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PA-25-304 - NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) is used for the submission of applications to the following Notices of Special Interest (NOSIs)
On This Page: 139
Active NOSIs
| Title | Notice Number | Organization | Release Date |
Expiration Date |
Activity Code(s) |
|---|---|---|---|---|---|
| Notice of Special Interest (NOSI): Innovative Interdisciplinary Research on Female Reproductive Aging | NOT-AG-24-074 | NIA | Dec 11, 2024 | May 8, 2028 | R21, R01 |
| Notice of Special Interest (NOSI): Somatic Cell Gene Editing Therapies to Improve Transplantation Outcomes | NOT-AI-24-085 | NIAID , NIDDK | Dec 3, 2024 | Nov 17, 2027 | R21, R01 |
| Notice of Special Interest (NOSI): Discovery and Development of Natural Products to Treat Substance Use Disorders (SUDs) | NOT-DA-25-032 | NIDA , NCCIH | Nov 25, 2024 | Jan 8, 2029 | R01, UG3/UH3, U01, R21 |
| Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Universal Influenza Vaccine | NOT-AI-24-081 | NIAID | Nov 21, 2024 | Nov 17, 2027 | R01, R21 |
| Notice of Special Interest (NOSI): Accelerating Malaria Vaccine and Monoclonal Antibody Discovery | NOT-AI-24-072 | NIAID | Nov 20, 2024 | Nov 17, 2027 | R01, R21 |
| Notice of Special Interest (NOSI): Leveraging Microbial Exposure for Improving Mouse Models of Human Immunity | NOT-AI-24-078 | NIAID | Nov 20, 2024 | Nov 17, 2027 | R01, R21 |
| Notice of Special Interest (NOSI): Establishing and Utilizing Pre-Clinical Animal Models to Study Post-TB Lung Disease Development | NOT-AI-24-082 | NIAID | Oct 30, 2024 | Jan 8, 2028 | R01, R21 |
| Notice of Special Interest (NOSI): Autoimmune Inner Ear Disease (Clinical Trials Not Allowed) | NOT-DC-25-003 | NIDCD , ORWH | Oct 23, 2024 | Oct 17, 2027 | R21 |
| Notice of Special Interest (NOSI): Basic and Translational Oral Health Research Related to HIV/AIDS | NOT-DE-25-038 | NIDCR | Sep 26, 2024 | Jan 8, 2028 | R01, R21 |
| Notice of Special Interest (NOSI): Effectiveness of Mobile Health Clinics to Advance Health Equity | NOT-MD-24-022 | NIMHD , NICHD , ODP , SGMRO , THRO | Sep 26, 2024 | Nov 17, 2027 | R01, K01, R21, K08, K99/R00, K23 |
| Notice of Special Interest (NOSI): Consequences of Prenatal Fentanyl Exposure | NOT-DA-26-003 | NIDA | Sep 13, 2024 | Sep 8, 2028 | R21, R01, R03 |
| Notice of Special Interest (NOSI): Application of Artificial Intelligence in Treatment Development for Substance Use Disorders | NOT-DA-26-005 | NIDA | Sep 13, 2024 | Sep 8, 2028 | R03, R01, R21 |
| Notice of Special Interest (NOSI): Advancing Precision Imaging for Enhanced Diagnosis and Treatment of Oral Lesions | NOT-DE-25-034 | NIDCR | Aug 30, 2024 | Sep 8, 2027 | UG3/UH3, R43/R44, R01, R41/R42, R21 |
| Notice of Special Interest (NOSI): Model-informed Drug Development (MIDD) Approaches to Facilitate the Development of Therapeutics for Substance Use Disorders | NOT-DA-26-002 | NIDA | Aug 27, 2024 | Sep 8, 2028 | R01, R21, R03 |
| Notice of Special Interest (NOSI): Research on Illicit Drug Markets | NOT-DA-26-008 | NIDA | Aug 23, 2024 | Sep 8, 2028 | R03, K02, R15, R01, K01, R21, K99/R00, F31, F32 |
| Notice of Special Interest (NOSI): Stimulate Research on the Diagnosis, Treatment, and Mechanistic Understanding of Postural Orthostatic Tachycardia Syndrome (POTS) | NOT-HL-24-018 | NHLBI , NINDS , OD , ORWH | Aug 13, 2024 | Jan 8, 2028 | UG3/UH3, R01, K08, K99/R00, K01, R21, K25, K23 |
| Notice of Special Interest (NOSI): Fundamental Science Research on Complementary and Integrative Health Approaches, Including Natural Products or Mind and Body Interventions | NOT-AT-24-041 | NCCIH | Aug 13, 2024 | Oct 18, 2027 | R21, R01 |
| Notice of Special Interest (NOSI): Supporting Research Using the Resources from the Osteoarthritis Initiative (OAI) | NOT-AR-24-019 | NIAMS , NIA | Aug 8, 2024 | Sep 8, 2027 | R01, R21 |
| Notice of Special Interest (NOSI): Ending the HIV Epidemic (EHE) | NOT-AI-24-059 | NIAID , NHLBI , NIA , NIAAA , NICHD , NIDA , NIMH , NIMHD , NINR , OAR | Aug 6, 2024 | Jan 10, 2026 | R01, R34, R21 |
| Notice of Special Interest (NOSI): Advancing Genomic Technology Development for Research and Clinical Application | NOT-HG-24-036 | NHGRI | Jul 25, 2024 | Jan 10, 2027 | R01, R41/R42, R21, R43/R44 |
| Notice of Special Interest (NOSI): Systems Modeling of Infection and Immunity Across Biological Scales | NOT-AI-24-060 | NIAID | Jul 23, 2024 | Sep 8, 2027 | R21, R01 |
| Notice of Special Interest (NOSI): Understanding the Immune Functions of DEAD/H-box Helicases | NOT-AI-24-058 | NIAID | Jul 22, 2024 | Jul 17, 2027 | R01, R21 |
| Notice of Special Interest (NOSI): Maximizing the Scientific Value of Secondary Analyses of Existing Cohorts and Datasets in Order to Address Research Gaps and Foster Additional Opportunities in Aging Research | NOT-AG-24-017 | NIA | Jul 18, 2024 | Jan 8, 2025 | R01, R21 |
| Notice of Special Interest (NOSI): Immune Responses to Arthropod Feeding on Vertebrate Hosts | NOT-AI-24-048 | NIAID | Jul 18, 2024 | Jul 17, 2027 | R01, R21 |
| Notice of Special Interest (NOSI) Using the Collaborative Cross (CC) Mouse Model for Immunoregulatory and Infectious Disease Research | NOT-AI-24-054 | NIAID | Jul 12, 2024 | Jul 17, 2027 | R01, R21 |
| Notice of Special Interest (NOSI): Understanding the Basic Mechanisms of Immune-related Adverse Events (irAEs) in Cancer Immunotherapy | NOT-CA-24-055 | NCI , NIAID , NIAMS , NIDCR , OD | Jul 11, 2024 | Nov 6, 2027 | K22, K99/R00, R01, R15, K01, R03, K08, R21 |
| Notice of Special Interest (NOSI): Advancing Research on SUD with brain-based computational models | NOT-DA-26-001 | NIDA | Jul 2, 2024 | Sep 8, 2027 | R01, R21, R61/R33, K01, R15, R03, K99/R00 |
| Notice of Special Interest (NOSI): Epigenetic Modulation of HBV cccDNA and integrated HBV DNA (iDNA): Implications for Epigenetic Treatment Strategies Against HBV in HIV/HBV Co-Infection | NOT-AI-24-050 | NIAID | Jun 28, 2024 | May 8, 2027 | R41/R42, R43/R44, R01, R21 |
| Notice of Special Interest (NOSI): Discovery and Development of Oral Small-molecule Direct-acting Antivirals Targeting Viruses of Pandemic Potential | NOT-AI-24-053 | NIAID | Jun 27, 2024 | Jul 17, 2027 | R21, R41/R42, R43/R44, R01 |
| Notice of Special Interest (NOSI): Improving Adherence to Treatment and Prevention Regimens and Maintenance of Health Behaviors to Promote Health | NOT-OD-24-146 | OBSSR , NCCIH , NCI , NEI , NHLBI , NIA , NIDA , NIMH , NIMHD , NINR , OAR , ODP , ORWH , SGMRO | Jun 24, 2024 | Jul 14, 2027 | P01, P30, R01, R03, UG3/UH3, R34, U24, R41/R42, R21, R43/R44, R21/R33, R61 |
| Notice of Special Interest (NOSI): NIDCR Support for Research on Understanding Phage Biology in the Oral Cavity | NOT-DE-24-014 | NIDCR | Jun 13, 2024 | Jan 8, 2028 | R21, R15, R01, R03 |
| Notice of Special Interest (NOSI): Interpersonal Communication Research to Advance Dental, Oral, and Craniofacial Health over the Lifecourse | NOT-DE-24-027 | NIDCR | May 23, 2024 | Sep 8, 2027 | R03, R21 |
| Notice of Special Interest (NOSI): Research Opportunities Centering the Health of Women Across the HIV Research Continuum | NOT-OD-24-119 | ORWH , FIC , NCCIH , NCI , NIA , NIAAA , NIAID , NIAMS , NICHD , NIDA , NIDDK , NIMH , NIMHD , NINDS , OAR , OBSSR , SGMRO | May 21, 2024 | Jan 8, 2026 | K99/R00, R01, R34, F32, K23, K25, K02, R15, K01, K43, R21, K24, R61/R33, K08, F30, R03, DP1, U34, F31, T32, R36 |
| Notice of Special Interest (NOSI): Exploring the Effects of Endocannabinoids and Exogenous Cannabinoids on Brain Development | NOT-DA-25-030 | NIDA | Apr 30, 2024 | May 8, 2028 | R01, K01, K25, R21, R03, K08, K99/R00 |
| Notice of Special Interest (NOSI): Research to Stimulate Development of Diagnostics, Therapeutics, and Vaccines for Herpes Simplex Virus (HSV) | NOT-AI-24-028 | NIAID | Mar 27, 2024 | Apr 6, 2027 | R21, R41/R42, R43/R44, R03, R01 |
| Notice of Special Interest: Womens Health Research | NOT-OD-24-079 | ORWH , FIC , NCATS , NCCIH , NCI , NEI , NHGRI , NHLBI , NIA , NIAAA , NIAID , NIAMS , NIBIB , NICHD , NIDA , NIDCD , NIDCR , NIDDK , NIEHS , NIGMS , NIMH , NIMHD , NINDS , NINR , NLM , OAR , OBSSR , ODP , ODS , ODSS , SGMRO | Mar 26, 2024 | Nov 5, 2027 | R15, R01, K01, R16, K08, R21, K43, F31, R43/R44, R41/R42, F30, R03, K23, F32, R34 |
| Notice of Special Interest (NOSI): Development of Imaging Techniques for High Resolution and Functional Scanning of In Vivo Human Sensory and Communication Systems | NOT-DC-24-025 | NIDCD | Mar 22, 2024 | May 8, 2027 | R01, U01, R43/R44, R41/R42, R21 |
| Notice of Special Interest (NOSI): Inborn Errors of Immunity/Primary Immunodeficiencies | NOT-AI-24-024 | NIAID | Mar 20, 2024 | Mar 17, 2027 | R03, R01, R21 |
| Notice of Special Interest (NOSI): Mechanisms of Osteoarthritis | NOT-AG-24-002 | NIA , NIAMS | Feb 28, 2024 | May 8, 2027 | R21, R01 |
| Notice of Special Interest (NOSI): Myelin plasticity in sculping addiction neurocircuitry | NOT-DA-25-028 | NIDA | Feb 26, 2024 | Jan 8, 2027 | F30, R03, F31, R01, K99/R00, R21, K01, F32 |
| Notice of Special Interest (NOSI): Developing and Testing Multi-level Physical Activity Interventions to Improve Health and Well-Being | NOT-OD-24-058 | ODP , NCCIH , NCI , NIA , NIAMS , NICHD , NIMHD , NINR , OBSSR , ODS , ORWH | Feb 20, 2024 | Jan 8, 2027 | U24, R01, R21, R34, UG3/UH3, R03 |
| Notice of Special Interest (NOSI): Validation of Digital Health and Artificial Intelligence/Machine Learning Tools for Improved Assessment in Biomedical and Behavioral Research | NOT-CA-24-031 | NCI , NHLBI , NIA , NIDA , NIMH , NINR , OBSSR , ODSS | Feb 15, 2024 | Jul 6, 2025 | R61/R33, R01, R21, R43/R44, R34, R41/R42 |
| Notice of Special Interest (NOSI): Determining the Tri-directional Relationship Among Oral Health, Nutrition, and Comprehensive Health | NOT-DE-24-011 | NIDCR | Feb 12, 2024 | Sep 8, 2027 | R21, R01 |
| Notice of Special Interest (NOSI): Use of Digital Technology and Mobile Health (mHealth) to Improve Diagnosis, Assessments, Interventions, Management and Outcomes for Individuals with Down Syndrome Across the Lifespan (R21 Clinical Trial Not Allowed) | NOT-OD-24-044 | OD , NEI , NICHD | Jan 17, 2024 | Feb 14, 2025 | R21 |
| Notice of Special Interest (NOSI): Fundamental Mechanisms and Functions of Co-transmission in the Brain | NOT-MH-24-105 | NIMH , NIAAA , NIDA | Jan 2, 2024 | Feb 4, 2027 | R03, R21, P50, R01, R15 |
| Notice of Special Interest (NOSI): NIDCD is Interested in Supporting Research on the Impact of Post-Acute Sequelae of SARS-CoV-2 Infection on Mission Specific Sensory and Communication Disorders | NOT-DC-24-001 | NIDCD | Dec 14, 2023 | Jan 30, 2027 | R41/R42, R43/R44, R01, R21 |
| Notice of Special Interest (NOSI): Quantum Sensing Technologies in Biomedical Applications | NOT-EB-23-022 | NIBIB , NCATS , NCI , NEI , NHLBI , NIGMS | Dec 13, 2023 | Jan 27, 2027 | R35, RM1, R21, R01, U01, R15, R13, K99/R00 |
| Notice of Special Interest: Health Influences of Gender as a Social and Structural Variable | NOT-OD-24-038 | ORWH , FIC , NCI , NHLBI , NIA , NIAID , NICHD , NIDA , NIMH , NINDS , OAR , SGMRO | Dec 8, 2023 | Oct 1, 2025 | K08, R01, K23, R21, K01, R03, F31, R34 |
| Notice of Special Interest (NOSI): Exploratory Cancer Immunology Projects and Technologies (ExCITe) | NOT-CA-24-016 | NCI | Dec 5, 2023 | Nov 17, 2026 | R21 |
| Notice of Special Interest (NOSI): Development and Application of Novel Chemical Approaches to Discover Therapeutic Targets for Substance Use Disorders | NOT-DA-25-027 | NIDA | Nov 28, 2023 | May 8, 2027 | K01, R21, F31, F30, R03, F32, R01, K99/R00 |
| Notice of Special Interest (NOSI): Data Informed, Place-Based Community-Engaged Research to Advance Health Equity | NOT-HL-23-110 | NHLBI , NCI , NIDCR , NIEHS , NIMH , NIMHD , NINR , OBSSR , ODP , ORWH | Nov 28, 2023 | Jan 8, 2027 | R01, R34, R21, UG3/UH3, K01, R03, P01, P50, K08, K23 |
| Notice of Special Interest (NOSI): Development of Organotypic Culture Models for Transplantation Immunology Research | NOT-AI-23-064 | NIAID | Nov 9, 2023 | Nov 17, 2026 | R21, R01 |
| Notice of Special Interest (NOSI): Interventions to promote mental well-being in populations that experience health disparities through social, cultural, and environmental connectedness | NOT-OD-23-194 | ODP , NCCIH , NIA , NIBIB , NIDCR , NIMH , NIMHD , OAR , ORWH , SGMRO | Nov 6, 2023 | Sep 8, 2026 | R21, R01, R34, UG3/UH3 |
| Notice of Special Interest (NOSI): Using Targeted Degradation of Protein and non-Protein Targets for the Development of Novel Anti-Infectives | NOT-AI-23-076 | NIAID | Oct 31, 2023 | Jul 17, 2026 | R03, R01, R21, R41/R42, R43/R44 |
| Notice of Special Interest (NOSI): Chronic Inflammation of the Oral Cavity - An Agent for Oral Mucosal Disease | NOT-DE-23-007 | NIDCR | Oct 30, 2023 | May 10, 2027 | R03, R01, R21 |
| Notice of Special Interest (NOSI): Applications of Data Science in Translational Dental, Oral, and Craniofacial Research | NOT-DE-24-003 | NIDCR | Oct 23, 2023 | May 8, 2026 | UE5, R41/R42, U01, K02, K25, F30, R13, D43, F99/K00, F33, F31, K99/R00, R16, D71, R15, R43/R44, K18, K43, K08, R01, R21, K23, K01, F32, R03, G11, K22 |
| Notice of Special Interest (NOSI): Research Projects to Develop Oncoaging Models for Cancer Research | NOT-CA-23-092 | NCI , NIA | Oct 16, 2023 | Jul 31, 2027 | R21, R01 |
| Notice of Special Interest (NOSI): The Road to Prevention of Stillbirth | NOT-HD-23-021 | NICHD | Oct 3, 2023 | Nov 17, 2026 | F31, R03, R15, K08, R01, R21, F30, U24, R43/R44, K23, R41/R42, R25, S06, F32, U01 |
| Notice of Special Interest (NOSI): Xylazine: Understanding Its Use and the Consequences | NOT-DA-24-012 | NIDA | Aug 28, 2023 | Jan 8, 2025 | R21, R03 |
| Notice of Special Interest in Research on Family Support and Rejection in the Health and Well-Being of SGM Populations | NOT-OD-23-166 | OD , NCI , NIA , NIAMS , NICHD , NIDDK , NIMH , NIMHD , OBSSR , ODP , ORWH , THRO | Aug 28, 2023 | May 8, 2026 | R21, R15, R01, R34, K25, K99/R00, K01, R03, P01, K08, K23 |
| Notice of Special Interest (NOSI): Epidemiology and Prevention in Alcohol Research | NOT-AA-23-018 | NIAAA , NCI | Aug 24, 2023 | Sep 6, 2026 | R03, R21, R01, UG3/UH3, R61/R33 |
| Notice of Special Interest (NOSI): Maternal Health and the Dental, Oral, and Craniofacial Development of their Children | NOT-DE-23-005 | NIDCR | Aug 3, 2023 | Mar 17, 2026 | R21, R01 |
| Notice of Special Interest (NOSI): Role of social function on SUD treatment and outcomes | NOT-DA-25-026 | NIDA | Aug 1, 2023 | Sep 8, 2026 | R01, R21 |
| Notice of Special Interest (NOSI): Accelerating Research in Understudied Skin Types | NOT-AR-24-009 | NIAMS | Jul 31, 2023 | Jul 17, 2026 | R21, R01, R34 |
| Notice of Special Interest (NOSI): Understanding Immune Evasion in Tickborne Diseases | NOT-AI-23-053 | NIAID | Jul 24, 2023 | Jul 17, 2026 | R21, R01, R03 |
| Notice of Special Interest (NOSI): Advancing Biomedical Research in Pulmonary Non-Tuberculous Mycobacterial (NTM) Infections | NOT-AI-23-050 | NIAID | Jun 27, 2023 | Jul 17, 2026 | R21, R41/R42, R43/R44, R01, U44 |
| Notice of Special Interest: Secondary Analyses of Existing Alcohol Research Data | NOT-AA-23-011 | NIAAA | Jun 26, 2023 | Sep 6, 2026 | R21, R03, R01 |
| Notice of Special Interest (NOSI): Using Targeted Degradation of Protein and non-Protein Targets for the Development of Novel Anti-Infectives | NOT-AI-23-049 | NIAID | Jun 23, 2023 | Jul 17, 2026 | R03, R01, R41/R42, R43/R44, R21 |
| Notice of Special Interest (NOSI): HIV Cure-Related Research in Diverse Populations | NOT-AI-23-046 | NIAID , NIDDK , NIMH | Jun 23, 2023 | May 8, 2026 | R01, R21 |
| Notice of Special Interest (NOSI): Promoting Research and Development of Vaccines Against Enteric Viruses | NOT-AI-23-048 | NIAID | Jun 15, 2023 | Jul 17, 2026 | R01, R43/R44, U44, R41/R42, R21 |
| Notice of Special Interest (NOSI): Understanding Mucosal Immunity Against Enteric Eukaryotic Pathogens to Advance Discovery of New Interventions | NOT-AI-23-045 | NIAID | Jun 15, 2023 | Jul 17, 2026 | R21, R01 |
| Notice of Special Interest (NOSI): Impacts of Psychedelic and Dissociative Drug Policy Changes on Public Health Outcomes | NOT-DA-24-010 | NIDA | Jun 13, 2023 | Sep 8, 2026 | R03, 333, R01, R15, R21 |
| Notice of Special Interest (NOSI): Research on HIV-associated Malignancies | NOT-CA-23-070 | NCI | Jun 8, 2023 | Sep 8, 2026 | R21, R01 |
| Notice of Special Interest (NOSI): RNA Modifications in Cancer Biology | NOT-CA-23-060 | NCI | Apr 17, 2023 | Jan 8, 2026 | R33, R21, U01, R61, R03 |
| Notice of Special Interest (NOSI): Supporting Exploratory/Developmental Research Focused on NIAMS Core Mission Areas | NOT-AR-23-006 | NIAMS | Apr 17, 2023 | Jan 8, 2027 | R21 |
| Notice of Special Interest (NOSI): Synthetic Biology for Biomedical Applications. | NOT-EB-23-002 | NIBIB , NCCIH , NCI , NHLBI , NIA , NIAID , NICHD , NIGMS | Apr 14, 2023 | May 17, 2026 | R01, R21, R35, R41/R42, R43/R44 |
| Notice of Special Interest (NOSI): Assembling the Addiction Organelle Interactome | NOT-DA-24-007 | NIDA | Apr 11, 2023 | Sep 8, 2026 | R21, K01, R36, R03, R01 |
| Notice of Special Interest (NOSI): Development of Innovative Informatics and Data Science Technologies, Tools, and Methods for Vision Research | NOT-EY-23-005 | NEI | Apr 3, 2023 | Feb 16, 2026 | R41/R42, R43/R44, R21 |
| Notice of Special Interest (NOSI): Leveraging glial cells to treat addiction | NOT-DA-24-006 | NIDA | Apr 3, 2023 | Sep 8, 2026 | R21, K01, R36, R01, R03 |
| Notice of Special Interest (NOSI): Promoting Language and Communication in Minimally Verbal/Non-Speaking Individuals with Autism | NOT-DC-23-009 | NIDCD | Apr 3, 2023 | Jun 6, 2026 | R13, R15, R01, U01, R21, R43/R44, R41/R42, R03 |
| Notice of Special Interest (NOSI): Encouraging Womens Health Research within the NIDCD Mission Areas | NOT-DC-23-006 | NIDCD | Mar 28, 2023 | May 6, 2026 | R15, R21, R01 |
| Notice of Special Interest (NOSI): NIDCR Support for Research on the Physiological Involvement of Oral Cavity in Coronavirus Disease 2019 (COVID-19) | NOT-DE-23-004 | NIDCR | Mar 8, 2023 | May 8, 2026 | R21, R01, UG3/UH3 |
| Notice of Special Interest: Advancing mHealth Interventions for Understanding and Preventing Alcohol-Related Domestic Violence | NOT-AA-23-003 | NIAAA | Mar 6, 2023 | Sep 8, 2026 | R01, R21, R34, K99/R00 |
| Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine | NOT-AI-23-031 | NIAID | Feb 23, 2023 | Jan 15, 2026 | R01, R41/R42, R43/R44, R21, U44 |
| Notice of Special Interest (NOSI): Priority Research Opportunities in Crisis Response Services | NOT-MH-23-140 | NIMH , NIDA , ORWH | Jan 18, 2023 | May 8, 2025 | R21, R01, R34 |
| Notice of Special Interest (NOSI): Targeting the Endocannabinoid System for Brain Health and Acute and Chronic Diseases | NOT-DA-22-048 | NIDA , NCI , NIDCR | Jan 9, 2023 | Jan 8, 2026 | R01, R21, DP2, DP1, K99/R00, K01, R36, K08, R15, K24 |
| Notice of Special Interest (NOSI): Fundamental Science Research on the Neural Circuits Underlying Sensory Processing | NOT-DC-23-001 | NIDCD | Jan 5, 2023 | Jan 8, 2026 | R21, R01, R15 |
| Notice of Special Interest (NOSI): Firearm Injury and Mortality Prevention Research | NOT-OD-23-039 | OBSSR , NCCIH , NIA , NIAAA , NICHD , NIDA , NIMH , NIMHD , NINR , ODP , ORWH , SGMRO | Dec 16, 2022 | Feb 5, 2026 | R01, R34, R21, U24, R61/R33, UG3/UH3 |
| Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine | NOT-AI-23-007 | NIAID | Nov 25, 2022 | Jan 8, 2026 | R21, R41/R42, R43/R44, R01 |
| Notice of Special Interest (NOSI): Advancing Research for Tickborne Diseases (TBDs) | NOT-AI-23-013 | NIAID , NIAMS , NIMH , NINDS | Nov 25, 2022 | Jan 8, 2026 | R43/R44, R15, R01, R21, R03, R41/R42 |
| Notice of Special Interest (NOSI): Complement in Fundamental Immunology | NOT-AI-23-012 | NIAID | Nov 23, 2022 | Jan 8, 2026 | R21, R01 |
| Notice of Special Interest (NOSI): Advancing Development of Rapid Point-of-Care Hepatitis C Virus Diagnostics | NOT-AI-23-001 | NIAID , NCI , NIBIB | Nov 23, 2022 | Jan 8, 2026 | R01, R41/R42, R43/R44, R21 |
| Notice of Special Interest: Promoting Research Opportunities on HIV/AIDS in NIAMS | NOT-AR-23-004 | NIAMS | Nov 21, 2022 | Jan 8, 2028 | R01, R21, 333 |
| Notice of Special Interest (NOSI): Chemoproteomic Approaches for Discovery of Targets and Therapeutics to Treat Substance Use Disorders | NOT-DA-24-005 | NIDA | Nov 7, 2022 | Jan 8, 2026 | R03, F32, R21, F31, R01, K99/R00, F30, K01 |
| Notice of Special Interest (NOSI) Targeting Epigenetic Regulators for Treating Addiction and Substance Use Disorders | NOT-DA-24-004 | NIDA | Nov 3, 2022 | Jan 8, 2026 | R03, R01, K99/R00, R21, F31, F30, F32, K01 |
| Notice of Special Interest (NOSI): Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R01, R21, R03) | NOT-DA-23-012 | NIDA | Nov 2, 2022 | Feb 8, 2026 | R01, R03, R21 |
| Notice of Special Interest (NOSI): Research on the Impact of Policy Changes and Emerging and Evolving Public Health Crises on NIDA Populations of Interest | NOT-DA-22-084 | NIDA | Oct 20, 2022 | Jan 8, 2026 | R15, R21, R01, R03 |
| Notice of Special Interest (NOSI): Opportunities for HIV Cure Interventions at the Time of ART Initiation | NOT-AI-22-072 | NIAID , NICHD , NIMH | Oct 6, 2022 | Sep 8, 2025 | R01, R21 |
| Notice of Special Interest (NOSI): Understanding Exposure and Health Effects of Micro and/or Nanoplastics | NOT-ES-23-002 | NIEHS | Oct 3, 2022 | Nov 17, 2027 | R21, R01 |
| Notice of Special Interest (NOSI): Targeting the Pathogen within the Arthropod Vector | NOT-AI-22-074 | NIAID | Oct 3, 2022 | Jan 8, 2026 | R01, R21 |
| "Notice of Special Interest (NOSI): High Priority Areas in Placental Research for Healthy Pregnancies" (Reissue) | NOT-HD-22-049 | NICHD | Sep 27, 2022 | Mar 16, 2025 | R01, R03, R21 |
| Notice of Special Interest (NOSI): Research on the Impact of Policy Changes and Emerging and Evolving Public Health Crises on NICHD Populations of Interest | NOT-HD-22-038 | NICHD , NIDA | Sep 14, 2022 | Jan 8, 2025 | R15, R03, R01, R21 |
| Notice of Special Interest (NOSI): Research on the Health of Bisexual and Bisexual+ People | NOT-OD-22-166 | OD , NCCIH , NIA , NIAAA , NIAID , NICHD , NIDA , NIDCR , NIMH , NIMHD , NINDS , ODP | Aug 11, 2022 | May 8, 2025 | K24, U01, R01, K01, R15, R03, K76, R34, K99/R00, T32, F32, UG3/UH3, R21, K23, F31 |
| Notice of Special Interest (NOSI): Opportunities for HIV Cure Interventions at the Time of ART Initiation | NOT-AI-22-056 | NIAID , NIMH | Aug 5, 2022 | Sep 8, 2025 | R01, R21 |
| Notice of Special Interest (NOSI): Community-Based Participatory Research (CBPR) Initiative in Reducing and Eliminating Health Disparities with a focus on addressing diverse representation in research on Down syndrome (R21 Clinical Trial Optional) | NOT-OD-22-142 | OD , NCI , NEI , NHLBI , NIA , NIAMS , NICHD , NIDCD , NIDCR , NIMHD , NINDS | Aug 5, 2022 | Mar 17, 2025 | R21 |
| Notice of Special Interest (NOSI): Promoting Mechanistic Research on Therapeutic and Other Biological Properties of Minor Cannabinoids and Terpenes | NOT-AT-22-027 | NCCIH , NCI , NEI , NIA , NIAAA , NIDA , NIDCR , NINDS , ODS , ORWH | Jul 27, 2022 | Jul 1, 2025 | R21, R01, UG3/UH3 |
| Notice of Special Interest (NOSI): Single-Cell Level Spatiotemporal Mapping of Dental and Craniofacial Embryogenesis | NOT-DE-22-003 | NIDCR | Jul 18, 2022 | Sep 8, 2025 | R15, R01, K18, K99/R00, K02, R21, K01, R03, R16, K22 |
| Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening | NOT-OD-22-179 | ODP , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO | Jul 14, 2022 | May 8, 2025 | R21, R01, R61/R33, UG3/UH3, R34, U01 |
| Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan | NOT-OD-22-178 | ODP , NCI , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO | Jul 14, 2022 | May 8, 2025 | R21, R01, UG3/UH3, R61/R33, R34, R03 |
| Notice of Special Interest (NOSI): Research on Addressing Violence to Improve Health Outcomes | NOT-OD-22-167 | OBSSR , NIA , NIAAA , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINR , ODP , ORWH , SGMRO | Jul 8, 2022 | Oct 5, 2025 | R21, R01, R34, UG3/UH3 |
| Notices of Special Interest (NOSI): High Priority Areas in Integrative Neuroscience Branch in the Division of Neuroscience and Behavior | NOT-DA-22-058 | NIDA | Jun 2, 2022 | Jan 8, 2026 | R21, R03, R36, K01, K99/R00, R01 |
| Notice of Special Interest (NOSI): Climate Change and Health | NOT-ES-22-006 | NIEHS , FIC , NCI , NHGRI , NHLBI , NIA , NIAID , NIAMS , NICHD , NIDCR , NIMH , NIMHD , NINDS , NINR , NLM , ODP | Jun 1, 2022 | May 8, 2025 | R21, F31, D43, K01, R03, K43, K99/R00, U01, U19, R01, F32, K23, F30, R21/R33 |
| Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan | NOT-OD-22-106 | ODP , NCI , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO | May 12, 2022 | May 8, 2025 | R03, R01, R34, R21, UG3/UH3, R61/R33, 333 |
| Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening | NOT-OD-22-107 | ODP , NIA , NIAAA , NIAMS , NICHD , NIDA , NIDCD , NIDCR , NIMH , NIMHD , NINDS , NINR , ODS , ORWH , SGMRO | May 12, 2022 | May 8, 2025 | 333, R01, R34, R21, R61/R33, U01, UG3/UH3 |
| Notice of Special Interest (NOSI): Basic Mechanisms of Cannabis and Cannabinoid Action in Cancer | NOT-CA-22-085 | NCI | May 5, 2022 | Jul 5, 2027 | K22, R01, K08, K01, R21, R03, K99/R00 |
| Notice of Special Interest (NOSI): Towards Developing a Cure for HBV in HIV/HBV Co-Infection | NOT-AI-22-043 | NIAID | Apr 29, 2022 | May 8, 2025 | R01, R41/R42, R21, R43/R44 |
| Notice of Special Interest: Achieving Tissue Robustness Through Harnessing Immune System Plasticity | NOT-DE-22-005 | NIDCR | Apr 26, 2022 | Sep 9, 2025 | R21, R01 |
| Notice of Special Interest (NOSI): Research using implementation science to support the delivery of evidence-based practices in community-based mental or general medical healthcare settings | NOT-MH-22-170 | NIMH , NIDA | Mar 25, 2022 | May 8, 2025 | R21, R01, R34 |
| Notice of Special Interest (NOSI): Leveraging Data Science to Bring Actionable Insights for Substance Use Prevention and Treatment | NOT-DA-23-006 | NIDA | Mar 1, 2022 | Sep 8, 2025 | R21, R01, R03, 333 |
| Notice of Special Interest (NOSI): Optimizing Vascularized Composite Allograft Survival | NOT-AI-22-023 | NIAID | Feb 23, 2022 | May 8, 2026 | R21, R01 |
| Notice of Special Interest (NOSI): Epidemiology of Drug Abuse | NOT-DA-22-004 | NIDA | Feb 23, 2022 | Sep 8, 2025 | R21, R01, 333, R03 |
| Notice of Special Interest (NOSI): Public Health Research on Cannabis | NOT-DA-22-003 | NIDA | Feb 18, 2022 | May 5, 2025 | R21, R01, 333, R03 |
| Notice of Special Interest (NOSI): Research Addressing Eye and Vision Health Equity/Health Disparities | NOT-EY-22-004 | NEI , NIMHD | Feb 14, 2022 | Jan 25, 2025 | R01, UG1, F31, R21, 333, K99/R00, K08, F30, K23, R43/R44, R34, R41/R42, F32 |
| Notice of Special Interest (NOSI): Priority Research Opportunities in Crisis Response Services | NOT-MH-22-110 | NIMH , NIDA , ORWH | Feb 8, 2022 | May 8, 2025 | R21, R01, R34, R43/R44 |
| Notice of Special Interest (NOSI): Research to Prevent Drug Use, Misuse and Addiction | NOT-DA-23-001 | NIDA , ODP | Jan 21, 2022 | May 8, 2025 | R01, R21, R34, R03 |
| Notice of Special Interest (NOSI): COVID-19 Pandemic Mental Health Research | NOT-MH-22-100 | NIMH | Jan 19, 2022 | Jan 8, 2025 | R21, R34, R01 |
| Notice of Special Interest (NOSI): Advancing NEI AGI Research on newly Identified Factors Into Models of Visual System Regeneration | NOT-EY-22-002 | NEI | Jan 10, 2022 | Feb 10, 2025 | R43/R44, R21, R15, R41/R42, R01, R24 |
| Notice of Special Interest: Development and Implementation of Clinical Informatics Tools to Enhance Patients Use of Genomic Information | NOT-HG-22-011 | NHGRI | Jan 6, 2022 | Dec 31, 2025 | R01, R21, U24, R43/R44, R41/R42 |
| Notice of Special Interest: Research on Pain, Pain Management, and Opioids in Aging | NOT-AG-22-004 | NIA | Dec 22, 2021 | Jan 8, 2025 | F31, P01, K99/R00, K08, R01, K01, R43/R44, F32, 332, F33, F99/K00, R15, K24, R21, K02, K25, R25, F30, K23, R36, R41/R42, SB1, K76, K22, K07, R13, R21/R33, U19 |
| Notice of Special Interest (NOSI) Pediatric COVID-19 and Respiratory Viral Co-infection | NOT-HL-22-004 | NHLBI , NICHD , NIAID | Dec 21, 2021 | Sep 8, 2025 | R01, R21 |
| Notice of Special Interest (NOSI): Epidemiology and Prevention of Alcohol Misuse in Understudied Young Adult Populations; Military, Workforce, and Community College | NOT-AA-22-001 | NIAAA | Dec 9, 2021 | Sep 9, 2025 | R21, R03, R01, R43/R44, R41/R42 |
| Notice of Special Interest (NOSI): Research in the Chemistry and Pharmacology of Addictive Drugs | NOT-DA-23-002 | NIDA | Nov 30, 2021 | Jan 8, 2025 | R03, R21, R01, K99/R00, R36, K01 |
| Notice of Special Interest (NOSI): Accelerating Progress in Celiac Disease Research | NOT-AI-22-004 | NIAID , NIAMS , NCCIH , NCI | Nov 23, 2021 | Jan 8, 2025 | R03, R21, U01, U44, R01, R34, P01, R61/R33 |
| Notice of Special Interest: Expanding the Otitis Media Research Workforce: Focus on Early Stage Investigators | NOT-DC-22-001 | NIDCD | Nov 23, 2021 | Sep 8, 2025 | R21, R01, U01 |
| Notice of Special Interest (NOSI): Mechanistic studies on the impact of substance use in sex and gender differences in HIV-associated neurocognitive disorders | NOT-DA-22-047 | NIDA , ORWH | Nov 19, 2021 | Jan 8, 2025 | R21, R01 |
| Notice of Special Interest (NOSI): The Functional Oral Microbiome | NOT-DE-21-015 | NIDCR , ORWH | Nov 19, 2021 | Sep 7, 2025 | R01, R21 |
| Notice of Special Interest (NOSI): Biologic Factors Underlying Dental, Oral, and Craniofacial Health Disparities | NOT-DE-21-013 | NIDCR , NCI , NIMHD | Oct 7, 2021 | Jan 8, 2025 | R21, R01 |
| Notice of Special Interest (NOSI): Bold New Bioengineering Research for Heart, Lung, Blood and Sleep Disorders and Diseases (Reissue) | NOT-HL-21-024 | NHLBI | Aug 17, 2021 | Jan 8, 2025 | R21 |
| Notice of Special Interest (NOSI): Advancing HIV/AIDS Research through Computational Neuroscience | NOT-DA-21-030 | NIDA | Jun 22, 2021 | Jan 8, 2025 | R01, R21, R03, DP2, DP1, K99/R00, K01, R36, P01, R15, K24 |
Expired NOSIs
| Title | Notice Number | Organization | Release Date |
Expiration Date |
Activity Code(s) |
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