Part 1. Overview Information

Key Dates

Dates in bold and italics reflect changes per NOT-GM-24-040

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

It is critical that applicants follow the Training (T) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

1. Use the NIH ASSIST system to prepare, submit and track your application online.
2. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and eRA Commons to track your application. Check with your institutional officials regarding availability.
   
   
3. Use Grants.gov Workspace to prepare and submit your application and eRA Commons to track your application.



Table of Contents
Part 1. Overview Information
Key Dates
Part 2. Full Text of Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Other Award Budget Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

Purpose and Background Information

The overall goal of the NIH Ruth L. Kirschstein National Research Service Award (NRSA) program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs. More information about NRSA programs can be found at the Ruth L. Kirschstein National Research Service Award website. The NRSA program has been the primary means of supporting predoctoral and postdoctoral research training programs since enactment of the NRSA legislation in 1974. 

Each NIGMS funded NRSA program is expected to provide a rigorous, well-designed research training program that includes mentored research experiences, courses, seminars, and additional training opportunities to equip trainees with the following skills required for careers in the biomedical research workforce:

• Technical (for example, appropriate methods, technologies, and quantitative/computational approaches).
• Operational (for example, independent knowledge acquisition, rigorous experimental design, interpretation of data, and conducting research in the safest manner possible).
• Professional (for example, management, leadership, communication, and teamwork).

Need for the Program

Advances in biomedical research depend upon a workforce composed of people trained in multiple disciplines and from different backgrounds who can provide the breadth of creativity, and individual interests, perspectives and experiences needed to identify and address important and complex scientific problems. Research shows that teams with members from different backgrounds that utilize their members' unique experiences and perspectives better capitalize on innovative ideas and outperform homogenous teams. There are many benefits that flow from an NIH-supported scientific workforce that leverages the talents of rigorous researchers from all backgrounds: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of research, enhancing public trust, and increasing the likelihood that health disparities and the needs of underserved populations are addressed in biomedical research (for more information, see Notice of NIH's Interest in Diversity). The NIH recognizes the need to promote broad participation in the scientific workforce, including by encouraging institutions to enhance the participation of individuals from groups underrepresented in the biomedical research workforce through means consistent with applicable law. NIGMS strives to ensure that future researchers will be drawn from the entire pool of potential contributors and seeks to expand opportunities to contribute to the biomedical research workforce by supporting individuals from a variety of backgrounds at multiple training and career stages in a variety of organizational settings across the country. 

At the same time, individuals from certain  groups and backgrounds often face organizational and environmental barriers that restrict their potential to advance their training and careers, and are underrepresented in the biomedical research workforce. For example:

• Individuals from underrepresented  racial and ethnic groups, including Black or African American, Hispanic or Latino, American Indian or Alaska Native, Native Hawaiian or other Pacific Islander comprise ~39% of the college age population, but earn only ~25% of bachelor’s degrees and ~17% of Ph.D. degrees in the life sciences (as per data from the Census Bureau, the National Center for Education Statistics, and the National Center for Science and Engineering Statistics). Additionally, increases in the numbers of biomedical Ph.Ds. awarded to scientists from these groups are not reflected at the faculty level (Gibbs, et al., eLife 2016) or in NIH funded K awardees or Research Project Grant investigators (Lauer and Bernard, 2023a, 2023b).
• The representation of scientists with disabilities decreases from 19% for undergraduate students to 9% of doctoral students and fewer than 2% of NIH and NSF-funded principal investigators (NIH ACD WGD Subgroup on Individuals with Disabilities Report, 2022).
• Individuals from certain disadvantaged backgrounds, for example those from families from the lowest socioeconomic quintile, were 50% less likely than those from the highest socioeconomic quintile to enroll in post secondary education, limiting subsequent access to doctoral education (see National Center for Education Statistics).

Authentic research experiences, both course-based and in the context of a research group, are a critical component of undergraduate Science, Technology, Engineering and Mathematics (STEM) education as they can support student mastery of scientific concepts, development of a professional scientific identity, and persistence in STEM degree programs (Indicators for Monitoring Undergraduate STEM Education, 2018). While authentic research experiences are beneficial for all students, they are particularly helpful for strengthening STEM disciplinary identity and belonging among students from historically underrepresented groups and first generation students (Barriers and Opportunities for 2-Year and 4-Year STEM Degrees, 2016). However, first generation students, low-income students, and students from historically underrepresented racial and ethnic groups are less likely to participate in undergraduate research for multiple reasons, including a lack of awareness about undergraduate research or how to access such opportunities, financial barriers, and lack of scientific mentorship (Undergraduate Research Experiences for STEM Students, 2017). 

Importantly, access to structured and formalized programs that provide financial support, high quality mentoring, robust peer and professional networks, and opportunities for skills development have been linked to higher levels of persistence in undergraduate training programs, as well as improved STEM degree completion rates, increased self-efficacy, strengthened science identity, and enhanced commitment to a research career (Indicators for Monitoring Undergraduate STEM Education, 2018; The Science of Effective Mentoring in STEMM, 2019). Therefore, there remains a strong need to develop additional opportunities to address these challenges and ensure undergraduate research training programs effectively support the skills and career development of students from all backgrounds.

Program Objective

The Overarching Objective of the Undergraduate Research Training Initiative for Student Enhancement (U-RISE) program is to promote broad participation in the biomedical research workforce by strengthening research training environments and expanding the pool of well-trained students who:

• Complete their baccalaureate degree, and
• Transition into and complete biomedical, research-focused higher degree programs (such as Ph.D. or M.D./Ph.D.).

The program should provide trainees with the following:

• A broad exposure to foundational biomedical disciplines.
• The skills to acquire the knowledge needed to advance their chosen fields and careers.
• The ability to think critically about important biomedical research questions and approaches that push forward the boundaries of their areas of study.
• A strong foundation in scientific reasoning, rigorous research design, experimental methods, quantitative and computational approaches, and data analysis and interpretation.
• The skills to conduct research in the safest manner possible, and a commitment to approaching and conducting biomedical research responsibly, ethically, and with integrity.
• Experiences conducting, interpreting, and presenting rigorous and reproducible biomedical research with increasing self-direction.
• The ability to work effectively in teams with colleagues from a variety of cultural and scientific backgrounds, and to promote inclusive and supportive scientific research environments.
• The skills to communicate scientific methodologies and findings to a wide variety of audiences (for example, discipline-specific, across disciplines, and for the public).
• The knowledge, professional skills and experiences required to identify and transition into careers in the biomedical research workforce (for example, the breadth of careers that sustain biomedical research in areas that are relevant to the NIH mission).

Program Considerations

Applicants are strongly encouraged to read information about the U-RISE program found on the NIGMS website and to contact program staff before preparing or submitting an application  to verify that the proposed program is eligible and in alignment with NIGMS funding priorities.

General Considerations: 

Consistent with existing NIGMS practices and applicable law:

• Funded programs may not use the race, ethnicity, or sex (including gender identity, sexual orientation, or transgender status) of a trainee or faculty candidate as an eligibility or selection criteria.
• NIGMS does not use the race, ethnicity, or sex of trainee candidates, trainees, or faculty in the application review process or funding decisions.   

At the same time, there are many permissible activities to promote broad participation in the biomedical research workforce, and to encourage the participation of individuals from underrepresented groups.  For example:

• Outreach activities to foster awareness of research training opportunities for potential trainees from all backgrounds.
• Targeted recruitment activities to diversify program applicant pools.
• Program admissions processes that consider factors beyond grade point average and standardized test scores – such as how a trainee candidate’s lived experiences and perspectives further their commitment to program goals and a biomedical research career.
• Efforts to create and sustain inclusive research training environments for trainees from diverse backgrounds, for example strengthening faculty skills to work effectively with trainees from various cultural and neurodiverse groups.
• Updating curricula, pedagogy, and academic supports to enhance student success and engagement.
• Expanding mentoring, networking, and skills development opportunities, and financial support for trainees.
• Utilizing data to identify, and as appropriate, feasibly address biases and barriers in the research training environment that impede trainee success.

Applicants and award recipients are encouraged to consult with their General Counsel to ensure all applicable laws and regulations are being followed in program design and implementation. 

NIGMS intends to fund applications that propose feasible, rigorous, well-designed research training programs that will build on the most effective elements of successful programs while furthering the goal of the U-RISE program.  For the purpose of this announcement, organizations are encouraged to recruit  prospective candidates from groups underrepresented on the national basis to grow and diversify the program applicant pool.  In addition, because underrepresentation can vary from setting to setting, organizations should design a recruitment strategy to promote broad participation based on their local context as well as on national needs. 

Programs are expected to be tailored to the organizational context, for example by using data to identify specific strengths and areas of improvement in the training environment, and developing strategies that leverage organizational strengths to address areas of need. Programs should not simply layer additional activities onto existing structures, but instead should use creative and transformational approaches to undergraduate biomedical research training, mentoring practices, and enhancing departmental and organizational capacity to create and sustain inclusive research training environments.

NIGMS training programs that aim to promote broad participation in the biomedical research workforce are intended to provide research training opportunities to students from the breadth of biomedical disciplines at the organization. Proposed programs focused on a single biomedical discipline or approach at an organization with multiple biomedically relevant departments will be a low priority for funding.

NIGMS recognizes the heterogeneity of trainee pathways from undergraduate education toward research-focused higher degree programs (such as Ph.D. or M.D./Ph.D.). Some students complete undergraduate education and transition immediately to such programs. Other students have pathways that include longer time frames to incorporate additional experiences such as postbaccalaureate training, research-based master’s degrees, or time away from biomedical research training. NIGMS intends to fund programs that support undergraduates completing their baccalaureate degrees and undertaking the appropriate next step toward the ultimate goal of transitioning to and completing a research-focused higher degree program. 

Funded programs are expected to:

• Be well integrated within one or more department(s)/program(s) and exert a strong, positive influence at the organizational level on undergraduate biomedical research training and mentoring practices.
• Have clearly defined training objectives that take into account the applicant organization's specific context, resources, and strengths, and show evidence of meeting the objectives in progress reports and in renewal applications.
• Implement evidence-informed training and mentoring activities (for example, approaches grounded in the literature and evaluations of existing relevant research training programs). Programs are expected to be responsive to evaluations, particularly with respect to trainee feedback.
• Provide rigorous, well-designed mentored authentic research experiences (including at least one summer research experience (SRE)), and additional opportunities that will build a strong cohort of research-oriented individuals. Programs are expected to assist students in identifying and arranging the SREs to broaden and deepen their research training (for additional details, see SRE policy). Training grant funds may not be used solely as a vehicle to provide financial aid for trainees to conduct research.
• Demonstrate effective oversight of trainee development and promote retention for the entire time the trainee is in the undergraduate program. Retention efforts are activities designed to sustain the scientific interests and participation of trainees from all backgrounds. Retention and oversight activities might include monitoring academic and research progress, building strong trainee cohorts, as well as increasing science identity, self-efficacy, and a sense of belonging within research training environments. Programs are expected to make efforts to identify individuals who may need additional academic and social supports to successfully complete the program, and ensure they receive the needed support.
• Promote inclusive, safe, accessible, and supportive research training environments to maximize success for all individuals in the training program. Specifically, funded programs should have organizational and departmental environments where individuals from all backgrounds are welcomed, feel integrated into, and supported by the biomedical research community. Safety in research training should encompass (1) environments free from harassment, discrimination, and intimidation, in which all are treated in a respectful and supportive manner, (2) laboratory and clinical settings where individuals exercise the highest standards of practice for chemical, biological and physical safety, and (3) practices at the organizational leadership and research community levels that demonstrate core values and behaviors to emphasize safety over competing goals.

Trainee Support: The training grant defrays the cost of stipends, tuition and fees, and training-related expenses, including health insurance, for the appointed trainees in accordance with the approved NIH NRSA support levels. Students are typically provided full-time support for 2-3 years of undergraduate biomedical research training. Thus, NIGMS expects that organizations will identify trainee candidates who, with satisfactory progress, can complete the entire 2-3 year training experience and be re-appointed after their initial appointment. Training grant funds are not intended to support short-term undergraduate biomedical research training.

Use of training grant support in the final three years of undergraduate research training is strongly encouraged to allow trainees to participate in authentic research experiences, courses, professional development and cohort-building activities that will prepare them to successfully transition into a biomedical, research-focused higher degree program (for example, Ph.D. or M.D./Ph.D.). New trainee cohorts are typically appointed in each year of the proposed program. 

Synergies of Federally Funded Training Programs: Funded research training programs are encouraged to complement and synergize with other ongoing federally supported research training programs at the applicant organization; however, the research training goals must be distinct from related, federally funded programs at the same organization. In cases where an organization has multiple NIGMS training grants, it is expected that these programs will work together to create administrative and training efficiencies to reduce costs and improve trainee services and outcomes.

Type of Application Submissions: Please note the following before applying:

• Applications will be considered a RENEWAL application only if the program described in the application was funded through PAR-19-218 or PAR- 21-146.
• RESUBMISSION applications are only accepted for RENEWAL applications.
  • Renewal applications that are not funded on the initial attempt may be revised and resubmitted as a Resubmission application (i.e., -A1).
  • New applications that are not funded are not allowed to submit a Resubmission application. Instead, applicants whose New applications were not funded are encouraged to apply again by submitting another New application that utilizes constructive feedback from the previous review while following the instructions for New applications (that is, do not refer to the prior application or critiques).

Clinical Trials: This NOFO does not allow appointed trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor. NIH strongly supports training towards a career in clinically relevant research; gaining experience in clinical trials under the guidance of a mentor or co-mentor is encouraged.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Other Award Budget Information

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Higher Education Institutions

• Public/State Controlled Institutions of Higher Education
• Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

• Hispanic-serving Institutions
• Historically Black Colleges and Universities (HBCUs)
• Tribally Controlled Colleges and Universities (TCCUs)
• Alaska Native and Native Hawaiian Serving Institutions
• Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

• Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
• Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

Governments

• Indian/Native American Tribal Governments (Federally Recognized)
• Indian/Native American Tribal Governments (Other than Federally Recognized)
• U.S. Territory or Possession

Other

• Native American Tribal Organizations (other than Federally recognized tribal governments)
• Faith-based or Community-based Organizations

To promote broad participation among research organizations with cross-disciplinary training programs, NIGMS recognizes separate organizational eligibility tracks:

• Research-intensive, that is, those with an average of NIH research project grant (RPG) funding greater than or equal to $7.5 million total costs per year over the past 3 fiscal years, and
• Research-active, that is, those with an average of RPG funding less than $7.5 million total costs per year over the past 3 fiscal years (RPG data are available through NIH RePORTER).

For example, applications submitted in FY2024 will use data from FY 2021, FY 2022 and FY 2023. 

Organizational eligibility for this NOFO is limited to research-active, baccalaureate-degree granting organizations as defined above. Research-intensive organizations are not eligible to apply for or receive U-RISE grants, but may be eligible to apply for MARC grants (see Part 1, Companion Funding Opportunity).

The application must be submitted by the eligible organization with a unique entity identifier (UEI) and a unique NIH eRA Institutional Profile File (IPF) number. For organizations with multiple campuses (e.g., main, satellite, etc.), eligibility can be considered for an individual campus only if a UEI and a unique NIH eRA IPF number are established for the individual campus. For organizations that use one UEI or NIH IPF number for multiple campuses, eligibility is determined for the campuses together.

Organizations funded through this NOFO are eligible for other NIGMS Training programs provided the other eligibility criteria are met. To avoid any potential for overlap, applicants are strongly encouraged to contact the program officers of each program before applying.

The sponsoring organization must assure eligibility and support for the proposed program. Appropriate information about eligibility and organizational commitment to the program should be detailed according to the Letters of Support attachment instructions in Section IV.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Applicant Organizations

Applicant organizations must complete and maintain the following registrations as described in the SF424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

• System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
• NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
• Unique Entity Identifier (UEI) – A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.
• eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
• Grants.gov – Applicants must have an active SAM registration in order to complete the Grants.gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Any individual(s) with the skills and knowledge necessary to carry out the proposed research training program as the Training Program Director/Principal Investigator (Training PD/PI) is invited to work with their organization to develop an application for support. Individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support. See, Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities, NOT-OD-22-019.

For organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

As described in the instructions for the Training Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) in Section IV.2 below, NIGMS encourages multiple PDs/PIs, particularly when each brings a unique perspective and skill set that will enhance training. Note the following:

• To provide research training leadership for the program, at least one of the Training PDs/PIs should have a record of using rigorous and transparent methods in experimental design, data collection, analysis, and reporting in a biomedical research field applicable to the program.
• Additional PDs/PIs may be included to strengthen the expertise of the PD/PI team. Examples include individuals such as program directors who regularly interact with students, or individuals with expertise in education, relevant social sciences, program evaluation, mentoring, efforts to promote broad participation in the biomedical sciences, or university administration. 

Any of the PDs/PIs may serve as the contact PD/PI. The contact PD/PI is expected to have a full-time appointment at the applicant organization unless extremely well-justified. If the full-time status of the contact PD/PI changes after the award, the organization must obtain prior program approval to appoint a new PD/PI or request a deviation from the full-time rule. The PD(s)/PI(s) will be responsible for:

• The overall direction, management, and administration of the program, including ensuring the training program is appropriately evaluated.
• The day-to-day administration of the program, including direct involvement with trainees.
• The selection and appointment of trainees to the research training program.
• The selection of faculty mentors for the program, assessment of mentor performance, and ensuring the program deals appropriately with substandard mentor performance.
• Facilitating arrangements for trainees to participate in summer research experiences (SREs) by the spring of each year. 
• Monitoring and assessing the program and submitting all documents and reports as required.
• Appointing members of the Advisory Committee (when applicable) and implementing their guidance as appropriate.

2. Cost Sharing

This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility

NIGMS will accept only one application per eligible organization. NIGMS will support only one U-RISE program per applicant organization.

NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

• A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
• A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
• An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications).

Preceptors/Mentors (Participating Faculty)

The selected faculty should demonstrate the ability to promote authentic research experiences for undergraduates (for example, through recent publications or abstracts at external scientific meetings with undergraduates). Research areas of the participating faculty must fall within the NIH mission. When building a training team, programs should include faculty who are committed to training, mentoring, and providing supportive and inclusive research environments. Programs are encouraged to recruit prospective preceptors/mentors from a wide variety of backgrounds, for example faculty from underrepresented groups (see  Notice of NIH's Interest in Diversity ), faculty at different career stages (for example, early-career as well as established faculty), and faculty from the breadth of biomedical disciplines at the applicant organization. 

Trainees

The applicant organization will select the trainees to be supported by the research training program. It is the responsibility of the organization to establish the qualifications, consistent with applicable law, of the trainees before they are supported by the program.

The individual to be trained must be a citizen or a noncitizen national of the United States or have been lawfully admitted for permanent residence at the time of appointment. Additional details on citizenship, training period, and aggregate duration of support are available in the NIH Grants Policy Statement.

All trainees are required to pursue their research training full time, normally defined as 40 hours per week, or as specified by the sponsoring organization in accordance with its own policies. Appointments are normally made in 12-month increments, and no trainee may be appointed for less than 9 months during the initial period of appointment, except with prior approval of NIGMS. NIGMS expects that, with satisfactory progress, trainees will complete the entire 2-3 year training experience. Training grant funds may not be used to support short-term undergraduate biomedical research training. 

Trainees funded through this program must be enrolled in a program leading to a baccalaureate degree.

Section IV. Application and Submission Information

1. Requesting an Application Package

The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission

It is critical that applicants follow the Training (T) Instructions in the How to Apply - Application Guide except where instructed in this Notice of Funding Opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations

All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission

The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this NOFO.

SF424(R&R) Cover

All instructions in the SF424 (R&R) Application Guide must be followed with the following additional instructions.

Descriptive Title of Applicant's Project: Use the format U-RISE at Name of Organization

SF424(R&R) Project/Performance Site Locations

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424 (R&R) Other Project Information

All instructions in the SF424 (R&R) Application Guide must be followed.

Are Human Subjects Involved: Check "No" unless the training program itself requires the trainees to take a workshop or course that will involve human subjects, for example, students collect and analyze samples from humans in a required course.

Are Vertebrate Animals Used: Check "No" unless the training program itself requires the trainees to take a workshop or course that will involve vertebrate animals, for example, students use vertebrate animals in a required laboratory class. 

Project Summary/Abstract: Use the page limitations, but do not follow the instructions provided in the SF424 (R&R) Application Guide; instead, applicants must follow the instructions below.

Provide an overview of the training program, including the mission, objectives, rationale, and program elements. Highlight activities that promote trainee skills development and facilitate undergraduate degree completion as well as the successful transition into and completion of biomedical, research-focused higher degree programs. Indicate the planned student year(s) and duration of appointments, the projected number of trainees and intended trainee outcomes.

Facilities & Other Resources: Do not follow the instructions provided in the SF424 (R&R) Application Guide for this section; instead, applicants must follow the instructions below.

Describe the scientific and educational facilities, resources, and environment that contribute to the probability of success of the research training program. Do not include any data or examples of data, hyperlinks, or any material not listed as allowable for Facilities & Other Resources section of the SF424 (R&R) Application Guide. Applications should address the following when describing the scientific and educational facilities, resources, and environment:

• The ways trainees will benefit from features of the scientific and educational environment, for example, classrooms, scientific facilities, offices, conference rooms, and other training spaces.
• How the scientific and educational facilities create a safe, accessible, and inclusive training environment for individuals from all backgrounds, including individuals from underrepresented groups (see Notice of NIH's Interest in Diversity). Include descriptions of the technological resources available and enhancements to physical spaces that increase access for trainees with disabilities. For example, the accessibility of:
  • Classrooms, scientific facilities, offices, conference rooms, and other training spaces.
  • Public and internal web pages.
  • Meetings or events.
  • Announcements, blogs, and other communication modalities.
  • Transportation, such as shuttle buses. 

If there are multiple performance sites, describe the resources available at each site.

Other Attachments: Please include a header or footer label on each page of the other attachments with the corresponding material title.

The following two attachments must be included as PDF files, or the application will not be reviewed:

1. Baseline Program Data (required): The application must provide baseline data on the proposed program. The data must reflect the pool of participating faculty, training grant eligible (TGE) undergraduates, and the characteristics of the TGE undergraduates for the current academic year. The data serve as a basis for review of planned activities, including recruitment. The number of TGE candidates will be used to determine the appropriate budget and number of funded positions. NIGMS will use the data provided in a manner consistent with applicable law.

• Census of Participating Departments or Interdepartmental Programs: For the current academic year, for each participating department or program, provide:
  • Faculty – Total number and number participating in the proposed program.
  • Undergraduates – Total number and number of training grant eligible (TGE) undergraduates (this number will reflect students who are citizens or non-citizen nationals of the U.S. or permanent residents). Include the total supported by any training award, and in the case of renewals/revisions, the number supported by this training grant.

NIGMS encourages the use of Suggested Formats C to aid in the structuring of the data

• Trainee Pool Characteristics: For each participating department or program, provide information on the characteristics of TGE undergraduates for the current academic year. Applicants are encouraged to use categories reflected in the Notice of NIH's Interest in Diversity or the NIH Trainee Diversity Report (such as race, ethnicity, gender, disability and disadvantaged background) as these data will be collected as part of annual progress reports for funded programs. Additional trainee candidate pool characteristics that are relevant to the goals of the training program may also be included. Applicants should use appropriate methods for data privacy, confidentiality, and security practices related to student data systems and reporting (for example, cell sizes for sensitive data).

NIGMS encourages the use of Suggested Formats D to aid in the structuring of the data.

Please name the file “Baseline_Program_Data.pdf”.

2. Recruitment Plan to Enhance Diversity (3-page maximum, required): The applicant must provide a Recruitment Plan to Enhance Diversity. Baseline data on the trainee pool should inform the Recruitment Plan to Enhance Diversity. Include outreach strategies and activities designed to recruit potential training program candidates who are from underrepresented groups, for example students from underrepresented racial and ethnic groups, individuals with disabilities, and students from disadvantaged backgrounds (see Notice of NIH's Interest in Diversity). Applicants are encouraged to consult the NIGMS web page for strategies to enhance diversity in training programs when designing their plans. Describe the specific efforts to be undertaken by the training program and how these might coordinate with trainee recruitment efforts of the organization. Centralized organizational efforts alone will not satisfy the requirement to recruit prospective trainees from underrepresented groups. Participating faculty are expected to be actively involved in recruitment efforts. Please name the file “Recruitment_Plan.pdf”.

The following attachments may be included but are not required:

• Advisory Committee (1-page maximum): An Advisory Committee is not a required component of a training program. However, if an Advisory Committee is intended, provide a plan for the appointment of an Advisory Committee to monitor progress of the training program in a PDF file. The roles, responsibilities, and desired expertise of committee members (for example, including disability inclusion experts), frequency of committee meetings, and other relevant information should be included. Describe how the Advisory Committee will assess the overall effectiveness of the program. Only pre-existing Advisory Committee members should be named in the application. Potential Advisory Committee members should not be identified or contacted prior to receiving an award. Please name the file “Advisory_Committee.pdf”.
• Training Activities (10-page maximum): The Training Activities attachment may include brief descriptions of required and representative elective courses, workshops, and training activities (for example, streamlined syllabi with topics, timelines, activities, and credits). This attachment is meant to provide additional details but is not meant to substitute for clear descriptions of the courses and training activities in the Program Plan. Please name the file “Training_Activities.pdf”.

The filename provided for each “Other Attachment” will be the name used for the bookmark in the electronic application in eRA Commons.

SF424(R&R) Senior/Key Person Profile Expanded

Follow all instructions provided in the SF424 (R&R) Application.

Biographical Sketch: The personal statement should describe the individual's commitment to scientific rigor, training, and mentoring, as well as to promoting inclusive, safe, and supportive scientific environments.

PHS 398 Cover Page Supplement

Follow all instructions provided in the SF424 (R&R) Application.

PHS 398 Training Subaward Budget Attachment(s)

Follow all instructions provided in the SF424 (R&R) Application Guide.

Training Budget

Follow all instructions provided in the SF424 (R&R) Application Guide with the following additional modifications:

• Include all allowable categories of funds requested to support trainees in the program.
• As per the instructions, request actual amounts for tuition/fees and provide justification. The amounts may be adjusted at the time of award.

Budget Justification: Follow all instructions provided in the SF424 (R&R) Application Guide with the following additions:

• State the number of requested funded trainee slots per year. Provide a justification for the number of requested funded slots per year in the context of the following:
  • Number of training grant eligible candidates provided in the trainee pool baseline data across all departments participating in the training program.
  • Number of participating faculty.
  • Other NIGMS-funded training grants at the organization that relate to the goals of this training program.
  • For Renewal Applications: The success in filling the awarded training positions. An explanation for the failure to fill previously requested slots should be provided in the application.
• Describe the total effort for key personnel in the budget justification (including effort charged to the grant and effort compensated by other sources).

PHS 398 Research Training Program Plan

The PHS 398 Research Training Program Plan Form is comprised of the following sections:

• Training Program Section
• Faculty, Trainees, and Training Record Section
• Other Training Program Section
• Appendix

Follow all instructions provided in the SF424 (R&R) Application Guide.

Attention must be given to the required Training Data Tables for New or Renewal applications. In the Program Plan, applicants should also summarize key data from the tables that highlight the characteristics of the training grant eligible pool, program faculty, organizational support, student outcomes, and other factors that contribute to the overall training environment of the program.
 

Training Program

Program Plan

The Program Plan attachment is required and must adhere to the NIH Table of Page Limits, as well as the organization and instructions provided below.

Do not follow the organization and instructions provided in the SF424 (R&R) application guide for the Program Plan attachment; instead, applicants must use the instructions below. The sections for the program plan are: 

• Rationale, Mission, and Objectives
• Curriculum and Overall Training Plan
• Career Development
• Program Oversight of Training and Mentoring
• Training Program Director(s)/Principal Investigator(s) (PDs/PIs)
• Preceptors/Mentors (Participating Faculty)
• Candidate Review Process
• Trainee Appointments and Financial Support
• Trainee Outcomes
• Program Evaluation Plan, Dissemination, and Data Storage

Start each section with the relevant heading below.

Rationale, Mission, and Objectives 

The application should describe how the program will promote broad participation in the biomedical research workforce by strengthening the research training environment and expanding the  pool of well-trained undergraduates who will:

• Have the technical, operational, and professional skills required to conduct research in a safe, ethically responsible, and rigorous manner.
• Complete their baccalaureate degree and transition into and complete biomedical, research-focused higher degree programs.

The application should describe how the program will, or will continue to, enhance the training environment - going beyond simply providing financial assistance for trainees to conduct research. Specifically, applicants should describe the following:

• The justification for the proposed research training program, considering the organizational context. Specifically describe how the proposed program:
  • Will enhance, but not duplicate current organizational efforts  to create and sustain inclusive research training environments. 
  • Is tailored to leverage the applicant organization's strengths to address its research training needs. 
  • Provides research training opportunities for trainees in the breadth of biomedical research disciplines available at the organization that are relevant to the NIH mission. 
• The current research training environment. Specifically:
  • Describe the research training program including, but not limited to, any relevant background information, an overview of the current research training activities of the participating department(s) or unit(s), and areas for improvement in the current research training practices. 
  • Demonstrate the presence of a sufficient number of potential trainees in appropriate disciplines, program faculty with the appropriate scientific, training and mentoring expertise (Tables 2 and 4), and current research training resources of the organization (Table 3) to support the proposed program.
• The training mission (broad statement of purpose of the program), and objectives (specific, measurable outcomes the program intends to achieve). The program-specific mission and objectives should align with the Overarching Objective of this funding opportunity while focusing on developing the skills required to complete the baccalaureate degree, and transition to and complete biomedical research focused higher degree programs.
  • Describe the training program goals in the context of the “Trainee Outcomes” data requested below that provides organizational baseline data on previous student outcomes.   Objectives should include, but not be limited to:
    • Baccalaureate degree completion rates,
    • Appropriate time-to-degree, and
    • The rate of and time frame for transitioning into and completing of research-focused higher degree programs. 

Curriculum and Overall Training Plan

The application should describe the curriculum and overall training plan, including the required and elective courses, structured activities, and research experiences. In developing the overall training plan, the application should describe:

• The trainees’ academic and research background needed to pursue the proposed training and plans to accommodate differences in preparation among trainees.
• Proposed changes or current research training practices (for example, curricular reforms) designed to keep pace with the rapidly evolving biomedical research enterprise.

The application may include additional supporting information (for example, streamlined syllabi with topics, timelines, activities, credits, etc.) in an optional Training Activities “Other Attachment”. The narrative should emphasize when the curriculum and overall training plan employ evidence-informed approaches and how these activities are designed to develop trainees' skills and accomplish the stated training mission and objectives. 

Applicants should address the following:

• Courses, skills development, and cohort activities. Describe: 
  • Representative examples of program activities for individual trainees and how they coordinate with the trainees’ degree granting department requirements. Examples can include degree requirements, didactic courses, laboratory experiences, seminars, journal clubs, career development activities, training in scientific writing and communication skills, etc. 
  • Activities that will build a strong cohort of research-oriented individuals while enhancing the science identity, self-efficacy, and a sense of belonging among the cohort members.
  • Plans to develop trainees' quantitative and computational skills.
  • Areas in the curriculum where key topics related to rigor and reproducibility in research (for example, experimental design) and responsible conduct of research (for example, safety, community engagement, societal considerations related to research) are reinforced or elaborated relative to what is outlined in the Methods for Enhancing Reproducible Research and Responsible Conduct of Research plans. 
  • Any ways in which the training activities will be available to other students in the program(s), department(s) or organization(s) from which the supported trainees are drawn.
• Authentic research experiences. Describe:
  • The mechanisms to ensure that trainees participate in authentic research experiences throughout the training period. Applications that propose classroom-centered research training activities should describe the learning objectives, course attributes, participating faculty, training frequency, and expected trainee outcomes. If trainee research experiences include other organizations, describe how the PD(s)/PI(s) will interact with the research mentors to promote trainee success.
  • The plans to ensure that trainees complete at least one summer research experience (SRE) that broadens and deepens their research training. Applicants are encouraged to include letters of support from organizations they intend to partner with for trainee SRE experiences. 
• For multidisciplinary and/or multi-departmental programs, indicate how the individual disciplinary and/or departmental components of the program are integrated and coordinated, and how they will relate to an individual trainee's experience. 
• The ways, when applicable, that the training plan is distinct from, but will share resources and synergize with, other relevant NIGMS-funded research training programs at the same organization (NIGMS training programs listed in Table 3). See the "Program Considerations" section above for additional context. The application should expand upon, but not duplicate, information on overlap and synergies described in the Organizational Support Letter. NIGMS expects that the training program will be distinct with respect to the training goals; however, collaborative activities such as the responsible conduct of research training, career and professional skill development, etc. are encouraged.

Career Development

The application should describe the following:

• How the pool of potential program candidates and trainees will be provided with information about the career outcomes of graduates of the program and about the overall biomedical research workforce employment landscape.
• How trainees in the program will be provided with adequate, appropriate and timely information regarding the steps required to transition into the next phase of the biomedical research workforce pathway (e.g., when applying to research-focused higher degree programs or funding opportunities).
• How the trainees will be sponsored or mentored by individuals who will enhance their career opportunities (e.g., contacts at national meetings and institutions with NIH-funded T32 training programs, as well as members of scientific societies, and the research community).

Program Oversight of Training and Mentoring

The application should include the planned strategy and administrative structure to oversee and monitor the program, and to ensure appropriate and timely trainee progress for the duration of the trainees' undergraduate careers. If a program coordinator or administrator position is planned to enhance oversight, a description of the person's administrative capabilities that are essential to coordinate the program should be included in the application. The application should describe the following (including who is responsible for the oversight):

• How the program ensures the use of evidence-informed training and mentoring practices that promote the development and retention of all trainees with the recognition that the variety of trainee backgrounds and experiences may necessitate the need to tailor the approaches. The plans should be specific for the student population and program proposed.
• How the program ensures that all participating department(s) and organization(s) are promoting the development and retention of trainees for the duration of their undergraduate careers. 
• Program mechanisms to ensure participating faculty:
  • Are instructed and evaluated as teachers and mentors (for example, pedagogy and mentor training).
  • Employ the highest standards of scientific rigor and impart those standards to their trainees.
  • Reinforce and augment the curricular material on responsible conduct of research, and methods for enhancing reproducibility.
  • Engage in activities that promote trainee career development (including but not limited to the utilization of Individual Development Plans) and fulfill the need of the trainees to obtain their degrees in a timely fashion with the skills, credentials, and experiences needed to transition to the next phase of the biomedical research career pathway, consistent with the trainees’ interests and values.
• The mechanisms employed to: 
  • Match trainees with the appropriate participating faculty (for example, laboratory rotations, faculty forums, and interviews).
  • Monitor mentoring, including oversight of the effectiveness of the trainee/research mentor match.
  • Address conflicts within the training environment that may impede trainee progress, for example, conflicts between mentor-mentee, peer-peer, faculty-student, staff-trainee, or faculty-faculty.
  • Remediate and, as appropriate, remove faculty displaying unsatisfactory mentorship qualities from the training program.

Training Program Director(s)/Principal Investigator(s) (PDs/PIs)

The application should describe how the Training Program Director(s)/Principal Investigator(s) (PDs/PIs) will promote the success of the trainees and training program. NIGMS strongly encourages multiple PDs/PIs, particularly when each brings a unique perspective and skill set that will enhance training as described in the Eligible Individuals section. In addition, the use of multiple PDs/PIs provides stability to the program in the event that one PD/PI leaves unexpectedly. The application should expand on the information in the biosketch(es) to address how the PD/PI or PD/PI team has:

• The scientific expertise, as well as the administrative and training experience, to provide strong leadership, direction, management, and administration of the proposed research training program. At least one member of the PD/PI team should have a record of using rigorous methods in experimental design, data collection, analysis, and reporting in the discipline(s) described in the application.
• The time to commit sufficient effort to ensure the program’s success given other professional obligations (the application should indicate the PD(s)/PI(s)’s percent effort in the proposed program). Describe the PD(s)/PI(s) commitment to the day-to-day administration of the program, including direct involvement with trainees.
• A demonstrated commitment to training future biomedical researchers, leading recruitment efforts to promote broad participation, and fostering inclusive research environments.
• Received training on how to effectively mentor trainees from all backgrounds, including trainees from groups underrepresented in the biomedical sciences (see Notice of NIH's Interest in Diversity). The training should have material on supporting trainees with disabilities, and how to eliminate  barriers to full participation.

The application should describe the administrative structure and leadership succession plan for critical positions (for example, all PD(s)/PI(s)).

Preceptors/Mentors (Participating Faculty)

Describe how the program has or will recruit a pool of prospective faculty from a wide variety of backgrounds to provide potential role models within the training program and to enhance the effectiveness of the training environment. Describe how mentors provide opportunities for research in the breadth of biomedical research disciplines available at the organization. The application should summarize and expand on the material presented in the “Training Tables” and biosketches and address how the participating faculty:

• Receive training in effective, evidence-informed teaching and mentoring practices that promote the development of trainees from all backgrounds.
• Have sufficient time to commit to training and mentoring given their other professional obligations.
• Ensure participating faculty research group sizes are not too large to allow effective training and mentoring.
• Cooperate, interact, and collaborate (which can include joint sponsorship of trainee research).
• Promote the use of the highest standards of practice to ensure the safety of all individuals in the research environment.
• Conduct and promote the development of trainee skills in approaches to rigorous and unbiased experimental design, methodology, analysis, interpretation, and reporting of results as well as ethically sound and responsible scientific research.
• Provide opportunities for trainees to conduct biomedical research with increasing self-direction.
• Demonstrate a commitment to effective mentoring, and to promoting inclusive, safe, accessible, and supportive scientific and training environments.
• Are willing to engage in activities to promote the trainees’ career goals and to support trainees participating in activities required to identify and transition into the next phase of the biomedical research career pathway consistent with the trainees' skills, interests, and values.

Candidate Review Process

The following areas should be addressed:

• Describe plans for a candidate review process that will allow a broad group of research-oriented trainees the ability to participate in the training program. The process should consider, consistent with applicable law, metrics beyond grade point average and standardized test scores. Programs are encouraged to consider individuals who have the potential to strongly benefit from, and with proper training and support, succeed in the program. If the program trainees are drawn from multiple departments, describe how the PD(s)/PI(s) will ensure that the review process is consistent across all relevant departments. As noted in the Program Considerations in section I above, funded programs may not use the race, ethnicity, or sex (including gender identity, sexual orientation, or transgender status) of a trainee candidate as an eligibility or selection criteria.

Trainee Appointments and Financial Support

Applicants must describe the proposed financial support structure and appointment processes. NIGMS-funded training programs are intended to maximally increase the development of a pool of promising trainees from a range of backgrounds.  Appointing only trainees who already have strong research credentials and skills, or appointing trainees for a shorter period than two years, is unlikely to achieve this goal. Applicants should describe:

• The selection and re-appointment processes for the training grant supported trainees from the larger training grant eligible pool. 
• The stage in the trainees’ careers they will be supported on the training grant and the length of appointments. 

Trainee Outcomes

This section is intended to provide student outcomes to:

• Provide baseline data for programs that have not been funded by NIGMS (that is, provide outcomes for students who would have been eligible for the proposed training program had it been previously funded by NIGMS), or 
• Measure the outcomes for organizations with existing NIGMS programs (for example, those submitting renewal applications or those submitting new applications to replace previously funded NIGMS T34/R25 programs that supported undergraduate students). For organizations with similar previously supported NIGMS programs, but are applying as “new” applications, only include previously appointed trainees/participants.

The application should provide the information below about recent outcomes through narrative descriptions and a summary of the data presented in the required training tables. Although the training tables for applications submitted as “new” applications only allow for five years of recent outcomes, the application may describe up to 15 years of outcomes in the narrative. Applicants may include tables in the narrative, but they must have different labels than the required Data Tables. Please see Program Considerations when determining if the application should be submitted as “New” or a "Renewal". Applicants are encouraged to describe the data for recent program graduates for existing programs or relevant students for new programs, including the following:

• Evidence that recent program graduates participated in authentic research experiences and scholarly activities to promote scientific identity (for example, presentations at external scientific meetings, co-authorship on peer-reviewed publications in Training Table 5, or other measures of scientific accomplishment appropriate to the field).
• The rate of baccalaureate degree attainment and time-to-degree for recent program graduates (Training Table 8). Explain how the time-to-degree was calculated. Include outcome data regarding the number of former individuals in the program who graduated with a baccalaureate degree in a STEM field (obtained goal), remained in the program (still in training), or did not obtain a baccalaureate degree (attrition). The application should include organizational comparator groups (for example, similar students who were not in the program) and the graduation rates for all students at the organization in the biomedical fields represented. 
• The success of recent program graduates transitioning into  the next phase in the biomedical research workforce pathway (for example, matriculation to a research-focused higher degree program or another program that supports that goal such as postbaccalaureate training; Training Table 8 ).

If disparities are observed, describe approaches to identify the causes and, where warranted, the approaches to feasibly address the issues in the Program Plan.

Program Evaluation Plan, Dissemination, and Data Storage

NIGMS-funded training programs must conduct ongoing program evaluations to monitor the success of the training and mentoring activities. Funded programs are expected to report on outcomes through annual progress reports and renewal applications. The application may include blank survey instruments, rubrics, or forms in an appendix, according to the instructions for the Appendix as described in the SF424 (R&R) Application Guide. Applicants should describe:

• The plan for program evaluation to determine whether the training program is effective in meeting the training mission and objectives. Describe plans to ensure the evaluator(s) have appropriate independence from directing program activities (note: the evaluator can come from same the organization if appropriately independent from directing program activities). 
• Methods to determine if the research training climate is perceived as inclusive, safe, and supportive of trainee development and retention by the trainees, faculty and staff. Include methods to attain reliable and representative input and to safeguard anonymity to ensure candid feedback.
• Mechanisms to ensure training program and organizational responsiveness to outcomes analyses, program evaluations, and trainee feedback regarding the effectiveness of the program and the research training climate.
• Activities to track and make available the educational and career outcomes of program graduates (for example, aggregate de-identified data published on the program's website).
• Activities designed to share outcomes and effective practices of the program with the broader community, for example, presenting program data or materials to members of the training community via web postings, or presentations.
• Strategy to ensure the secure storage and preservation of program data and outcomes and how the data will be centralized, safeguarded, and retrievable during leadership and staff changes.

Note: Training Program Evaluation is not a form of human subject research. Training grants prepare individuals for careers in the biomedical research workforce by developing and implementing evidence-informed educational practices including didactic, research, mentoring, and career development elements. While funded programs are expected to conduct ongoing program evaluations and assessments to monitor the effectiveness of the training and mentoring activities, training grant funds are not intended to support Human Subjects Research (see additional information on Human Subjects Research from NIH and HHS).

Plan for Instruction in Methods for Enhancing Reproducibility

Applicants are required to comply with the instructions for the Plan for Instruction in Methods for Enhancing Reproducibility as provided in the SF424 (R&R) Application Guide.

Plan for Instruction in the Responsible Conduct of Research

Applicants are required to comply with the instructions for the Plan for Instruction in the Responsible Conduct of Research as provided in the SF424 (R&R) Application Guide, along with the following additional instructions:

Describe how the Responsible Conduct of Research (RCR) components are well integrated into the overall curriculum, how they are taught at multiple stages of trainee development and in a variety of formats and contexts. Explain how the teaching of RCR synergizes with elements of the curriculum designed to enhance trainees’ abilities to conduct rigorous and reproducible research. Describe how all participating faculty will reiterate and augment key elements of responsible conduct when trainees are performing mentored research in their laboratories.

Progress Report (only for Renewal applications)

The progress report is intended to demonstrate that the program successfully promoted broad participation in the biomedical research workforce by strengthening the research training environment and expanding the pool of well-trained students who completed their baccalaureate degree, and transitioned into and completed biomedical, research-focused higher degree programs.  Renewals are only allowed for programs funded through PAR-19-218 or PAR-21-146. Follow the instructions in the SF424 (R&R) Application Guide, with the following exceptions: For the "Program Overview" section - adhere to the page limit indicated in the SF424 (R&R) application guide but follow the instructions below instead. 

Implementation of Proposed Activities

• Describe the programmatic elements proposed in the previous application and the successes and challenges regarding their implementation. Provide explanations for failing to implement previously proposed programmatic elements. Areas to address may include but are not limited to the following:
  • Strengthening the research training environment to promote trainee success. 
  • Incorporating evidence-informed training and mentoring practices into the program.
  • Teaching rigor and transparency, and the responsible and safe conduct of research throughout the training experience.
  • Enhancing accessibility and inclusive research training environments.
  • Overseeing all aspects of the program (for example, the mentor/mentee matches, the participating faculty, and trainee progress, including summer research experiences).
  • Preparing trainees to complete their baccalaureate degree, and transition into and complete a research-focused higher degree program.
• Highlight how the training program evolved in response to changes in relevant scientific and technical knowledge, and educational practices.
• Describe how the funds provided under Training Related Expenses were used to benefit the training program.

Results and Changes from Program Evaluations

• Present the results of program evaluations and any changes to the program made based on them. Indicate the period for the data presented. If the methods for data collection differ from the Program Evaluation plan, explain the differences. Discuss the evidence that the specific and measurable objectives described in the previous application were achieved, and if not, provide a justification.
• Expand upon the "Training Outcomes" section and highlight successes or areas for improvement. Identification of areas for improvement is necessary for supporting a healthy and maximally effective training program and an inability to recognize them will be viewed as a deficiency.
• Discuss the evidence that the scientific research climate is inclusive, safe, and supportive of trainee development and success.
• Describe how the program responded to student feedback, analyses, critiques, surveys, and other program assessments. Describe the potential barriers to success and indicate changes to the program designed to address these barriers.

Impact and Dissemination

• Describe the impact of the program (for example, on the curriculum, training environment, or organizational policies and practices).
• Indicate whether the program staff disseminated the outcomes and effective practices to the broader training community. Describe how the program makes training and career outcomes publicly available.

Faculty, Trainees, And Training Record

Participating Faculty Biosketches

Participating faculty should provide a personal statement that describes the appropriateness of their research background for the proposed training program, and their commitment to the following:

• Training, mentoring, and promoting inclusive, safe, accessible, and supportive research environments.
• Maintaining a record of, and providing training in rigorous and unbiased experimental design, methodology, analysis, interpretation, and reporting of results.
• Teaching trainees to conduct biomedical research with increasing responsibility and self-direction.
• Supporting trainees participating in activities required to transition to the next phase of the biomedical research workforce pathway (for example, when applying to research-focused higher degree, or funding opportunities) that are consistent with the trainees’ skills, interests, and values.

Letters of Support

Organizational Eligibility and Support Letter (10-page maximum). The application must include a signed letter on letterhead from a President, Provost, Dean, or similar key leader that (i) certifies organizational eligibility, and (ii) describes the activities and resources provided by the organization that will ensure the success of the planned training program and its trainees. If this letter is not included, the application will be considered incomplete and will not be reviewed. The letter must describe:

(i) Organizational Eligibility: Certify that the applicant organization, as described by UEI and NIH IPF number:

• Is research-active, that is, has an average of RPG funding less than $7.5 million total costs (both direct and F&A/indirect costs) per year over the past 3 fiscal years, as described in Section III, “Eligible Organization”. 
• Grants its own baccalaureate degrees. 

(ii) Organizational Support: Describe the organizational commitment to the following areas (as applicable):

• Providing trainees access to student support services, such as healthcare, counseling, and housing.
• Supporting the PDs/PIs, participating faculty and other key administrative staff associated with the planned training program (for example, salary support, protected time).
• Ensuring sufficient start-up funding to permit early-stage faculty to participate in training, or funding to ensure that authentic research experiences training may continue if a mentor experiences a hiatus in external funds.
• Fostering and rewarding excellence in training and mentoring (for example, through organizational polices regarding tenure and promotion).
• Supporting the remediation or removal of participating faculty from the program who are poorly performing mentors.
• Supporting research training at the undergraduate level (for example,  support of an office of undergraduate research, undergraduate biomedical research counting towards course credit hours or degree requirements, protected time and resources for faculty to develop and sustain course-based undergraduate research experiences). 
• Supporting the scientific and educational facilities, technology, and curricular components in the proposed research training program (for example, classroom enhancements, funds for course development, appropriate course scheduling, accessibility equipment). Expand upon, but do not duplicate information provided in the Facilities and Other Resources attachment.
• Developing and promoting a culture in which the highest standards of safety, scientific rigor, reproducibility, and responsible conduct are advanced.
• Policies to promote  broad participation, including from individuals from underrepresented groups, at all levels of the research training environment (trainees, staff, faculty, and leadership).
• Ensuring a positive, supportive, safe, accessible, and inclusive research and training environment for individuals from all backgrounds. For example, ensuring that the communication and physical spaces are welcoming, comfortable, and safe to use and navigate. 
• Understanding and providing resources to remove barriers and challenges confronting people with disabilities (for example, ableism frameworks, ableist language, lack of accessibility, attitudinal and discriminatory practices) that prevent or impede people with disabilities from entering and succeeding in the scientific workforce.
• Ensuring that proper policies, procedures, and oversight are in place to prevent harassment and other discriminatory practices and to appropriately respond to allegations of such discriminatory practices, including providing notification of removal or disciplinary action involving Program Directors/Principal Investigators or other Senior/Key Personnel; see NOT-OD-22-129).
• Providing resources and expertise for evaluating the training outcomes of the program.
• For organizations that have other relevant NIGMS-funded training grants, what distinguishes the proposed program with respect to the scientific research training area from existing ones at the same organization. The letter should describe how the programs will collaborate and share resources when appropriate for non-discipline specific activities, and how the training faculty, pool of potential trainees, and resources are sufficiently robust to support the proposed program in addition to existing ones. 

Other Letters of Support. Additional letters of support (for example, from partner organizations) are permitted; however, these letters may not contain any information required in the Organizational Support Letter described above.

Combine all Letters of Support into a single PDF file.

Data Tables

The application must include the required Training Data Tables for undergraduate training applications. Applications that do not contain the required tables, or that submit any additional tables in this attachment will be considered noncompliant and may not be reviewed.

Appendix:

Limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide; any instructions provided here are in addition to the SF424 (R&R) Application Guide instructions.

PHS Assignment Request Form

All instructions in the SF424 (R&R) Application Guide must be followed.

3. Unique Entity Identifier and System for Award Management (SAM)

See Part 2 . Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov

4. Submission Dates and Times

Part 1 . Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH’s electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

5. Intergovernmental Review (E.O. 12372)

This initiative is not subject to intergovernmental review.

6. Funding Restrictions

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The National Research Service Award (NRSA) policies apply to this program. An NRSA appointment may not be held concurrently with another Federally sponsored fellowship, traineeship, or similar Federal award that provides a stipend or otherwise duplicates provisions of the NRSA.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement. Note, however, that pre-award costs are not allowable charges for stipends or tuition/fees on training grants because these costs may not be charged to the grant until a trainee has actually been appointed, and the appropriate paperwork submitted to the NIH awarding component. Any additional costs associated with the decision to allow research elective credit for short-term research training are not allowable charges on a training grant.

NIGMS does not permit automatic carryover of training grant funds from one budget period to the next.

7. Other Submission Requirements and Information

Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.

Important reminders:

All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organization’s profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide.

See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and NIGMS. Applications that are incomplete or non-compliant will not be reviewed.

Applicants Requesting $500,000 or more for direct costs (less consortium F&A) in any year

Applicants requesting $500,000 or more in direct costs in any year are not required to contact a Scientific/ Research Contact prior to submitting an application. The Policy on the Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs as described in the SF424 (R&R) Application Guide is not applicable to this NOFO.

Post Submission Materials

Applicants are required to follow the instructions for post-submission materials, as described in the policy.

Section V. Application Review Information

Only the review criteria described below will be considered in the review process.

Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.

For this particular announcement, note the following: NIGMS recognizes that rigorous, well-designed research training programs that further the goal of the U-RISE program  can take place in a wide variety of organizational environments and with mentors who have varying levels of NIH research project grant support. Reviewers should evaluate proposed programs considering their stated objectives, organizational context, available resources, and the capacity of those resources to meet the stated objectives. Reviewers should evaluate with the understanding that U-RISE eligible organizations are limited in the amount of NIH RPG funding in order to be eligible for the program, and that applicants vary in the amount of NIH RPG funding within the research-active category.  Reviewers should note that identification of current challenges and short-comings can be viewed as positive factors if accompanied by sound plans for how the applicant would use the U-RISE award to overcome or remediate them.

Reviewers should also note that while any information relevant to the program goals can be included as part of the review process, the race, ethnicity, or sex (including gender identity, sexual orientation, or transgender status) of trainee candidates, trainees, or faculty may not, in and of themselves, be used as factors in the evaluation of applications.

Overall Impact

Reviewers will provide an overall impact score in consideration of the following review criteria and additional review criteria (as applicable for the proposed program). The overall impact score should reflect the reviewers' assessment of the likelihood that the proposed program will promote broad participation in the biomedical research workforce by strengthening research training environments and expanding the pool of well-trained students who complete their baccalaureate degree, and transition into and complete biomedical, research-focused higher degree programs (such as Ph.D. or M.D./Ph.D). Specifically, whether the structured training activities, mentoring, and research experiences will equip the trainees with:

• A broad exposure to foundational biomedical disciplines.
• The skills to acquire the knowledge needed to advance their chosen fields and careers.
• The ability to think critically about important biomedical research questions and approaches that push forward the boundaries of their areas of study.
• A strong foundation in scientific reasoning, rigorous research design, experimental methods, quantitative and computational approaches, and data analysis and interpretation.
• The skills to conduct research in the safest manner possible, and a commitment to approaching and conducting biomedical research responsibly, ethically, and with integrity.
• Experiences conducting, interpreting, and presenting rigorous and reproducible biomedical research with increasing self-direction.
• The ability to work effectively in teams with colleagues from a variety of cultural and scientific backgrounds, and to promote inclusive and supportive scientific research environments.
• The skills to communicate scientific methodologies and findings to a wide variety of audiences (for example discipline-specific, across disciplines, and for the public).
• The knowledge, professional skills and experiences required to identify and transition into careers in the biomedical research workforce (for example, the breadth of careers that sustain biomedical research in areas that are relevant to the NIH mission). 

Reviewers will consider each of the review criteria below in the determination of the merit of the training program and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major research training impact.

As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.

As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

Applications will be evaluated for merit by (an) appropriate Scientific Review Group(s), convened by NIGMS in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons. Following initial peer review, recommended applications will receive a second level of review by the National Advisory General Medical Sciences Council. As part of the scientific peer review, all applications:

• May undergo a selection process in which only those applications deemed to have the highest merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
• Will receive a written critique.
• Compete for available funds with all other recommended applications. 

Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board.

The following will be considered in making funding decisions, consistent with applicable law:

• Merit of the proposed research training program as determined by scientific peer review.
• Availability of funds.
• Relevance of the proposed research training program to NIGMS priorities.
• Broad geographic and organizational distribution.
• Contributions to portfolio breadth as outlined in the NIGMS Strategic Plan.

After the peer review of the application is completed, the PD/PI will be able to access their Summary Statement (written critique) via the eRA Commons. Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.

Information regarding the disposition of applications is available in the NIH Grants Policy Statement Section 2.4.4 Disposition of Applications.

Section VI. Award Administration Information

If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement.

A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the recipient’s business official.

Recipients must comply with any funding restrictions described in Section IV.6. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.

Any application awarded in response to this NOFO will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities, including of note, but not limited to:

• Federal-wide Standard Terms and Conditions for Research Grants
• Prohibition on Certain Telecommunications and Video Surveillance Services or Equipment
• Acknowledgment of Federal Funding

If a recipient is successful and receives a Notice of Award, in accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.

Should the applicant organization successfully compete for an award, recipients of federal financial assistance (FFA) from HHS will be required to complete an HHS Assurance of Compliance form (HHS Assurance of Compliance form (HHS 690)) in which the recipient agrees, as a condition of receiving the grant, to administer programs in compliance with federal civil rights laws that prohibit discrimination on the basis of race, color, national origin, age, sex and disability, and agreeing to comply with federal conscience laws, where applicable. This includes ensuring that entities take meaningful steps to provide meaningful access to persons with limited English proficiency; and ensuring effective communication with persons with disabilities. Where applicable, Title XI and Section 1557 prohibit discrimination on the basis of sexual orientation, and gender identity, The HHS Office for Civil Rights provides guidance on complying with civil rights laws enforced by HHS. See https://www.hhs.gov/civil-rights/for-providers/provider-obligations/index.html and https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html.

HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator’s scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO.

• For guidance on meeting the legal obligation to take reasonable steps to ensure meaningful access to programs or activities by limited English proficient individuals see https://www.hhs.gov/civil-rights/for-individuals/special-topics/limited-english-proficiency/fact-sheet-guidance/index.html and https://www.lep.gov.

• For information on an institution’s specific legal obligations for serving qualified individuals with disabilities, including providing program access, reasonable modifications, and to provide effective communication, see https://www.hhs.gov/civil-rights/for-individuals/disability/index.html.

• HHS funded health and education programs must be administered in an environment free of sexual harassment, see https://www.hhs.gov/civil-rights/for-individuals/sex-discrimination/index.html. For information about NIH's commitment to supporting a safe and respectful work environment, who to contact with questions or concerns, and what NIH's expectations are for institutions and the individuals supported on NIH-funded awards, please see https://grants.nih.gov/grants/policy/harassment.htm.

• For guidance on administering programs in compliance with applicable federal religious nondiscrimination laws and applicable federal conscience protection and associated anti-discrimination laws see https://www.hhs.gov/conscience/conscience-protections/index.html and https://www.hhs.gov/conscience/religious-freedom/index.html.

Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at https://www.hhs.gov/ocr/about-us/contact-us/index.html or call 1-800-368-1019 or TDD 1-800-537-7697.

In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a federal agency previously entered and is currently in FAPIIS. The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicant’s integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 and 2 CFR Part 200.206 “Federal awarding agency review of risk posed by applicants.” This provision will apply to all NIH grants and cooperative agreements except fellowships.”

Not Applicable

Note: The NIH Policy for Data Management and Sharing is effective for due dates on or after January 25, 2023.

Consistent with the NIH Policy for Data Management and Sharing, when data management and sharing is applicable to the award, recipients will be required to adhere to the Data Management and Sharing requirements as outlined in the NIH Grants Policy Statement. Upon the approval of a Data Management and Sharing Plan, it is required for recipients to implement the plan as described.

When multiple years are involved, recipients will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement.  Continuation support will not be provided until the required forms are submitted and accepted.

Failure by the recipient institution to submit required forms in a timely, complete, and accurate manner may result in an expenditure disallowance or a delay in any continuation funding for the award.

The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.

The institution must submit a completed Statement of Appointment (PHS Form 2271) for each trainee appointed or reappointed to the training grant for 8 weeks or more. Recipients must submit the PHS 2271 data electronically using the xTrain system. More information on xTrain is available at xTrain (eRA Commons). An appointment or reappointment may begin any time during the budget period, but not before the budget period start date of the grant year.

A final RPPR, the expenditure data portion of the Federal Financial Report, are required for closeout of an award as described in the NIH Grants Policy Statement. NIH NOFOs outline intended research goals and objectives. Post award, NIH will review and measure performance based on the details and outcomes that are shared within the RPPR, as described at 45 CFR Part 75.301 and 2 CFR Part 200.301.

In accordance with the regulatory requirements provided at 45 CFR 75.113 and 2 CFR Part 200.113 and Appendix XII to 45 CFR Part 75 and 2 CFR Part 200, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period. The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS). This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 and 2 CFR Part 200 – Award Term and Condition for Recipient Integrity and Performance Matters.

In carrying out stewardship of grant programs, NIGMS will periodically evaluate this Research Training Program, employing the representative measures identified below. In assessing the effectiveness of training investments, NIGMS may use information from progress reports and public databases, PD/PIs, and from participants themselves. Where necessary, PDs/PIs and participants may be appropriately contacted after the completion of the grant period for updates on participants’ subsequent outcomes.

NIGMS staff may conduct site visits of funded programs in order to obtain information about the training environment and other specific issues that are not easily assessed through other means.

The overall evaluation of the NIGMS-wide program will be based on metrics that may include, but are not limited to, the following:

• Characteristics of the applicant and awardee pool for the program, such as:
  • Organization types represented
  • Geographical distribution of programs
  • Demographic data
• Indicators of trainees' scientific accomplishments or productivity, such as:
  • Peer-reviewed research publications by trainees
  • Presentations at scientific conferences
  • Professional recognitions
• Measures of trainees' educational outcomes or career progression, such as:
  • Trainee degree completion rates
  • Time-to-degree for trainees
  • Trainee career outcomes
  • Persistence of graduates in biomedical research careers

Section VII. Agency Contacts

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten on-time submission, and post-submission issues)

Finding Help Online: https://www.era.nih.gov/need-help (preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

General Grants Information (Questions regarding application processes and NIH grant resources)
Email: [email protected] (preferred method of contact)
Telephone: 301-480-7075

Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace)
Contact Center Telephone: 800-518-4726
Email: [email protected]

Marie Harton, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Email: [email protected] 

Joyce Stamm, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]

Jeremy McIntyre, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Email: [email protected] 

National Institute of General Medical Sciences (NIGMS)
Email: [email protected]

Justin Rosenzweig
National Institute of General Medical Sciences (NIGMS)
Email: [email protected]

Section VIII. Other Information

Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Awards are made under the authorization of Section 487 of the Public Health Service Act as amended (42 USC 288) and under Federal Regulations 42 CFR 66.