Department of Health and Human Services
Part 1. Overview Information
Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

Funding Opportunity Title

Biomedical Research Facilities (C06 Clinical Trial Not Allowed)

Activity Code

C06 Research Facilities Construction Grant

Announcement Type

New

Related Notices
  • January 17, 2019 - Notice of Clarification of Eligibility for PAR-19-128. See Notice NOT-OD-19-060.
  • January 07, 2019 - PRE-APPLICATION PAR-19-128 BIOMEDICAL RESEARCH FACILITIES (C06) WEBINAR. See Notice NOT-OD-19-052.
Funding Opportunity Announcement (FOA) Number

PAR-19-128

Companion Funding Opportunity

None

Number of Applications

Only one application per institution is allowed, as defined in Section III. 3. Additional Information on Eligibility.

Catalog of Federal Domestic Assistance (CFDA) Number(s)

 93.352

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) invites qualified academic institutions to apply for support to modernize existing or construct new biomedical research facilities. Applications will be accepted from public and nonprofit private institutions of higher education. Applications from both research-intensive institutions and Institutions of Emerging Excellence in biomedical research from all geographic regions in the nation are strongly encouraged.

NIH recognizes the importance of all institutions of higher learning in contributing to the nation’s research capacity. The goal of this FOA is to upgrade or create novel biomedical research infrastructure to strengthen biomedical research programs. The proposed project must serve the applicant-defined institution-wide biomedical research needs. Each project is expected to provide long-term improvements to the institutional research infrastructure. Targeted are the modernization of core facilities and the development of other infrastructure serving an institution-wide research community on a shared basis.

Key Dates
Posted Date

December 20, 2018

Open Date (Earliest Submission Date)

February 4, 2019

Letter of Intent Due Date(s)

February 1, 2019

Application Due Date(s)

March 4, 2019, by 5:00 PM local time of applicant organization..

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

Not Applicable

Scientific Merit Review

May-June 2019

Advisory Council Review

October 2019

Earliest Start Date

October 1, 2019

Expiration Date

March 5, 2019

Due Dates for E.O. 12372

As described in the NIH Grants Policy Statement, an applicant must provide a copy of the application to the State Single Point of Contact (SPOC) no later than the time the application is submitted to NIH. SPOC comments must be submitted to NIH with the application, or the application must indicate the date on which the application was provided to the SPOC for review.

Required Application Instructions

It is critical that applicants follow the Research (R) Instructions in the SF424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.


There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

  1. Use the NIH ASSIST system to prepare, submit and track your application online.
  2. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and eRA Commons to track your application. Check with your institutional officials regarding availability.

  3. Use Grants.gov Workspace to prepare and submit your application and eRA Commons to track your application.
  4. Table of Contents

    Part 1. Overview Information
    Part 2. Full Text of the Announcement

    Section I. Funding Opportunity Description
    Section II. Award Information
    Section III. Eligibility Information
    Section IV. Application and Submission Information
    Section V. Application Review Information
    Section VI. Award Administration Information
    Section VII. Agency Contacts
    Section VIII. Other Information

    Part 2. Full Text of Announcement
    Section I. Funding Opportunity Description

    This Funding Opportunity Announcement (FOA) invites qualified institutions of higher education to seek support to modernize and improve existing research facilities (e.g., laboratory space or animal facilities), or to construct new biomedical research space and furnish it with necessary fixed equipment. The objective of this FOA is to support the development of modern facilities that will enable and enhance the conduct of cutting-edge biomedical research. Any facility supported by this FOA must serve a broad research community, locally at the applicant institution or regionally.

    NIH recognizes that modern physical infrastructure is necessary for the conduct of cutting-edge research. As science progresses and new technologies become available, dedicated space is required to house specialized equipment and to carry out novel experimental protocols. Projects will vary and depend on the present institutional infrastructure and long-term institutional research plans. Focusing on the advancement of science through the modernization of physical space will be a common and integral feature of all proposed projects. When completed, projects will have a significant institution-wide impact, bringing the research capacities and capabilities to a new level. An institution may request funds to modernize a core facility to create an environment required for research-driven specialized technological services. Likewise, funds may be requested to consolidate space for an institution-wide core which would provide streamlined workflows for contemporary multi-disciplinary investigations. Modernizing laboratory space used on a shared basis to meet the growing needs consistent with an institutional strategic vision for biomedical research is another example of a suitable request. A successful project will serve research teams and a broad range of research efforts.

    Various factors are typically considered when developing or modernizing research infrastructure. For applications submitted to this FOA, defined research needs will drive the requests for modern engineering solutions. As science progresses and new technologies become available, required dedicated space must comply with relevant technical specifications to provide a well-controlled environment, to enable novel experimental approaches, and to house specialized equipment.

    Modern physical infrastructure requires the implementation of advanced engineering designs. Some protocols may be only conducted in designated clean rooms, such as barrier facilities for pathogen-free research or space for synthesis of compounds meeting standards for human subject experiments. Certain equipment requires specially shielded rooms. In some situations, the precision of experimental setups requires accurate monitoring of laboratory environmental conditions. The laboratory space also needs to be adequately maintained to serve its desired function over the years. The formal structure of an institutional core typically offers effective oversight to ensure that the required engineering standards of a space it occupies are met and maintained over time. Also, such centralized facilities are organized to provide rigorous scientific support for the conduct of research.  

    NIH recognizes the importance of all institutions of higher learning in contributing to the nation’s research capacity. NIH intends to make available 25% of the funds to support projects from Institutions of Emerging Excellence (as defined in 42 USC 283k(c)(2)). These institutions play a special role in advancing biomedical research as they leverage their research abilities to address problems of special relevance or unmet health needs. Often these institutions are located in the geographical areas in which deficits in research resources and health-related services/technologies may adversely affect health status of the population. Serving individuals from disadvantaged backgrounds by carrying activities related to training, health services, or biomedical research contributes to protecting health of such populations. Such institutions often serve as centers for dissemination of health information, training development, and advancement of research.

    It is expected that all projects - both from research-intensive institutions and Institutions of Emerging Excellence - will have long-term effect and benefit the broad biomedical research community at the applicant institution by providing a modern research environment, accessible on a shared basis.

    Requests for regular maintenance, replacement of aging or failing equipment, and other routine work are not appropriate for this FOA, and such requests will not be supported. Inappropriate are requests for upgrades of a space serving a single investigator. Also, equally inappropriate are requests to support facilities for billable medical care, office space, or classrooms.

    Applicants may request funds for costs of design and implementation of the project. Specifically, the allowable costs include the architectural and engineering design fees, contingency fees, construction and fixed equipment costs, and commissioning costs of the facility - compare the Funding Restrictions section for further details of allowable and non-allowable costs. Applicants are encouraged to follow sustainable design principles and to use green technologies.

    To appropriately conceive, develop, construct, and successfully complete the project, a Program Director/Principal Investigator (PD/PI) should possess knowledge of the relevant scientific field, have a vested professional interest in the success of the project, demonstrate leadership skills, and assemble a team with technical expertise related to all aspects of the project. The PD/PI does not need to be a currently NIH-funded investigator but should have the appropriate standing in the institutional administration and the research community to lead and oversee the project.

    The project should be consistent with the following criteria and documentation requirements:

    • The project is essential for research activities supported and the space involved will be used for these activities.
    • The building must have a useful life consistent with program purposes, including the time to construct and complete the project plus 20 years of use following the occupancy of the research space; the building must be architecturally and structurally suitable for conversion to the type of research space required.
    • If the space is rented, evidence must be provided that the terms of the lease and expected subsequent 20-year use of the facility are consistent with the proposed project. Specifically, a signed document from the building owner must be provided that the terms of the lease agreement and subsequent use of the facility will comply with the 20-year term of the Notice of Federal Interest (NFI) requirement following the occupancy of the facility. A statement of agreement by the owner of the space must be included. These documents will be verified if/when the application is considered for funding.
    • If the project will affect a site listed (or eligible for inclusion) in the National Register of Historic Places, the requirements specified in "Preservation of Cultural and Historic Resources" must be followed.

    PDs/PIs are strongly encouraged to contact the Scientific/Research Contact listed in Section VII. Agency Contacts to discuss their planned projects before submitting applications.

    See Section VIII. Other Information for award authorities and regulations.

    Section II. Award Information
    Funding Instrument

    Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

    Application Types Allowed

    New

    The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.

    Funds Available and Anticipated Number of Awards

    The number of awards is contingent upon the submission of a sufficient number of meritorious applications.

    NIH intends to fund an estimate of 8-15 awards, corresponding to a total of up to $50,000,000, for fiscal year 2019.

    NIH intends to make available 25% of $50,000,000 to Institutions of Emerging Excellence.

    Award Budget

    Application budget is not limited but need to reflect the actual needs of the proposed project. The the maximum award budget is $8,000,000. Applications with budget less than $3,000,000 will not be considered. Since the scope of different projects will vary it is anticipated that the size of the awards will vary.

    Award Project Period

    The total project period may not exceed five years. Funds will be provided in a single award with a 60-month budget and project period.

    Architectural and engineering design fees are immediately available to applicants at the time of the Notice of Award (NoA); all other award funds are restricted until ORIP approves the design documents; upon the approval NIH will issue a revised NoA to release the restricted award funds.

    NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA.

    Section III. Eligibility Information
    1. Eligible Applicants
    Eligible Organizations

    Higher Education Institutions

    • Public/State Controlled Institutions of Higher Education
    • Private Institutions of Higher Education

    The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

    • Hispanic-serving Institutions
    • Historically Black Colleges and Universities (HBCUs)
    • Tribally Controlled Colleges and Universities (TCCUs)
    • Alaska Native and Native Hawaiian Serving Institutions
    • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
    Foreign Institutions

    Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
    Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

    Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

    Required Registrations

    Applicant Organizations

    Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

    • Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.
    • System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
    • NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. 
    • eRA Commons - Applicants must have an active DUNS number to register in eRA Commons. Organizations can register with the eRA Commons as they are working through their SAM or Grants.gov registration, but all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
    • Grants.gov – Applicants must have an active DUNS number and SAM registration in order to complete the Grants.gov registration.

    Program Directors/Principal Investigators (PD(s)/PI(s))

    All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

    Eligible Individuals (Program Director/Principal Investigator)

    Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed construction as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

    Multiple PDs/PIs are not allowed.

    The PD/PI should hold appropriate stature within the institutional administration structure and be able to oversee various facets of the entire project. The PD/PI should also demonstrate his/her leadership skills to recruit and guide expert Key Personnel with complementary scientific and technical skills to successfully plan, design, and accomplish the construction project.

    2. Cost Sharing

    This FOA does not require cost sharing.

    3. Additional Information on Eligibility
    Number of Applications

    Only one application per institution (identified by NIH IPF number) is allowed.

    The NIH will not accept duplicate or highly overlapping applications under review at the same time.  This means that the NIH will not accept:

    • A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
    • A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
    • An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101).
    Section IV. Application and Submission Information
    1. Requesting an Application Package

    The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

    2. Content and Form of Application Submission

    It is critical that applicants follow the the Research (R) Instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

    Letter of Intent

    Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

    By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information:

    • Descriptive title of proposed activity
    • Name, address, and telephone number(s) of the PD/PI
    • Names of other key personnel
    • Participating institution
    • Number and title of this funding opportunity

    The letter of intent should be sent to:

    Willie D. McCullough, Ph.D. 
    Office of Research Infrastructure Programs (ORIP)
    Email: ORIPCONSTRUCTION@od.nih.gov    

    Page Limitations

    All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed, with the following exceptions or additional requirements:

    • For this FOA, there is no Research Strategy.
    • The Project Narrative attachment of the SF424 (R&R) Other Project Information form is limited to 12 pages, excluding Line Drawings and specifically required Tables.

    Instructions for Application Submission

    The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.

    SF424(R&R) Cover

    All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

    Estimated Project Funding: Applicants must provide the 'Total Federal Funds Requested', 'Total Federal and Non-Federal Funds', and 'Estimated Program Income’.

    Is Application Subject to Review by State Executive Order 12372 Process: Applicants should indicate "yes" and provide the date the application was submitted to the State.     

    SF424(R&R) Project/Performance Site Locations

    All instructions in the SF424 (R&R) Application Guide must be followed.  

    SF424(R&R) Other Project Information

    All instructions in the SF424 (R&R) Application Guide must be followed.

    Project Narrative: The Project Narrative should consist of three sections: Overview, Scientific Justification, and Development of the Facility.

    The Overview section (in lieu of Specific Aims) cannot exceed 1 page and must summarize the project, stating its goals, and outlining the proposed approaches to achieve them. Specifically, this section should include a description of the space affected by the project and any equipment which is requested in this application – Tables 1 and 2 in Other Attachments may be referenced to simplify the presentation. A brief statement should be also included to summarize how the project will enhance institutional-wide research programs and benefit research groups.

    A timeline for different stages of the project and its completion within the 5-year budget period should be included in Other Attachments.

    It is up to the PD/PI to allocate the remaining 11 pages of the Project Narrative to the sections: Scientific Justification and Development of the Facility. A successful application does not need to reach the page limitation; however, it must justify the request from the scientific perspective and describe technical design approaches with enough details to make clear the merits of the overall project. These merits include plans for long-term use of the space by many researchers.

    The Scientific Justification section should focus on how the project will increase the institution-wide biomedical research capabilities and capacities. Defined biomedical research needs should drive the request and this section should make connections to the research community which would benefit from the project. To justify the need for the modernization of a core facility or an institutional laboratory, the PD/PI should describe the space and/or fixed equipment currently available to the institutional research community. The PD/PI should also identify present infrastructure deficiencies that impede biomedical research.

    The PD/PI should briefly describe the research needs of the community who will rely on the proposed facility.

    For example, in the case of research-intensive institutions, a presentation of how the conduct of selected active NIH-funded research projects would be advanced by the new or improved infrastructure, will strengthen the justification. Table 3 in Other Attachments may be used to reference individual projects active, at the time of the application submission, and the specific infrastructure needs of the research program these projects are part of. It should be made clear that these needs won’t expire when the listed grants end and there is an existing sufficiently strong research community at the institution which will be able to rely on the new infrastructure.

    Centers and other resources which support a regional or nation-wide community of researchers should describe their role in enabling specific research activities and illustrate this point by giving examples of NIH-funded research projects which would be directly enhanced by the proposed infrastructure improvements. Here, Table 3 in Other Attachments may be referenced. Long-term plans for support of infrastructure and research programs should be outlined to illustrate the institutional commitment for the scientific program.

    In the case of Institutions of Emerging Excellence, the PI should outline the currently undertaken efforts towards the advancement of biomedical research and relate these efforts to the long-term growth plans. Deficits in the available research infrastructure and plans to correct them should be a part of the justification of the needs for the new infrastructure. This justification should be specific about the research area to be supported and address the relevant expertise and other available resources on which the expansion plans are built. It should be made clear how the proposed improvement in the infrastructure will enhance biomedical research at the institution. Table 3 in Other Attachments may be included, as applicable.

    The narrative about the long-term institutional commitment to support biomedical research should be a part of the justification of the needs for the new or upgraded infrastructure. This justification should be specific about the research area to be supported and address the present relevant expertise and available infrastructure on which the expansion plans are built. It should be made clear how the proposed improvement in the infrastructure will enhance biomedical research at the institution.

    The presentation of this section should provide a bridge between the long-term institutional vision for biomedical research and the proposed infrastructure developments. The narrative of this section should make it clear how the facility will be used by or provide services to many researchers.

    This section should conclude with a paragraph about how the PD/PI will work with the project Key Personnel on overseeing the planning process and its execution. The team members’ individual roles and their responsibilities at different stages of the project should establish their expected contribution towards the overall goal. It is also important for the PD/PI to describe how the team will be organized and demonstrate how its members will work together at different stages of the project. The PD/PI should document that the team as a group has expertise and skills necessary to design and construct the facility so that the scientific objectives are met.

    The Development of the Facility section should present technical specifications, details of the architectural and engineering design, and the proposed construction processes. The PD/PI should provide enough details about implementation of the project, including technical challenges that will need to be overcome. This narrative should start with the location of the building in which the facility is to be housed (if a new structure is to be erected) or the location of the existing building (if a present facility is to be modernized) in relation to other buildings in the immediate area. In either case the narrative should also describe the location of the project in the building. The level of detail of the application's Line Drawings, data in Tables 1 and 2 in Other Attachments and the narrative of this section must provide sufficient information for reviewers to determine the functionality of the overall design plans, and the safety and reliability of the proposed facility. The design specifications must adhere to the federal and industry standards and meet the requirements set by standard operating procedures described in the section Scientific Justification, as applicable.

    In the narrative, all requested fixed equipment should be justified as being relevant to the function of the facility. Also, the needs of all fixed equipment in the context of the engineering aspects of the project such as mechanical, electrical, and plumbing (MEP) specifications for their installation should be presented - compare data in Table 2 in Other Attachments, below.

    The PD/PI should provide engineering and architectural criteria as relevant to the project, including:

    • MEP specifications, such as hot and cold water, and steam requirements; number of air changes per hour, and any special ventilation requirements;
    • fire protection requirements; building automation systems; security/surveillance;
    • biohazard and radiation safety requirements; chemicals used;
    • width of corridors and doors and surface finishes;
    • quality of life issues (e.g., light levels, natural lighting, noise, vibration);
    • functional relationships and zoning of the area.

    All these criteria should be the justified in the context of the specific function(s) of the requested facility, and a description of how they will be met should be provided.

    In summary, all requests must be justified in terms of both the scientific needs and the corresponding technical requirements for the facility. In particular, to address the rationale for the technical design, plans for the use of the facility must be clearly outlined. Attention must be paid to federal and industry biosafety standards and codes, so upon the completion of this project, the occupancy permit can be secured, and the facility can serve its research purpose.

    The NIH Design Requirements Manual (DRM) is a useful document that provides design guidelines for NIH-funded construction projects. The project design documents should follow the most recently published standards for biomedical research facilities.

    Whenever practicable, the applicant should employ sustainable design practices and green technologies. Sustainability is the outcome of an integrated process of facility development and operation, incorporating a balance of life-cycle cost, environmental impact, and occupant health, safety, security, and productivity. The following primary elements of sustainable design should be discussed, as applicable:

    • Optimization of energy use;
    • Protection and conservation of indoor water (i.e., fixtures that reduce amount of water used; recycling of waste water) and outdoor water (i.e., natural site drainage and low impact storm water retention);
    • Indoor environmental quality, including ventilation and thermal comfort, humidity control, day lighting;
    • Reducing the environmental impact of materials by using low-emitting materials and minimizing use of ozone depleting compounds, construction waste reuse and recycling, maximizing recycled and bio-based content.

    If an award is made, for all improvements and repair projects that impact 40% or more of the overall floor area of a building, the applicant must obtain certification, during the design phase, from the U.S. Green Building Council's Leadership in Energy and Environmental Design (LEED) or the Green Building Initiative's Green Globes System Certification rating system.

    Other Attachments: In the Other Attachments section, the PD/PI must include the following required documents, as indicated below, each as a separate attachment: attachments must be given a file name using the headings below (e.g., Line Drawings, Budget Justification):

    1) Line Drawings (required): Each line drawing must fit on an 8.5” x 11” sheet of paper. (Do not submit "blueprints".) All floor plans must be legible, with the scale clearly indicated on each page. The floor plans must indicate the location of equipment and illustrate safety clearances and workspace. If applicable, submit drawings of the existing and proposed space. The drawings must indicate:

    • size dimensions, function, and the net and gross square feet for each room;
    • location of the proposed construction/renovation area in the existing building;
    • changes or additions to existing mechanical, electrical and plumbing systems; notes that annotate these changes may be made directly on the plan;
    • functional layout of the proposed facility, showing the location of entries and exits, egress routes, clearances, and the location of fixed equipment.

    Although the line drawings do not count toward the page limits, do not include additional text.

    2) Table 1 (required): list the size (dimensions) and square footage of each component (e.g., clean room, laboratory, closet etc.) that will be directly affected by the project.

    3) Table 2 (required): list of requested fixed equipment. Table 2 should include information such as the manufacturer, model number, size, capacity, total cost, and location in the facility. Total cost of each item must be supported by vendor quotes in the Budget Justification and Vendor Quotes attachment (see below).

    4) Table 3 (optional): list of active research grants which are directly related to the project. This table must have the following columns: (1) Funding Agency; (2) Grant Number; (3) PD/PI Name; (4) Annual Direct Costs in FY2018; (5) Start and End Dates. Do not list more than 12 relevant grants.

    5) Project timeline (required): To demonstrate how the project will be completed within the five-year budget and award period.

    6) Budget Justification and Vendor Quotes (required): Justify and describe the application budget for the project. All vendor quotes should be attached here, along with a justification for each piece of equipment. This will be an attachment that will include a brief narrative justification of the proposed project budget and vendor quotes.

    7) Institutional Support Letter (required). A letter from a high-ranking institutional official (e.g., Dean, Provost, President) indicating institutional support for the research activities to be conducted in the new facility, to document that it will be used as proposed. The letter must be co-signed by an institutional Signing Official.

    8) Certification of Title to Site (required): Applicants must include a legal opinion describing the interest the applicant institution has in the performance site. The legal opinion should describe any mortgages or other foreclosable liens on the property, including the principal amount of the mortgage (and rate of interest); the dates of the mortgage; the terms and conditions of repayment; the appraised value of the property; and any provisions designed to protect the Federal interest in the property. The facility must be utilized for biomedical research purposes for which it was improved for at least 20 years beginning on the date of beneficial occupancy of the space. Any lease agreement must cover a time period sufficient for the usage requirement and be a minimum of 20 years in length from the completion of the facility.

    9) Support Letter (optional): A maximum of five optional support letters may be attached. Attach the support letters in a single file; name the attachment Support Letters.

    SF424(R&R) Senior/Key Person Profile Expanded

    All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

    The PD/PI must recruit Key Personnel with complementary scientific and technical skills. The PD/PI should be a PhD-level scientist who has a vested interest in the success of the project; for example, a College Dean who oversees research space, Director of an Institute or Center, or a Scientific Director of a Core Facility. Also, an individual with technical proficiency in engineering or architectural matters related to the design and oversight of the facilities (a Facilities Person) must be identified for this application. This person with will closely work with the PD/PI and an outside consulting firm on all technical aspect of the projects; including planning, designing, carrying out, completing, and commissioning of the facility. A project role for this person should be specified as “Other” or “Other Professional” and a biographical sketch with relevant information about professional qualifications and expertise should be attached. Other Key Personnel, such as a manager of the facility and other scientists or technical experts, should be added to the team as needed to achieve the goals of the project promptly and efficiently.

    SF424C Budget Information for Construction Programs

    All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

    The Budget Information for Construction Programs (SF424C) must be used to attach an overall application budget page for the total requested funds.

    Applicants must provide the “Total Federal Funds Requested”, “Total Federal and Non-Federal Funds”, and “Estimated Program Income’ on the SF424 (R&R) Cover form.

    PHS 398 Cover Page Supplement

    All instructions in the SF424 (R&R) Application Guide must be followed.   

    PHS Assignment Request Form

    All instructions in the SF424 (R&R) Application Guide must be followed. 

    3. Unique Entity Identifier and System for Award Management (SAM)

    See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov.

    4. Submission Dates and Times

    Part I. Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

    Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH’s electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time.  If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Policy on Late Application Submission.

    Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

    Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

    5. Intergovernmental Review (E.O. 12372)

    This initiative is subject to intergovernmental review.

    6. Funding Restrictions

    All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

    Pre-award costs are allowable only as described in the NIH Grants Policy Statement.

    Funds will be awarded in a single action using a 60-month budget and project period.  

    The requested budget can support design, construction activity and purchase of fixed equipment and its installation costs. The fixed equipment may include infrastructure equipment, such as HVAC units serving the facility and other large fixed equipment connected to the building structure and services. Also, requests can be made for fixed laboratory equipment and its installation costs. Examples of such equipment include, but are not limited to:

    • fume hoods and laminar flow stations;
    • biosafety cabinets;
    • fixed casework and laboratory benches;
    • autoclaves and other sterilizing equipment.

    Allowable costs also include:

    • appraisals;
    • bid advertising;
    • inspection and commissioning fees;
    • project management;
    • contingency fees (Allowable contingency fees are limited to 15 percent of the total allowable costs before bids are received and must be reduced to 10 percent after a construction contract has been awarded.);
    • filing fees for recording of Notice of Federal Interest (NFI).

    Not-allowable costs include:

    • personnel costs not related to actual construction;   
    • bonus payments to contractors;
    • consultant fees not related to actual construction;
    • damage judgement suits;
    • movable equipment;
    • scientific instruments (e.g., microscopes, scanners, spectrometers);
    • FDA approval process following the completion of the construction project;   
    • F&A costs;
    • supplies;
    • fund-raising expenses;
    • interior and exterior decorating fees (e.g., purchase of artwork, sculpture, etc.).

    To protect the Federal interest in improved real property, grantees will be required to file a Notice of federal Interest (NFI) in the Land Record Office of the jurisdiction where the facility will be located as required by 45 CFR 75.323 and the NIH GPS. The NFI is required when use and disposition conditions apply to the property as stated in the NoA. The time of recordation shall be when construction begins. A copy of the recorded NFI must be provided to the Grants Management Office within 10 days following the date of recordation - see Section VII Agency Contacts Funds will be awarded in a single action using a five-year budget and project period.

    If awarded, all funds will be restricted except for Project Design and Engineering Fees. NIH must approve the design documents before releasing the restricted funds. The awardee will be asked to submit the design documents for technical review. The purpose of the NIH design review is to ensure that applicable design standards are incorporated into the drawings and specifications so that the program requirements can be met. It is expected that the technical review process will be conducted in three stages for:

    • Schematic Design Documents (SDDs) (15-30%),
    • Development Design Documents (DDDs) (50-65%), and
    • Construction Design Documents (CDDs) (95-100%).

    Review at each stage may take 4-6 weeks. The applicant must submit SDDs within 4 months following the receipt of the Notice of Award (NoA), but considering the technical review timeline, the earliest possible submission of the design documents is encouraged following the receipt of the NoA.

    The Environmental Analysis Form is not required at the time of the application submission. Instead, a Grants Management Specialist will request this information as part of the Just-in-Time process (NOT-OD-10-120).

    7. Other Submission Requirements and Information

    Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide.  Paper applications will not be accepted.

    Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

    For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.

    Important reminders:
    All PDs/PIs must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

    The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization’s profile in the eRA Commons and for the System for Award Management (SAM). Additional information may be found in the SF424 (R&R) Application Guide.

    See more tips for avoiding common errors.

    Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review, NIH. Applications that are incomplete or non-compliant will not be reviewed.

    Post Submission Materials

    Applicants are required to follow the instructions for post-submission materials, as described in the policy. Any instructions provided here are in addition to the instructions in the policy.

    Section V. Application Review Information
    1. Criteria

    Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.

    Overall Impact

    Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

    Scored Review Criteria

    Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

    Scientific Merit and Organization of the Total Program and Its Component Parts to be Carried Out in the Facility

    Does the applicant provide sufficient evidence of meritorious research program(s) that will benefit from completion of the project? How well are the component parts of the research program (that will be carried out in the facility) coordinated and managed?  How will the proposed repair, renovation, or modernization activity facilitate the applicant institution’s ability to conduct, expand, improve, or maintain biomedical or behavioral research? 

    Is there sufficient justification for improving this core facility?  To what extent will the proposed change in the research environment facilitate the applicant institution’s ability to conduct, expand, improve, or maintain biomedical or behavioral research? How will the proposed repair, renovation, or modernization activity increase efficiency in the use of energy, water, and/or materials to reduce adverse effects on the environment?   

    Administrative and Leadership Capabilities of the Applicant’s Officers and Staff

    How effective is the facility manager likely to be, based on 1) the administrative approach to managing the facility, 2) the ability to interact with appropriate institutional officials to see that the ongoing needs of the facility are satisfied, and 3) the skills necessary to complete the project on time and within budget?

    How effective is the PD/PI likely to be, based on 1) leadership qualities and experience, 2) institutional commitment and support, and 3) the appropriate scientific and fiscal administration skills necessary to complete this project on time and within budget?  Does the applicant provide evidence of future commitment in maintaining this facility?   

    Anticipated Effect of the Project on Other Relevant Research Programs and Facilities in the Geographic Area and Nationwide

    How likely is the proposed activity to benefit research at other institutions in the local geographic area, given the availability or absence of similar or related facilities?  In which ways is the proposed activity likely to affect similar or related national facilities or benefit research nationwide?   

    Need for the Project or Additional Space

    How compelling are: 1) the identified need(s) in the research capabilities in the applicant organization and elsewhere that the proposed repair, renovation, or modernization activity is intended to address; 2) tangible benefits to the institutional research capability of the proposed activity; and 3) state-of-the-art research capabilities or efficiencies that would otherwise not be available?

    Are requests for equipment justified and of direct benefit to the facility?  Will the requested equipment remedy identified deficiencies or fill gaps in the animal facility?  

    Project Design

    Design Plan: How likely is the design plan to meet the identified need(s), based on: 1) proposed demolition areas and/or renovation areas, including associated room adjacencies, traffic patterns for the movement of people, animals, and materials (clean and dirty) through the facility, and relative location of needed ancillary areas (e.g., changing rooms for animal facilities); 2) total net and gross square feet of space to be renovated; 3) proposed timeline and sequence of construction; 4) potential problems, alternative strategies, and benchmarks for success presented; and 5) implement sustainable design principles?

    Engineering Criteria: How likely are the engineering systems to meet the identified need(s), based on: 1) the engineering criteria, including information about the mechanical, electrical, and plumbing systems, and utilities in the renovation; 2) descriptions of changes or additions to existing mechanical and electrical systems; and 3) the number of air changes per hour, electrical power, light levels, hot and cold water, and steam?

    Architectural Criteria: How likely are the architectural criteria and finishes to meet the identified need(s), based on: 1) the size dimensions, function, and net and gross square feet for each component; 2) architectural criteria such as the width of corridors and doors and surface finishes for the project; and 3) quality of life issues (e.g., natural lighting, noise, vibration)?

    Line Drawings:  How likely are the line drawings to meet the identified need(s), based on: 1) the indicated function of the space; 2) the scale of the line drawings, and indication of adjacencies and operational relationships of equipment; 3) changes to be made to the space; and 4) location of major equipment, fume hoods, sinks, showers, and other major items indicated in the drawings?   

    Additional Review Criteria

    As applicable for the project proposed, reviewers will evaluate the following additional items while determining the merit of the project, and in providing an overall impact score, but will not give separate scores for these items.

    Protections for Human Subjects

    Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

    Inclusion of Women, Minorities, and Children 

    Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

    Vertebrate Animals

    Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

    Biohazards

    Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.

    Resubmissions

    Not Applicable

    Renewals

    Not Applicable

    Revisions

    Not Applicable

    Additional Review Considerations

    As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

    Applications from Foreign Organizations

    Not Applicable

    Select Agent Research

    Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).

    Resource Sharing Plans

    Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

    Budget and Period of Support

    Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

    2. Review and Selection Process

    Applications will be evaluated by (an) appropriate Scientific Review Group(s), convened by CSR, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.


    As part of the scientific peer review, all applications:

    • May undergo a selection process in which only those applications deemed to have the merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
    • Will receive a written critique.

    Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the Council of Councils. The following will be considered in making funding decisions:

    • Impact score assigned to the application by the NIH peer review group
    • Relevance of the project for which construction is proposed to the objectives and priorities of
    • the particular program authorized by the Public Health Service Act
    • Scientific merit of the research activities that will be carried out in the proposed facility
    • Scientific or professional standing or reputation of the applicant and of its existing or proposed officers and research staff
    • Availability, by affiliation or other association, of other scientific or health personnel and facilities to the extent necessary to carry out effectively the program proposed for the facility, including the adequacy of an acceptable biohazard control and containment program when warranted
    • The need for the facility and its total effects on similar or related facilities in the locale, and the need for appropriate geographic distribution of similar facilities
    • The project cost and design
    • Availability of funds.
    • Geographical location.
    3. Anticipated Announcement and Award Dates

    After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons. Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.  

    Information regarding the disposition of applications is available in the NIH Grants Policy Statement.

    Section VI. Award Administration Information
    1. Award Notices

    If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement.

    A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee’s business official.

    Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.      

    Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website.  This includes any recent legislation and policy applicable to awards that is highlighted on this website.

    2. Administrative and National Policy Requirements

    All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General  and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.

    Recipients of federal financial assistance (FFA) from HHS must administer their programs in compliance with federal civil rights law. This means that recipients of HHS funds must ensure equal access to their programs without regard to a person’s race, color, national origin, disability, age and, in some circumstances, sex and religion. This includes ensuring your programs are accessible to persons with limited English proficiency.  HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator’s scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research.

    For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this FOA. HHS provides general guidance to recipients of FFA on meeting their legal obligation to take reasonable steps to provide meaningful access to their programs by persons with limited English proficiency. Please see https://www.hhs.gov/civil-rights/for-individuals/special-topics/limited-english-proficiency/index.html. The HHS Office for Civil Rights also provides guidance on complying with civil rights laws enforced by HHS. Please see https://www.hhs.gov/civil-rights/for-individuals/section-1557/index.html; and https://www.hhs.gov/civil-rights/for-providers/laws-regulations-guidance/index.html. Recipients of FFA also have specific legal obligations for serving qualified individuals with disabilities. Please see https://www.hhs.gov/civil-rights/for-individuals/disability/index.html. Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at https://www.hhs.gov/ocr/about-us/contact-us/index.html or call 1-800-368-1019 or TDD 1-800-537-7697. Also note it is an HHS Departmental goal to ensure access to quality, culturally competent care, including long-term services and supports, for vulnerable populations. For further guidance on providing culturally and linguistically appropriate services, recipients should review the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care at http://minorityhealth.hhs.gov/omh/browse.aspx?lvl=2&lvlid=53.

    In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements.  FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award.  An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a Federal agency previously entered and is currently in FAPIIS.  The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicant’s integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 “Federal awarding agency review of risk posed by applicants.”  This provision will apply to all NIH grants and cooperative agreements except fellowships.

    Cooperative Agreement Terms and Conditions of Award

    Not Applicable

    3. Reporting

    Progress reports for multiyear funded awards are due annually on or before the anniversary of the budget/project period start date of award. The reporting period for multiyear funded award progress report is the calendar year preceding the anniversary date of the award. Information on the content of the progress report and instructions on how to submit the report are posted at http://grants.nih.gov/grants/policy/myf.htm.

    A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement. Following completion and occupancy of the facility, grantees must certify on a yearly basis for 20 years that the facility is used to conduct biomedical research.

    The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later.  All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000.  See the NIH Grants Policy Statement for additional information on this reporting requirement. 

    In accordance with the regulatory requirements provided at 45 CFR 75.113 and Appendix XII to 45 CFR Part 75, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period.  The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS).  This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313).  As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available.  Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 – Award Term and Conditions for Recipient Integrity and Performance Matters.

    Section VII. Agency Contacts

    We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

    Application Submission Contacts

    eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten submission by the due date, and post-submission issues)

    Finding Help Online: http://grants.nih.gov/support/ (preferred method of contact)
    Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

    General Grants Information (Questions regarding application instructions, application processes, and NIH grant resources)
    Email: GrantsInfo@nih.gov (preferred method of contact)
    Telephone: 301-945-7573

    Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace)
    Contact Center Telephone: 800-518-4726
    Email: support@grants.gov

    Scientific/Research Contact(s)

    Willie D. McCullough, Ph.D. 
    Office of Research Infrastructure Programs (ORIP)
    Telephone: 301-435-0783
    Email: mccullow@mail.nih.gov

    Peer Review Contact(s)

    Ross D. Shonat, Ph.D.
    Center for Scientific Review (CSR)
    Telephone: 301-435-2786
    Email: ross.shonat@nih.gov

    Financial/Grants Management Contact(s)

    Gavin Wilkom, M.I.M.
    National Center for Advancing Translational Sciences (NCATS)
    Office of Research Infrastructure Programs (ORIP)
    Telephone: 301-435-0964
    Email: wilkomg@mail.nih.gov

    Section VIII. Other Information

    Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

    Authority and Regulations

    Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284), 42 USC 283k, and under Federal Regulations 42 CFR Part 52b and 45 CFR Part 75.

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