Notice to Announce Additional Research Objectives and Funding for PAS-10-046: Stimulating Hematology Investigation: New Endeavors (SHINE) (R01)

Notice Number: NOT-DK-12-007

Release Date: July 16, 2012

NOT-DK-12-004
NOT-DK-11-004

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIDDK is pleased to announce additional funding and expansion of research objectives for PAS-10-046: Stimulating Hematology Investigation: New Endeavors (SHINE) (R01).

This Notice provides three updates to PAS-10-046:

1) An additional $1,000,000 has been set-aside in fiscal year 2013 to make approximately 2 - 4 awards issued under this FOA in addition to those funded within NIDDK regular funding policies;

2) A new research objective for the SHINE program is, "Regulatory Determinants of Hematopoietic Stem Cell (HSC) Self-Renewal versus Lineage Commitment and Terminal Differentiation". R01 applications requesting support for this research topic will now be accepted under PAS-10-046.

This additional research area has been added in response to an NIDDK-sponsored workshop on this topic on February 20, 2012, see: http://www2.niddk.nih.gov/News/Calendar/Hema2012.htm. Applications that focus on leukemia and its pathogenesis will not be accepted. You are encouraged to contact a Program Official to discuss your plans. Research areas to be addressed include, but are not limited to:

• Clarification of cell-cycle dependent epigenetic and transcriptional events that determine HSC self-renewal vs. lineage commitment
• Use of novel live cell imaging technologies to understand the molecular basis of symmetric and asymmetric divisions and their role in determining HSC self-renewal vs. lineage commitment
• Identification and characterization of epigenetic and transcriptional regulation changes that stabilize hematopoietic lineage fate decisions and promote terminal differentiation of HSC
• Clarification of how the hematopoietic stem cell niche influences the epigenetic and transcriptional regulation of HSC self-renewing potential vs. lineage commitment, including signaling networks that impact the fate of HSC.

3) The seven topics that comply with the SHINE program for Fiscal Year 2013 are:

• Regulatory Determinants of HSC Fate
• Stress Erythropoiesis
• Biology and Pathophysiology of Myelodysplastic Syndromes (MDS)
• Ribosomes and Their Role in Disease
• Heme Regulation during Erythropoiesis
• Anemia of Inflammation and of Chronic Disease
• Iron Overload

All other policies and aspects of this FOA remain in effect.

Please direct all inquiries to:

Terry Rogers Bishop, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
6707 Democracy Boulevard, Room 619
Bethesda, MD 20892-5458
TEL: 301-594-7726
FAX: 301-480-3510
EMAIL: [email protected]

Daniel Wright, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
6707 Democracy Boulevard, Room 621
Bethesda, MD 20892-5458
TEL: 301-594-7714
FAX: 301-480-3510
EMAIL: [email protected]