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2025
Certificate of Confidentiality (CoC) System Is Accepting Requests
NIH has received OMB approval under the Paperwork Reduction Act (PRA) to collect information through the NIH Certificate of Confidentiality (CoC) system. NIH is now accepting requests in the CoC System for Research Not Funded by NIH and Institutional Official verifications.
Updates to NIH Inclusion Policy
When you prepare inclusion plans for your next applications or data for progress reports, review the updated NIH Policy and Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research, effective August 16, 2025 for both new and ongoing clinical research projects.
Flexibilities for Registration and Results Reporting of Prospective Basic Experimental Studies with Human Participants
NIH is indefinitely extending the period of delayed enforcement for registration and results reporting for basic experimental studies involving humans (BESH) responsive to designated BESH NOFOs, including those with application due dates on or after September 25, 2025.
Short-Term Supplement Model for Human Subjects Research Supported by Foreign Subawards
To address concerns for participant safety risks for ongoing projects, NIH has established a short-term supplement model to support clinical research and clinical trials conducted under an active foreign subaward.
How Does the NIH Initiative to Prioritize Human-Based Research Affect Research Proposing the Use of Laboratory Animals?
In July 2025, NIH announced it will no longer develop new funding opportunities focused exclusively on animal models of human disease. Rather, going forward, new funding opportunities will be designed more broadly with language that also encourages various approaches be considered.
Reminder About Inclusion of Participants in Clinical Research
NIH continues to follow all laws (e.g., 42 USC 289a-2) and existing NIH policies that help NIH ensure clinical research includes the appropriate participant demographics to make certain the scientific question under study is addressed in a robust and generalizable manner.