Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) (PA-24-175)

National Cancer Institute (NCI)

Scientific Program Contact:
Sergey Radaev, PhD
Phone: 240-276-5630
Email: sradaev@mail.nih.gov

Grants Management Contact:
Amy Bartosch
Email: amy.bartosch@nih.gov

NCI-Specific Information:

The NCI Mentored Research Scientist Development Award (K01) supports the early career-stage researchers only in the areas of cancer control and population sciences and cancer prevention. The eligible candidates include postdoctoral fellows and non-tenured junior faculty (e.g., Assistant Professor or equivalent). The application will not be considered for funding if the PD/PI has already been promoted to Associate Professor or equivalent at the time of award.

Research Areas of Interest: NCI only accepts K01 applications that are submitted in response to one of the following Notices:

• NOT-CA-24-022: Notice of Special Interest: National Cancer Institute Supports Applications for the Mentored Research Scientist Development Awards (K01) within the Mission of the Division of Cancer Control and Population Sciences.
• NOT-CA-24-023: Notice of Special Interest: National Cancer Institute Supports Applications for the Mentored Research Scientist Development Awards (K01) within the Mission of the Division of Cancer Prevention.

For application acceptance in the subject area of Cancer Control and Population Sciences, applicants must include “NOT-CA-24-022” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. NCI K01 applications without this information in box 4B will not be accepted and will be withdrawn.

For application acceptance in the subject area of Cancer Prevention, applicants must include “NOT-CA-24-023” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. NCI K01 applications without this information in box 4B will not be accepted and will be withdrawn.
Prospective applicants are strongly encouraged to discuss their proposal with the NCI scientific program contact before preparing an application.
Additional NCI-specific information/requirements can be found at: K01.

For Diversity Career Development Awards, please see the Center to Reduce Cancer Health Disparities (CRCHD) at Cure Overview.

NCCIH Specific Information:

NCCIH uses the K01 program to support new and junior investigators in supervised career development experiences that lead to research independence. It also supports investigators who need protected time in supervised career development experiences to train in a new field.

• Before the application receipt date, investigators are strongly encouraged to discuss their proposed research interest with an NCCIH Program Officer in the specific scientific area and/or intervention that is closely related to the proposed project to confirm its relevance to NCCIH 's mission and research priorities. A list of NCCIH program officials can be found at NCCIH Contact Area.
• Applications proposing the use of natural products or devices in an interventional research project should explicitly describe the status of the Investigational New Drug (IND) or Investigational Device Exemption (IDE). Applicants interested in natural products research are encouraged to review NCCIH's Natural Product Integrity Policy.
• NCCIH will not fund applications proposing a clinical trial to test efficacy or effectiveness through this mechanism. Applicants are encouraged to discuss their proposed scope of work with an NCCIH program officer, and to review resources available at NCCIH’s Clinical Research Toolbox.
• Applicants are strongly encouraged to provide clear evidence that adequate resources are available at the institution for the successful completion of the proposed research project. Applications should include explicit statements from the institution and the mentor(s) addressing the following:
  • Detailed information about who will provide the necessary resources;
  • Funding source and amount of additional funding (as needed);
  • Support staff available and committed to the project;
  • Allocation of sufficient protected time for the K awardee to conduct the research;
  • Availability of biostatistical support for the duration of the study - including the planning period; and
  • A contingency plan (for the institution and mentor) for completion of the study in the event the awardee leaves the institution earlier than the end date of the award.

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

NHLBI Specific Information:

The NHLBI only uses the K01 for highly innovative research in humans only in the following areas:

• Epidemiological research that elucidates the mechanisms, etiology, pathogenesis, prevention, diagnosis and treatment of heart, lung, blood, sleep (HLBS) diseases, including chronic HLBS disorders resultant of infectious diseases and associated treatment complications (e.g., HIV/AIDS).
• Biostatistics research leading to the development of innovative methods for designing studies and analyzing data in clinical and population-based research (e.g., Clinical trials and epidemiologic, genomic, proteomic, or metabolomic studies) in HLBS diseases, including chronic HLBS disorders resultant of infectious diseases and associated treatment complications (e.g., HIV/AIDS).
• Outcomes research involving the comparison of screening, diagnostic, preventive or treatment strategies for HLBS diseases, including chronic HLBS disorders resultant of infectious diseases and associated treatment complications (e.g., HIV/AIDS).
• Implementation research that addresses strategies for sustained adoption of proven, effective multilevel interventions for HLBS diseases, including chronic HLBS disorders resultant of infectious diseases and associated treatment complications (e.g., HIV/AIDS).
• State of the art research studies reflected above that use large data sources and electronic health records are encouraged.
• Data science disciplines, including but not limited to Artificial Intelligence, Machine Learning, Deep Learning, Healthcare Data Analytics, Public Health Data Analytics, Imaging Analytics, Predictive Analytics, and Bioinformatics, for the creation, management, analysis, and integration of complex, large data sets in support of data-driven discovery in heart, lung, blood, and sleep health and disease.

NHLBI has a 6-year limit of cumulative support on institutional and mentored Ks (e.g., K12 or KL2 plus the K01).

The NHLBI does not support Re-Entry research applications through the K01 mechanism. Re-Entry opportunities are available at: Re-Entry Administrative Supplement

Salary Support: Up to $100,000 plus fringe benefits per year. Please see NOT-HL-16-309
Research Support: Up to $30,000 per year.

NHGRI Specific Information:

NHGRI supports resources, approaches, and technologies that accelerate genomic research focused on the ethical, legal, and social implications of genomic advances; the structure and biology of genomes; the genomics of disease; the implementation and effectiveness of genomic medicine; computational genomics and data science; and the impact of genomic advances, technology, and implementation on health disparities and health equity. Within these areas, approaches that are comprehensive across the genome or are generalizable across variants, tissues, diseases, or functions may be in scope for NHGRI.

NHGRI recognizes the importance of diversity in the genomic workforce, without which the promise of genomics cannot be fully achieved.

All K01 applicants must justify the need for additional training and explain how the training will facilitate their ability to conduct cutting-edge research in the research areas outlined above.

Prospective applicants are strongly encouraged to contact a Scientific Program Contact to discuss their concept for this initiative during the development stages of the application.

Salary Support: Commensurate with the applicant institution's salary structure for persons of equivalent qualifications, experience, and rank.
Research Support: Up to $40,000 per year
In addition to Research Support, which may be used to travel to scientific conferences, applicants can request additional travel costs of up to $1500 per year to attend the NHGRI Research Training and Career Development Annual Meeting while supported on the K01. These additional travel funds cannot be re-budgeted to attend another meeting.

NIAAA Specific Information:

NIAAA supports faculty level early-stage investigator development under this announcement. Applicants are encouraged to refer to the NIAAA Strategic Plan for NIAAA research priorities. Applicants are to comply with the NIH and NIAAA Data Management and Sharing policies, NOT-OD-21-013 and NOT-AA-23-001. Prospective applicants are strongly encouraged to contact the appropriate NIAAA staff contact prior to preparing an application.

• All applications must include a strong and credible plan for the applicant’s transition to research independence, outlining milestones and providing evidence of significant institutional commitment to the development of the K01 applicant as an independent researcher at the sponsoring institution.
• Candidates with less than 4 years of post-doctoral research experience, who are enrolled in the T32 training programs are strongly encouraged to apply for a K99/R00 award.
• At the time of submission, candidates must have less than 10 years post-doctoral research experience.
• At the time of award, candidates must have secured a full-time faculty or faculty equivalent appointment in an appropriate research-intensive environment.

Salary Support: Up to $90,000 plus fringe benefits per year, commensurate with the applicant institution’s salary structure for persons of equivalent qualifications, experience, and rank. Institutional Base Salary will be verified at the time of award.
Research Support: Up to $50,000 per year. 

NICHD Specific Information:

The NICHD accepts K01 applications from eligible individuals in only the following subject areas. Applications on other research topics will be withdrawn without review.

Medical Rehabilitation Research: Applicants must have clinical training in a rehabilitation-related profession (e.g., P.T., O.T., R.N., or Speech and Language pathologist), possess a doctoral level degree (e.g., Ph.D., D.Eng., Ed.D.), and be committed to a career as an independent investigator in medical rehabilitation.

Child Abuse and Neglect: Applicants must be committed to developing careers as independent investigators in child abuse and neglect research.

Population Research: Population research is defined as demographic, behavioral, and social scientific research on fertility, family and household structures, mortality and morbidity, migration, immigration, population and the environment, and population distribution and characteristics. NICHD supports research that addresses the intersection of demographic processes and health, examines health from a population perspective, and/or integrates demographic or social scientific approaches to understanding health with behavioral or biomedical approaches. The K01 award in Population Research is intended to provide mentored training experiences for:

• Investigators in demography or other areas of population research who require additional technical and scientific inquiry skills in order to launch independent research careers;
• Investigators in demography or population research who seek research experience in different disciplines (e.g., anthropology, geography, biological sciences, epidemiology, public health, medicine);
• Investigators in other disciplines (e.g., anthropology, geography, biological sciences, epidemiology, public health, medicine) who propose new training in demography or population research.

The K01 program in Population Research generally is limited to individuals at the Assistant Professor level. However, recent Associate Professors in the latter two categories are also eligible, as are Associate Professors who initially applied as Assistant Professors and are submitting a revised application (resubmission). For further details on the Population Research K01, see /grants/guide/notice-files/NOT-HD-07-010.html.

Research related to Down syndrome: NICHD will accept K01 applications for projects related to Down Syndrome. Applications should be aligned with the overall INCLUDE Project Research Plan, which consists of three components:

• Component 1: Targeted, high risk-high reward, basic science studies in areas highly relevant to Down syndrome
• Component 2: Cohort Study to connect existing resources and expand to inclusion of individuals with Down syndrome

Component 3: Inclusive clinical trials research for co-occurring conditions in individuals with Down syndrome

All K01 applicants must justify the need for additional training and explain how the training will facilitate their ability to conduct cutting-edge research in one of these topic areas. NICHD has a 6-year limit of cumulative support on institutional and individual mentored Ks.

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

NIDCD Specific Information:

NIDCD uses the K01 program to support new and junior basic research investigators in supervised career development experiences through a formal structured program to enhance the skill sets of the applicant by mentor(s) with established research lines and expertise in the field or technique that the applicant intends to develop or acquire; and a research project based on preliminary data that fits the applicant career development level and serves to incorporate the skills or technique he/she aims to acquire in the career development plan. NIDCD also uses the program to support investigators who need protected time in supervised career development experiences to train in a new field.

• Application must demonstrate its contribution to NIDCD and its fit to NIDCD's Mission, Research Priorities, and Strategic Plan.
• Applicants are strongly encouraged to provide clear evidence that adequate resources are available at the institution for the successful completion of the proposed research project.
• Applications should include explicit statements from the institution and the mentor(s) addressing the following:
  • Detailed information about who will provide the necessary resources;
  • Funding source and amount of additional funding (as needed);
  • Support staff available and committed to the project;
  • Availability of biostatistical support for the duration of the study - including the planning period; and
  • A contingency plan (for the institution and mentor) for completion of the study in the event the awardee leaves the institution earlier than the end date of the award.

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $30,000 per year.

NIDCR Specific Information:

NIDCR uses the Parent K01 to support re-entry of individuals into the dental, oral and craniofacial research workforce whose active careers have been interrupted by family responsibilities or other qualifying circumstances.

Eligibility Circumstances: Candidates must have been actively involved in dental, oral or craniofacial research at the time of career interruption. The duration of the career interruption should be at least one year and no more than eight years. Examples of qualifying interruptions include a complete or partial hiatus from research activities for child rearing; an incapacitating illness or injury of the candidate, spouse, partner, or a member of the immediate family; military service; relocation to accommodate a spouse, partner, or other close family member; and pursuit of non-research endeavors that would permit earlier repayment of debt incurred in obtaining a doctoral degree. The candidate should be within two years of a complete or partial hiatus from research activities at the time of application.

For Mentored Research Scientist Development Award (K01 - Independent Clinical Trial Not Allowed), please refer to NIDCR Notice of Special Interest (NOSI): Applications of Data Science in Translational Dental, Oral, and Craniofacial Research NOT-DE-23-002 calling for a variety of data science-oriented projects focused on developing and using data and data science resources, methods, and tools for dental, oral, and craniofacial (DOC) research.

Individuals who do not have an independent research plan to propose for this K01 re-entry program should consider the NIH Research Supplements to Promote Re-Entry, Reintegration into, and Retraining in Health-Related Research Careers (NOT-OD-23-170). Candidates supported by NIDCR Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers remain eligible for this K01 re-entry program. Prospective applicants are encouraged to contact NIDCR to determine eligibility for the NIDCR K01 re-entry award.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

NIDDK Specific Information:

The purpose of the NIDDK K01 award is to provide an intensive, supervised, research and career development experience for nonclinical, doctoral researchers as they transition to independent research careers. NIDDK encourages K01 applications in all areas of research supported by the NIDDK ( Research Programs). Information on the NIDDK K01 can be found at K01. The NIDDK provides further information on all K-award programs on our training and career development web site: K Awards.

Applicants for the K01 (new and resubmission) at NIDDK must have:

• a research-based doctorate (usually a Ph.D.) or comparable nonclinical doctoral degree. Individuals who have a clinical doctorate from another country and are not board-eligible in the United States are eligible for the K01
• completed at least 2 years, but no more than 7 years, of postdoctoral research training

Prospective applicants are strongly encouraged to contact NIDDK program staff to discuss relevance of the proposed studies to NIDDK's research interests and appropriateness of the K01 for accomplishing their overall career development goals.

Salary Support: Up to $90,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.
K01 awardees are also strongly encouraged to attend the NIDDK K Awardees’ Workshop while supported on the K01 (one-time attendance for this biennial meeting). Up to $1500 will be provided for K01 awardees to attend this meeting (in addition to the above-listed Research Support).

National Institute of Environmental Health Sciences (NIEHS)

Scientific Program Contact:
Carol Shreffler, Ph.D.
Phone: (984) 287-3322
Email: Shreffl1@niehs.nih.gov

Grants Management Contact
Lisa A. Edwards
Phone: (984) 287-3258
Email: archer@niehs.nih.gov

NIEHS Specific Information:

The maximum funding period is 3 years.

NIEHS only supports applicants at the assistant professor level. Candidates must be within 3 years of their appointment to their first independent faculty position at the time of submission (receipt date) of the application. Applicants in postdoctoral appointments and other non-permanent appointments such as research assistant or instructor are not eligible.

Candidates must name a primary mentor who has active NIEHS research grant support, or a substantial history of NIEHS funded research grant support. The candidate's postdoctoral mentor(s) may not be the mentor for the candidate on the K01 award. The candidate’s research should be independent from previous mentor. If the candidate is at the same institution as the former postdoctoral or other research mentor, the independence of candidate’s proposed research from the former mentor's research should be addressed in the application.

The application must also provide a document on institutional letterhead that describes its commitment to the candidate and the candidate's career development, independent of the receipt of the K award. It is also essential to document the institution's commitment to the retention, development, and advancement of the candidate during the period of the award. For additional information about NIH requirements for the institution’s commitment letter, applicants are referred to G.410 - PHS 398 Career Development Award Supplemental Form instructions under Institutional Commitment to Candidate's Research Career Development.

The Career Development and Research Plan must be consistent with the research interests of NIEHS. For further information on the research interests of the Institute, please see: NIEHS

Potential applicants are strongly encouraged to contact the program official identified in the contact table before preparing an application to discuss eligibility requirements and the relevance of the proposed research to the Institute’s research priorities.

Salary Support: Up to $75,000 plus fringe benefits per year
Research Support: Up to $50,000 per year

NIMH Specific Information:

The NIMH supports a broad spectrum of basic and translational research, including basic neuroscience, human genetics, adult and developmental translational research, services and intervention research, and AIDS-related research (NIMH Extramural Research Programs).

• Eligibility for the K01 is limited to individuals with no more than 6 years of postdoctoral research experience at the time of application (either the initial or resubmission application). NIMH encourages applicants to limit the requested support to no more than four years. The requested duration of support should be appropriately justified, taking into consideration prior research experience and the proposed mentored career development goals that are essential for developing an independent, NIMH-funded research program. See NOT-MH-22-310 and Career Development Programs K-Series​ for further details about NIMH’s support for K programs.
• An application must include a strong and credible plan for the candidate’s transition to research independence, including milestones, and evidence of significant institutional commitment to the continued development of the K01 candidate as an independent researcher at the applicant institution. Applicants are expected to plan to apply for independent research support during the later years of their mentored career award.
• It is recommended that NIMH mentored K applicants proposing clinical trials review the following guidance: (NIMH Career Development Programs K-Series).
• Prospective applicants are strongly encouraged to contact Institute career development staff (Contacts for Research Training and Career Development Programs) before preparing an application to discuss the relevance of the proposed research to the Institute’s current research priorities and for guidance on the proposed research and career development plans.

Salary Support: Up to $90,000 plus fringe benefits per year.
Research Support: Up to $50,000 per year.

NINR Specific Information:

NINR uses the K01, Career Development Program, to provide support for individuals who have a Bachelor's degree or higher in nursing to pursue career development research training. Applications must have a clear focus in science areas related to the NINR mission, which is to lead nursing research to solve pressing health challenges and inform practice and policy – optimizing health and advancing health equity into the future. Applicants should also consider NINR prioritizes research framed through five lenses detailed in the NINR Strategic Plan.

Those interested in applying for this opportunity are strongly encouraged to contact the NINR Scientific Program Contact noted in this announcement. The applicant may contact the NINR Program Director by emailing a copy of their draft NIH Biosketch along with any questions and a draft synopsis of interests and research/training aims. NINR limits the length of the K01 award to a 3-year period.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

National Library of Medicine (NLM)

Scientific Program Contact:
For Public Health and Population Health Informatics, Social and Behavioral Science Informatics, Health Disparities and Health Equity related Informatics:
Meryl Sufian, PhD
Chief Program Officer
Phone: 301-496-4671
Email: Meryl.Sufian@nih.gov

For Clinical Informatics:
Goutham Reddy, MD
Phone: (301) 827-6728
Email: goutham.reddy@nih.gov

For Bioinformatics, Translational Bioinformatics, and Personal Health Informatics:
Allison Dennis, PhD
Phone: (301) 827-9721
Email: Allison.Dennis@nih.gov

Grants Management Contact:
Andrea Culhane
Phone: 301-402-0069
E-mail: andrea.culhane@nih.gov

NIH Office of Data Science Strategy (ODSS)

ODSS program contact:
Bryan Kim Ph.D.
Email: bryan.kim@nih.gov

Office of Data Science Strategy Specific Information:

The NIH Office of Data Science Strategy (ODSS) is committed to growing a strong and diverse data science community and ensuring that data science advances in biomedical and health research can benefit all populations. ODSS is interested in supporting Career Development Award projects in data science areas including but not limited to: artificial intelligence, clinical informatics, cloud computing, statistics, computational science, software design and programming, bioinformatics, visualization, machine learning, predictive analytics, supercomputing, modeling and simulation, digital health, data sharing and access, data management, data security and data privacy in human subject’s research, and research ethics and integrity. Applications are strongly encouraged from individuals from diverse backgrounds, including from groups that are underrepresented in the biomedical, clinical, behavioral and social sciences, in alignment with the Notice of NIH’s Interest in Diversity (NOT-OD-20-031).

Office of Research on Women’s Health

Scientific Program Contact:
Carolyn Bondar, Ph.D.
Phone: (301) 824-7194
Email: carolyn.bondar@nih.gov

ORWH Specific Information:

ORWH focuses on advancing research that is relevant to the health of women and supporting women in biomedical careers. Applicants should ensure their proposed work intersects with the goals, objectives, and guiding principles of the trans-NIH Strategic Plan for Women’s Health Research (NIH-Wide Strategic Plan for Research on the Health of Women). ORWH does not award grants but co-funds applications and research projects that have received an award from one of the participating NIH Institutes and Centers listed in the announcement. Visit the ORWH website (ORWH) or contact the appropriate ORWH staff to learn more.