Notice of Change in Research Objectives for PAS-16-033, Stimulating Hematology Investigation: New Endeavors (SHINE) (R01)

Notice Number: NOT-DK-18-020

Key Dates
Release Date: August 30, 2018

Related Announcements
PAS-16-033

Issued by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)

Purpose

The NIDDK, NIA and NHLBI are pleased to jointly announce support for a newly emerging topic in the field of nonmalignant hematology research through the "Stimulating Hematology Investigation:  New Endeavors (SHINE) (R01)" program (PAS-16-033). 

Background

The SHINE program allows ICs to maintain a flexible, pro-active role in supporting timely, high impact, leading edge research by the hematology research community using a Program Announcement with Set-aside funds.  The emerging new topic, “Integrated Biology of Erythrocyte Maturation” was informed by a workshop held on May 29, 2018.  For an agenda and a listing of topics discussed, please click here . 

Investigator-initiated research project grant applications (R01) are invited to propose research in specific areas of basic and translational hematology research where needs and opportunities for progress are particularly timely.  Specific research topic areas supported by the SHINE program, as outlined below, will change over time and be updated annually through Notices published in the NIH Guide to Grants and Contracts.  R01 applications proposing to use model organisms and/or human samples are appropriate.  Incoming applications will be assigned to one of the three participating Institutes according to standard receipt and referral guidelines.

New scientific knowledge gained through research supported by the SHINE program will vary. In general, knowledge gaps and research opportunities addressed by the SHINE program will include those defined and highlighted by IC-sponsored workshops and other public meetings.  The overall objectives of the SHINE program are to catalyze discoveries in basic molecular and cellular biology to provide new insights into the pathogenesis, prevention, detection, and potential treatment of benign hematologic diseases, to attract new investigators into basic and translational hematology research, to promote productive interdisciplinary research collaborations, and to reinforce interactions and communication between ICs and the hematology research community. Because research topics featured in the SHINE program will change over time, the program will be dynamic and reflect evolving frontiers of hematology research needs and opportunities.


Specific Areas of Research Interest

Relevant research questions for this new SHINE topic include, but are not limited to:

  • What are the cellular regulators that direct erythroblast nuclear condensation? What kinds of cellular signaling networks promote remodeling and maturation? What are the signals that modulate a successful transition to enucleated reticulocyte?

  • How does the reticulocyte accomplish post-transcriptional regulation of mRNA, proteins, and sub-cellular localization of organelles and other cellular structures?

  • How do structures of the red cell membrane, such as lipids or membrane and skeletal proteins ensure erythrocyte integrity and survival in the peripheral blood? What are the interactions between cellular components that lead to mechanical stability, response to fluid shear stress, and membrane deformability?

  • What extrinsic and intrinsic factors (e.g. proteins, lipids, metabolites, environmental conditions) modify erythrocyte structure and function in normal and diseased states?

  • What are the mechanisms in the bone marrow, periphery, or intrinsic to the erythrocytes that allow for and regulate heterogeneity/variation of normal erythrocytes? What are the signals for degradation in developing erythroid progenitors or fully mature erythrocyte?

  • How do regulators of erythroid maturation or erythrocyte survival differ across stages of vertebrate blood cell development (e.g. yolk sac versus fetal liver versus bone marrow) or across the life span (e.g. in children versus older adults)?

With the publication of this Notice, the following SHINE-eligible topics are encouraged:

  • Regulatory Determinants of Hematopoietic Stem Cell Fate:  See:  NOT-DK-12-007

  • Role of Noncoding RNA in Hematopoiesis.  See NOT-DK-14-001

  • Role of Macrophages in Blood Cell Development.  See NOT-DK-15-011

  • Effects of Aging on Hematopoiesis.  See NOT-DK-16-007

  • Metabolic Modulators of Hematopoiesis.  See NOT-DK-17-002

  • Remodeling the Hematopoietic Stem Cell Niche.  NOT-DK-17-016

  • Biology of Erythrocyte Maturation (This Notice). 

Applicants are strongly encouraged to contact one of the NIDDK, NIA or NHLBI Scientific/Research staff to discuss plans for preparation of an R01 application.

All other aspects of this Funding Opportunity Announcement remain the same.

Inquiries

Please direct all inquiries to:

Terry Rogers Bishop, Ph.D.
Hematopoietic Stem Cells, Hematopoiesis, Globin Gene expression
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-594-7726
Email:  terry.bishop@nih.gov

Cindy N. Roy, Ph.D.
Iron in Hematology, Heme Biosynthesis, Bone Marrow Failure/Myelodysplastic Syndrome, Terminal Erythropoiesis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-594-8805
Email: cindy.roy@nih.gov

John W. Thomas, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0065
Email:  thomasj@nhlbi.nih.gov

Malgorzata Klauzinska, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-827-8276
Email:  klauzing@nih.gov

Rebecca Fuldner, Ph.D.
National Institute on Aging (NIA)
Telephone:  301-402-7748
Email:  fuldnerr@nia.nih.gov

John P. Williams, Ph.D.
National Institute on Aging (NIA)
Telephone:  301-827-6373
Email: williamsj6@mail.nih.gov