Check Out the Latest How to Apply – Application Guide

NIH updated the How to Apply – Application Guide in December 2025 to reflect recent policy and procedure updates. 

Find details on all of the major changes and revisions since the last major release at Significant Changes. Here are a few highlights of updated or new instructions: 

  • Foreign justification attachments.
  • ORCID iD requirements.
  • Biographical Sketch Common Form.   
  • NIH Biographical Sketch Supplement.
  • Current and Pending (Other) Support (CPOS) Common Form. 

Learn more about the topics above in our Extramural Nexus article on foreign justification, eRA ORCID iD, and the Forms Directory

Use the Application Guide along with the guidance in your chosen funding opportunity to submit grant applications.  

Before you apply, we encourage you to Get Advice from NIH Program Contacts to discuss whether your plans are a good fit for the program and funding opportunity. Learn more about the NIH Grants Process, including guidance and advice when you Plan to Apply and Write an Application

Categories: New Resources

Related News

Submitting Applications with International Collaborations

In 2025, we announced an updated NIH Policy on Foreign Subawards (NOT-OD-25-104) and introduced the Collaborative International Research application and award structure using the PF5 activity code (NOT-OD-25-155) which was implemented earlier this year.  

Tips Before You Submit

How Do I Address Potential Foreign Risks in My Small Business Program Application?

The Small Business Innovation and Economic Security Act strengthens the government’s ability to prevent adversarial nations from exploiting federally funded technologies. Here we offer a practical guide to help small businesses avoid security risks from foreign countries of concern when applying.

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