NIH Extramural Nexus (News)

NIH is committed to supporting rigorous and ethically conducted animal research that minimizes the number of animals needed to achieve scientifically valid results. Through a Request for Information, NIH seeks feedback on the feasibility, current capabilities, expected benefits, and expected burdens associated with annual reporting on the number of live, vertebrate animals subject to and defined by the Public Health Service Policy on Humane Care and Use of Laboratory Animals. 

As previously shared in November 2025 and April 2026, NIH implemented emergency modifications to peer review processes following the resumption of activities after the lapse in appropriations (NOT-OD-26-012, NOT-OD-26-069). These modifications remain in effect through the January 2027 Advisory Council round (NOT-OD-26-114).

Earlier this year, we asked the research community to weigh in on a proposed Clinical Trial Specific Application Form that would consolidate clinical trial information currently provided across two application components into a single, semi-structured form with page limits (NOT-OD-26-058). On behalf of the NIH Clinical Trials Application Working Group, I am pleased to share what we heard, and how your feedback will help shape our next steps.

On August 19, 2026, NIH released for public comment a Draft Biosafety Policy for Research Involving Biohazards for public comment. When finalized, the policy will replace the current NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules.

In June, we sought your feedback on a proposed approach to cap the number of Research Project Grants (RPG) a researcher can be principal investigator on simultaneously (NOT-OD-26-086). The proposal explored whether limits on simultaneous RPG support could contribute to a more balanced research portfolio. Here, we share some high-level outcomes from your thoughtful and helpful comments, which will inform our next steps.

NIH is seeking public comment on proposed changes to the reporting of peer review outcomes for grant applications (NOT-OD-26-088). Comments will be accepted electronically until October 13, 2026.

What does scientific impact look like today? For decades, measures such as publication counts, citation rates, and grant funding have been primarily used to assess the success of researchers. Yet biomedical research has become increasingly collaborative, interdisciplinary, and data-intensive. Progress often depends on teams of investigators, shared datasets and software, rigorous validation of findings, and sustained mentorship and training efforts.

We are seeking your feedback on whether distributing Research Project Grants (RPGs) funding across more investigators could increase overall scientific productivity and innovation (see NOT-OD-26-086). Through this Request for Information (RFI), NIH is presenting a proposal as one possible approach to advance stewardship, workforce sustainability, and the goals of the NIH Unified Funding Strategy. Comments may be sent electronically here by August 3, 2026.