Advancing the Use of 3D Technologies Using Human Auditory, Vestibular and Chemosensory Organoids to Create New Approach Models (NAMs) for Treatments

Post Date: December 2, 2025

Expiration Date: December 2, 2026

The auditory, vestibular, and chemosensory systems are elaborate cellular ecosystems and while molecular research has made significant strides in biological advancements, faster timelines for effective molecular therapeutic deliverables remain a challenge. Contributing to these challenges are the lack of advanced model systems that improve cell system mimicry and facilitate increased throughputs.

The purpose of this highlighted topic is to encourage collaborative research efforts combining the use of human auditory, vestibular, and chemosensory organoids, with 3D technologies, such as bioprinting, creation of biolinks and tissue replicates, and AI facilitated data driven in silico platforms.  Such research efforts will expedite faster and more accurate treatments and therapeutics for disease and disorders. With the advancement of iPSC technologies, personalized human organoid research holds increased promise when combined with other ex vivo assessment platforms to rapidly advance precision medicine approaches.  These NAMs require post-development characterization to provide accurate functional cell mimicry and recapitulation of the native correlative biological function.  Applications focused on improvement of reproducibility and stability are highly encouraged.  Taken together, these new and combined approaches could provide faster and increased accuracy of cellular platforms and accelerate the development of clinical deliverables.