PA-25-303 NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

National Center for Complementary and Integrative Health (NCCIH)

Scientific Program Contacts:
Email:  [email protected]

Grants Management Contact:
Email: [email protected]

National Cancer Institute (NCI)

Scientific Program Contacts:
Email: [email protected]

Grants Management Contact:
Office of Grants Administration
Email: [email protected]

National Eye Institute (NEI)

Scientific Program Contact:
E-mail: [email protected]

Grants Management Contact:
Email: [email protected]

NEI conducts and supports a broad range of basic and clinical research, clinical trials, epidemiologic studies, research training, and career development in the sciences related to vision. To learn more, visit our Research Programs and Contact page- https://www.nei.nih.gov/grants-and-training/funding-opportunities/programs-and-research-priorities. Applicants are strongly encouraged to consult NEI Program staff at least 10 weeks prior to the application due date to confirm the appropriateness of the proposed project for the funding opportunity.

Basic Experimental Studies involving Humans (BESH) are studies that fall within the NIH definition of a clinical trial and also meet the definition of basic research. The research has the purpose of understanding fundamental aspects of phenomena and uses an experimental manipulation or intervention. Minimal risk research categorized as BESH must reference PA-25-303.

National Institute on Aging (NIA)

Scientific Program Contacts:
Email: [email protected]

Grants Management Contact:
Email: [email protected]

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Scientific Program Contacts:
Email: [email protected]

Grants Management Contact:
Email:  [email protected] 

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Scientific Program Contact:

Email: [email protected]

Grants Management Contact:
Email: [email protected]

NICHD Research Priorities
NICHD funds research in areas relevant to normal and abnormal human development, including contraception, fertilization, pregnancy, childbirth, prenatal and postnatal development, childhood development through adolescence, intellectual and developmental disabilities, and rehabilitation medicine.
Grant applications and project proposals must fall within the missions of the scientific branches of NICHD's Division of Extramural Research or its National Center for Medical Rehabilitation Research. Potential applicants are strongly encouraged to visit these pages for recent scientific advances and emerging public health topics.

If you have questions about projects within a specific research area, you may find an NICHD program officer at https://www.nichd.nih.gov/grants-contracts/research-areas/priorities or contact:

NICHD Referral Office
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Email: [email protected]

National Institute on Drug Abuse (NIDA)

Scientific Program Contact:
Email: [email protected]  

Grants Management Contact:
Chief Grants Management Officer
Email: [email protected] 

National Institute on Deafness and Other Communication Disorders (NIDCD)

Scientific Program Contact:
Email: [email protected]

Grants Management Contact:
Email: [email protected]  

NIDCD accepts low-risk clinical trial applications submitted under PA-20-183 that address communication disorders in the NIDCD’s scientific mission areas of hearing, balance, taste, smell, voice, speech and language, with the goal of producing evidence necessary to advance scientific knowledge and inform the development of intervention(s) for subsequent clinical trials.                                                                

The NIDCD defines a low-risk clinical trial as a trial meeting ALL the following criteria:
• Typically does not require an Investigational New Drug (IND) or Investigational Device Exemption (IDE) from the FDA. This includes clinical trials involving utilization of a licensed product/device for an approved dose, population, and indication. Or it can be a study that has an IND or IDE but is otherwise determined to be a low-risk trial
• The Potential risk of the intervention to the subjects is low. For example, interventions encountered in routine medical care or procedures, or behavioral interventions
• Intends to gather scientific data/evidence to inform subsequent studies but is not aimed or sufficiently powered to directly change health policy or standard of care, and is not an NIH defined Phase III Clinical Trial 
• Application budgets are not limited but are generally expected to be less than $500,000 in direct costs in any year. Applicants requesting $500,000 or more must submit a request to NIDCD prior to submitting an application.                                                                                    

Low risk research categorized as Basic Science Experimental Studies involving Humans (BESH), referred to in NOT-OD-18-212, are acceptable under this opportunity. Applications proposing mechanistic studies with human subjects may alternatively be submitted under the Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) PA-20-184.

For an application that states that the study poses a nonsignificant risk to participants, NIDCD may request verification from the applicant including the risk determination documentation from the FDA prior to award. This will be outlined in the Notice of Award Terms and Conditions when applicable.

High-risk clinical trials are referred to the companion U01 funding opportunity, PAR-24-050 NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders.

Applicants are encouraged to consult NIDCD staff at least 10 weeks prior to the application due date to confirm the appropriateness of the proposed project for the funding opportunity.

National Institute of Dental and Craniofacial Research (NIDCR)

Scientific Program Contact:
Email: [email protected]

Grants Management Contact:
Email: [email protected]

National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)

Scientific Program Contact:

National Institute of Environmental Health Sciences (NIEHS)

Scientific Program Contact:
Email: [email protected]

Grants Management Contact:
Email: [email protected]

National Institute of Mental Health (NIMH)

Scientific Program Contact:

NIMH Program Staff contacts Inquiries may be directed to [email protected].
Also, see Division web pages (below)

The National Institute of Mental Health (NIMH)
Division web pages:

• Division of Neuroscience and Basic Behavioral Science (DNBBS)
• Division of Translational Research (DTR)
• Division of AIDS Research (DAR)
• Division of Services and Intervention Research (DSIR)
• Division of Data Science and Technology (DST)

National Institute on Minority Health and Health Disparities (NIMHD)

Scientific Program Contact:

Division of Clinical and Health Services Research

Email: [email protected]

Division of Community Health and Population Science

Grants Management Contact:
Email:   [email protected]

National Institute of Neurological Disorders and Stroke (NINDS)

Scientific Program Contact:

Program Directors and Managers

Grants Management Contact:
Chief Grants Management Officer
Email: [email protected]

Only applications that fall within the scientific mission of the NINDS will be accepted and considered for funding by NINDS (NINDS Mission).

To assess the relevance of an application topic, applicants are strongly encouraged to contact NINDS program staff before submitting. A listing of NINDS program staff can be found at: Program Directors and Managers.

National Institute of Nursing Research (NINR)

Scientific Program Contact:
Email: [email protected]

Grants Management Contact:
Email: [email protected]