Required Application Instructions

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions will not be reviewed.

Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information

The NIH Research Education Program (R25) supports research educational activities that complement other formal training programs in the mission areas of the NIH Institutes and Centers. The over-arching goals of the NIH R25 program are to: (1) complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs; (2) enhance the diversity of the biomedical, behavioral and clinical research workforce; (3) help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences; and (4) foster a better understanding of biomedical, behavioral and clinical research and its implications.

The over-arching goal of this National Institute of General Medical Sciences (NIGMS) Bridges to Baccalaureate R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on:

1. Courses for Skills Development: For example, advanced courses in a specific discipline or research area, or specialized research techniques.

2. Research Experiences: For example, for undergraduate students: to provide hands-on exposure to research, to reinforce their intent to graduate with a science degree, and/or to prepare them for graduate school admissions and/or careers in research; for college science teachers: to enhance their science teaching.

3. Curriculum or Methods Development: For example, to improve biomedical science education, or develop novel instructional approaches or computer-based educational tools; to provide supplemental instruction for gateway courses; to develop "CURE" courses in community college first and second year classrooms.

Background

Every facet of the United States scientific research enterprise from basic laboratory research to clinical and translational research to policy formation requires superior intellect, creativity and a wide range of skill sets and viewpoints. NIH's ability to help ensure that the nation remains a global leader in scientific discovery and innovation is dependent upon a pool of highly talented scientists from diverse backgrounds who will help to further NIH's mission.

Research shows that diverse teams working together and capitalizing on innovative ideas and distinct perspectives outperform homogenous teams. Scientists and trainees from diverse backgrounds and life experiences bring different perspectives, creativity, and individual enterprise to address complex scientific problems. There are many benefits that flow from a diverse NIH-supported scientific workforce, including: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of the researchers, advancing the likelihood that underserved or health disparity populations participate in, and benefit from health research, and enhancing public trust.

In spite of tremendous advancements in scientific research, information, educational and research opportunities are not equally available to all. This program encourages institutions to diversify their student and faculty populations and thus to enhance the participation of individuals currently underrepresented in the biomedical, clinical, behavioral and social sciences research enterprise, as described in NOT-OD-15-053.

NIGMS Interest In Diversity

The mission of the National Institute of General Medical Sciences (NIGMS) is to support research that increases our understanding of life processes and lays the foundation for advances in disease, diagnosis, treatment, and prevention. To ensure the vitality and continued productivity of the research enterprise,

NIGMS seeks to enhance the number of individuals from groups underrepresented in the biomedical workforce by providing training opportunities during multiple training and career stages at varied institutions and educational settings across the country. By enhancing the number of students from underrepresented groups pursuing advanced training in the biomedical sciences, NIGMS strives to ensure that the future generation of researchers draws from the entire pool of talented individuals, bringing different aptitudes, perspectives, creativity, and experiences to address complex scientific problems. Training and retaining a diverse workforce ensures that the nation remains a competitive global leader in discovery and innovation in biomedical research.

Need for the Program

Underrepresentation of certain groups in science, technology and engineering fields increases throughout the training stages. For example, students from underrepresented racial and ethnic groups including, Blacks or African Americans, Hispanics or Latinos, American Indians or Alaska Natives, Native Hawaiians and other Pacific Islanders, currently comprise ~39% of the college age population (Census Bureau), but earn only ~17% of bachelor's degrees and ~7% of the Ph.D.'s in the biological sciences (NSF, 2015). Active interventions are required to prevent the loss of talent at each level of educational advancement. For example, a report from the President's Council of Advisors on Science and Technology recommended support of programs to retain underrepresented undergraduate science, technology, engineering and math students as a means to effectively build a diverse and competitive scientific workforce (PCAST Report, 2012).

Programmatic Approach

The Bridges to the Baccalaureate Program provides an opportunity to develop new, or expand existing, effective institutional programs aimed at a key juncture within higher education, namely the transition from a two-year community college program to baccalaureate degree completion in biomedical sciences. NIGMS anticipates that carefully planned interventions at this key point of the educational pathway will increase the supply of biomedical science graduates, a necessary step in enhancing the diversity of the NIH-funded biomedical workforce. The proposed Bridges to the Baccalaureate Program must select and employ well-integrated strategies, rooted in education research, that provide students what they need to progress to the next stage of the science education pathway. Applications must include facets of all three activities in their research plan.

Bridges applications are intended to reflect the plans and priorities of the participating institutions as well as the collective plans and priorities of the partnerships/consortia. Participating institutions should create a partnership program, or enhance an existing program, that will focus attention and adequate resources on the institution(s) granting associate degrees and so enhance competitiveness of their science graduates and science programs. Collaborative agreements should be designed to fit the needs and situations of the institutions involved.

The Bridges to Baccalaureate Program recognizes the heterogeneity of institutional settings and institutional missions. Therefore, each application must conduct a self-assessment of each participating institution that includes baseline data on enrollment, transfer, research training, and subsequent graduation of its UR students in biomedical sciences. Specific aims must be based on this self-assessment and must be consonant with the purpose of the Bridges to Baccalaureate program. The four-year partner institution should demonstrate that it has the resources needed to support Bridges students upon and after transfer, to facilitate the student's successful baccalaureate degree completion.

This FOA requires a multiple PD/PI application (See Sections III.1 and IV.2).

Outcomes: The goal of the Bridges to the Baccalaureate Program is to develop a diverse group of highly trained biomedical scientists to address the Nation's biomedical workforce needs. The short-term and intermediate-term goals of the program are to increase the number of students who transfer to a 4yr institution to study in biomedical sciences, and complete a baccalaureate degree, respectively. At the institutional level, the program expects that at least 70% of Bridges-supported students, upon or before graduation from the associate degree program, transfer to baccalaureate degree programs in the biomedical sciences, and at least 50% of transferring Bridges students successfully complete their baccalaureate degree in the biomedical sciences. NIGMS anticipates that Bridges grantees will improve upon these outcomes.

Research education programs may complement ongoing research training and education occurring at the applicant institution, but the proposed educational experiences must be distinct from those training and education programs currently receiving Federal support. R25 programs may augment institutional research training programs (e.g., T32, T90) but cannot be used to replace or circumvent Ruth L. Kirschstein National Research Service Award (NRSA) programs.

See Section VIII. Other Information for award authorities and regulations.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Higher Education Institutions

• Public/State Controlled Institutions of Higher Education
• Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

• Hispanic-Serving Institutions
• Historically Black Colleges and Universities (HBCUs)
• Tribally Controlled Colleges and Universities (TCCUs)
• Alaska Native and Native Hawaiian Serving Institutions
• Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

The sponsoring institution must assure support for the proposed program. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program.

Institutions with existing Ruth L. Kirschstein National Research Service Award (NRSA) institutional training grants (e.g., T32) or other Federally funded training programs may apply for a research education grant provided that the proposed educational experiences are distinct from those training programs receiving federal support. In many cases, it is anticipated that the proposed research education program will complement ongoing research training occurring at the applicant institution.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Applicant Organizations

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

• Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.
• System for Award Management (SAM) (formerly CCR) Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
• NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
• eRA Commons - Applicants must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or Grants.gov registration. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
• Grants.gov Applicants must have an active DUNS number and SAM registration in order to complete the Grants.gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Applicants must designate a PD/PI from each participating institution (lead/grantee and partner institutions). The PD/PI of the Lead Institution must be designated as the Contact PD/PI. The PDs/PIs must have a regular full-time appointment (i.e., not adjunct, part-time, retired, or emeritus) at the applicant institutions, and should have student counseling, academic administrative and/or scientific research experience. The PDs/PIs will be expected to monitor and assess the program and submit all documents and reports as required.

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

A Lead Institution may also partner on one or more other applications submitted by other Lead Institutions. See Section III.1 (Eligible Individuals) for further instructions.

The NIH will not accept duplicate or highly overlapping applications under review at the same time. This means that the NIH will not accept:

• A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
• A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
• An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101).

The 2-year institutions in the Bridges to the Baccalaureate Program must offer programs in scientific fields that either lead to an associate degree or faciltiate transfer to a baccalaureate degree program in biomedical sciences. Institutions offering both associate and baccalaureate degrees may not form partnerships within their own institution for graduates of or transfers from their own associate degree programs to enter their own baccalaureate programs, even if a student is moving to another department, school, or college. The program seeks to promote and enhance partnerships BETWEEN institutions.

Each proposed Bridges to the Baccalareate Program must consist of a partnership composed of at least two institutions, including the lead applicant institution. One must be an institution that offers the associate degree as the primary degree in the relevant (e.g., biomedical) sciences. Another institution must be a college or university granting the baccalaureate degree in biomedical sciences. Two different scenarios are anticipated for these partnerships: a) one baccalaureate degree-granting institution as the lead applicant institution partnering with one or more associate degree-granting institutions, or b) one associate degree-granting institution as the lead applicant institution partnering with one or more baccalaureate degree-granting institutions. An eligible applicant or partner institution may participate in more than one Bridges to the Baccalaureate partnership if such multiple partnerships are strongly justified by the potential to magnify the programs' and institutions' outcomes. However, an institution may be the lead in only one Bridges to Baccalaureate grant at one time.

Researchers from diverse backgrounds, including racial and ethnic minorities, persons with disabilities, and women are encouraged to participate as preceptors/mentors. Mentors should have research expertise and experience relevant to the proposed program. Mentors must be committed to continue their involvement throughout the total period of the mentee's participation in this award.

As described in Part 2, Section I, eligible participants are individuals from groups identified as underrepresented in the biomedical, clinical, behavioral and social sciences, such as:

A. Individuals from racial and ethnic groups that have been shown by the National Science Foundation to be underrepresented in health-related sciences on a national basis (see data at http://www.nsf.gov/statistics/showpub.cfm?TopID=2&SubID=27) and the report Women, Minorities, and Persons with Disabilities in Science and Engineering). The following racial and ethnic groups have been shown to be underrepresented in biomedical research: Blacks or African Americans, Hispanics or Latinos, American Indians or Alaska Natives, Native Hawaiians and other Pacific Islanders.

B. Individuals with disabilities, who are defined as those with a physical or mental impairment that substantially limits one or more major life activities, as described in the Americans with Disabilities Act of 1990, as amended. See NSF data at http://www.nsf.gov/statistics/wmpd/2013/pdf/tab7-5_updated_2014_10.pdf.

C. Individuals from disadvantaged backgrounds, defined as:

1. Individuals who come from a family with an annual income below established low-income thresholds. These thresholds are based on family size, published by the U.S. Bureau of the Census; adjusted annually for changes in the Consumer Price Index; and adjusted by the Secretary for use in all health professions programs. The Secretary periodically publishes these income levels at http://aspe.hhs.gov/poverty/index.shtml.

2. Individuals who come from an educational environment such as that found in certain rural or inner-city environments that has demonstrably and directly inhibited the individual from obtaining the knowledge, skills, and abilities necessary to develop and participate in a research career.

Applicants must obtain the SF424 (R&R) application package associated with this funding opportunity using the "Apply for Grant Electronically" button in this FOA or following the directions provided at Grants.gov.

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, including Supplemental Grant Application Instructions except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions will not be reviewed.

For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications.

All page limitations described in the SF424 (R&R) Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission

The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.

Follow all instructions provided in the SF424 (R&R) Application Guide.

Follow all instructions provided in the SF424 (R&R) Application Guide.

Follow all instructions provided in the SF424 (R&R) Application Guide with the following additional modifications:

Facilities & Other Resources. Describe the educational environment, including the facilities, laboratories, participating departments, computer services, and any other resources to be used in the development and implementation of the proposed program. List all thematically related sources of support for research training and education following the format for Current and Pending Support.

Other Attachments. An Advisory Committee is not a required component of a Research Education program. However, if an Advisory Committee is intended, provide a plan for the appointment of an Advisory Committee to monitor progress of the research education program. The composition, roles, responsibilities, and desired expertise of committee members, frequency of committee meetings, and other relevant information should be included. Describe how the Advisory Committee will evaluate the overall effectiveness of the program. Proposed Advisory Committee members should be named in the application if they have been invited to participate at the time the application is submitted. Renewal applications with Advisory Committees should include the names of all committee members during the past project period. Please name your file "Advisory_Committee.pdf"

The filename provided for each "Other Attachment" will be the name used for the bookmark in the electronic application in eRA Commons.

Follow all instructions provided in the SF424 (R&R) Application Guide. Include Preceptor/Faculty and Program Coordinator Biosketches here. If a program coordinator(s) is identified, include their biographical sketches.

Follow all instructions provided in the SF424 (R&R) Application Guide with the following additional modifications:

• Include all personnel other than the PD(s)/PI(s) in the Other Personnel section, including clerical and administrative staff.
• Bridges Student Participants: State the number of Bridges students from each partner institution and the total number of Bridges students to be supported by the proposed research education program during the academic year and summer.
• Travel: Include travel for Bridges students in this section.
• Participant/Trainee Support Costs: Participant/Trainee Support Costs are not applicable to the Bridges to the Baccalaureate program. The Bridges student salaries and fringe benefits are included under section B (Other Personnel).
• If a program coordinator(s) is included, their duties and responsibilities must be well described in the budget.

The Bridges to the Baccalaureate Program involves two or more institutions. One of the participating institutions must be designated as the lead applicant institution and funding for the other institution(s) in the partnership must be requested via a subcontract to be administered by the applicant institution. When submitting a detailed budget, the applicant institution should submit its budget using the Research & Related Budget form. All other institutions should have their individual budgets attached separately to the Research & Related Subaward Budget Attachment(s) Form. See the SF424 (R&R) Application Guide for further instruction regarding the use of the subaward budget.

Follow all instructions provided in the SF424 (R&R) Application Guide.

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

Research Strategy

The Research Strategy section must be used to upload the Research Education Program Plan, which must include the following components described below:

• Proposed Research Education Program
• Program Director/Principal Investigator
• Program Faculty
• Program Participants
• Institutional Environment and Commitment
• Diversity Recruitment Plan
• Plan for Instruction in the Responsible Conduct of Research
• Evaluation Plan

Research Education Program Plan

Proposed Research Education Program. While the proposed research education program may complement ongoing research training and education occurring at the applicant institution, the proposed educational experiences must be distinct from those research training and research education programs currently receiving federal support. When research training programs are on-going in the same department, the applicant organization should clearly distinguish between the activities in the proposed research education program and the research training supported by the training program. Each application must provide baseline data on enrollment, transfer and subsequent graduation of its UR students in biomedical and behavioral sciences. The program outcome measures and impact on the participating institutions should be presented relative to baseline data.

Provide a brief description of the following to address the anticipated value-added of the Bridges program to participating institutions:

• Results of institutional self-assessment(s) that led to identification of areas selected for improvement at the participating community college(s) and the rationale for incorporating particular courses for skills development, research experiences, and curriculum development activities into the proposed Bridges program into the proposed Bridges program;
• The proposed developmental activities that will enable UR students to make a seamless transition from the participating community college(s) to the bachelor's degree-granting institution(s) and successfully complete the baccalaureate degree program in biomedical/behavioral sciences;
• How the proposed Bridges program will be integrated into any of the existing academic/student development programs, and how this program will collaborate with or complement other externally and institutionally funded student training and educational programs;
• The anticipated overall impact of the proposed Bridges program to the partnership's capacity to prepare and graduate UR students for biomedical and behavioral research careers.

Other Programmatic Elements:

Provide programmatic detail on the proposed developmental activities that address the needs and requirements (as identified by the institutional self-assessments) of students who are enrolled full-time at the participating community college(s) and must be designed to improve their competitiveness for transfer and completion of the baccalaureate degree in biomedical/behavioral sciences. Provide a brief rationale for, and a detailed description of, each activity proposed and the role of faculty/personnel involved. Describe how each activity will contribute toward realization of the specific aims. Discuss any perceived impediments to implementing the proposed activities and alternative strategies to achieve the specific aims.

Student development activities may include essential research education such as research design workshops, and research classroom activities that form mandatory components of the program.

In describing the proposed mentored research experiences during the academic year/summer, applicants must demonstrate that participants will have meaningful research experiences in the laboratories or research groups of investigators who are actively engaged in biomedical/behavioral research and who have peer-reviewed publications. Proposed summer research experiences must be at least two consecutive months in duration.

The application should describe a system for monitoring Bridges student progress throughout the post-secondary experience, including their retention, transfer, and successful completion of the baccalaureate degree.

Program Director/Principal Investigator. Describe the selection process for Faculty. Describe arrangements for administration of the program. Provide evidence that the PDs/PIs are actively engaged in research and/or teaching in an area related to the mission of NIH, and can organize, administer, monitor, and evaluate the research education program. Describe the complementary and integrated expertise of the PDs/PIs; their leadership approach, and governance appropriate for the planned project.

Program Faculty. Researchers from diverse backgrounds, including racial and ethnic minorities, persons with disabilities, and women are encouraged to participate as program faculty. Faculty should have research expertise and experience relevant to the proposed program and demonstrate a history of, or the potential for, their intended roles.

Provide evidence that faculty and staff have the necessary skills, knowledge and experience to conduct the proposed student development and research activities. Clearly delineate the roles and expectations of participating faculty and/or program coordinators from each institution.

Provide a list of faculty research mentors/preceptors and describe each faculty member's research area and current research funding, using Training Table 2, Participating Faculty Members.

Program Participants. Applications must describe the intended participants, and the eligibility criteria and/or specific educational background characteristics that are essential for participation in the proposed research education program. Identify the career levels for which the proposed program is planned. Bridges student participants are those students who will receive support in the form of salaries/wages under this program. Student participants must be U.S. citizens or non-citizen nationals or permanent residents, and be an individual from a background nationally underrepresented in the biomedical and behavioral sciences. Describe the criteria and procedures for identification, selection and retention of students into the Bridges program.

Applications must describe the intended participants, and the eligibility and/or specific educational background characteristics that are essential for participation in the proposed research education program. Identify the career levels essential for participation in the planned program.

Bridges student participants are those students who will receive support in the form of salaries/wages under this program. Student participants must be U.S. citizens or non-citizen nationals or permanent residents, and be an individual from a background nationally underrepresented in the biomedical and behavioral sciences.

Provide the institutional baseline data (average number over the previous five year period) on the enrollment, transfer and graduation of students in biomedical and behavioral sciences-related disciplines.

Institutional Environment and Commitment. Describe the institutional environment, reiterating the availability of facilities and educational resources (described separately under "Facilities & Other Resources"), that can contribute to the planned Research Education Program. Evidence of institutional commitment to the research educational program is required. A letter of institutional commitment must be attached as part of Letters of Support (see below). Appropriate institutional commitment should include the provision of adequate staff, facilities, and educational resources that can contribute to the planned research education program.

Provide a brief description of the following to address the Institutional Environment:

• Applicant and the partner institution(s) in the consortium, including the geographic location of partner institution(s) in the context of the lead applicant institution, and the rationale for selecting these institutions for the partnership;
• Biomedical and behavioral sciences-related disciplines in which associate degree programs are offered at the two-year institution(s), the relevant curricula;
• Current status of articulation agreement for the transfer of courses and credits from these institution(s) to the baccalaureate institution(s);
• Biomedical and behavioral sciences-related disciplines in which bachelor's degree programs are offered at the baccalaureate institution(s), and the relevant curricula and general degree requirements;
• Currently active undergraduate student development and research-training programs at all institutions in the consortium/partnership (include NIH, other federal, or non-federal funding);); and
• Student advising and career counseling services/programs available at the applicant and partner institutions, and their successes in preparing and graduating UR students.

Provide a brief description of the following to address the Institutional Commitment:

• The commitment by the senior leadership of each institution in the partnership to the broader principles of diversity and to the training, education, and success of UR students in biomedical and behavioral sciences;

The Bridges-supported activities (courses for skills development, research experiences, and curriculum or methods development) are expected to be institutionalized, or plans should be in place to institutionalize these activities after the second year of the grant.; for progress reports, describe evidence of program elements adopted by the institution(s) more broadly;

• Evidence of support for the proposed institutionalization plan from the department chair(s), dean(s) of the college(s), and/or other relevant members of the institutions' central administration; and
• Documentation of the financial and other support available to the Bridges students after they transfer to the partner four-year institution(s).

Progress Report (for Renewal Application). For renewal applications, a detailed Progress Report must be included. Applications with more than one previous funding cycle must provide information on each of the past three consecutive funding cycles. In the report, state the original goals and specific aims, anticipated milestones and outcomes, as well as a summary of the specific accomplishments of the Bridges to the Baccalaureate Program in the context of the previous application's baseline.

Describe the impact of the Bridges program on the institution as a result of the program-supported activities in areas such as courses/curricular enhancements, faculty and student development, developing alliances and articulation agreements, increases in student retention rate, improvement of student academic achievement, and increases in numbers of students transferring to and successfully completing baccalaureate and subsequently more advanced degrees in biomedical and behavioral sciences.

Applicants are encouraged to use NIGMS CareerTrac to provide data on student outcomes for up to 15 years, if applicable. The expected student outcomes include the following:

• Number of total Bridges participant slots awarded in the previous funding cycle
• Number of Bridges participant slots requested in renewal application
• Number of Bridges participants currently supported
• Number of Bridges participants who withdrew while at 2yr institution
• Number of Bridges participants who completed the Bridges program (alumni)
• Number of Bridges alumni who transferred to a 4yr institution
• Number of Bridges alumni who remain at 4yr institution
• Number of Bridges alumni who withdrew from 4yr institution
• Number of Bridges alumni who completed baccalaureate degree program
• Number of Bridges alumni who entered post baccalaureate program
• Number of Bridges alumni who enrolled in MS program
• Number of Bridges alumni who completed MS program
• Number of Bridges alumni who enrolled in PhD program
• Number of Bridges alumni who completed a PhD program
• Number of Bridges alumni who enrolled in MD program
• Number of Bridges alumni who completed MD program
• Number of Bridges alumni who are employed in research-related positions
• Number of Bridges alumni who are employed in non-research-related positions

Describe in the Progress Report what has been learned through the program evaluation and what has been added, modified or deleted as a result of program evaluation. Evaluation reports, if available, can be included in the Appendix. Describe any previously funded Bridges activities that are now continuing (or will continue) on institutional funds.

Recruitment Plan to Enhance Diversity: NIH encourages institutions to diversify their student and faculty populations to enhance the participation of individuals from groups identified as underrepresented in the biomedical, clinical, behavioral and social sciences, such as:

A. Individuals from racial and ethnic groups that have been shown by the National Science Foundation to be underrepresented in health-related sciences on a national basis (see data at http://www.nsf.gov/statistics/showpub.cfm?TopID=2&SubID=27) and the report Women, Minorities, and Persons with Disabilities in Science and Engineering). The following racial and ethnic groups have been shown to be underrepresented in biomedical research: Blacks or African Americans, Hispanics or Latinos, American Indians or Alaska Natives, and Native Hawaiians and other Pacific Islanders.

B. Individuals with disabilities, who are defined as those with a physical or mental impairment that substantially limits one or more major life activities, as described in the Americans with Disabilities Act of 1990, as amended. See NSF data at, http://www.nsf.gov/statistics/wmpd/2013/pdf/tab7-5_updated_2014_10.pdf.

C. Individuals from disadvantaged backgrounds, defined as:

1. Individuals who come from a family with an annual income below established low-income thresholds. These thresholds are based on family size, published by the U.S. Bureau of the Census; adjusted annually for changes in the Consumer Price Index; and adjusted by the Secretary for use in all health professions programs. The Secretary periodically publishes these income levels at http://aspe.hhs.gov/poverty/index.shtml.

2. Individuals who come from an educational environment such as that found in certain rural or inner-city environments that has demonstrably and directly inhibited the individual from obtaining the knowledge, skills, and abilities necessary to develop and participate in a research career.

The disadvantaged background category (C1 and C2) is applicable to programs focused on high school and undergraduate candidates.

Literature shows that women from the above backgrounds (categories A, B, and C) face particular challenges at the graduate level and beyond in scientific fields. (See, e.g., Inside the Double

Bind, A Synthesis of Empirical Research on Undergraduate and Graduate Women of Color in Science, Technology, Engineering, and mathematics http://her.hepg.org/content/t022245n7x4752v2/fulltext.pdf).

New applications must include a description of plans to enhance recruitment, including the strategies that will be used to enhance the recruitment of trainees from underrepresented backgrounds and may wish to include data in support of past accomplishments.

Renewal applications must include a detailed account of experiences in recruiting individuals from underrepresented groups during the previous funding period. Information must be included on successful and unsuccessful recruitment strategies including aggregate information on the distribution of:

• Individuals who applied for admission to the research education program,
• Individuals who were offered admission to the research education program,
• Individuals who participated in the research education program.

For those individuals who participated in the research education program, the report should include information about the duration of education and aggregate information on the number of individuals who finished the program in good standing. Additional information on the required Recruitment and Retention Plan to Enhance Diversity is available at Frequently Asked Questions: Recruitment and Retention Plan to Enhance Diversity (Diversity FAQs).

Applications lacking a diversity recruitment and retention plan will not be reviewed.

Plan for Instruction in the Responsible Conduct of Research. All applications must include a plan to fulfill NIH requirements for instruction in the Responsible Conduct of Research (RCR). The plan must address the five, required instructional components outlined in the NIH policy: 1) Format - the required format of instruction, i.e., face-to-face lectures, coursework, and/or real-time discussion groups (a plan with only on-line instruction is not acceptable); 2) Subject Matter - the breadth of subject matter, e.g., conflict of interest, authorship, data management, human subjects and animal use, laboratory safety, research misconduct, research ethics; 3) Faculty Participation - the role of the program faculty in the instruction; 4) Duration of Instruction - the number of contact hours of instruction, taking into consideration the duration of the program; and 5) Frequency of Instruction instruction must occur during each career stage and at least once every four years. See also NOT-OD-10-019. The plan should be appropriate and reasonable for the nature and duration of the proposed program. Renewal (Type 2) applications must, in addition, describe any changes in formal instruction over the past project period and plans to address any weaknesses in the current instruction plan. All participating faculty who served as course directors, speakers, lecturers, and/or discussion leaders during the past project period must be named in the application.

Applications lacking a plan for instruction in responsible conduct of research will not be reviewed.

Evaluation Plan. Applications must include a plan for evaluating the activities supported by the award. The application must specify baseline metrics (e.g., numbers, educational levels, and demographic characteristics of participants), as well as measures to gauge the short or long-term success of the research education award in achieving its objectives. Wherever appropriate, applicants are encouraged to obtain feedback from participants to help identify weaknesses and to provide suggestions for improvements.

The application should describe a system for monitoring Bridges student progress throughout the post-secondary experience, including their retention, transfer, and successful completion of the baccalaureate degree. This plan should include metrics as described in Section VI.4 Evaluation which can be facilitated by use of the of NIH CareerTrac database (see Section VI.3 Reporting). Specified evaluation metrics should be tied to the goals of the Bridges program. The CareerTrac system supports tracking of trainee accomplishments - such as fellowships, awards, employment, other education, product or policy developments, publications, funding received, posters at scientific conferences, and students mentored. CareerTrac is intended to be a tool to enable NIH staff to evaluate the effectiveness and impact of its health research training programs and also to help NIH in overall coordination of its various research training programs. .

Multiple PD/PI Leadership Plan

The Bridges program requires a PD/PI from each participating institution, and a multi-PD/PI plan is required. The PDs/PIs assume responsibility for the overall execution of the Bridges to the Baccalaureate program.

Bridges PD/PIs should address how they will share and discharge those duties and responsibilities specific to a Bridges program including:

• Selection of students;
• The coordination and implementation of developmental research education
• Processes to coordinate efforts to prepare and submit required reports, e.g., annual progress Reports, changes in program activities if any, etc.
• Interactions with the program evaluator to monitor and evaluate the progress of individual program elements and the overall functioning of the Bridges to the Baccalaureate Program.

Letters of Support

Applications must include a Consortium Agreement letter of intent or commitment (attach it at line item for Letters of Support) acknowledging each institution's participation in the proposed Bridges to the Baccalaureate Program. The letter must outline each institution's respective role in administering the program, and these roles must be consistent with the goals and objectives of the proposed Bridges program. This letter is to be signed by a representative of each participating institution's central administration, and all program directors (PD/PIs). The institutional business official's signature on the letter indicates that all parties agree with the following statement:

"The appropriate programmatic and administrative personnel of each organization involved in this grant application are aware of the NIH consortium agreement policy and are prepared to establish the necessary inter-institutional agreement(s) consistent with that policy." Information on the NIH Policy regarding consortium agreements is available at: https://grants.nih.gov/grants/policy/nihgps_2012/nihgps_ch15.htm."

Resource Sharing Plans

Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following Guide.

Appendix

Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide .

Form only available in FORMS-D application packages for use with due dates on or before January 24, 2018.

When conducting clinical research, follow all instructions for completing PHS Inclusion Enrollment Report as described in the SF424 (R&R) Application Guide.

Form only available in FORMS-E application packages for use with due dates on or after January 25, 2018.

When involving NIH-defined human subjects research, clinical research, and/or clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information
All instructions in the SF424 (R&R) Application Guide must be followed.

Delayed Onset Study: All instructions in the SF424 (R&R) Application Guide must be followed.

See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov

Part I. Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Add Applications that miss the due date and time are subjected to the NIH Policy on Late Application Submission.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

This initiative is not subject to intergovernmental review.

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement.

The following summarizes the non-allowable costs under the Bridges to the Baccalaureate Program:

• Any salary support or other costs for student participants who are not from underrepresented groups, students who did not begin post-secondary education at the associate degree-granting institution(s).
• Student participant support in the form of a "stipend" (note: "stipend" differs technically from "salary/wages," which is allowable).
• Housing, food, or recruitment expenses.
• Costs for textbooks for academic courses that are required for graduation, incentives (including calculators, laptop computers, etc.), memberships, or subscriptions to internet services or journals.
• Faculty salary to supplement the actual academic-year salary, or increase the base by which the academic-year salary is calculated/established.
• Faculty research mentors' time or effort compensation.

Foreign Travel by PD(s)/PI(s), faculty, coordinators, research mentors, or Bridges students.

Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Guidelines for Applicants Experiencing System Issues. For assistance with application submission, contact the Application Submission Contacts in Section VII.

Important reminders:
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization's profile in the eRA Commons and for the System for Award Management (SAM). Additional information may be found in the SF424 (R&R) Application Guide.

See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review, NIH. Applications that are incomplete or non-compliant will not be reviewed.

Applicants are required to follow our Post Submission Application Materials policy.

Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical, behavioral, and clinical research are evaluated for scientific and technical merit through the NIH peer review system.

For this particular announcement, note the following: The goal of this R25 program is to support educational activities that prepare students for successful transfer from a 2yr- to a 4yr-institution followed by subsequent baccalaureate degree completion in the biomedical sciences. Access to and provision for opportunities for students to engage in meaningful research experiences and to improve upon or acquire skills necessary for successful succession to the next academic or career step is a critical component of the Bridges program.

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to strongly advance research education by fulfilling the goal of this R25 Education Program, in consideration of the following review criteria and additional review criteria, as applicable for the project proposed.

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact.

Significance

Does the proposed program address a key audience and an important aspect or important need in research education? Is there convincing evidence in the application that the proposed program will significantly advance the stated goal of the program? Does the Bridges application provide a value-added that the other programs do not provide? Does the Bridges application fill a gap not addressed by the other student development programs? Is the application a logical reflection of the institutional self-assessment? Does the research plan show potential to enhance the diversity of the biomedical workforce?

Investigator(s)

Are the PDs/PIs capable of providing both administrative and scientific leadership to the development and implementation of the proposed program? Is there evidence that an appropriate level of effort will be devoted by the program leadership to ensure the program's intended goal is accomplished? If applicable, is there evidence that the participating faculty have experience in mentoring students and teaching science? If applicable, are the faculty good role models for the participants by nature of their scientific accomplishments? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?

Innovation

Taking into consideration the nature of the proposed research education program, does the applicant make a strong case for this program effectively reaching an audience in need of the program's offerings? Where appropriate, is the proposed program developing or utilizing innovative approaches and latest best practices to improve the knowledge and/or skills of the intended audience? Does this proposed program duplicate, or overlap with, existing research education, training and/or career development activities currently supported at the applicant institution or available elsewhere? Adaptations of existing research education programs may be considered innovative under special circumstances, e.g., the addition of unique components and/or a proposal to determine portability of an existing program. If the participating institutions have other student development programs, do they align and synergize with the Bridges application?

Approach

Does the proposed program clearly state its goals and objectives, including the educational level of the audience to be reached, the content to be conveyed, and the intended outcome? Is there evidence that the program is based on a sound rationale, as well as sound educational concepts and principles? Is the plan for evaluation sound and likely to provide information on the effectiveness of the program? If the proposed program will recruit participants, are the planned recruitment, retention, and follow-up (if applicable) activities adequate to ensure a highly qualified participant pool? Alternatively, if the application provides opportunities for students who need additional academic support, are the proposed activities aligned to provide the support needed? Is there a sound rationale for the developmental activities proposed?

Environment

Will the scientific and educational environment of the proposed program contribute to its intended goals? Is there a plan to take advantage of this environment to enhance the educational value of the program? Is there tangible evidence of institutional commitment? Is there evidence that the faculty have sufficient institutional support to create a sound educational environment for the participants? Where appropriate, is there evidence of collaboration and buy-in among participating programs, departments, and institutions? Are adequate plans provided for coordination and communication among multiple sites? Do the partner institutions collectively provide a means to facilitate classroom undergraduate reasearch experiences or individual lab/research group expreriences either on site or at relevant off-site facilities?

As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.

Protections for Human Subjects

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Inclusion of Women, Minorities, and Children

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer

Vertebrate Animals

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer

Biohazards

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Resubmissions

For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.

Renewals

For Renewals, the committee will consider the progress made in the last funding period, and the success of the program in attracting and retaining individuals from diverse populations, including populations underrepresented in biomedical, behavioral and clinical research on a national basis.

Revisions

Not Applicable

As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

Recruitment Plan to Enhance Diversity

Peer reviewers will separately evaluate the recruitment plan to enhance diversity after the overall score has been determined. Reviewers will examine the strategies to be used in the recruitment of individuals from underrepresented groups. The review panel's evaluation will be included in the summary statement. Plans will be rated as acceptable or unacceptable, and the summary statement will provide the consensus of the review committee.

Training in the Responsible Conduct of Research

Taking into account the specific characteristics of the proposed research education program, the level of participant experience, the reviewers will evaluate the adequacy of the proposed RCR training in relation to the following five required components: 1) Format - the required format of instruction, i.e., face-to-face lectures, coursework, and/or real-time discussion groups (a plan with only on-line instruction is not acceptable); 2) Subject Matter - the breadth of subject matter, e.g., conflict of interest, authorship, data management, human subjects and animal use, laboratory safety, research misconduct, research ethics; 3) Faculty Participation - the role of the program faculty in the instruction; 4) Duration of Instruction - the number of contact hours of instruction, taking into consideration the duration of the program; and 5) Frequency of Instruction instruction must occur during each career stage and at least once every four years. See also: NOT-OD-10-019. The review panel's evaluation will be included in the summary statement. Plans will be rated as acceptable or unacceptable, and the summary statement will provide the consensus of the review committee.

Applications from Foreign Organizations

Not Applicable

Select Agent Research

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Resource Sharing Plans

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer

Budget and Period of Support

Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by NIGMS, in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.

As part of the scientific peer review, all applications:

• May undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
• Will receive a written critique.

Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications submitted in response to this FOA. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:

• Scientific and technical merit of the proposed project as determined by scientific peer review.
• Availability of funds.
• Relevance of the proposed project to program priorities.

After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons. Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.

Information regarding the disposition of applications is available in the NIH Grants Policy Statement.

If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement.

A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee's business official.

Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.

Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.

Recipients of federal financial assistance (FFA) from HHS must administer their programs in compliance with federal civil rights law. This means that recipients of HHS funds must ensure equal access to their programs without regard to a person's race, color, national origin, disability, age and, in some circumstances, sex and religion. This includes ensuring your programs are accessible to persons with limited English proficiency. HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator's scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research.

For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this FOA. HHS provides general guidance to recipients of FFA on meeting their legal obligation to take reasonable steps to provide meaningful access to their programs by persons with limited English proficiency. Please see http://www.hhs.gov/ocr/civilrights/resources/laws/revisedlep.html. The HHS Office for Civil Rights also provides guidance on complying with civil rights laws enforced by HHS. Please see http://www.hhs.gov/ocr/civilrights/understanding/section1557/index.html; and http://www.hhs.gov/ocr/civilrights/understanding/index.html. Recipients of FFA also have specific legal obligations for serving qualified individuals with disabilities. Please see http://www.hhs.gov/ocr/civilrights/understanding/disability/index.html. Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at http://www.hhs.gov/ocr/office/about/rgn-hqaddresses.html or call 1-800-368-1019 or TDD 1-800-537-7697. Also note it is an HHS Departmental goal to ensure access to quality, culturally competent care, including long-term services and supports, for vulnerable populations. For further guidance on providing culturally and linguistically appropriate services, recipients should review the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care at http://minorityhealth.hhs.gov/omh/browse.aspx?lvl=2&lvlid=53.

When multiple years are involved, awardees will be required to submit the Research Performance Progress Report (RPPR) annually. Continuation support will not be provided until the required forms are submitted and accepted. Programs that involve participants should report on education in the responsible conduct of research and complete a Training Diversity Report, in accordance with the RPPR Instruction Guide. Programs that involve participants should report on education in the responsible conduct of research. Grantees are encouraged to use NIGMS CareerTrac to report Bridges student outcomes in progress for RPPRs.

Describe what has been learned through the program evaluation and any changes made in the program as a result of the evaluation.

The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.

Failure by the grantee institution to submit required forms in a timely, complete, and accurate manner may result in an expenditure disallowance or a delay in any continuation funding for the award.

• The institution must set up an eRA Commons account for each participating Bridges student who will receive a salary. PDs/PIs should work with their organizational officials to ensure that student accounts are created. Once a student has an eRA Commons ID, the PD/PI is required to report students with one month or more training in the progress report (RPPR).
• An appointment or reappointment may begin any time during the budget period, but not before the budget period start date of the grant year.DO NOT use xTrain to appoint Bridges student participants. See Guide Notice NOT-GM-14-117 for more information about appointing students and using the NIGMS CareerTrac System, which is used for tracking student outcomes.

A final progress report and the expenditure data portion of the Federal Financial Report are required for closeout of an award as described in the NIH Grants Policy Statement.

In carrying out its stewardship of human resource-related programs, the NIH or its Institutes and Centers will periodically evaluate their R25 research education programs, employing the measures identified below. In assessing the effectiveness of its research education investments, NIH may request information from databases, PD/PIs, and from participants themselves. Where necessary, PD/PIs and participants may be contacted after the completion of a research education experience for periodic updates on participants' subsequent educational or employment history and professional activities.

Upon the completion of a program evaluation, NIH and its ICs will determine whether to (a) continue a program as currently configured, (b) continue a program with modifications, or (c) discontinue a program.

In evaluating this research education program NIGMS expects to use the following evaluation measures:

• Aggregate number and demographic characteristics of participants
• Content of courses for skills development
• Effectiveness of the new curricula or methods assessed by skills/competencies gained compared to existing curricula or methods
• Innovations in course structure, student advising, group learning, and teaching methodsDissemination and/or adoption of the new curricula or methods
• Participants' feedback on the program
• New knowledge or skills acquired
• Subsequent educational/career progress, including:
• Enhanced student engagement in research as reflected by authorship on peer-reviewed papers and presentations at scientific conferences
• Number and percentages of undergraduate (UG), UR students who transfer from 2yr-4yr institution
• Enhanced student participation and competitiveness in applying for and receiving research fellowships, scholarships, or other awards.
• Number and percentages of UG, UR students who complete BS/BA degrees in biomedical sciences
• Completion of BS/BA degrees in biomedical sciences by gender, race/ethnicity, disability and disadvantaged background,
• Number and percentages of UG, UR alumni who enroll in an advanced degree or postbaccalaureate program
• Number and percentages of UG UR alumni who complete advanced degrees in biomedical sciences by gender, race/ethnicity, disability and disadvantaged background
• Number and percentages of UG, UR alumni who enter the biomedical workforce and at what stage in their academic career (after associate degree completion, BS completion, etc.)

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

eRA Service Desk (Questions regarding ASSIST, eRA Commons registration, submitting and tracking an application, documenting system problems that threaten submission by the due date, post submission issues)
Finding Help Online: https://grants.nih.gov/support/ (preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

Grants.gov Customer Support (Questions regarding Grants.gov registration and submission, downloading forms and application packages)
Contact Center Telephone: 800-518-4726
Email: [email protected]

GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources)
Email: [email protected] (preferred method of contact)
Telephone: 301-945-7573

Mercedes Rubio, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Telephone: 301-594-3900
Email: [email protected]

Brian Pike, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Telephone:301-594-3900
Email: [email protected]

Lori Burge
National Institute of General Medical Sciences (NIGMS)
Telephone: 301-451-3781
Email: [email protected]

Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Part 75.