Notice To Announce Continued Funding and Updated Research Objectives for PAS-16-033 "Stimulating Hematology Investigation: New Endeavors (SHINE) (R01)

Notice Number: NOT-DK-17-002

Key Dates
Release Date: November 23, 2016

Related Announcements

Issued by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Heart, Lung, and Blood Institute (NHLBI


In a continuing effort to support emerging fields in nonmalignant hematology research, NIDDK and NHLBI are pleased to announce continued funding and additional research objectives for PAS-16-033 "Stimulating Hematology Investigation: New Endeavors (R01)"

The collaborative SHINE program (PAS-16-033) has set aside approximately $1,750,000 between the two Institutes to make approximately 6-8 awards in addition to those funded in accordance with FY2018 funding policies.  These funds will be used for highly meritorious applications received in response to PAS-16-033 in the specific scientific areas mentioned below.

(1) As announced in the inauguration of the SHINE program (PAS-10-046, the predecessor of PAS-16-033)), specific topic areas will change to meet timely needs and opportunities for hematology research progress. Applicants are encouraged to contact NIDDK or NHLBI Scientific/Research staff to discuss plans for preparation of an R01 application.

(2) With the publication of this Notice, the following SHINE-eligible topics are encouraged:

•          Regulatory Determinants of Hematopoietic Stem Cell Fate.  See:  NOT-DK-12-007.
•          Role of Noncoding RNA in Hematopoiesis.  See NOT-DK-14-001.
•          Role of Macrophages in Blood Cell Development.  See NOT-DK-15-011.
•          Effects of Aging on Hematopoiesis.  See NOT-DK-16-007.
•          Metabolic Modulators of Hematopoiesis. See next paragraph.

(3)  The addition of the "Metabolic Modulators of Hematopoiesis" topic was informed by the Mitochondrial Biology Symposium: Novel Roles of Mitochondria in Health and Disease held May 19-20, 2016 by NIDDK in collaboration with NHLBI. Cellular metabolism plays critical roles in energy production, the maintenance of a reservoir of cellular building blocks such as amino and nucleic acids, and coordinating stress and survival responses in most cell types. Hematopoietic cells are likely to require specialized coordination of metabolic processes across their unique stages of development and across their lifespan. Relevant research questions for this new SHINE topic include, but are not limited to:

  • Do energy requirements of quiescent and differentiating hematopoietic cells differ? What are the specialized regulators that regulate metabolism across their development?
  • What are the transcriptional regulators facilitating metabolic transitions between quiescent and proliferative hematopoietic cell states in vitro and ex vivo?
  • What are the metabolic factors that regulate hematopoietic stem cell quiescence, cell cycle, and differentiation in vitro and ex vivo?
  • How are the structure and function of mitochondrial networks impacted in quiescent, proliferative, and differentiated hematopoietic cell states?
  • What are the roles of cellular metabolites in epigenetic regulation of non-malignant hematopoiesis?
  • What are the roles of cellular metabolites in the regulation of hematopoietic differentiation?

All other aspects of this Funding Opportunity Announcement remain the same.


Please direct all inquiries to:

Cindy N. Roy, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: (301) 594-8805

Manjit Hanspal, Ph.D.
Molecular, Cellular, and Systems Blood Science Branch
Division of Blood Diseases and Resources
National Heart, Lung, and Blood Institute   
Telephone: (301) 435-0050

John W. Thomas, Ph.D.
National Heart, Lung, and Blood Institute 
Telephone: (301) 435-0065