Flexibilities for Registration and Results Reporting of Prospective Basic Experimental Studies with Human Participants

NIH is indefinitely extending the period of delayed enforcement for registration and results reporting, originally announced in NOT-OD-18-212 for basic experimental studies involving humans (BESH) responsive to designated BESH notices of funding opportunities (NOFOs), including those with application due dates on or after September 25, 2025. During the period of delayed enforcement, NIH continues to expect registration and results reporting for these BESH but with the continued flexibility to register and report results on alternative publicly available platforms, although use of ClinicalTrials.gov is encouraged. 

For more information, please see the full guide notice and visit the BESH resources webpage, and the Special Considerations for BESH webpage.