NIH Pathway to Independence Award (Parent K99/R00 – Independent Clinical Trial Required) (PA-20-187)

Scope Note

Table of IC-Specific Information, Requirements and Staff Contacts 

Release Date: May 5, 2020
Expiration Date: May 8, 2023 

NIH Institute or Center Contacts Institute/Center Specific Information

National Cancer Institute (NCI) 

Scientific Program Contact:
Michael Schmidt, Ph.D
(Applicant last name beginning with A-F)
Email: mschmidt@mail.nih.gov
 

Sonia B. Jakowlew, Ph.D
(Applicant last name beginning with G-N)
Email: jakowles@mail.nih.gov
 

Corinne Boulanger-Espeut, Ph.D
(Applicant last name beginning with O-Z)
Email: boulangc@mail.nih.gov


Grants Management Contact:

Amy Bartosch

NCI Specific Information:
The NCI accepts K99/R00 applications in all areas of cancer research.
Additional NCI-specific information/requirements can be found at: K99
 
NCI does not allow carry-over of unspent funds from the K99 phase into the R00 phase.
 
Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $30,000 per year.

National Eye Institute (NEI) 

Scientific Program Contact:
Neeraj Agarwal, Ph.D.              
Phone: (301) 451-2020
Email: agarwalnee@mail.nih.gov 

Grants Management Contact:
Karen Robinson-Smith
Phone: (301) 451-2020
Email: karen.robinson.smith@nei.nih.gov  

 

 

NEI Specific Information:

NEI will accept applications for funding that are responsive to programmatic priority areas for research within vision and ophthalmology as detailed in the National Plan for Eye and Vision Research found at www.nei.nih.gov.


Clinical Trials (CT): NEI will only accept “Mechanistic or Minimal Risk CTs” under this funding opportunity.  A mechanistic trial is defined as "A study designed to understand a biological of behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention.  "Minimal risk" means that the probability and magnitude of harm or discomfort anticipated in the research are not greater in and of themselves than those ordinarily encountered in daily life or during the performance of routine physical or psychological examinations or tests.

Salary Support: NEI will provide salary support commensurate with the applicant institution's salary structure for persons of equivalent qualifications, experience, and rank. 
Research Support: Up to $25,000 per year.

National Heart, Lung, and Blood Institute (NHLBI) 

Scientific Program Contact:
Extramural programs:
Li-Shin Huang, Ph.D. 
Phone: 301-435-0535
Email: li-shin.huang@nih.gov 

Phone: (301) 435-0535
Email:  fredrikssonk@mail.nih.gov

Intramural programs:
Kristen Z. Morgan, Ph.D. 
Phone: 301-827-5163 
Email: direducation@nhlbi.nih.gov

Grants Management Contact:

Shaheed Ziyout 
Phone: 301-827-8152
Email: shaheed.ziyout@nih.gov

NHLBI Specific Information:

Please refer to Research Training and Career Development - Postdoctoral for specific information on NHLBI programs and career development policies. 

NHLBI encourages career development award applications that propose mentored training in data science disciplines, including but not limited to Artificial Intelligence, Machine Learning, Deep Learning, Healthcare Data Analytics, Public Health Data Analytics, Imaging Analytics, Predictive Analytics, and Bioinformatics, for the creation, management, analysis, and integration of complex, large data sets in support of data-driven discovery in heart, lung, blood, and sleep health and disease. Proposals must meet all other requirements specified in the parent announcement.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

Eligibility:  If an individual has a faculty appointment and is eligible to apply for an independent research funding as the PD/PI of an NIH research grant, he/she is no longer eligible for the K99/R00 mechanism. Additionally, individuals holding certain Career Development Awards that require a faculty appointment (such as the American Heart Association CDA) are not eligible to apply for the K99/R00 mechanism. K99 awardees cannot hold a faculty appointment. If a K99 awardee is allowed to apply to an independent NIH research grant (or equivalent) funding during the K99 phase, they will be considered independent and will need to relinquish the K99 award and will not be eligible for transition to the R00 phase. To maintain R00 eligibility, awardees in the K99 mentored phase should discuss any potential changes to their academic appointment with an NHLBI Scientific Program Contact. Physician scientists with a clinical faculty appointment, distinct from their research/academic appointment, may still be eligible and should approach an NHLBI Scientific Program Contact for guidance.

Temporary 1-cycle extension of eligibility for NHLBI applicants to the NIH K99/R00 award due to the COVID-19 pandemic

National Human Genome Research Institute (NHGRI) 

Scientific Program Contact:
Heather A. Colley
National Human Genome Research Institute (NHGRI)
Telephone: 301-480-2332
Email: heather.colley@nih.gov

Grants Management Contact:
Deanna Ingersoll
Phone: 301-435-7858
Email: Deanna.Ingersoll@nih.gov
NHGRI Specific Information: 

NHGRI supports the development of resources, approaches, and technologies that accelerate and support studies focused on the structure and biology of genomes; the genomics of disease; the implementation and effectiveness of genomic medicine; and genomic data science and bioinformatics. NHGRI also supports ethical, legal, regulatory, policy, economic, cultural, and societal issues raised by the advancement and use of genomics. More details about the institute’s vision and priority areas can be found in the 2020 NHGRI Strategic Vision.

Prospective applicants are strongly encouraged to contact the Scientific Program Contact to discuss their concept for this initiative during the development stages of the application.

Salary Support: NHGRI will provide K99 salary support commensurate with the applicant institution's salary structure for persons of equivalent qualifications, experience, and rank.
Research Support: Up to $30,000 per year for K99 phase. In addition to Research Support, awardees  are strongly encouraged to attend at least one NHGRI Research Training and Career Development Annual Meeting during the K99 phase.  Travel may be requested up to $1500 each per NHGRI meeting.

National Institute on Aging (NIA)

Scientific Program Contact:
NIA Training Office
National Institute on Aging (NIA)
Email: NIAtraining@nih.gov

Grants Management Contact:

Ms. Jessi Perez, NIA
Phone: 301.402.7739
NIA Specific Information: 

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.





 
National Institute on Alcohol Abuse and Alcoholism (NIAAA) 

Scientific Program Contact:
Changhai Cui
301-443-1678
Changhai.cui@nih.gov
 

Grants Management Contact:
Judy Fox
Phone: (301) 443-4704
Email: jfox@mail.nih.gov
NIAAA-Specific Information
 
NIAAA supports post- doctoral/non-faculty level career development award (K99/R00) to ensure the development of highly qualified investigators in alcohol-related research.  Under this announcement research must focus on NIAAA’s research priorities as described in the NIAAA Strategic Plan. Examples include but are not limited to research in social, behavioral, biological,  mathematical sciences, and health services as related to alcohol use disorder and alcoholism.
 
Applications that include human subject research must comply with NIAAA policy on providing plans for submitting grant-related human subjects data to a NIAAA-sponsored data repository, the NIAAA Data Archive (NIAAA DA ), as described in NOT- AA- 19- 020.
 
To help you decide which award best suits your needs, as well as additional guidance on application specifics, see Research Training and Career Development/Training Opportunities by Grant Mechanism.
 
Salary Support: Up to $90,000 plus fringe benefits per year.
 
Research Support: Up to $50,000 per year.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 

Scientific Program Contact:
Kristy Nicks, Ph.D.
Phone: 301-594-5055
Email: kristy.nicks@nih.gov

Grants Management Contact:
Yen Thach
Phone: (301) 594-3505 
Email: thachy@mail.nih.gov
NIAMS Specific Information: 

Information about NIAMS funding mechanisms is available atActivity Codes

Salary Support: NIAMS will provide up to $60,000 per year for salary support (up to $75,000 per year for applicants with an M.D. degree), plus fringe benefits per year.
Research Support: Up to $20,000 per year.






 

National Institute of Biomedical Imaging and Bioengineering (NIBIB) 


Scientific Program Contact:
Tina Gatlin, Ph.D.
Phone: 301-480-1608
Email: christine.gatlin@nih.gov


Grants Management Contact:
Kathryn (Katie) Ellis
Phone: 302-451-4791
Email: kellis@mail.nih.gov

NIBIB Specific Information:

K99/R00

NIBIB welcomes applications from postdoctoral scientists seeking to establish an independent research career in scientific program areas relevant to NIBIB.

Before preparing an  application, prospective applicants are encouraged to fill out the NIBIB K99/R00 Eligibility Inquiry Form and forward it along with the requested attachments to the Scientific Program Contact in order to verify eligibility, determine if the application is appropriate for a K99 award through NIBIB, and ensure that the application is submitted to the appropriate funding opportunity.

More information on this and other NIBIB Career Awards can be found here.

Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

Eunice Kennedy ShriverNational Institute of Child Health and Human Development (NICHD) 

Scientific Program Contact:
Dennis A. Twombly, Ph.D.
Phone:  301-451-3371
Email:  dtwombly@mail.nih.gov
 
Grants Management Contact:
Ryan Talesnik  
Phone: (301) 435-6976 
Email: talesnikr@mail.nih.gov
NICHD Specific Information:

NICHD offers research career development awards in areas relevant to normal and abnormal human development, including contraception, fertilization, pregnancy, childbirth, prenatal and postnatal development, and childhood development through adolescence.  The mission areas also include research on intellectual and developmental disabilities and rehabilitation medicine.  More detailed information can be found at: Research By NICHD.
The K99/R00 program is designed for postdoctoral fellows (PhDs, MDs, or other) whose formal research training is nearly complete, and who expect to find a tenure-track or equivalent faculty position within 2 years of receiving the award.  Those whose career development would benefit from further research training should also consider the mentored Career Development Awards offered by NICHD (e.g., K01, K08, K23, K25).   Prospective applicants are strongly encouraged to email or call the NICHD Scientific/Research Contact to help choose among these career development award mechanisms, to determine K99/R00 eligibility, and to assess relevance of the proposed project to the NICHD mission. 
Awardees must spend at least one year on the K99 phase of the award.
 
Salary Support: For the K99 phase of the award, NICHD provides salary of up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.
 
National Institute on Deafness and Other Communication Disorders (NIDCD) 

Scientific Program Contact:
Alberto L. Rivera-Rentas, Ph.D.
Research Training Officer
Division of Scientific Programs
Phone: (301) 451-3245
Email: riverara@nidcd.nih.gov 

Grants Management Contact:
Mr. Christopher Myers
Phone: (301) 402-0909
Email: myersc@mail.nih.gov

NIDCD Specific Information:

NIDCD uses the K99/R00 program to support outstanding senior postdoctoral investigators in NIDCD research areas that are ready to complete their transition to become an independent investigator.

  • Application must demonstrate its contribution to NIDCD and its fit to NIDCD's Mission,Research Priorities, and Strategic Plan.
  • Applicants are strongly encouraged to provide clear evidence that adequate resources are available at the institution for the successful completion of the proposed research project.
  • Applications should include explicit statements from the institution and the mentor(s) addressing the following:
    • Detailed information about who will provide the necessary resources;
    • Funding source and amount of additional funding (as needed);
    • Support staff available and committed to the project;
    • Availability of biostatistical support for the duration of the study - including the planning period; and
    • A contingency plan (for the institution and mentor) for completion of the study in the event the awardee leaves the institution earlier than the end date of the award.

 
Salary Support: Up to $75,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.

National Institute of Dental and Craniofacial Research (NIDCR) 

Scientific Program Contact:
Anissa J. Brown, PhD
Research Training and Career Development Branch
National Institute of Dental and Craniofacial Research
Telephone: (301) 594-4805
Email: anissa.brown@nih.gov

Grants Management Contact:
Dede Rutberg, MBA 
Phone: (301) 594-4798
Email: rutbergd@mail.nih.gov
NIDCR Specific Information:

The NIDCR welcomes applications from postdoctoral scientists seeking to establish an independent research career in research areas relevant to the NIDCR Strategic Plan. Applicants are expected to provide evidence that adequate resources are available at the K99 phase institution for the successful completion of the proposed clinical trial. Detailed information should be provided about who will provide the necessary resources, including descriptions of the funding source and amount of funds (as needed).

Prospective applicants are strongly encouraged to contact the program official identified in the contact table before preparing an application to discuss eligibility requirements and the relevance of the proposed research to NIDCR’s research priorities. 
 
Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.
 
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 

Scientific Program Contact:
Diabetes, Endocrinology, and Metabolic Diseases:
Yan Li, Ph.D. 
Phone: (301) 435-3721
Email: liy7@niddk.nih.gov

Digestive & Liver Diseases, Nutrition, and Obesity:
David E. Saslowsky, Ph.D. 
Phone: (301) 594-8876
Email: David.Saslowsky@nih.gov 

Kidney and Urologic Diseases:
Tracy L. Rankin, Ph.D. 
Phone: (301) 594-4748
Email: rankint@mail.nih.gov 

Hematologic Disorders:
Cindy N. Roy, Ph.D. 
Phone: (301) 594-8805
Email: cindy.roy@nih.gov

Grants Management Contact:
Aricia M. Ajose, MPA
Phone: (301) 594-9023
Email: ajosea@mail.nih.gov

NIDDK Specific Information:

NIDDK will accept K99/R00 applications from well-qualified postdoctoral fellows and physician scientists working in the areas of research supported by NIDDK: diabetes, endocrinology, metabolic diseases, obesity, nutrition, digestive and liver diseases, kidney and urological disorders, and hematologic diseases. Information on the NIDDK K99/R00 program can be found at K99/R00. Applicants are encouraged to contact the appropriate program official identified here prior to submission and may want to consider applying for alternative career development awards, depending on individual needs.  These include the NIDDK K01 award and the K08 and K23 awards:
 

 
The NIDDK provides further information on all K-award programs on our training and career development website: K Awards
 
K99/R00 Budget information:

  • NIDDK will provide support up to $90,000 total costs for the K99 phase and up to $249,000 total costs for the R00 phase.

 
Urologic surgeons may request a minimum of 50% effort for the K99 phase.

National Institute on Drug Abuse (NIDA) 

Scientific Program Contact:
Michele L. Rankin, Ph.D.
Phone: (301) 480-3832
Email: NIDA_Training@nida.nih.gov

Grants Management Contact:
Carol Alderson 
Phone: (301) 827-6685
Email: ca10h@nih.gov
NIDA Specific Information:

Applicants are encouraged to visit the following Web site to learn more about NIDA research training-related opportunities and resources:Research Training - Home

Salary Support: Up to $90,000 plus fringe benefits per year.
Research Support: Up to $50,000 per year. 

National Institute of Environmental Health Sciences (NIEHS) 

Scientific Program Contact:
Carol Shreffler, Ph.D.
Phone: (984) 287-3322
Email: Shreffl1@niehs.nih.gov 

Grants Management Contact:

Lisa A. Edwards
Phone: (984) 287-3258
Email: archer@niehs.nih.gov

NIEHS Specific Information:

NIEHS supports research to discover how the environment affects people in order to promote healthier lives, and invites applications from qualified postdoctoral fellows who plan to pursue an independent research career in the environmental health sciences. The Institute funds a substantial portfolio of research conducted by investigators in many disciplines that span the range from basic mechanistic research to clinical and epidemiologic studies using human subjects. More information can be found on the NIEHS web site at: NIEHS Supported Research

NIEHS assigns K99/R00 applications to Program Officers across the division based on the scientific focus of the application. Prospective applicants are also encouraged to contact the Program Officer within their scientific area before submitting the application to determine the relevance of their proposed topic area to NIEHS at: NIEHS Contacts

Salary Support: Up to $75,000 plus fringe benefits per year (Practicing physicians may request up to $90,000 per year plus fringe benefits
Research Support: Up to $20,000 per year
 
National Institute of Mental Health (NIMH) 

Scientific Program Contact:
NIMH Training Contacts 

Grants Management Contact:
Terri Jarosik
Phone: (301) 443-3858
Email: Theresa.Jarosik@nih.gov
NIMH Specific Information:

The NIMH welcomes applications from postdoctoral scientists seeking to establish an independent research career in areas of research supported by the Institute. The NIMH supports a broad spectrum of basic and translational research, including basic neuroscience, human genetics, adult and developmental translational research, services and intervention research, and AIDS-related research (NIMH Extramural Research Programs).  Prospective applicants are strongly encouraged to contact Institute career development staff (Research Training and Career Development Programs) before preparing an application to discuss the relevance of the proposed research to the Institute’s current research priorities and for guidance on the proposed research and career development plans. Applicants are expected to describe a clearly defined path for transition to independence, including milestones, in their applications.  

Awardees are expected to complete at least one full year of mentored training under the K99 phase before transitioning to the R00 phase. Individuals who already have extensive postdoctoral training and expect to transition to an independent position in less than one year may not be appropriate candidates for this program. Prior to commencing the third year of the independent investigator (R00) award phase, NIMH awardees are expected to have submitted an investigator-initiated research grant (R01) application. 

Exceptions to the Four-year Eligibility LimitIn unusual circumstances, exceptions to the 4-year limit may be approved. An exception may be considered when a significant change in fields of study has occurred, such as moving from physical science to life science research, or when a significant break in training has occurred as a result of family responsibilities, medical leave, or military service. Such unique exceptions will be considered on a case by case basis. Investigators are expected to contact NIMH staff to discuss issues regarding eligibility prior to applying and to learn if their circumstance warrants an exception. If approved, a cover letter with the application should include an explanation of the special circumstances that warrant consideration for an exception. The applicant should provide similar information in the career development section of the application.
See Career Development Programs K-Series for further details about NIMH’s support for K programs.
 
It is recommended that NIMH mentored K applicants proposing clinical trials review the following guidance: (Career Development Programs K-Series).

Salary Support: Up to $75,000 plus fringe benefits per year.  Practicing physician-scientists may be eligible for up to $100,000 salary plus fringe benefits per year.
Research Support: Up to $20,000 per year.
National Institute on Minority Health and Health Disparities (NIMHD)

Scientific Program Contacts: 
For initial inquiries contact:
NIMHDtraining@nih.gov


Grants Management Contact:
Priscilla Grant, JD
Phone: (301) 594-5412
Email: pg38h@nih.gov 
NIMHD Specific Information:

NIMHD supports various mentored career development activities involving research to improve minority health and reduce health disparities, organized around three main Research Interest Areas: Clinical and Health Services Research, Community Health and Population Sciences, and Integrative Biological and Behavioral Sciences. Projects are encouraged to use approaches that encompass multiple domains of influence (e.g., biological, behavioral, socio-cultural, environmental, physical environment, health systems) and multiple levels of influence (e.g., individual, interpersonal, community, societal) to understand and address health disparities. See the NIMHD Research Framework for examples of health determinants of interest. Prospective applicants are strongly encouraged to contact the program official identified in the contact table before preparing an application to discuss eligibility requirements and the relevance of the proposed research to the Institute’s research priorities.

Salary Support: Up to $75,000 plus fringe benefits per year. 
Research Support: Up to $25,000 per year.

















 
National Institute of Neurological Disorders and Stroke (NINDS) 

Scientific Program Contact:
Stephen Korn, Ph.D.
Phone: (301) 496-4188
Email: korns@ninds.nih.gov 

Grants Management Contact:
Tijuanna E. DeCoster, MPA, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
Phone: 301-496-9231
Email: decostert@ninds.nih.gov
NINDS Specific Information:

Applicants are strongly encouraged to contact Dr. Korn with any questions about eligibility or other questions about the K99/R00 program.  Applicants should consult the NINDS training website for NINDS specific information and instructions: K00/R00 NIH Pathway Independence Award

Note: NINDS does not allow carry-over of K99 funds into the R00 period. When the postdoctoral position ends, the K99 terminates. The R00 can begin as early as the start date of the awardee's job, contingent on NINDS receiving the R00 application with sufficient advance notice.

Salary Support: Normally, salary up to $75,000 plus fringe benefits for each K99 year. Practicing clinician-scientists may be eligible for up to $125,000 salary. 
Research Support: Up to $20,000 per year.


 
National Institute of Nursing Research (NINR) 

Scientific Program Contact:
Mary Elizabeth (Libbey) Bowen, PhD
National Institute of Nursing Research (NINR)
Telephone: 301-841-5345
Email: libbey.bowen@nih.gov

Grants Management Contact:Ron Wertz
Phone: 301-594-2807
Email: wertzr@mail.nih.gov






 
NINR Specific Information:

NINR uses the K99/R00, NIH Pathway to Independence Award Program, to provide support for individuals who have a Bachelor's degree or higher in nursing to pursue career development research training that extends their potential for research. The Institute is committed to training new investigators, with attention to the areas of greatest need and to strategies for encouraging young investigators and members of groups underrepresented in science.

Applications must have a clear focus in science areas related to the NINR mission, which is to promote and improve the health of individuals, families, and communities.  Applicants should also consider NINR areas of special interest identified in NOT-NR-21-001.

Those interested in applying for this opportunity are strongly encouraged to contact the NINR Program Director for Extramural Training). The applicant may contact the NINR Program Director by emailing a copy of their draft NIH Biosketch along with any questions and a draft synopsis of interests and research/training aims.

Salary Support: Up to $100,000 plus fringe benefits per year.
Research Support: Up to $25,000 per year.
National Center for Complementary and Integrative Health (NCCIH) 

Scientific Program Contact:
Lanay Mudd, PhD
Phone: (301) 594-9346
Email: lanay.mudd@nih.gov

Grants Management Contact:
Shelley Carow
Phone: 301-594-3788 
Email: CarowS@MAIL.NIH.GOV

NCCIH Specific Information:

NCCIH uses the K99/R00 program to support outstanding postdoctoral investigators who are seeking to establish an independent career and have the potential to become a future leader in an area of research supported by the Center.

  • The K99 phase may ONLY include observational, basic or mechanistic research projects in areas of NCCIH’s interest and priorities. A mechanistic study is defined as one designed to understand the mechanism of action of an intervention, a biological process, or the pathophysiology of a disease. NCCIH will accept applications that propose a study in the K99 phase with human participants when the primary outcome/endpoint is explicitly mechanistic, rather than a clinical outcome, even if the mechanistic study meets the NIH definition of a clinical trial.
  •  NCCIH will not fund applications proposing a clinical trial to test efficacy or effectiveness in either the K99 or R00 phase. Applicants are encouraged to discuss their proposed scope of work with an NCCIH program officer, and to review resources available at NCCIH’s Clinical Research Toolbox.
  • Before the application receipt date, investigators are strongly encouraged to discuss their proposed research interest with an NCCIH Program Officer in the specific scientific area and/or intervention that is closely-related to the proposed project to confirm its relevance to NCCIH's mission and research priorities. A list of NCCIH program officials can be found at Contacts
  • The K99/R00 is appropriate for applicants who are prepared for an accelerated career path, who will be ready to compete for R01 and R01-like grant funding in the next three years. Individuals interested in a longer time frame of mentored research support should consider the K01, K08, or K23.
  • Applications proposing the use of natural products or devices in an interventional research project should explicitly describe the status of the Investigational New Drug (IND) or Investigational Device Exemption (IDE). Applicants interested in natural products research are encouraged to review NCCIH's Natural Product Integrity Policy.
    Applications should include explicit statements from the institution and the mentor(s) addressing the following:
    • Detailed information about who will provide the necessary resources;
    • Funding source and amount of additional funding (as needed);
    • Support staff available and committed to the project;
    • Availability of biostatistical support for the duration of the study - including the planning period; and
    • A contingency plan (for the institution and mentor) for completion of the study in the event the awardee leaves the institution earlier than the end date of the award.

 
Salary Support: Commensurate with the applicant institution's salary structure for persons of equivalent qualifications, experience, and rank.
Research Support: Up to $20,000 per year in the K99 phase.  


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