National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
T34 Undergraduate NRSA Institutional Research Training Grants
See Section III. 3. Additional Information on Eligibility.
The goal of the Maximizing Access to Research Careers (MARC) program is to promote broad participation in the biomedical research workforce by strengthening research training environments and expanding the pool of well-trained students who:
Specifically, this funding announcement provides support to eligible, domestic organizations to develop and implement effective, evidence-informed approaches to biomedical undergraduate training and mentoring to support the development of a biomedical research workforce that will benefit from the full range of perspectives, experiences and backgrounds needed to advance discovery. NIGMS expects organizations to engage in outreach and recruitment activities to encourage individuals from underrepresented groups to participate in the program. The proposed research training programs will incorporate didactic, research, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the nation.
This program is limited to applications from baccalaureate degree-granting research-intensive organizations (that is, those with NIH Research Project Grant (RPG) funding averaging greater than or equal to $7.5 million in total costs (direct and F&A/indirect) per year over the last three fiscal years (FY)).
This Notice of Funding Opportunity (NOFO) does not allow appointed Trainees to lead an independent clinical trial, but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.
Not Applicable
Application Due Dates | Review and Award Cycles | ||||
---|---|---|---|---|---|
New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision (as allowed) | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
May 29, 2024 | May 29, 2024 | Not Applicable | November 2024 | January 2025 | June 2025 |
May 28, 2025 | May 28, 2025 | Not Applicable | November 2025 | January 2026 | June 2026 |
May 27, 2026 | May 27, 2026 | Not Applicable | November 2026 | January 2027 | June 2027 |
All applications are due by 5:00 PM local time of applicant organization.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Not Applicable
It is critical that applicants follow the Training (T) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.
There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.
The overall goal of the NIH Ruth L. Kirschstein National Research Service Award (NRSA) program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs. More information about NRSA programs can be found at the Ruth L. Kirschstein National Research Service Award website. The NRSA program has been the primary means of supporting predoctoral and postdoctoral research training programs since enactment of the NRSA legislation in 1974.
Each NIGMS funded NRSA program is expected to provide a rigorous, well-designed research training program that includes mentored research experiences, courses, seminars, and additional training opportunities to equip trainees with the following skills required for careers in the biomedical research workforce:
Advances in biomedical research depend upon a workforce composed of people trained in multiple disciplines and from different backgrounds who can provide the breadth of creativity, and individual interests, perspectives and experiences needed to identify and address important and complex scientific problems. Research shows that teams with members from different backgrounds that utilize their members' unique experiences and perspectives better capitalize on innovative ideas and outperform homogenous teams. There are many benefits that flow from an NIH-supported scientific workforce that leverages the talents of rigorous researchers from all backgrounds: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of research, enhancing public trust, and increasing the likelihood that health disparities and the needs of underserved populations are addressed in biomedical research (for more information, see Notice of NIH's Interest in Diversity). The NIH recognizes the need to promote broad participation in the scientific workforce, including by encouraging institutions to enhance the participation of individuals from groups underrepresented in the biomedical research workforce through means consistent with applicable law. NIGMS strives to ensure that future researchers will be drawn from the entire pool of potential contributors and seeks to expand opportunities to contribute to the biomedical research workforce by supporting individuals from a variety of backgrounds at multiple training and career stages in a variety of organizational settings across the country.
At the same time, individuals from certain groups and backgrounds often face organizational and environmental barriers that restrict their potential to advance their training and careers, and are underrepresented in the biomedical research workforce. For example:
Authentic research experiences, both course-based and in the context of a research group, are a critical component of undergraduate Science, Technology, Engineering and Mathematics (STEM) education as they can support student mastery of scientific concepts, development of a professional scientific identity, and persistence in STEM degree programs (Indicators for Monitoring Undergraduate STEM Education, 2018). While authentic research experiences are beneficial for all students, they are particularly helpful for strengthening STEM disciplinary identity and belonging among students from historically underrepresented groups and first generation students (Barriers and Opportunities for 2-Year and 4-Year STEM Degrees, 2016). However, first generation students, low-income students, and students from historically underrepresented racial and ethnic groups are less likely to participate in undergraduate research for multiple reasons, including a lack of awareness about undergraduate research or how to access such opportunities, financial barriers, and lack of scientific mentorship (Undergraduate Research Experiences for STEM Students, 2017).
Importantly, access to structured and formalized programs that provide financial support, high quality mentoring, robust peer and professional networks, and opportunities for skills development have been linked to higher levels of persistence in undergraduate training programs, as well as improved STEM degree completion rates, increased self-efficacy, strengthened science identity, and enhanced commitment to a research career (Indicators for Monitoring Undergraduate STEM Education, 2018; The Science of Effective Mentoring in STEMM, 2019). Therefore, there remains a strong need to develop additional opportunities to address these challenges and ensure undergraduate research training programs effectively support the skills and career development of students from all backgrounds.
The Overarching Objective of the Maximizing Access to Research Careers (MARC) (T34) program is to promote broad participation in the biomedical research workforce by strengthening research training environments and expanding the pool of well-trained students who:
The program should provide trainees with the following:
Applicants are strongly encouraged to read information about the MARC program found on the NIGMS website and to contact program staff before preparing or submitting an application to verify that the proposed program is eligible and in alignment with NIGMS funding priorities.
General Considerations: Consistent with existing NIGMS practices and applicable law:
At the same time, there are many permissible activities to promote broad participation in the biomedical research workforce, and to encourage the participation of individuals from underrepresented groups. For example:
Applicants and award recipients are encouraged to consult with their General Counsel to ensure all applicable laws and regulations are being followed in program design and implementation.
NIGMS intends to fund applications that propose feasible, rigorous, well-designed research training programs that will build on the most effective elements of successful programs while furthering the goal of the MARC program. For the purpose of this announcement, organizations are encouraged to recruit prospective candidates from groups underrepresented on the national basis to grow and diversify the program applicant pool. In addition, because underrepresentation can vary from setting to setting, organizations should design a recruitment strategy to promote broad participation based on their local context as well as on national needs.
Programs are expected to be tailored to the organizational context, for example by using data to identify specific strengths and areas of improvement in the training environment, and developing strategies that leverage organizational strengths to address areas of need. Programs should not simply layer additional activities onto existing structures, but instead should use creative and transformational approaches to undergraduate biomedical research training, mentoring practices, and enhancing departmental and organizational capacity to create and sustain inclusive research training environments.
NIGMS training programs that aim to promote broad participation in the biomedical research workforce are intended to provide research training opportunities to students from the breadth of biomedical disciplines at the organization. Proposed programs focused on a single biomedical discipline or approach at an organization with multiple biomedically relevant departments will be a low priority for funding.
NIGMS recognizes the heterogeneity of trainee pathways from undergraduate education toward research-focused higher degree programs (such as Ph.D. or M.D./Ph.D.). Some students complete undergraduate education and transition immediately to such programs. Other students have pathways that include longer time frames to incorporate additional experiences such as postbaccalaureate training, research-based masters degrees, or time away from biomedical research training. NIGMS intends to fund programs that support undergraduates completing their baccalaureate degrees and undertaking the appropriate next step toward the ultimate goal of transitioning to and completing a research-focused higher degree program.
Funded programs are expected to:
Trainee Support: The training grant defrays the cost of stipends, tuition and fees, and training-related expenses, including health insurance, for the appointed trainees in accordance with the approved NIH NRSA support levels. Students are typically provided full-time support for 2-3 years of undergraduate biomedical research training. Thus, NIGMS expects that organizations will identify trainee candidates who, with satisfactory progress, can complete the entire 2-3 year training experience and be re-appointed after their initial appointment. Training grant funds are not intended to support short-term undergraduate biomedical research training.
Use of training grant support in the final three years of undergraduate research training is strongly encouraged to allow trainees to participate in authentic research experiences, courses, professional development and cohort-building activities that will prepare them to successfully transition into a biomedical, research-focused higher degree program (for example, Ph.D. or M.D./Ph.D.). New trainee cohorts are typically appointed in each year of the proposed program.
Synergies of Federally Funded Training Programs: Funded research training programs are encouraged to complement and synergize with other ongoing federally supported research training programs at the applicant organization; however, the research training goals must be distinct from related, federally funded programs at the same organization. In cases where an organization has multiple NIGMS training grants, it is expected that these programs will work together to create administrative and training efficiencies to reduce costs and improve trainee services and outcomes.
Type of Application Submissions: Please note the following before applying:
Clinical Trials: This NOFO does not allow appointed trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor. NIH strongly supports training towards a career in clinically relevant research; gaining experience in clinical trials under the guidance of a mentor or co-mentor is encouraged.
See Section VIII. Other Information for award authorities and regulations.
Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Not Allowed: Only accepting applications that do not propose clinical trials.
Note: Appointed Trainees are permitted to obtain research experience in a clinical trial led by a mentor or co-mentor.
The number of awards is contingent upon NIH appropriations and the number of meritorious applications submitted.
Application budgets should reflect the actual needs of the proposed project.
Recipients are expected to be familiar with and comply with applicable cost policies and the NRSA Guidelines (NIH Grants Policy Statement - Institutional Research Training Grants). Funds may be used only for those expenses that are directly related to and necessary for the research training and must be expended in conformance with OMB Cost Principles, the NIH Grants Policy Statement, and the NRSA regulations, policies, guidelines, and conditions set forth in this document.
Awards may be for project periods up to five years in duration and are renewable.
Kirschstein-NRSA awards provide stipends as a subsistence allowance to help defray living expenses during the research training experience.
NIH will contribute to the combined cost of tuition and fees at the rate in place at the time of award.
Stipend levels, as well as funding amounts for tuition and fees and the institutional allowance are announced annually in the NIH Guide for Grants and Contracts, and are also posted on the Ruth L. Kirschstein National Research Service Award (NRSA) webpage.
Travel for trainees to attend scientific meetings and workshops that the organization determines to be necessary for the individuals research training experience is an allowable expense. NIGMS will provide up to $1,000 per trainee to travel (for programs supported at organizations outside the continental United States, $1,250 for travel per trainee per year will be provided). Plans for trainee travel should be well justified. Trainees must be appointed to the training grant at the time of the actual travel for this to be an allowable cost.
Summer Research Experience (SRE): Trainees are required to participate in at least one summer research experience (SRE), typically for at least 8-weeks, that will broaden and deepen their research training. SRE funds include per diem funds, and travel costs to and from the host organization. Funds for the SRE will be provided as follows:
NIGMS provides funds for the summer research experience for up to 50% of the awarded number of trainees at the time a competing award is made. For additional budget guidance on the summer research requirement, see T34 Summer Research Experience Policy. SRE funds may not be used to support trainees at foreign organizations.
NIGMS will provide funds to help defray other research training expenses, such as health insurance, staff salaries, consultant costs, equipment, research supplies, and faculty/staff travel directly related to the research training program.
Training related expenses (TRE) are limited to a maximum of $10,000/trainee/year. The maximum cap for the TRE portion of a proposed MARC budget is $320,000/year.
NIGMS expects organizations to prioritize the provision of trainee benefits, such as health insurance, using TRE funds. Remaining funds may be used for allowable costs associated with:
TRE expenses must be justified as specifically required by the proposed program and must not duplicate items generally available at the applicant organization.
Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs (exclusive of tuition and fees, consortium costs in excess of $25,000, and expenditures for equipment), rather than on the basis of a negotiated rate agreement.
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
1. Eligible Applicants
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
Governments
Other
To promote broad participation among research organizations with cross-disciplinary training programs, NIGMS recognizes separate organizational eligibility tracks:
For example, applications submitted in FY2024 will use data from FY 2021, FY 2022 and FY 2023.
Organizational eligibility for this NOFO is limited to research-intensive, baccalaureate-degree granting organizations as defined above. Research-active organizations are not eligible to apply for or receive MARC grants but may be eligible to apply for U-RISE grants (see Part 1, Companion Funding Opportunity).
The application must be submitted by the eligible organization with a unique entity identifier (UEI) and a unique NIH eRA Institutional Profile File (IPF) number. For organizations with multiple campuses (e.g., main, satellite, etc.), eligibility can be considered for an individual campus only if a UEI and a unique NIH eRA IPF number are established for the individual campus. For organizations that use one UEI or NIH IPF number for multiple campuses, eligibility is determined for the campuses together.
Organizations funded through this NOFO are eligible for other NIGMS Training programs provided the other eligibility criteria are met. To avoid any potential for overlap, applicants are strongly encouraged to contact the program officers of each program before applying.
The sponsoring organization must assure eligibility and support for the proposed program. Appropriate information about eligibility and organizational commitment to the program should be detailed according to the Letters of Support attachment instructions in Section IV.
Non-domestic (non-U.S.) Entities (Foreign Institutions) are
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Applicant Organizations
Applicant organizations must complete and maintain the following registrations as described in the SF424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.
Program Directors/Principal Investigators (PD(s)/PI(s))
All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
Any individual(s) with the skills and knowledge necessary to carry out the proposed research training program as the Training Program Director/Principal Investigator (Training PD/PI) is invited to work with their organization to develop an application for support. Individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support. See, Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities, NOT-OD-22-019.
For organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.
As described in the instructions for the Training Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) in Section IV.2 below, NIGMS encourages multiple PDs/PIs, particularly when each brings a unique perspective and skill set that will enhance training. Note the following:
Any of the PDs/PIs may serve as the contact PD/PI. The contact PD/PI is expected to have a full-time appointment at the applicant organization unless extremely well-justified. If the full-time status of the contact PD/PI changes after the award, the organization must obtain prior program approval to appoint a new PD/PI or request a deviation from the full-time rule. The PD(s)/PI(s) will be responsible for:
2. Cost Sharing
This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement.
NIGMS will accept only one application per eligible organization. NIGMS will support only one MARC program per applicant organization.
NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:
The selected faculty should demonstrate the ability to promote authentic research experiences for undergraduates (for example, through recent publications or abstracts at external scientific meetings with undergraduates). Research areas of the participating faculty must fall within the NIH mission. When building a training team, programs should include faculty who are committed to training, mentoring, and providing supportive and inclusive research environments. Programs are encouraged to recruit prospective preceptors/mentors from a wide variety of backgrounds, for example faculty from underrepresented groups (see Notice of NIH's Interest in Diversity ), faculty at different career stages (for example, early-career as well as established faculty), and faculty from the breadth of biomedical disciplines at the applicant organization.
The applicant organization will select the trainees to be supported by the research training program. It is the responsibility of the organization to establish the qualifications, consistent with applicable law, of the trainees before they are supported by the program.
The individual to be trained must be a citizen or a noncitizen national of the United States or have been lawfully admitted for permanent residence at the time of appointment. Additional details on citizenship, training period, and aggregate duration of support are available in the NIH Grants Policy Statement.
All trainees are required to pursue their research training full time, normally defined as 40 hours per week, or as specified by the sponsoring organization in accordance with its own policies. Appointments are normally made in 12-month increments, and no trainee may be appointed for less than 9 months during the initial period of appointment, except with prior approval of NIGMS. NIGMS expects that, with satisfactory progress, trainees will complete the entire 2-3 year training experience. Training grant funds may not be used to support short-term undergraduate biomedical research training.
Trainees funded through this program must be enrolled in a program leading to a baccalaureate degree.
1. Requesting an Application Package
The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.
2. Content and Form of Application Submission
It is critical that applicants follow the Training (T) Instructions in the How to Apply - Application Guide except where instructed in this Notice of Funding Opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Page Limitations
All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.
Instructions for Application Submission
The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this NOFO.
All instructions in the SF424 (R&R) Application Guide must be followed with the following additional instructions.
Descriptive Title of Applicants Project: Use the format MARC at Name of Organization
SF424(R&R) Project/Performance Site Locations
All instructions in the SF424 (R&R) Application Guide must be followed.
SF424 (R&R) Other Project Information
All instructions in the SF424 (R&R) Application Guide must be followed.
Are Human Subjects Involved: Check "No" unless the training program itself requires the trainees to take a workshop or course that will involve human subjects, for example, students collect and analyze samples from humans in a required course.
Are Vertebrate Animals Used: Check "No" unless the training program itself requires the trainees to take a workshop or course that will involve vertebrate animals, for example, students use vertebrate animals in a required laboratory class.
Project Summary/Abstract: Use the page limitations, but do not follow the instructions provided in the SF424 (R&R) Application Guide; instead, applicants must follow the instructions below.
Provide an overview of the training program, including the mission, objectives, rationale, and program elements. Highlight activities that promote trainee skills development and facilitate undergraduate degree completion as well as the successful transition into and completion of biomedical, research-focused higher degree programs. Indicate the planned student year(s) and duration of appointments, the projected number of trainees and intended trainee outcomes.
Facilities & Other Resources: Do not follow the instructions provided in the SF424 (R&R) Application Guide for this section; instead, applicants must follow the instructions below.
Describe the scientific and educational facilities, resources, and environment that contribute to the probability of success of the research training program. Do not include any data or examples of data, hyperlinks, or any material not listed as allowable for Facilities & Other Resources section of the SF424 (R&R) Application Guide. Applications should address the following when describing the scientific and educational facilities, resources, and environment:
If there are multiple performance sites, describe the resources available at each site.
Other Attachments: Please include a header or footer label on each page of the other attachments with the corresponding material title.
The following two attachments must be included as PDF files, or the application will not be reviewed:
1. Baseline Program Data (required): The application must provide baseline data on the proposed program. The data must reflect the pool of participating faculty, training grant eligible (TGE) undergraduates, and the characteristics of the TGE undergraduates for the current academic year. The data serve as a basis for review of planned activities, including recruitment. The number of TGE candidates will be used to determine the appropriate budget and number of funded positions. NIGMS will use the data provided in a manner consistent with applicable law.
NIGMS encourages the use of Suggested Formats C to aid in the structuring of the data
NIGMS encourages the use of Suggested Formats D to aid in the structuring of the data.
Please name the file Baseline_Program_Data.pdf.
2. Recruitment Plan to Enhance Diversity (3-page maximum, required): The applicant must provide a Recruitment Plan to Enhance Diversity. Baseline data on the trainee pool should inform the Recruitment Plan to Enhance Diversity. Include outreach strategies and activities designed to recruit potential training program candidates who are from underrepresented groups, for example students from underrepresented racial and ethnic groups, individuals with disabilities, and students from disadvantaged backgrounds (see Notice of NIH's Interest in Diversity). Applicants are encouraged to consult the NIGMS web page for strategies to enhance diversity in training programs when designing their plans. Describe the specific efforts to be undertaken by the training program and how these might coordinate with trainee recruitment efforts of the organization. Centralized organizational efforts alone will not satisfy the requirement to recruit prospective trainees from underrepresented groups. Participating faculty are expected to be actively involved in recruitment efforts. Please name the file Recruitment_Plan.pdf.
The following attachments may be included but are not required:
The filename provided for each Other Attachment will be the name used for the bookmark in the electronic application in eRA Commons.
SF424(R&R) Senior/Key Person Profile Expanded
Follow all instructions provided in the SF424 (R&R) Application.
Biographical Sketch: The personal statement should describe the individual's commitment to scientific rigor, training, and mentoring, as well as to promoting inclusive, safe, and supportive scientific environments.
PHS 398 Cover Page Supplement
Follow all instructions provided in the SF424 (R&R) Application.
PHS 398 Training Subaward Budget Attachment(s)
Follow all instructions provided in the SF424 (R&R) Application Guide.
Follow all instructions provided in the SF424 (R&R) Application Guide with the following additional modifications:
Budget Justification: Follow all instructions provided in the SF424 (R&R) Application Guide with the following additions:
PHS 398 Research Training Program Plan
The PHS 398 Research Training Program Plan Form is comprised of the following sections:
Follow all instructions provided in the SF424 (R&R) Application Guide.
Attention must be given to the required Training Data Tables for New or Renewal applications. In the Program Plan, applicants should also summarize key data from the tables that highlight the characteristics of the training grant eligible pool, program faculty, organizational support, student outcomes, and other factors that contribute to the overall training environment of the program.
Program Plan
The Program Plan attachment is required and must adhere to the NIH Table of Page Limits, as well as the organization and instructions provided below.
Do not follow the organization and instructions provided in the SF424 (R&R) application guide for the Program Plan attachment; instead, applicants must use the instructions below. The sections for the program plan are:
Start each section with the relevant heading below.
Rationale, Mission, and Objectives
The application should describe how the program will promote broad participation in the biomedical research workforce by strengthening the research training environment and expanding the pool of well-trained undergraduates who will:
The application should describe how the program will, or will continue to, enhance the training environment - going beyond simply providing financial assistance for trainees to conduct research. Specifically, applicants should describe the following:
Curriculum and Overall Training Plan
The application should describe the curriculum and overall training plan, including the required and elective courses, structured activities, and research experiences. In developing the overall training plan, the application should describe:
The application may include additional supporting information (for example, streamlined syllabi with topics, timelines, activities, credits, etc.) in an optional Training Activities Other Attachment. The narrative should emphasize when the curriculum and overall training plan employ evidence-informed approaches and how these activities are designed to develop trainees' skills and accomplish the stated training mission and objectives.
Applicants should address the following:
Career Development
The application should describe the following:
Program Oversight of Training and Mentoring
The application should include the planned strategy and administrative structure to oversee and monitor the program, and to ensure appropriate and timely trainee progress for the duration of the trainees' undergraduate careers. If a program coordinator or administrator position is planned to enhance oversight, a description of the person's administrative capabilities that are essential to coordinate the program should be included in the application. The application should describe the following (including who is responsible for the oversight):
Training Program Director(s)/Principal Investigator(s) (PDs/PIs)
The application should describe how the Training Program Director(s)/Principal Investigator(s) (PDs/PIs) will promote the success of the trainees and training program. NIGMS strongly encourages multiple PDs/PIs, particularly when each brings a unique perspective and skill set that will enhance training as described in the Eligible Individuals section. In addition, the use of multiple PDs/PIs provides stability to the program in the event that one PD/PI leaves unexpectedly. The application should expand on the information in the biosketch(es) to address how the PD/PI or PD/PI team has:
The application should describe the administrative structure and leadership succession plan for critical positions (for example, all PD(s)/PI(s)).
Preceptors/Mentors (Participating Faculty)
Describe how the program has or will recruit a pool of prospective faculty from a wide variety of backgrounds to provide potential role models within the training program and to enhance the effectiveness of the training environment. Describe how mentors provide opportunities for research in the breadth of biomedical research disciplines available at the organization. The application should summarize and expand on the material presented in the Training Tables and biosketches and address how the participating faculty:
Candidate Review Process
The following areas should be addressed:
Trainee Appointments and Financial Support
Applicants must describe the proposed financial support structure and appointment processes. NIGMS-funded training programs are intended to maximally increase the development of a pool of promising trainees from a range of backgrounds. Appointing only trainees who already have strong research credentials and skills, or appointing trainees for a shorter period than two years, is unlikely to achieve this goal. Applicants should describe:
Trainee Outcomes
This section is intended to provide student outcomes to:
The application should provide the information below about recent outcomes through narrative descriptions and a summary of the data presented in the required training tables. Although the training tables for applications submitted as new applications only allow for five years of recent outcomes, the application may describe up to 15 years of outcomes in the narrative. Applicants may include tables in the narrative, but they must have different labels than the required Data Tables. Please see Program Considerations when determining if the application should be submitted as New or a "Renewal". Applicants are encouraged to describe the data for recent program graduates for existing programs or relevant students for new programs, including the following:
If disparities are observed, describe approaches to identify the causes and, where warranted, the approach to feasibly address the issues in the Program Plan.
Program Evaluation Plan, Dissemination, and Data Storage
NIGMS-funded training programs must conduct ongoing program evaluations to monitor the success of the training and mentoring activities. Funded programs are expected to report on outcomes through annual progress reports and renewal applications. The application may include blank survey instruments, rubrics, or forms in an appendix, according to the instructions for the Appendix as described in the SF424 (R&R) Application Guide. Applicants should describe:
Note: Training Program Evaluation is not a form of human subject research. Training grants prepare individuals for careers in the biomedical research workforce by developing and implementing evidence-informed educational practices including didactic, research, mentoring, and career development elements. While funded programs are expected to conduct ongoing program evaluations and assessments to monitor the effectiveness of the training and mentoring activities, training grant funds are not intended to support Human Subjects Research (see additional information on Human Subjects Research from NIH and HHS).
Plan for Instruction in Methods for Enhancing Reproducibility
Applicants are required to comply with the instructions for the Plan for Instruction in Methods for Enhancing Reproducibility as provided in the SF424 (R&R) Application Guide.
Plan for Instruction in the Responsible Conduct of Research
Applicants are required to comply with the instructions for the Plan for Instruction in the Responsible Conduct of Research as provided in the SF424 (R&R) Application Guide, along with the following additional instructions:
Describe how the Responsible Conduct of Research (RCR) components are well integrated into the overall curriculum, how they are taught at multiple stages of trainee development and in a variety of formats and contexts. Explain how the teaching of RCR synergizes with elements of the curriculum designed to enhance trainees abilities to conduct rigorous and reproducible research. Describe how all participating faculty will reiterate and augment key elements of responsible conduct when trainees are performing mentored research in their laboratories.
Progress Report (only for Renewal applications)
The progress report is intended to demonstrate that the program successfully promoted broad participation in the biomedical research workforce by strengthening the research training environment and expanding the pool of well-trained students who completed their baccalaureate degree, and transitioned into and completed biomedical, research-focused higher degree programs. Renewals are only allowed for programs funded through PAR-19-219 or PAR-21-147. Follow the instructions in the SF424 (R&R) Application Guide, with the following exceptions: For the "Program Overview" section - adhere to the page limit indicated in the SF424 (R&R) application guide but follow the instructions below instead.
Implementation of Proposed Activities
Results and Changes from Program Evaluations
Impact and Dissemination
Participating Faculty Biosketches
Participating faculty should provide a personal statement that describes the appropriateness of their research background for the proposed training program, and their commitment to the following:
Letters of Support
Organizational Eligibility and Support Letter (10-page maximum). The application must include a signed letter on letterhead from a President, Provost, Dean, or similar key leader that (i) certifies organizational eligibility, and (ii) describes the activities and resources provided by the organization that will ensure the success of the planned training program and its trainees. If this letter is not included, the application will be considered incomplete and will not be reviewed. The letter must describe:
(i) Organizational Eligibility: Certify that the applicant organization, as described by UEI and NIH IPF number:
(ii) Organizational Support: Describe the organizational commitment to the following areas (as applicable):
Other Letters of Support. Additional letters of support (for example, from partner organizations) are permitted; however, these letters may not contain any information required in the Organizational Support Letter described above.
Combine all Letters of Support into a single PDF file.
Data Tables
The application must include the required Training Data Tables for undergraduate training applications. Applications that do not contain the required tables, or that submit any additional tables in this attachment will be considered noncompliant and may not be reviewed.
Limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide; any instructions provided here are in addition to the SF424 (R&R) Application Guide instructions.
All instructions in the SF424 (R&R) Application Guide must be followed.
See Part 2 . Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov
Part 1 . Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.
Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIHs electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications.
Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.
5. Intergovernmental Review (E.O. 12372)
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The National Research Service Award (NRSA) policies apply to this program. An NRSA appointment may not be held concurrently with another Federally sponsored fellowship, traineeship, or similar Federal award that provides a stipend or otherwise duplicates provisions of the NRSA.
Pre-award costs are allowable only as described in the NIH Grants Policy Statement. Note, however, that pre-award costs are not allowable charges for stipends or tuition/fees on training grants because these costs may not be charged to the grant until a trainee has actually been appointed, and the appropriate paperwork submitted to the NIH awarding component. Any additional costs associated with the decision to allow research elective credit for short-term research training are not allowable charges on a training grant.
NIGMS does not permit automatic carryover of training grant funds from one budget period to the next.
Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.
Important reminders:
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.
The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organizations profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide.
See more tips for avoiding common errors.
Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and NIGMS. Applications that are incomplete or non-compliant will not be reviewed.
Applicants requesting $500,000 or more in direct costs in any year are not required to contact a Scientific/ Research Contact prior to submitting an application. The Policy on the Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs as described in the SF424 (R&R) Application Guide is not applicable to this NOFO.
Post Submission Materials
Applicants are required to follow the instructions for post-submission materials, as described in the policy.
Only the review criteria described below will be considered in the review process.
Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.
For this particular announcement, note the following: NIGMS recognizes that rigorous, well-designed research training programs that further the goal of the MARC program can take place in a wide variety of organizational environments and with mentors who have varying levels of NIH research project grant support. Reviewers should evaluate proposed programs considering their stated objectives, organizational context, available resources, and the capacity of those resources to meet the stated objectives. Reviewers should evaluate with the understanding that organizations vary in the amount of NIH RPG funding within the research-intensive category. Reviewers should note that identification of current challenges and shortcomings can be viewed as positive factors if accompanied by sound plans for how the applicant would use the MARC award to overcome or remediate them.
Reviewers should also note that while any information relevant to the program goals can be included as part of the review process, the race, ethnicity, or sex (including gender identity, sexual orientation, or transgender status) of trainee candidates, trainees, or faculty may not, in and of themselves, be used as factors in the evaluation of applications.
Reviewers will provide an overall impact score in consideration of the following review criteria and additional review criteria (as applicable for the proposed program). The overall impact score should reflect the reviewers' assessment of the likelihood that the proposed program will promote broad participation in the biomedical research workforce by strengthening research training environments and expanding the pool of well-trained students who complete their baccalaureate degree, and transition into and complete biomedical, research-focused higher degree programs (such as Ph.D. or M.D./Ph.D.). Specifically, whether the structured training activities, mentoring, and research experiences will equip the trainees with:
Reviewers will consider each of the review criteria below in the determination of the merit of the training program and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major research training impact.
Rationale, Mission, and Objectives
Curriculum and Overall Training Plan
Career Development
Program Oversight of Training and Mentoring
Organizational Commitment to the Program
For applications designating multiple PDs/PIs
Candidate Review Process
Trainee Appointments and Financial Support
Trainee Outcomes
Program Evaluation Plan, Dissemination, and Data Storage
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.
Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.
Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.
Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.
Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.
All applications for support under this funding announcement must include a plan to fulfill NIH requirements for instruction in the Responsible Conduct of Research (RCR). Taking into account the specific characteristics of the training program, the level of trainee experience, and the particular circumstances of the trainees, the reviewers will evaluate the proposed RCR training in relation to the following five required components:
1) Format - Evaluate whether the plan satisfactorily addresses the format of instruction, e.g., lectures, coursework and/or real-time discussion groups, including face-to-face interaction (A plan involving only on-line instruction is not acceptable.)
2) Subject Matter – Evaluate whether the plan includes a sufficiently broad selection of subject matter, such as conflict of interest, authorship, data management, human subjects and animal use, laboratory safety, research misconduct, research ethics, community engagement, societal implications of scientific research.
3) Faculty Participation - Assess whether the plan adequately describes how faculty will participate in the instruction. For renewal applications, all training faculty who served as course directors, speakers, lecturers, and/or discussion leaders during the past project period should be named in the application.
4) Duration of Instruction - Evaluate whether the plan meets the minimum requirements for RCR, i.e., at least eight contact hours of instruction.
5) Frequency of Instruction – Evaluate whether the plan meets the minimum requirements for RCR, i.e., at least once during each career stage (undergraduate, post-baccalaureate, predoctoral, postdoctoral, and faculty levels) and at a frequency of no less than once every four years.
For renewal applications, evaluate how well the progress report:
Reviewers will examine the recruitment strategies, including:
For Resubmissions of Renewal Applications, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project. Undue weight should not be given for simply responding to previous comments; instead the content of the responses and how the application will be improved by any proposed changes should be considered.
In evaluating the progress report, reviewers should note that identification of challenges and program shortcomings can be viewed as positive factors if accompanied by sound plans for overcoming or remediating them.
Implementation of Proposed Activities
Results and Discussion from Program Evaluations
Impact and Dissemination
Not Applicable
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.
Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research training program and the number of requested funded trainee positions in the context of the number of training grant eligible candidates provided in the trainee pool baseline data, the size of the entire program, the number of participating faculty, and other NIGMS-funded training programs at the organization.
Applications will be evaluated for merit by (an) appropriate Scientific Review Group(s), convened by NIGMS in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons. Following initial peer review, recommended applications will receive a second level of review by the National Advisory General Medical Sciences Council. As part of the scientific peer review, all applications:
Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board.
The following will be considered in making funding decisions, consistent with applicable law:
After the peer review of the application is completed, the PD/PI will be able to access their Summary Statement (written critique) via the eRA Commons. Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement Section 2.4.4 Disposition of Applications.
If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement.
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the recipients business official.
Recipients must comply with any funding restrictions described in Section IV.6. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this NOFO will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities, including of note, but not limited to:
If a recipient is successful and receives a Notice of Award, in accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.
Should the applicant organization successfully compete for an award, recipients of federal financial assistance (FFA) from HHS will be required to complete an HHS Assurance of Compliance form (HHS Assurance of Compliance form (HHS 690)) in which the recipient agrees, as a condition of receiving the grant, to administer programs in compliance with federal civil rights laws that prohibit discrimination on the basis of race, color, national origin, age, sex and disability, and agreeing to comply with federal conscience laws, where applicable. This includes ensuring that entities take meaningful steps to provide meaningful access to persons with limited English proficiency; and ensuring effective communication with persons with disabilities. Where applicable, Title XI and Section 1557 prohibit discrimination on the basis of sexual orientation, and gender identity, The HHS Office for Civil Rights provides guidance on complying with civil rights laws enforced by HHS. See https://www.hhs.gov/civil-rights/for-providers/provider-obligations/index.html and https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html.
HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigators scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO.
Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at https://www.hhs.gov/ocr/about-us/contact-us/index.html or call 1-800-368-1019 or TDD 1-800-537-7697.
In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a federal agency previously entered and is currently in FAPIIS. The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicants integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 and 2 CFR Part 200.206 Federal awarding agency review of risk posed by applicants. This provision will apply to all NIH grants and cooperative agreements except fellowships.
Not Applicable
Note: The NIH Policy for Data Management and Sharing is effective for due dates on or after January 25, 2023.
Consistent with the NIH Policy for Data Management and Sharing, when data management and sharing is applicable to the award, recipients will be required to adhere to the Data Management and Sharing requirements as outlined in the NIH Grants Policy Statement. Upon the approval of a Data Management and Sharing Plan, it is required for recipients to implement the plan as described.
When multiple years are involved, recipients will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement. Continuation support will not be provided until the required forms are submitted and accepted.
Failure by the recipient institution to submit required forms in a timely, complete, and accurate manner may result in an expenditure disallowance or a delay in any continuation funding for the award.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.
The institution must submit a completed Statement of Appointment (PHS Form 2271) for each trainee appointed or reappointed to the training grant for 8 weeks or more. Recipients must submit the PHS 2271 data electronically using the xTrain system. More information on xTrain is available at xTrain (eRA Commons). An appointment or reappointment may begin any time during the budget period, but not before the budget period start date of the grant year.
A final RPPR, the expenditure data portion of the Federal Financial Report, are required for closeout of an award as described in the NIH Grants Policy Statement. NIH NOFOs outline intended research goals and objectives. Post award, NIH will review and measure performance based on the details and outcomes that are shared within the RPPR, as described at 45 CFR Part 75.301 and 2 CFR Part 200.301.
In accordance with the regulatory requirements provided at 45 CFR 75.113 and 2 CFR Part 200.113 and Appendix XII to 45 CFR Part 75 and 2 CFR Part 200, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period. The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS). This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 and 2 CFR Part 200 – Award Term and Condition for Recipient Integrity and Performance Matters.
In carrying out stewardship of grant programs, NIGMS will periodically evaluate this Research Training Program, employing the representative measures identified below. In assessing the effectiveness of training investments, NIGMS may use information from progress reports and public databases, PD/PIs, and from participants themselves. Where necessary, PDs/PIs and participants may be appropriately contacted after the completion of the grant period for updates on participants subsequent outcomes.
NIGMS staff may conduct site visits of funded programs in order to obtain information about the training environment and other specific issues that are not easily assessed through other means.
The overall evaluation of the NIGMS-wide program will be based on metrics that may include, but are not limited to, the following:
We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten on-time submission, and post-submission issues)
Finding Help Online: https://www.era.nih.gov/need-help (preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
General Grants Information (Questions regarding application processes and NIH grant resources)
Email: [email protected] (preferred method of contact)
Telephone: 301-480-7075
Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace)
Contact Center Telephone: 800-518-4726
Email: [email protected]
Lameese Akacem, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]
Kalynda Gonzales Stokes, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]
Justin Rosenzweig
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Section 487 of the Public Health Service Act as amended (42 USC 288) and under Federal Regulations 42 CFR 66.