara.blachman-demner@nih.gov

Peer Review Contact(s)

Examine your eRA Commons account for review assignment and contact information (information appears two weeks after the submission due date).

Financial/Grants Management Contact(s)