Mentored Quantitative Research Development Award (Parent K25 – Independent Clinical Trial Required) (PA-20-197)

Scope Note

Table of IC-Specific Information, Requirements and Staff Contacts

Release Date: May 7, 2020
Expiration Date: May 8, 2023

NIH Institute or Center Contacts Institute/Center Specific Information
National Cancer Institute (NCI)

Scientific Program Contact:
Sonia B. Jakowlew, Ph.D.
Email: [email protected]

Grants Management Contact:
Jason Gill
Email: [email protected]
NCI Specific Information:

The NCI K25 award is aimed at fostering the research careers of scientists with post-doctorate degree training in quantitative science disciplines, including physics, chemistry, mathematics, statistics, economics, computer science, imaging science, and informatics, or engineering, who have little or no training in the biological or biomedical sciences and are now committed to developing research programs in understanding human biology and human disease as it relates to cancer-focused research. Early-stage investigators and established investigators who wish to incorporate cancer-focused research into their quantitative science or engineering projects or reorient their quantitative science or engineering research interests to cancer-focused research and who have not already obtained research project (i.e., R01 or equivalent) grant support for biological or biomedical projects, are eligible for this award.

Individuals with less than three years of post-doctorate degree training experience in quantitative sciences or engineering should consider the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) (F32) instead.

NCI requires that the K25 applicant identify a mentor whose research is cancer focused.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $50,000 per year.
National Heart, Lung, and Blood Institute (NHLBI)

Scientific Program Contact:
Wayne C. Wang, Ph.D.
Phone: (301) 435-0535
Email: [email protected]

Karen Neilson Ph.D.
Phone: (301) 451-1975
Email: [email protected]

Seung Kyoon Woo, Ph.D.
Phone: (301) 435-0535
Email: [email protected]


Grants Management Contact:
Taryn Cobb
Phone: (301) 827-8025
Email: [email protected]
NHLBI Specific Information:

Please refer to Training and Career Development for specific information on NHLBI programs and career development policies.
NHLBI has a 6 year limit of cumulative support on institutional and mentored Ks (e.g., K12 or KL2 plus the K25).

NHLBI encourages career development award applications from quantitative scientists that propose mentored training to establish expertise in data science, including but not limited to Artificial Intelligence, Machine Learning, Deep Learning, Healthcare Data Analytics, Public Health Data Analytics, Imaging Analytics, Predictive Analytics, and Bioinformatics, or propose training to complement existing data science expertise with relevant biomedical/clinical knowledge for the creation, management, analysis, and integration of complex, large data sets in support of data-driven discovery in heart, lung, blood, and sleep health and disease. Proposals must meet all other requirements specified in the parent announcement.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $40,000 per year.

National Human Genome Research Institute (NHGRI)

Scientific Program Contact:
Shurjo K. Sen, Ph.D.
Phone: (301) 827-7028
Email: [email protected]

Grants Management Contact:
Deanna Ingersoll
Phone: (301) 435-7858
Email: [email protected]

NHGRI Specific Information:

The purpose of the K25 is to develop research leaders in genomic data science. Information about the institute’s vision and priority areas can be found in the 2020 NHGRI Strategic Vision.

Prospective applicants are strongly encouraged to contact the Scientific Program Contact to discuss their mentored research concept for this initiative during the development stages of the application.

Salary Support: Commensurate with the applications institution’s salary structure for persons of equivalent qualifications, experience and rank.
Research Support: Up to $40,000 per year.

In addition to Research Support, awardees are strongly encouraged to attend at least one NHGRI Research Training and Career Development Annual Meeting while supported on the K25. Travel may be requested up to $1500 each per NHGRI meeting.


National Institute on Aging (NIA)

Scientific Program Contact:
NIA Training Office
Email: [email protected]

Grants Management Contact:
Jessi Perez, NIA
Phone: (301) 402-7739
Email: [email protected]
NIA Specific Information:

See: Training and Career Development.

Salary Support: Up to 75,000 plus fringe benefits per year.
Research Support: Up to $40,000 per year.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Scientific Program Contact:
John Matochik, Ph.D.
Phone: (301) 451-7319
Email: [email protected]

Grants Management Contact:
Judy Fox
Phone: (301) 443-4704
Email: [email protected]
NIAAA Specific Information

NIAAA supports faculty level early stage investigators and new investigators through career development awards by providing protected time and mentoring in an environment where they can develop the skills and expertise for independent research. Under this announcement mentored research must focus on NIAAA’s research priorities as described in the NIAAA Strategic Plan. Examples include, but are not limited to, research in behavioral, biomedical (basic or clinical), and bioimaging, or bioengineering as related to alcohol use disorder and alcoholism.

Potential applicants are strongly encouraged to contact the program official identified in the contact table before preparing an application to discuss eligibility requirements and the relevance of the proposed research to the Institute’s research priorities.


All applications must include a strong and credible plan for the applicant's transition to research independence, outlining milestones and providing evidence of significant institutional commitment to the development of the K applicant as an independent researcher at the sponsoring institution.

Candidates with less than 4 years of post-doctoral research experience, who are enrolled in the T32 training programs are strongly encouraged to apply for a K99/R00 award.

At the time of the award, the candidate must have a secured full time faculty or faculty equivalent appointment in an appropriate research-intensive environment.

The application must also provide a document on institutional letterhead that describes its commitment to the candidate and the candidate's career development, independent of the receipt of the K award. It is also essential to document the institution's commitment to the retention, development, and advancement of the candidate during the period of the award. For additional information about NIH requirements for the institution’s commitment letter, applicants are referred to G.410 - PHS 398 Career Development Award Supplemental Form instructions under Institutional Commitment to Candidate's Research Career Development.
Applications that include human subject research must comply with NIAAA policy on providing plans for submitting grant-related human subjects data to a NIAAA-sponsored data repository, the NIAAA Data Archive (NIAAA DA ), as described in NOT- AA- 19- 020.
To help you decide which award best suits your needs, as well as additional guidance on application specifics, see Research Training and Career Development/Training Opportunities by Grant Mechanism ​.

Salary Support: Up to $100,000 plus fringe benefits per year. A minimum of 75% effort must be devoted to the career award.
Research Support: Up to $50,000 per year.
National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Scientific Program Contact:
Tina Gatlin, Ph.D.
Phone: 301-480-1608
Email: [email protected]


Grants Management Contact:
Kathryn (Katie) Ellis
Phone: 302-451-4791
Email: [email protected]






NIBIB Specific Information:

NIBIB uses the K25 to support research-oriented quantitative scientists and engineers with little or no experience in medicine and the life sciences to develop relevant research skills that will allow them to conduct basic or clinical biomedical imaging or bioengineering research and to become independent investigators, playing leading roles in multi-disciplinary research teams. Examples of quantitative scientific and technical backgrounds considered appropriate for this award include, but are not limited to: mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, and engineering. NIBIB will only support individuals who are within 10 years of the completion of their PhD. The duration of support can be 3 or 4 years.

Under this FOA, NIBIB will only support applications proposing early stage clinical trials through Phase I, first-in-human, safety, feasibility, or other small clinical trials that inform the early stage technology development in the submitted application. NIBIB will not support applications proposing Phase II, III, IV or pivotal clinical trials, or trials in which the primary outcome is efficacy, effectiveness, or a post-market concern.

Before preparing an application, prospective applicants are encouraged to fill out the NIBIB K25 Eligibility Inquiry Form and forward it along with the requested attachments to the Scientific Program Contact in order to verify eligibility, determine if the application is appropriate for a K25 award through NIBIB, and ensure that the application is submitted to the appropriate FOA.

Applicants whose applications include human subjects research are especially encouraged to contact the NIBIB Scientific Program Contact for guidance in advance of submitting an application, to ensure their proposed project is in compliance with NIH human subjects research and clinical trials policies (/policy/clinical-trials.htm) and consistent with the types of clinical trial applications that NIBIB supports.

More information on this and other NIBIB Career Awards can be found here.

Salary Support: Up to $90,000 plus fringe benefits per year.
Research Support: Up to $40,000 per year.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Scientific Program Contact:
Dennis A. Twombly, Ph.D.
Phone: (301) 451-3371
Email: [email protected]

Grants Management Contact:
Bryan S. Clark, MBA
Phone: (301) 435-6975
Email: [email protected]

NICHD Specific Information:

NICHD offers fellowships, training grants, and career development awards in areas relevant NICHD’s mission, including normal and abnormal human development; male and female fertility and infertility; developing and evaluating contraceptive methods; pregnancy and childbirth; prenatal and postnatal development; childhood development and behavior through adolescence; improving the safety and efficacy of pharmaceuticals for use in pregnant women, infants, and children; HIV infection and transmission, AIDS, and associated infections; pediatric growth and endocrine research; developmental biology and typical and atypical development; intellectual and developmental disabilities; reproductive biology and medicine; gynecologic health conditions, including pelvic floor disorders; childhood injury and critical illness; population dynamics; and medical rehabilitation. More detailed information and Program Staff contacts may be found at: Extramural Scientific Branches, and for the National Center for Medical Rehabilitation Research at: National Center for Medical Rehabilitation Research (NCMRR).

NICHD has a 6 year limit of cumulative support on institutional K awards (e.g., K12, KL2) and individual mentored K awards (e.g., K01, K08, K23, K25).

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year

National Institute on Deafness and Other Communication Disorders (NIDCD)

Scientific Program Contact:
Alberto L. Rivera-Rentas, Ph.D.
Phone: (301) 496-1804
Email: [email protected]

Grants Management Contact:
Christopher Myers
Phone: (301) 402-0909
Email: [email protected]



NIDCD Specific Information:

NIDCD uses the K25 program to support individuals with quantitative scientific and engineering backgrounds without sustained involvement in biomedical or behavioral research who wish to focus their research in areas supported by NIDCD.

  • Application must demonstrate its contribution to NIDCD and its fit to NIDCD's Mission, Research Priorities, and Strategic Plan.
  • Applicants are strongly encouraged to provide clear evidence that adequate resources are available at the institution for the successful completion of the proposed research project.
  • Applications should include explicit statements from the institution and the mentor(s) addressing the following:
    • Detailed information about who will provide the necessary resources;
    • Funding source and amount of additional funding (as needed);
    • Support staff available and committed to the project;
    • Availability of biostatistical support for the duration of the study - including the planning period; and
    • A contingency plan (for the institution and mentor) for completion of the study in the event the awardee leaves the institution earlier than the end date of the award.


Salary Support: Up to $80,000 plus fringe benefits per year.
Research Support: Up to $30,000 per year.

National Institute of Dental and Craniofacial Research (NIDCR)

Scientific Program Contact:
Anissa J. Brown, PhD
Research Training and Career Development Branch
National Institute of Dental and Craniofacial Research
Telephone: (301) 594-4805
Email: [email protected]Grants Management Contact:
Dede Rutberg, MBA
Phone: (301) 594-4798
Email: [email protected]
NIDCR Specific Information:

NIDCR supports career development of investigators with quantitative scientific and engineering backgrounds whose research has thus far not been focused primarily on questions of health and disease in areas that align with the NIDCR Strategic Plan.
Applicants are expected to provide evidence that adequate resources are available at the institution for the successful completion of the proposed research project.
Prospective applicants are strongly encouraged to contact NIDCR before preparing an application to discuss eligibility requirements and the alignment of the proposed basic, clinical or behavioral biomedical research to NIDCR dental, oral and craniofacial research priorities.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Scientific Program Contact:
Diabetes, Endocrinology, and Metabolic Diseases:
Lisa M. Spain, Ph.D.
Phone: (301) 451-9871
Email: [email protected]

Digestive & Liver Diseases, Nutrition, and Obesity:
Voula Osganian, M.D., Sc.D., M.P.H
Phone: (301) 594-8876
[email protected]

Kidney and Urologic Diseases:
Tracy L. Rankin, M.P.H.
Phone: (301) 594-4748
Email: [email protected]

Grants Management Contact:
Eunica Haynes
Phone: (301) 827-4018
Email: [email protected]
NIDDK Specific Information:

The NIDDK wishes to encourage scientists to enter biomedical research areas important to the NIDDK: diabetes, endocrinology, metabolic diseases, obesity, nutrition, digestive and liver diseases, kidney and urological disorders, and hematologic diseases. Information on the NIDDK K25 can be found at K25: Mentored Quantitative Research Career Development Award
The NIDDK provides further information on all K-award programs on our training and career development web site: Research Training & Career Development.

Salary Support: Up to $90,000 plus fringe benefits per year.
Research Support: Up to $40,000 per year.
National Institute on Drug Abuse (NIDA)

Scientific Program Contact:
Lindsey Friend, Ph.D.
Phone: (301) 594-4673
Email: [email protected]

Grants Management Contact:
Carol Alderson
Phone: (301) 827-6685
Email: [email protected]
NIDA Specific Information:

Salary Support: Up to $90,000 plus fringe benefits per year.
Research Support: Up to $50,000 per year. Examples include supplies, equipment, technical personnel, travel, and statistical services.

Please note that the aggregate total of NIH mentored career award support (both institutional and individual) cannot exceed 6 years. A prospective K25 applicant who was appointed to an institutional K12 award must contact NIDA prior to submitting an individual mentored K application to confirm eligibility. Please contact [email protected] for additional details.
National Institute of Environmental Health Sciences (NIEHS)

Scientific Program Contact:
Carol Shreffler, Ph.D.
Phone: (984) 287-3322
Email: [email protected]

Grants Management Contact: Ashley Singh
Phone: (984) 287-3323
Email: [email protected]
NIEHS Specific Information:

Research projects and career development experiences proposed in response to this Announcement will be expected to have a defined impact on the environmental health sciences and be directly responsive to the mission of the NIEHS, which is to discover how the environment affects people in order to promote healthier lives. Applications from data scientists with backgrounds in computer science, physics, mathematics, statistics, and engineering who are proposing to develop tools and methods for application to environmental health data are encouraged. Ecologic, biomonitoring, biotransformation or biodegradation studies are not considered within the NIEHS mission and are not responsive. Applications from individuals with backgrounds in chemistry or environmental engineering will only be responsive when the degree and previous research are in the physical sciences. For further information on the research interests of the Institute, please see:
NIEHS

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $40,000 per year.

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