NIH Pathway to Independence Award (Parent K99/R00 – Independent Clinical Trial Required) (PA-24-193)

National Cancer Institute (NCI) 

Scientific Program Contact:
Michael Schmidt, Ph.D.
(Applicant last name beginning with A-M)
Email: mschmidt@mail.nih.gov
 

Sonia B. Jakowlew, Ph.D.
(Applicant last name beginning with N-R)
Email: jakowles@mail.nih.gov
 

Corinne Boulanger-Espeut, Ph.D.
(Applicant last name beginning with S-Z)
Email: boulangc@mail.nih.gov

Grants Management Contact:

Amy Bartosch

Email: amy.bartosch@nih.gov

NCI Specific Information: 

NCI accepts K99/R00 applications in all areas of cancer research. 

Additional NCI-specific information/requirements can be found at: http://www.cancer.gov/grants-training/training/funding/K99.
 
NCI does not allow carry-over of unspent funds from the K99 phase into the R00 phase.
 
Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $30,000 per year.

NCCIH Specific Information:

NCCIH uses the K99/R00 program to support outstanding postdoctoral investigators who are seeking to establish an independent career and have the potential to become a future leader in an area of research supported by the Center.

• The K99 phase may ONLY include observational, basic or mechanistic research projects in areas of NCCIH’s interest and priorities. A mechanistic study is defined as one designed to understand the mechanism of action of an intervention, a biological process, or the pathophysiology of a disease. NCCIH will accept applications that propose a study in the K99 phase with human participants when the primary outcome/endpoint is explicitly mechanistic, rather than a clinical outcome, even if the mechanistic study meets the NIH definition of a clinical trial.
• NCCIH will not fund applications proposing a clinical trial to test efficacy or effectiveness in either the K99 or R00 phase. Applicants are encouraged to discuss their proposed scope of work with an NCCIH program officer, and to review resources available at NCCIH’s Clinical Research Toolbox.
• Before the application receipt date, investigators are strongly encouraged to discuss their proposed research interest with an NCCIH Program Officer in the specific scientific area and/or intervention that is closely-related to the proposed project to confirm its relevance to NCCIH's mission and research priorities. A list of NCCIH program officials can be found at http://NCCIH.nih.gov/grants/contact#area.
• The K99/R00 is appropriate for applicants who are prepared for an accelerated career path, who will be ready to compete for R01 and R01-like grant funding in the next three years. Individuals interested in a longer time frame of mentored research support should consider the K01, K08, or K23.
• Applications proposing the use of natural products or devices in an interventional research project should explicitly describe the status of the Investigational New Drug (IND) or Investigational Device Exemption (IDE). Applicants interested in natural products research are encouraged to review NCCIH's Natural Product Integrity Policy.
  Applications should include explicit statements from the institution and the mentor(s) addressing the following:
  • Detailed information about who will provide the necessary resources;
  • Funding source and amount of additional funding (as needed);
  • Support staff available and committed to the project;
  • Availability of biostatistical support for the duration of the study - including the planning period; and
  • A contingency plan (for the institution and mentor) for completion of the study in the event the awardee leaves the institution earlier than the end date of the award.

 
Salary Support: Commensurate with the applicant institution's salary structure for persons of equivalent qualifications, experience, and rank.

Research Support: Up to $20,000 per year in the K99 phase.

National Heart, Lung, and Blood Institute (NHLBI) 

Scientific Program Contact:
Extramural programs:
Li-Shin Huang, Ph.D. 
Phone: 301-435-0535
Email: li-shin.huang@nih.gov 

Karin F. Lidman, Ph.D.
Phone: (301) 435-0535
Email:  fredrikssonk@mail.nih.gov

Intramural programs:
Kristen Z. Morgan, Ph.D. 
Phone: 301-827-5163 
Email: direducation@nhlbi.nih.gov 

Grants Management Contact:

Shaheed Ziyout 
Phone: 301-827-8152
Email: shaheed.ziyout@nih.gov

NHLBI Specific Information:

Please refer to https://www.nhlbi.nih.gov/grants-and-training/training-and-career-development/postdoctoral for specific information on NHLBI programs and career development policies. 

NHLBI encourages career development award applications that propose mentored training in data science disciplines, including but not limited to Artificial Intelligence, Machine Learning, Deep Learning, Healthcare Data Analytics, Public Health Data Analytics, Imaging Analytics, Predictive Analytics, and Bioinformatics, for the creation, management, analysis, and integration of complex, large data sets in support of data-driven discovery in heart, lung, blood, and sleep health and disease. Proposals must meet all other requirements specified in the parent announcement.

Eligibility:  If an individual has a faculty appointment and is eligible to apply for an independent research funding as the PD/PI of an NIH research grant, he/she is no longer eligible for the K99/R00 mechanism. Additionally, individuals holding certain Career Development Awards that require a faculty appointment (such as the American Heart Association CDA) are not eligible to apply for the K99/R00 mechanism. K99 awardees cannot hold a faculty appointment. If a K99 awardee is allowed to apply to an independent NIH research grant (or equivalent) funding during the K99 phase, they will be considered independent and will need to relinquish the K99 award and will not be eligible for transition to the R00 phase. To maintain R00 eligibility, awardees in the K99 mentored phase should discuss any potential changes to their academic appointment with an NHLBI Scientific Program Contact. Physician scientists with a clinical faculty appointment, distinct from their research/academic appointment, may still be eligible and should approach an NHLBI Scientific Program Contact for guidance.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

NHGRI Specific Information: 

NHGRI supports resources, approaches, and technologies that accelerate genomic research focused on the ethical, legal, and social implications of genomic advances; the structure and biology of genomes; the genomics of disease; the implementation and effectiveness of genomic medicine; computational genomics and data science; and the impact of genomic advances, technology, and implementation on health disparities and health equity. Within these areas, approaches that are comprehensive across the genome or are generalizable across variants, tissues, diseases, or functions may be in scope for NHGRI.

NHGRI recognizes the importance of diversity in the genomic workforce, without which the promise of genomics cannot be fully achieved.

Prospective applicants are strongly encouraged to contact the Scientific Program Contact to discuss their concept for this initiative during the development stages of the application.

Salary Support: NHGRI will provide K99 salary support commensurate with the applicant institution's salary structure for persons of equivalent qualifications, experience, and rank.
Research Support: Up to $30,000 per year for K99 phase.

In addition to Research Support, which may be used to travel to scientific conferences, applicants can request additional travel costs of up to $1500 per year to attend the NHGRI Research Training and Career Development Annual Meeting while supported on the K01. These additional travel funds cannot be re-budgeted to attend another meeting.

National Institute on Aging (NIA)

Scientific Program Contact:
Jamie Lahvic, Ph.D.
Email: NIAtraining@nih.gov

Grants Management Contact:

Ms. Jessi Perez, NIA

Phone: 301.402.7739

Email:  jessi.perez@nih.gov

NIA Specific Information: 

 For more information, see the NIA K99/R00 webpage.

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

National Institute on Alcohol Abuse and Alcoholism (NIAAA) 
 
Scientific Program Contact: 
NIAAA Staff Contact

  
Grants Management Contact: 
Judy Fox 
Phone: (301) 443-4704 
Email: jfox@mail.nih.gov

Lauren Early 
Phone: (301) 443-2434 
Email: lauren.early@nih.gov

NIAAA Specific Information: 
 

NIAAA supports post-doctoral/non-faculty level career development award (K99/R00) to ensure the development of highly qualified investigators in alcohol-related research. Applicants are encouraged to refer to the NIAAA Strategic Plan for NIAAA research priorities. Applicants are to comply with the NIH and NIAAA Data Management and Sharing policies, NOT-OD-21-013 and NOT-AA-23-001. Prospective applicants are strongly encouraged to contact the appropriate NIAAA staff contact prior to preparing an application.

Salary Support: Up to $90,000 plus fringe benefits per year, commensurate with the applicant institution’s salary structure for persons of equivalent qualifications, experience, and rank. Institutional Base Salary will be verified for the K99 Phase at the time of award. 
Research Support: Up to $50,000 per year.

NIAMS Specific Information: 

Information about NIAMS funding mechanisms is available athttp://www.niams.nih.gov/Funding/Funding_Opportunities/activity_codes.asp. 

Salary Support: NIAMS will provide up to $60,000 per year for salary support (up to $75,000 per year for applicants with an M.D. degree), plus fringe benefits per year.
Research Support: Up to $20,000 per year.

National Institute of Biomedical Imaging and Bioengineering (NIBIB) 

Scientific Program Contact:
Tina Gatlin, Ph.D.
Phone: 301-480-1608
Email: gatlincl@nih.gov

Grants Management Contact:
Mutema Nyankale
Phone: 240-921-3990
Email: mutema.nyankale@nih.gov

NIBIB Specific Information:

NIBIB welcomes applications from postdoctoral scientists seeking to establish an independent research career in scientific program areas relevant to NIBIB. In general, NIBIB interests include the development and integration of advanced bioengineering, sensing, imaging, and computational technologies for the improvement of human health and medical care. An application is not within the NIBIB mission if its principal focus is the development of a technology with the goal of understanding basic biological function or pathological mechanisms.

Additionally, NIBIB only supports projects developing platform technologies that are applicable to a broad spectrum of disorders and diseases. However, applicants may propose research that utilizes only a single tissue, organ, or physiological condition as a model system to facilitate the development of what is expected to be a more broadly applicable enabling technology.
 

Before preparing an application, prospective applicants are encouraged to fill out the NIBIB K99/R00 Eligibility Inquiry Form and forward it along with the requested attachments to the Scientific Program Contact in order to verify eligibility, determine if the application is appropriate for a K99 award through NIBIB, and ensure that the application is submitted to the appropriate NOFO.  
 

More detailed information can be found at https://www.nibib.nih.gov/training-careers/training-opportunities/nih-pathway-independence-award-parent-k99r00. 
 
Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

NICHD Specific Information:

NICHD offers fellowships, training grants, and career development awards in areas relevant NICHD’s mission, including normal and abnormal human development; male and female fertility and infertility; developing and evaluating contraceptive methods; pregnancy and childbirth; prenatal and postnatal development; childhood development and behavior through adolescence;  improving the safety and efficacy of pharmaceuticals for use in pregnant women, infants, and children;  HIV infection and transmission, AIDS, and associated infections; pediatric growth and endocrine research; developmental biology and typical and atypical development; intellectual and developmental disabilities; reproductive biology and medicine; gynecologic health conditions, including pelvic floor disorders; childhood injury and critical illness; population dynamics; and medical rehabilitation. 

More detailed information and Program Staff contacts may be found at:  https://www.nichd.nih.gov/about/org/der/branches, and for the National Center for Medical Rehabilitation Research at: http://www.nichd.nih.gov/about/org/ncmrr/Pages/overview.aspx.

The K99/R00 program is designed for postdoctoral fellows (PhDs, MDs, or other) whose formal research training is nearly complete, and who expect to find a tenure-track or equivalent faculty position within 2 years of receiving the award.  Those whose career development would benefit from further research training should also consider the mentored Career Development Awards offered by NICHD (e.g., K01, K08, K23, K25).   Prospective applicants are strongly encouraged to email or call the NICHD Scientific/Research Contact to help choose among these career development award mechanisms, to determine K99/R00 eligibility, and to assess relevance of the proposed project to the NICHD mission. 
Awardees must spend at least one year on the K99 phase of the award. NICHD has a 6-year limit of cumulative support on institutional K awards (e.g., K12, KL2) and individual mentored K awards (e.g., K01, K08, K23, K25).
 
Salary Support: For the K99 phase of the award, NICHD provides salary of up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.
 

NIDCD Specific Information:

NIDCD uses the K99/R00 program to support outstanding senior postdoctoral investigators in NIDCD research areas that are ready to complete their transition to become an independent investigator.

• Application must demonstrate its contribution to NIDCD and its fit to NIDCD's Mission, Research Priorities, and Strategic Plan.
• Applicants are strongly encouraged to provide clear evidence that adequate resources are available at the institution for the successful completion of the proposed research project.
• Applications should include explicit statements from the institution and the mentor(s) addressing the following:
  • Detailed information about who will provide the necessary resources;
  • Funding source and amount of additional funding (as needed);
  • Support staff available and committed to the project;
  • Availability of biostatistical support for the duration of the study - including the planning period; and
  • A contingency plan (for the institution and mentor) for completion of the study in the event the awardee leaves the institution earlier than the end date of the award.

 
Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

National Institute of Dental and Craniofacial Research (NIDCR) 

Scientific Program Contact:
NIDCRtraining@nidcr.nih.gov 

 

Grants Management Contact:
Gabriel Hidalgo, M.B.A.
Phone: (301)-827-4630

Email: gabriel.hidalgo@nih.gov

NIDCR Specific Information:

NIDCR welcomes applications from postdoctoral scientists seeking to establish an independent research career in research areas relevant to the NIDCR Strategic Plan.

For the NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Not Allowed), please refer to   NIDCR Notice of Special Interest (NOSI): Applications of Data Science in Translational Dental, Oral, and Craniofacial Research NOT-DE-23-002 calling for a variety of data science-oriented projects focused on developing and using data and data science resources, methods, and tools for dental, oral, and craniofacial (DOC) research.

Prospective applicants are encouraged to contact the scientific program to discuss eligibility requirements and the relevance of the proposed research to NIDCR’s research priorities.  
  
Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.
 

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 

Scientific Program Contact:
Diabetes, Endocrinology, and Metabolic Diseases:
Yan Li, Ph.D. 
Phone: (301) 435-3721
Email: liy7@niddk.nih.gov

Digestive & Liver Diseases, Nutrition, and Obesity:
Voula Osganian, M.D., Sc.D., M.P.H

Phone: (301) 827-6939

Email: voula.osganian@nih.gov

Kidney and Urologic Diseases:
Tracy L. Rankin, Ph.D. 
Phone: (301) 594-4748
Email: rankint@mail.nih.gov 

Hematologic Disorders:
Cindy N. Roy, Ph.D. 
Phone: (301) 594-8805
Email: cindy.roy@nih.gov

Grants Management Contact:
Aricia M. Ajose, MPA
Phone: (301) 594-9023
Email: ajosea@mail.nih.gov

NIDDK Specific Information:

NIDDK will accept K99/R00 applications from well-qualified postdoctoral fellows and physician scientists working in the areas of research supported by NIDDK (https://www.niddk.nih.gov/research-funding/research-programs).. Information on the NIDDK K99/R00 program can be found at https://www.niddk.nih.gov/research-funding/process/apply/funding-mechanisms/k-awards/k99-r00.  Applicants are encouraged to contact the appropriate program official identified here prior to submission and may want to consider applying for alternative career development awards, depending on individual needs.  These include the NIDDK K01 award and the K08 and K23 awards:

• NIDDK K01: https://www.niddk.nih.gov/research-funding/process/apply/funding-mechanisms/k-awards/k01
• NIDDK K08: https://www.niddk.nih.gov/research-funding/process/apply/funding-mechanisms/k-awards/k08
• NIDDK K23: https://www.niddk.nih.gov/research-funding/process/apply/funding-mechanisms/k-awards/k23

The NIDDK provides further information on all K-award programs on our training and career development website: https://www.niddk.nih.gov/research-funding/process/apply/funding-mechanisms/k-awards.
 
K99/R00 Budget information:

• NIDDK will provide support up to $90,000 total costs for the K99 phase and up to $249,000 total costs for the R00 phase.
• During the K99 phase, NIDDK will provide:
  • up to $75,000 per year for salary
  • appropriate fringe benefits
  • up to $25,000 per year for research support

Urologic surgeons may request a minimum of 50% effort for the K99 phase.

K99 awardees are encouraged to attend the NIDDK K Awardees’ Workshop while supported on the K99 (one-time attendance for this biennial meeting).  Up to $1500 will be provided for K99 awardees to attend this meeting (in addition to the above-listed Research Support).

NIDA Specific Information:

Applicants are encouraged to visit the following Web site to learn more about NIDA research training-related opportunities and resources: https://nida.nih.gov/research/research-training-career-development/training-career-development-fellowships-grants. 

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $50,000 per year.

NIEHS Specific Information:

The Career Development and Research Plan must be consistent with the research interests of NIEHS. The Institute funds a substantial portfolio of research conducted by investigators in many disciplines that span the range from basic mechanistic research to clinical and epidemiologic studies using human subjects. For further information on the research interests of the Institute, please see:  https://www.niehs.nih.gov/.

Potential applicants are strongly encouraged to contact the program official identified in the contact table before preparing an application to discuss eligibility requirements and the relevance of the proposed research to the Institute’s research priorities. 

NIEHS assigns K99/R00 applications to Program Officers across the division based on the scientific focus of the application. Prospective applicants are also encouraged to contact the Program Officer within their scientific area before submitting the application.  Please see:  http://www.niehs.nih.gov/funding/grants/contacts/index.cfm

Salary Support: Up to $75,000 plus fringe benefits per year (Practicing physicians may request up to $90,000 per year plus fringe benefits).
Research Support: Up to $20,000 per year.

NIMH Specific Information:
 

The NIMH supports a broad spectrum of basic and translational research, including basic neuroscience, human genetics, adult and developmental translational research, services and intervention research, and AIDS-related research (http://www.nimh.nih.gov/about/organization/nimh-extramural-research-programs.shtml). 

Prospective applicants are strongly encouraged to contact Institute career development staff (http://www.nimh.nih.gov/funding/training/contacts-for-research-training-and-career-development-programs.shtml) before preparing an application to discuss the relevance of the proposed research to the Institute’s current research priorities and for guidance on the proposed research and career development plans. Applicants should consult the NIMH training website for NIMH specific information and instructions: https://www.nimh.nih.gov/funding/training/nih-pathway-to-independence-award-k99-r00. 

Salary Support: Up to $75,000 plus fringe benefits per year.  Practicing physician-scientists may be eligible for up to $100,000 salary plus fringe benefits per year.  
Research Support: Up to $20,000 per year.   

NIMHD Specific Information:

NIMHD supports various mentored career development activities involving research to improve minority health and reduce health disparities, organized around three main Research Interest Areas: Clinical and Health Services Research, Community Health and Population Sciences, and Integrative Biological and Behavioral Sciences. Projects are encouraged to use approaches that encompass multiple domains of influence (e.g., biological, behavioral, socio-cultural, environmental, physical environment, health systems) and multiple levels of influence (e.g., individual, interpersonal, community, societal) to understand and address health disparities.

See the NIMHD Research Framework for examples of health determinants of interest. Prospective applicants are strongly encouraged to contact the program official identified in the contact table before preparing an application to discuss eligibility requirements and the relevance of the proposed research to the Institute’s research priorities.

Salary Support: Up to $75,000 plus fringe benefits per year. 
Research Support: Up to $25,000 per year.

NINDS Specific Information:

Applicants are strongly encouraged to contact Dr. Korn with any questions about eligibility or other questions about the K99/R00 program.  Applicants should consult the NINDS training website for NINDS specific information and instructions: https://www.ninds.nih.gov/Funding/Training-Career-Development/Award/K99R00-NIH-Pathway-Independence-Award

Note: NINDS does not allow carry-over of K99 funds into the R00 period. When the postdoctoral position ends, the K99 terminates. The R00 can begin as early as the start date of the awardee's job, contingent on NINDS receiving the R00 application with sufficient advance notice.

Salary Support: Normally, salary up to $75,000 plus fringe benefits for each K99 year. Practicing clinician-scientists may be eligible for up to $125,000 salary. 
Research Support: Up to $20,000 per year.

National Institute of Nursing Research (NINR) 

Scientific Program Contact:
Mary Elizabeth (Libbey) Bowen, PhD
Phone: 301-841-5345
Email: libbey.bowen@nih.gov

Grants Management Contact:

Ron Wertz
Phone: 301-594-2807
Email: wertzr@mail.nih.gov






 

NINR Specific Information:

NINR uses the K99/R00, NIH Pathway to Independence Award Program, to provide support for individuals who have a Bachelor's degree or higher in nursing to pursue career development research training that extends their potential for research. The Institute is committed to training new investigators, with attention to the areas of greatest need and to strategies for encouraging young investigators and members of groups underrepresented in science.

Applications must have a clear focus in science areas related to the NINR mission, which is to lead nursing research to solve pressing health challenges and inform practice and policy – optimizing health and advancing health equity into the future.  Applicants should also consider NINR prioritizes research framed through five lenses detailed in the NINR Strategic Plan.

Those interested in applying for this opportunity are strongly encouraged to contact the NINR Scientific Program Contact noted in this announcement. The applicant may contact the NINR Program Director by emailing a copy of their draft NIH Biosketch along with any questions and a draft synopsis of interests and research/training aims.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

National Library of Medicine (NLM) 
 
 Scientific Program Contacts:

For Public Health and Population Health Informatics, Social and Behavioral Science Informatics, Health Disparities and Health Equity related Informatics:

Meryl Sufian, PhD

Chief Program Officer

Phone: 301-496-4671  
Email: Meryl.Sufian@nih.gov

For Clinical Informatics:

Goutham Reddy, MD
Phone: (301) 827-6728
Email: goutham.reddy@nih.gov
 

For Bioinformatics, Translational Bioinformatics, and Personal Health Informatics:

Allison Dennis, PhD
Phone: (301) 827-9721
Email: Allison.Dennis@nih.gov

Grants Management Contact:
Samantha Tempchin
Phone: (301) 496-4221
Email: tempchins@mail.nih.gov  
 

NLM Specific Information:
  
NLM supports research career development in clinical/public health informatics, basic bioinformatics, translational bioinformatics, data science, and personal informatics. We define informatics as the intersection of computer, information and behavioral sciences with one or more application domains. Application domains of interest include health care delivery, basic biomedical research, clinical and translational research, public health and others. Whatever the application domain, the research career focus must be informatics or data science. 

Salary Support: Up to $75,000 plus fringe benefits per year.

Salary level must be commensurate with the applicant institution's salary structure for persons of equivalent qualifications, experience, and rank.
Research Support: Up to $50,000 per year.
 

 

NIH Office of Data Science Strategy (ODSS)

ODSS program contact: 
Bryan Kim Ph.D.
Email: bryan.kim@nih.gov

Office of Data Science Strategy Specific Information:

The NIH Office of Data Science Strategy (ODSS) is committed to growing a strong and diverse data science community and ensuring that data science advances in biomedical and health research can benefit all populations. ODSS is interested in supporting Career Development Award projects in data science areas including but not limited to: artificial intelligence, clinical informatics, cloud computing, statistics, computational science, software design and programming, bioinformatics, visualization, machine learning, predictive analytics, supercomputing, modeling and simulation, digital health, data sharing and access, data management, data security and data privacy in human subject’s research, and research ethics and integrity. Applications are strongly encouraged from individuals from diverse backgrounds, including from groups that are underrepresented in the biomedical, clinical, behavioral and social sciences, in alignment with the Notice of NIH’s Interest in Diversity (NOT-OD-20-031).

Office of Research on Women’s Health

Scientific Program Contact:

Carolyn Bondar, Ph.D.

Phone: (301) 824-7194

Email: carolyn.bondar@nih.gov

ORWH Specific Information:

ORWH focuses on advancing research that is relevant to the health of women and supporting women in biomedical careers. Applicants should ensure their proposed work intersects with the goals, objectives, and guiding principles of the trans-NIH Strategic Plan for Women’s Health Research (https://orwh.od.nih.gov/about/trans-nih-strategic-plan-womens-health-research). ORWH does not award grants but co-funds applications and research projects that have received an award from one of the participating NIH Institutes and Centers listed in the announcement. Visit the ORWH website (https://orwh.od.nih.gov/) or contact the appropriate ORWH staff to learn more.