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Table of ICO-Specific Contacts and Information
| NIH Institute or Center Contacts | Institute/Center Specific Information |
|---|---|
National Cancer Institute (NCI) Scientific Program Contact: Grants Management Contact: | |
National Center for Complementary and Integrative Health (NCCIH) Scientific Program Contact: Grants Management Contact: | Note: Mechanistic only |
Scientific Program Contact: Grants Management Contact: | Clinical trials involve studies in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes. The NEI accepts applications for minimal risk clinical trials in its mission. Minimal participant risk means that the probability and magnitude of harm or discomfort anticipated in the research are not greater in and of themselves than those ordinarily encountered in daily life or during the performance of routine physical or psychological examinations or tests (45 CFR 46). Please see NOT-EY-23-001 for further information. For an application that states that the study poses a minimal risk to participants, NEI may request verification from the applicant including the risk determination documentation from the FDA and IRBs prior to award. This will be outlined in the Notice of Award Terms and Conditions when applicable. |
National Human Genome Research Institute (NHGRI) Scientific Program Contact: Grants Management Contact: | In general, NHGRI supports studies that provide generalizable methods and knowledge. Approaches that are comprehensive across the genome or are generalizable across variants, tissues, diseases, or function may be in scope for NHGRI to the extent they address priority areas described in the NHGRI 2020 Strategic Vision: https://www.genome.gov/2020SV Applications for studies relevant only to a particular disease or organ system should be directed to the appropriate Institute or Center. Applications whose primary scientific objective is to understand a single biological or behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention do not fall under the mission of NHGRI. |
National Heart, Lung, and Blood Institute (NHLBI) Scientific Program Contacts: Division of Blood Diseases and Resources Center for Translation Research and Implementation Science Division of Lung Diseases Division of Cardiovascular Sciences Grants Management Contact: | As announced in NOT-HL-19-690, NHLBI will accept applications in response to the NIH Parent (R01 Clinical Trial Required) FOA that propose:
Please refer to NOT-HL-19-690 for additional information/clarification. |
National Institute on Aging (NIA) Scientific Program Contact: Grants Management Contact: | |
National Institute on Alcohol Abuse and Alcoholism (NIAAA) Scientific Program Contact: Grants Management Contact: | |
National Institute of Allergy and Infectious Diseases (NIAID) Scientific Program Contact: Grants Management Contact: | |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Scientific Program Contact: Grants Management Contact: Email: [email protected] | Note: Mechanistic only |
National Institute of Biomedical Imaging and Bioengineering (NIBIB) Scientific Program Contact: Grants Management Contact: | For this Notice of Funding Opportunity, NIBIB funding of clinical trials will be in accordance with NOT-EB-21-005 "NIBIB Guidance for Support of Clinical Trial Applications". Briefly, NIBIB will only support mission-focused early stage clinical trial applications, i.e., feasibility, Phase I, first-in-human, safety, or other small clinical trials, that inform early stage technology development. NIBIB will not support applications proposing pivotal, Phase II, III, IV, or trials in which the primary outcome is efficacy, effectiveness, or a post-market concern. Also, mechanistic trials are not supported unless the primary focus of the project is on technology development. |
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Scientific Program Contact: Grants Management Contact: | |
National Institute on Drug Abuse (NIDA) Scientific Program Contact: Grants Management Contact: Chief Grants Management Officer | |
National Institute on Deafness and Other Communication Disorders (NIDCD) Scientific Program Contact: Grants Management Contact: | NIDCD accepts low-risk clinical trial applications that address communication disorders in the NIDCD’s scientific mission areas of hearing, balance, taste, smell, voice, speech and language, with the goal of producing evidence necessary to advance scientific knowledge and inform the development of intervention(s) for subsequent clinical trials. The NIDCD defines a low-risk clinical trial as a trial meeting ALL the following criteria: For an application that states that the study poses a nonsignificant risk to participants, NIDCD may request verification from the applicant including the risk determination documentation from the FDA prior to award. This will be outlined in the Notice of Award Terms and Conditions when applicable. High-risk clinical trials are referred to the companion U01 funding opportunity, PAR-24-050 NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders. |
National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Scientific Program Contacts: Division of Kidney, Urologic and Hematologic Diseases Office of Obesity Research Email: [email protected] Grants Management Contact: | NIDDK accepts applications for low risk clinical trials in its mission. Please see NOT-DK-21-004 for further information. |
National Institute of Environmental Health Sciences (NIEHS) Scientific Program Contact: Grants Management Contact: | |
National Institute of General Medical Sciences (NIGMS) Scientific Program Contact: Grants Management contact: Email: [email protected] | As announced in NOT-GM-22-027, NIGMS will accept applications in response applications to the NIH Parent (R01 Clinical Trial Required) FOA that propose: Studies that meet NIH’s definition of a clinical trial AND are mechanistic in nature. The primary objective of the trial should be to provide mechanistic understanding of the biology underlying one or more of the NIGMS clinical research areas. Studies focusing on mechanism of action of an intervention in these clinical areas are also potentially acceptable, subject to the limitations stated below. NIH provides examples of mechanistic clinical trials in NOT-OD-18-010. A strong evidence base of fundamental biological and clinical information supporting a robust, mechanistic hypothesis for the trial should already exist in peer-reviewed literature. Please refer to NOT-GM-22-027 for additional information. |
National Institute of Mental Health (NIMH) Scientific Program Contacts: Division of Neuroscience and Basic Behavioral Science (DNBBS) Division of Translational Research (DTR) Division of AIDS Research (DAR) Division of Services and Intervention Research (DSIR) Division of Data Science and Technology (DST) Center for Global Mental Health Research (CGMHR) Email: [email protected] Grants Management Contact: | As stated in NOT-MH-23-375, NIMH only accepts clinical trial applications proposing mechanistic studies under the Parent R01 Clinical Trial Required (PA-25-305). For consideration by the NIMH, applicants who wish to submit clinical trials that propose to test efficacy, effectiveness or safety should not submit to this NOFO. Instead, clinical trials testing efficacy, effectiveness or safety must be submitted to one of the NOFOs listed on the Support for Clinical Trials at NIMH webpage |
National Institute on Minority Health and Health Disparities (NIMHD) Scientific Program Contacts: Division of Clinical and Health Services Research Division of Community Health and Population Science Division of Integrative Biological and Behavioral Sciences Email: [email protected] Grants Management Contact: | The National Institute on Minority Health and Health Disparities (NIMHD) will accept investigator-initiated research projects (R01) for all program areas supported by the Institute. |
National Institute of Neurological Disorders and Stroke (NINDS) Scientific Program Contact: Grants Management Contact: | As announced in NOT-NS-18-011, NINDS only accepts clinical trial applications proposing mechanistic studies for the Clinical Trial Required Parent R01 (PA-25-305). Applications that include a prospective biomedical or behavioral research study of human subjects that is designed to answer specific questions about pharmacologic, behavioral, biologic, surgical, or device interventions should be submitted to an NINDS clinical trial-specific funding announcement (listed on the NINDS website at Clinical Research). |
National Institute of Nursing Research (NINR) Scientific Program Contact: Grants Management Contact: | |
National Library of Medicine (NLM) Scientific Program Contact: Grants Management Contact: |