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1. IACUC Membership and Functions |
- institution provides training and resources to assist IACUC members in understanding and evaluating issues brought before the committee |
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- at least 5 members, appointed by CEO |
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- members include veterinarian, scientist, non-scientist, and non-afilliated non-lab animal user 2 |
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- responsible for oversight and evaluation of institution's program |
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- reports to Institutional Official (IO) |
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- conducts semiannual evaluations of institutional animal care and use program |
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- conducts semiannual inspections of institutional animal facilities |
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- reviews and investigates concerns about animal care and use at institution3 |
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- procedures for review, approval and suspension of animal activities4 |
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- procedures for review & approval of significant changes to approved activities |
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- policies for special procedures (e.g. restraint, multiple survival surgery, fluid restriction)5 |
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2. IACUC RECORDS AND REPORTING REQUIREMENTS6 |
Reports to Institutional Official (IO) |
- reports of semiannual program reviews & facility inspections are submitted to IO7 |
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- include minority IACUC views |
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- describe departures from Guide or PHS Policy and reasons for departure8 |
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- distinguish significant from minor deficiencies |
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- include plan and schedule for correction of each deficiency identified9 |
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Reports to Office of Laboratory Animal Welfare (OLAW) |
- reports include any minority IACUC views |
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- annual report to OLAW documents program changes & dates of IACUC semiannual review |
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- promptly advises OLAW of serious/ongoing Guide deviations or PHS Policy noncompliance |
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- promptly advises OLAW of any suspension of activity by the IACUC |
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Reports to United States Department of Agriculture (USDA) |
- annual report contains required information |
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- reporting mechanism in place for IACUC-approved exceptions to the regulations and standards |
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- reports within 15 days failure to adhere to timetable for correction of deficiencies |
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- reports suspension of activity by the IACUC to USDA and any Federal funding agency |
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Records |
- minutes of IACUC meetings and semiannual reports maintained for 3 years |
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- IACUC review documentation maintained for 3 years after end of study |
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- IACUC review of activities involving animals includes all required information10 |
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3. VETERINARY CARE (See also next section - Veterinary Medical Care) |
- institutional arrangement for veterinarian with training or experience in lab animal medicine11 |
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- veterinary access to all animals |
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- provision for backup veterinary care |
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- must provide guidance on handling, immobilization, sedation, analgesia, anesthesia, euthanasia |
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- must provide guidance/oversight on surgery programs and oversight of postsurgical care |
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- veterinary authority to oversee all aspects of animal care and use |
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4. PERSONNEL QUALIFICATIONS AND TRAINING |
- institution has established and implemented an effective training program |
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- includes professional/management/supervisory personnel |
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- includes animal care personnel |
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- includes research investigators, instructors, technicians, trainees, students |
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Training program content |
- humane practices of animal care (e.g. housing, husbandry, handling)12 |
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- humane practices of animal use (e.g. research procedures, use of anesthesia, pre- & post-operative care)13 |
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- research/testing methods that minimize numbers necessary to obtain valid results |
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- research/testing methods that minimize animal pain or distress |
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- use of hazardous agents, including access to OSHA chemical hazard notices where applicable |
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5. OCCUPATIONAL HEALTH AND SAFETY OF PERSONNEL |
Institutional program for a safe and healthy workplace |
- program is established and implemented |
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- covers all personnel who work in laboratory animal facilities |
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- based on hazard identification and risk assessment |
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- personnel training (e.g. zoonoses, hazards, pregnancy/illness/immunosuppression precautions) |
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- personal hygiene procedures (e.g., work clothing, eating/drinking/smoking policies) |
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- procedures for use, storage & disposal of hazardous biologic, chemical, and physical agents |
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- specific procedures for personnel protection (e.g., shower/change facilities, injury prevention) |
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Program for medical evaluation and preventive medicine for personnel |
- pre-employment evaluation including health history |
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- immunizations as appropriate (e.g. rabies, tetanus) & tests |
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- zoonosis surveillance as appropriate (e.g. Q-fever, tularemia, Hantavirus, plague) |
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- procedures for reporting and treating injuries, including bites, etc. |
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Special precautions for personnel who work with primates |
- tuberculosis screening includes all exposed personnel |
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- training and implementation of procedures for bites & scratches |
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- education regarding Cercopithecine herpesvirus 1 (Herpes B) |
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