EXPIRED
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
U24 Resource-Related Research Projects – Cooperative Agreements
See Part 2, Section III. 3. Additional Information on Eligibility.
This notice of funding opportunity (NOFO) invites applications for REsearch Across Complementary and Integrative Health Institutions (REACH) Virtual Resource Centers. REACH Virtual Resource Centers will foster institutional partnerships and provide resources to support research activities and research training for faculty who work at accredited complementary and integrative health clinical institutions, such as schools of acupuncture, chiropractic, osteopathy, naturopathy, physical therapy, and music and art therapy. The REACH Virtual Resource Centers will provide a variety of services and resources, including, but not limited to, administrative support, research support, grantsmanship, mentoring and training, and teambuilding, to support clinician-scientists located at complementary and integrative health clinical institutions to form multi- and interdisciplinary research teams and pursue externally funded research aligned with NCCIH strategic priorities for health promotion and restoration, resilience, disease prevention, symptom (e.g., pain) management, and/or whole person health. REACH Centers should focus on resources to support investigators pursuing clinical research (e.g., observational, epidemiological, mechanistic clinical research, mixed methods, feasibility studies, etc.). It is expected that REACH Virtual Resource Centers will (1) improve the quality and quantity of Federal research grant applications submitted by clinician-scientist faculty at complementary and integrative health clinical institutions; (2) aid the formation of multi- and interdisciplinary research partnerships across partnering complementary and integrative health clinical institutions; (3) help to enhance the research environment at complementary and integrative health clinical institutions; and (4) support a pipeline for clinician-scientists trained in complementary and integrative health practices to pursue research careers at clinical institutions.
This Notice of Funding Opportunity (NOFO) requires a Plan for Enhancing Diverse Perspectives (PEDP).
July 30, 2024
Application Due Dates | Review and Award Cycles | ||||
---|---|---|---|---|---|
New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
August 30, 2024 | August 30, 2024 | September 07, 2024 * | November 2024 | January 2025 | April 2025 |
All applications are due by 5:00 PM local time of applicant organization.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
No late applications will be accepted for this Notice of Funding Opportunity (NOFO).
Not Applicable
It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts).
Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide, follow the program-specific instructions.
Applications that do not comply with these instructions may be delayed or not accepted for review.
Background
The National Center for Complementary and Integrative Health (NCCIH) recognizes a compelling need to support the development of clinician- scientists trained in complementary and integrative health practices to pursue clinically informed research careers. Academic institutions training health care practitioners in the use of complementary approaches (i.e., complementary and integrative health clinical institutions) often lack key resources to fully support clinician- scientist research careers of their faculty. The REACH Virtual Resource Centers are intended to fill that gap by fostering partnerships with accredited, academic institutions providing clinical degrees in complementary and integrative professions and by providing a wide array of research and training resources to support clinician scientist faculty at accredited complementary and integrative health clinical institutions, such as schools of acupuncture, chiropractic, osteopathy, naturopathy, physical therapy, and music and art therapy.
This initiative aligns with NCCIH strategic research priorities for workforce development and with recommendations of the NCCIH Working Group Report on Clinician-Scientist Workforce Development, specifically the following recommendations:
NCCIH currently invests in individual-level efforts to support complementary health practitioner clinician scientists, including administrative supplements for individual practitioners to gain a research experience on a funded grant (NOT-AT-24-032) and supplemental slots on NCCIH- funded T32 programs to support a practitioner at the pre- or post-doctoral level to pursue research training (NOT-AT-24-033). This notice of funding opportunity (NOFO) will support institutional level partnerships and provide resources for clinician-scientist faculty located at complementary and integrative health clinical institutions to pursue research careers
Objectives
The REACH Virtual Resource Centers will be scientific hubs that provide resources to virtually support the research environment and provide resources for faculty at partnering complementary and integrative health clinical institutions to pursue a research career. It is expected that the REACH Virtual Resource Centers program will lead to the following outcomes:
Scope
The REACH Virtual Resource Centers are expected to provide a range of resources for clinician- scientist faculty at partnering complementary and integrative health clinical institutions to support the development, submission, and management of Federal research grant applications (e.g., NIH, U.S. Department of Veterans Affairs , and U.S. Department of Defense sources of funding). REACH Centers should propose and provide resources that would support investigators pursuing clinical research aligned with NCCIH s trategic research p riorities on complementary and integrative health approaches for health promotion, restoration, resilience, disease prevention, symptom (e.g., pain) management, and/or whole person health.
Research could focus on the study of a number of approaches that may include natural products, such as dietary supplements, plant-based products, and probiotics, as well as approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), such as spinal manipulation or mobilization, massage, tai chi, qi gong, yoga, acupuncture, hypnosis, guided imagery, breathing exercises, progressive relaxation, meditation, biofeedback, mindfulness techniques, or music or art therapies; and multicomponent interventions, such as naturopathic medicine, traditional Chinese medicine, Ayurvedic medicine, chiropractic care, or a combination of two or more of the specific complementary health approaches. Proposed resources should support investigators utilizing clinical research designs including observational or epidemiological studies, clinical mechanistic studies, qualitative and mixed methods research, and work to develop and test clinical interventions.
For this NOFO, a resource is defined as an activity that provides research and technical capabilities and expertise to researchers and is available to faculty located at a partnering complementary and integrative health clinical institution. Plans for overall financial support of the resource can include fees for service if they are well justified.
Overall, REACH Virtual Resource Centers should provide a scientific hub that virtually supports clinician- scientist faculty at partnering complementary and integrative health institutions to expand their research skills, develop collaborative interdisciplinary research teams that may span multiple institutions, and develop and submit competitive NIH or other agency- or organization-sponsored research grant applications. The REACH Center resources should also help support the preparation, submission, management, and execution of successfully funded grant applications. REACH virtual resource center applicants must propose resources in each of the following categories :
Applications must propose a center-run process to support small-scale pilot projects for scholars from partnering complementary and integrative health institutions. The pilot projects should have potential to form the basis for subsequent independent research applications consistent with NCCIH strategic priorities for health promotion and restoration, resilience, disease prevention, symptom management, and/or whole person health. REACH Center applications must provide a formal plan to solicit, review, and select/prioritize requests for pilot funding, and to evaluate the pilot study progress and outcomes. Descriptions of actual pilot projects that could be supported should not be included. The selection of pilot projects will be made in consultation with the NIH Project Scientist(s) and approved by the NIH Program Officer(s). The details of the full governance of cooperative agreements structure are provided in Section VI.2, Cooperative Agreement Terms and Conditions of Award.
Applicants for the REACH Virtual Resource Centers should provide a strong rationale for the resources they propose based on the needs of their partnering clinical institutions and should demonstrate their ability to provide expertise for the proposed resources. Administrative and research support costs that are directly charged should be integral to the project and not costs that are also recovered as indirect costs. The institution applying to host the REACH Center must demonstrate a strong concentration of NIH-funded investigators with expertise in complementary and integrative health research, a track record of collaboration among participating faculty at the REACH Center, and the ability to provide expertise for all proposed resources, including coordinated mentoring for complementary and integrative health research. There must be an institutional letter of support from the Dean, Provost, or equivalent rank of the submitting institution, detailing their qualifications and support for and resources provided to the proposed REACH Center.
The REACH Center must propose specific milestones and metrics to evaluate the effectiveness of the proposed resources, such as tracking outreach efforts, engagement, training, mentoring, team building, and grant applications. Funded REACH Centers will be evaluated based on NCCIH- approved milestones and metrics, which must include goals for the number of NIH grant applications submitted, scored, and funded to faculty located at the partnering integrative health clinical institutions.
Partnerships with Complementary and Integrative Health Institutions
The proposed REACH Center should demonstrate its ability to partner with accredited, U.S. domestic complementary and integrative health clinical institutions, such as schools of acupuncture, chiropractic, osteopathy, naturopathy, physical therapy, and music and art therapy. Please note that for schools of osteopathy, only those institutions that teach manual manipulation as part of the core curriculum required for all students for a doctoral degree will be considered as an eligible partnering complementary and integrative health institution. Although not required, previous institutional experience collaborating with complementary and integrative health clinical institutions and/or other less resourced institutions to build research capacity is preferred. Applicants with previous collaborative experience should provide information on relevant metrics to demonstrate the success of those institutional relationships (e.g., formation of multidisciplinary research teams, publications, research presentations, grant applications, etc.).
The application must include letters of support from at least three different accredited complementary and integrative health clinical institutions that agree to partner with the REACH Center to provide access for their faculty to the available resources, as well as plans to reach out and expand partnerships to additional institutions throughout the course of the project period. The initial partnerships must demonstrate a breadth of clinical disciplines and cannot all come from a single complementary or integrative health discipline (e.g., letters of support from three schools of acupuncture would not be acceptable, but letters of support from two schools of acupuncture and one school of chiropractic would be acceptable). The letters of support must demonstrate the willingness of the partnering complementary and integrative health institutions to engage with the REACH Center to help support the research careers of their faculty, and the letters must commit in kind support to provide at least 2.4 person-months effort (i.e., 20 percent) protected time for selected faculty to participate in REACH Center activities for at least 1 year.
Applicants should consider strategies to enhance diverse perspectives from partnering institutions, faculty, staff, and students within the PEDP. The PEDP will be assessed as part of the scientific and technical peer review evaluation, as well as considered among programmatic matters with respect to funding decisions.
Responsiveness Criteria:
Applications nonresponsive to terms of this RFA will not be reviewed.
Technical Assistance and Teaming Webinar
NCCIH will provide a technical assistance and teaming webinar for potential applicants and institutional partners for REACH Virtual Resource Centers on Tuesday, June 18, 2024 from 2:00 to 3:30 p.m. ET. Please register to attend the webinar at https://nih.zoomgov.com/webinar/register/WN_fkLQksJ2TUWcnFTOxEtIog. Attending the technical assistance and teaming webinar is encouraged for all potential applicants and potential partnering institutions, but it is not required for submission of an application.
Plan for Enhancing Diverse Perspectives (PEDP)
The NIH recognizes that teams comprised of investigators with diverse perspectives working together and capitalizing on innovative ideas and distinct viewpoints outperform homogeneous teams. There are many benefits that flow from a scientific workforce rich with diverse perspectives, including: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of the research, advancing the likelihood that underserved populations participate in, and benefit from research, and enhancing public trust.
To support the best science, the NIH encourages inclusivity in research guided by the consideration of diverse perspectives. Broadly, diverse perspectives can include but are not limited to the educational background and scientific expertise of the people who perform the research; the populations who participate as human subjects in research studies; and the places where research is done.
This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Assessment of applications containing a PEDP are based on the scientific and technical merit of the proposed project. Consistent with federal law, the race, ethnicity, or sex of a researcher, award participant, or trainee will not be considered during the application review process or when making funding decisions. Applications that fail to include a PEDP will be considered incomplete and will be administratively withdrawn before review.
The PEDP will be submitted as Other Project Information as an attachment (see Section IV). Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance materials.
See Section VIII. Other Information for award authorities and regulations.
Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.2 for additional information about the substantial involvement for this NOFO.
The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Not Allowed: Only accepting applications that do not propose clinical trials.
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
NCCIH intends to commit $2.75 million total costs in FY2025 to support up to two awards.
Application budgets may not exceed $850,000 per year in direct costs and should reflect the actual needs of the proposed project.
The scope of the proposed project should determine the project period. The maximum project period is 5 years.
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Local Governments
Federal Governments
Other
Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Applicant Organizations
Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications for additional information
Program Directors/Principal Investigators (PD(s)/PI(s))
All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support. Individuals from diverse backgrounds, including individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support. See, Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities, NOT-OD-22-019.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide.
For this NOFO, the Program Director/Principal Investigator (PD/PI) must devote at least 2.4 person-months of effort. If multiple PDs/PIs are proposed, the combined effort must equal at least 2.4 person-months, and each of the multiple PDs/PIs must devote at least 1.2 person-months.
This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1.2 Definition of Terms.
Number of Applications
Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:
The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.
It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows Institute and Center (IC) staff to estimate the potential review workload and plan the review.
By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information:
The letter of intent should be sent to:
Jessica McKlveen, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-594-8018
Email: jessica.mcklveen@nih.gov
All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed, with the following exceptions or additional requirements :
For this specific NOFO, the Research Strategy section is limited to 20 pages.
The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO.
All instructions in the How to Apply - Application Guide must be followed.
All instructions in the How to Apply - Application Guide must be followed.
All instructions in the How to Apply - Application Guide must be followed.
Plan for Enhancing Diverse Perspectives (PEDP)
Examples of items that advance inclusivity in research and may be appropriate for a PEDP can include, but are not limited to:
Examples of items that are not appropriate in a PEDP include, but are not limited to:
For further information on the Plan for Enhancing Diverse Perspectives (PEDP), please see PEDP guidance materials.
All instructions in the How to Apply - Application Guide must be followed.
Key personnel should describe their experience and record of accomplishments in facilitating the development of interdisciplinary collaborations, managing clinical research on complementary and integrative health approaches for symptom management, and providing support for developing F ederal grant applications. Teams should include personnel with scientific, technical, and administrative expertise.
All instructions in the How to Apply - Application Guide must be followed.
The PD/PI is required to devote 2.4 person-months to provide overall center guidance and resource management. If multiple PDs/PIs are proposed, the combined effort must equal at least 2.4 person-months, and each of the multiple PDs/PIs must devote at least 1.2 person-months.
In the budget justification, provide detailed information about support received or anticipated from other entities. This could include additional funding from another government agency, user fees, or institutional support, for example. These costs should not be included in the SF-424 budget pages; they should be included only in the budget justification. Administrative and research support costs that are being charged as direct costs should be integral to the project and not also recovered as indirect costs.
When transition to other means of support is feasible for specific resources, the funding requested should align with a transition plan. In such cases, the application should request reduced support for specific resources as the project period progresses and describe plans to transition to other sources of support is appropriate.
Up to $100,000 direct costs per year may be budgeted to support small-scale pilot studies conducted by scholars at partnering complementary and integrative health clinical institutions. Generally, the pilot funds will be distributed in the form of subcontracts to the third-party researcher's institutions.
PEDP implementation costs:
Applicants may include allowable costs associated with PEDP implementation (as outlined in the Grants Policy Statement section 7): https://grants.nih.gov/grants/policy/nihgps/html5/section_7/7.1_general.htm.
All instructions in the How to Apply - Application Guide must be followed.
All instructions in the How to Apply - Application Guide must be followed.
All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:
Specific Aims: Describe the overall aims of the resources the REACH C enter proposes to provide. Include an aim focused on outreach, capacity building, and sustainability activities to develop partnerships with additional complementary and integrative health clinical institutions throughout the period of support.
Research Strategy: The application must detail virtual resources that the REACH C enter will provide to qualified investigators located at partnering accredited complementary and integrative health clinical institutions. Applicants must propose to provide resources in a dministrative support, r esearch support, grantsmanship, mentoring and training, and team building categories. Applicants must provide strong justification for how the proposed resources will enable the REACH Center to meet the overall objectives of the program based on the needs of their initial partnering complementary and integrative health clinical institutions. The proposed resources should be well- designed to support investigators interested in pursuing clinical research on complementary and integrative health approaches and health promotion and restoration, resilience, disease prevention, symptom management (e.g., pain), and/or whole person health, including observational or epidemiological studies, clinical mechanistic studies, qualitative and mixed methods research, and/or work to develop and test clinical interventions. The REACH C enter may propose many different models for supporting NIH grant applications from faculty at partnering institutions, which may include submitting applications as a multiple PD/PI partner when appropriate.
REACH Center applications must propose to support small- scale pilot projects with potential to form the basis for subsequent independent research applications consistent with NCCIH strategic priorities for health promotion and restoration, resilience, disease prevention, symptom management, and/or whole person health. Applications must provide a formal plan to solicit, review, and select/prioritize requests for pilot funding, and to evaluate the pilot study progress and outcomes. Descriptions of actual pilot projects should not be included, but rather the overarching areas in which small-scale projects would be solicited should be discussed.
The institution applying to host the REACH Center must demonstrate a strong concentration of NIH-funded investigators with expertise in complementary and integrative health research, a track record of collaboration among participating faculty at the REACH Center, and the ability to provide expertise for all proposed resources including coordinated mentoring for complementary and integrative health 4research. Applicants must demonstrate partnerships with at least three complementary and integrative health clinical institutions representing a breadth of clinical practices. The Research Strategy must provide plans for how the REACH Center and the partnering institutions will interact, and how faculty at the partnering institutions will access and use the proposed resources. Applications should also address outreach and must include plans to expand partnerships to additional integrative health clinical institutions over the course of the award. Applicants should provide a strong rationale for their ability to partner with complementary and integrative health clinical institutions to achieve the objectives of the REACH Center program, including any previous experience collaborating with less resourced institutions to build research capacity, if available. Applicants with previous collaborative experience should provide information on relevant metrics to demonstrate the success of those institutional relationships (e.g., formation of multidisciplinary research teams, publications, research presentations, grant applications, etc.). Plans to recruit and retain staff to provide administrative and research support for proposed resources should be provided if needed, along with plans to replace support staff who leave.
Applications must describe milestones appropriate for assessing the use and value of proposed resources, as well as the overall productivity of the REACH Center, including benchmarks for the total number of NIH grant applications submitted, scored, and awarded to faculty from the partnering complementary and integrative health clinical institutions. The application should provide a plan to evaluate REACH Center activities with both short-term and long-term measures of success.
Letters of Support:
A letter of support from the Dean, Provost, or equivalent rank of the submitting college is required. The letter of support must demonstrate support for the development of the REACH Center, and the letters must specify qualifications of the institution to host the REACH Center, including, but not limited to, the demonstration of:
Letters of support from at least three partnering accredited U.S. domestic complementary and integrative health clinical institutions representing at least two different clinical disciplines are required. Eligible clinical institutions include, but are not limited to, schools of acupuncture, chiropractic, osteopathy, naturopathy, physical therapy, and music and art therapy. For schools of osteopathy, only those institutions that teach manual manipulation as part of the core curriculum required for all students for a doctoral degree will be considered as an eligible partnering complementary and integrative health institution. The letters of support must demonstrate the willingness of the partnering complementary and integrative health institutions to engage with the REACH Center to support the research careers of their faculty, and the letters must commit in kind support to provide at least 20 percent effort protected time for selected faculty to participate in REACH Center activities for at least 1 year.
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.
Other Plan(s): Note: Effective for due dates on or after January 25, 2023, the Data Management and Sharing Plan will be attached in the Other Plan(s) attachment in FORMS-H application forms packages.
All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:
Appendix: Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply - Application Guide.
No publications or other material, with the exception of blank questionnaires or blank surveys, may be included in the Appendix.
When involving human subjects research, clinical research, and/or NIH-defined clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:
If you answered Yes to the question Are Human Subjects Involved? on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record.
Study Record: PHS Human Subjects and Clinical Trials Information
All instructions in the How to Apply - Application Guide must be followed.
Delayed Onset Study
Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply - Application Guide must be followed.
All instructions in the How to Apply - Application Guide must be followed.
See Part 2. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov
Part I. contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.
Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIHs electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications.
Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the How to Apply – Application Guide.
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Pre-award costs are allowable only as described in the NIH Grants Policy Statement Section 7.9.1 Selected Items of Cost.
Applications must be submitted electronically following the instructions described in the How to Apply - Application Guide. Paper applications will not be accepted.
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.
Important reminders:
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. See Section III of this NOFO for information on registration requirements.
The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organizations profile in the eRA Commons and for the System for Award Management. Additional information may be found in the How to Apply - Application Guide.
See more tips for avoiding common errors.
Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and responsiveness by NCCIH. Applications that are incomplete, non compliant, and/or nonresponsive will not be reviewed.
Applications must include milestones for REACH Center activities. Applications that fail to include REACH Center milestones will be considered incomplete and will be withdrawn. .
Applications must include a PEDP submitted as Other Project Information as an attachment. Applications that fail to include a PEDP will be considered incomplete and will be administratively withdrawn before review.
In order to expedite review, applicants are requested to notify the NCCIH Referral Office by email at jessica.mcklveen@nih.gov when the application has been submitted. Please include the NOFO number and title, PD/PI name, and title of the application.
Applicants are required to follow the instructions for post-submission materials, as described in the policy
Only the review criteria described below will be considered in the review process. Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.
Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).As part of the overall impact score, reviewers should consider and indicate how the Plan to Enhance Diverse Perspectives affects the scientific merit of the project.
Reviewers will consider each of the review criteria below in the determination of scientific merit and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Does the proposed Center address the needs of the research resource that it will administer? Is the scope of activities proposed for the Center appropriate to meet those needs? Will successful completion of the aims bring unique advantages or capabilities to the research resource?
Specific to this NOFO:
Will the Resource Center support progress in the field?
Is it likely that the Resource Center activities will support the overall objectives of the REACH program to (1) improve the quality and quantity of grant applications submitted by faculty at complementary and integrative health clinical institutions; (2) aid the formation of multi- and interdisciplinary research partnerships across partnering complementary and integrative health clinical institutions; (3) help to enhance the research environment at complementary and integrative health clinical institutions; and (4) support a pipeline for clinician scientists trained in complementary and integrative health practices to pursue research careers at clinical institutions
How well will the plan for soliciting pilot projects better enable investigators to submit future, competitive grant applications?
Are the PD(s)/PI(s) and other personnel well suited to their roles in the Center? Do they have appropriate experience and training, and have they demonstrated experience and an ongoing record of accomplishments in managing clinical research? Do the investigators demonstrate significant experience with coordinating collaborative clinical research? If the Center is multi-PD/PI, do the investigators have complementary and integrated expertise and skills; are their leadership approach, governance, plans for conflict resolution, and organizational structure appropriate for the Center? Does the applicant have experience overseeing selection and management of subawards, if needed?
Specific to this NOFO:
Is a sound plan in place for recruiting and retaining staff with the appropriate skills, knowledge, and experience with providing administrative and research support related to the proposed resources?
Is a sound plan in place for rapidly replacing staff who leave the Resource Center to minimize service disruptions?
Is there evidence that most of the investigators involved in the REACH Center have a track record of successfully receiving NIH funding?
Does the application propose novel organizational concepts in coordinating the research resource that the Center will serve? Are the concepts, strategies, or instrumentation novel to one type of research program or applicable in a broad sense? Is a refinement, improvement, or new application of organizational concepts proposed?
Specific to this NOFO:
Are the plans to ensure virtual access for all proposed resources innovative?
Are innovative approaches to increasing the utility or efficiency of the proposed resources proposed?
Are the overall strategy, operational plan, and organizational structure well-reasoned and appropriate to accomplish the goals of the research resource that the Center will serve? Will the investigators promote strategies to ensure a robust and unbiased scientific approach across the resource, as appropriate for the work proposed? Are potential problems, alternative strategies, and benchmarks for success presented? If the resource is in the early stages of operation, does the proposed strategy adequately establish feasibility and manage the risks associated with the activities of the resource? Are an appropriate plan for work flow and a well-established timeline proposed?
Specific to this NOFO:
How well does the application demonstrate the ability to partner with complementary and integrative health clinical institutions for research capacity building? If previous partnerships with resource- limited institutions were described, how well does the application demonstrate that those partnerships were successful?
How are proposed resources in administrative support, research support, grantsmanship, mentoring and training, and team building justified to meet the needs of partnering institutions? Are the resources well- designed to support investigators pursuing clinical research on complementary and integrative health approaches for health promotion and restoration, resilience, disease prevention, symptom (e.g., pain) management, and/or whole person health symptom management?
Is there an adequate plan to solicit, review, prioritize, and support small-scale pilot project(s)? Is there an adequate description of eligibility criteria, evaluation, and assessment of the likelihood of the proposed pilot project(s) to lead to a competitive NIH (or equivalent) research application?
How strong are the plans for how faculty at partnering institutions will access and use the proposed resources?
How strong are the plans to outreach to additional complementary and integrative health clinical institutions during the period of support?
How feasible and comprehensive is the plan for evaluation of the Resource Center activities? How well does the evaluation plan include both short-term and long-term measures of utility and success, quantifiable measures of intermediate results and success, as well as plans to utilize evaluation results to improve operations?
If applicable, how will an adequate and feasible plan to transition to other sources of support be achieved?
Will the institutional environment in which the Center will operate contribute to the probability of success in facilitating the research program it serves? Are the institutional support, equipment, and other physical resources available to the investigators adequate for the Center proposed? Will the Center benefit from unique features of the institutional environment, infrastructure, or personnel? Are resources available within the scientific environment to support electronic information handling?
Specific to this NOFO:
Does the institution applying to host the REACH Center have a strong concentration of NIH-funded investigators with expertise in complementary and integrative health, a track record of collaboration, and the ability to provide expertise for all proposed resources, including coordinated mentoring?
Is the proposed REACH Center adequately equipped to provide virtual resources to support the environment of the partnering institutions? How accessible would the resources be at the partnering institutions?
As applicable for the project proposed, reviewers will evaluate the following additional items to determine scientific and technical merit and will provide an overall impact score, but will not give separate scores for these items.
For research that involves human subjects but does not involve one of the categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Subjects.
When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of individuals of all ages (including children and older adults) to determine if it is justified in terms of the scientific goals and research strategy proposed. For additional information on review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical Research.
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following three points: (1) a complete description of all proposed procedures including the species, strains, ages, sex, and total numbers of animals to be used; (2) justifications that the species is appropriate for the proposed research and why the research goals cannot be accomplished using an alternative non-animal model; and (3) interventions including analgesia, anesthesia, sedation, palliative care, and humane endpoints that will be used to limit any unavoidable discomfort, distress, pain and injury in the conduct of scientifically valuable research. Methods of euthanasia and justification for selected methods, if NOT consistent with the AVMA Guidelines for the Euthanasia of Animals, is also required but is found in a separate section of the application. For additional information on review of the Vertebrate Animals Section, please refer to the Worksheet for Review of the Vertebrate Animals Section.
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.
Not applicable
Not applicable
Are the proposed milestones feasible, well- developed, and quantifiable regarding the specific goals and accomplishments of the Resource Center? Are they appropriate for assessing the ongoing value of the proposed activities? Are appropriate benchmarks for the total number of Federal grant applications submitted, scored, and awarded to faculty from the partnering complementary and integrative health clinical institutions included?
As applicable for the project proposed, reviewers will consider each of the following items but will not give scores for these items and should not consider them in providing an overall impact score.
Not applicable
Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Reviewers will comment on whether the Resource Sharing Plan(s) (e.g., Sharing Model Organisms) or the rationale for not sharing the resources, is reasonable.
For networks involving key biological and/or chemical resources, reviewers will comment on the brief plans proposed for identifying and ensuring the validity of those resources.
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by NCCIH, in accordance with NIH peer review policies and practices, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.
As part of the scientific peer review, all applications will receive a written critique.
Applications may undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
Appeals of initial peer review will not be accepted for applications submitted in response to this NOFO.
Applications will be assigned to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications submitted in response to this NOFO. Following initial peer review, recommended applications will receive a second level of review by the National Advisory Council for Complementary and Integrative Health. The following will be considered in making funding decisions:
Please note that reviewers will not consider race, ethnicity, age, or gender of a researcher, award participant, or trainee, even in part, in providing critiques, scores, or funding recommendations. NIH will not consider such factors in making its funding decisions.
After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons. Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement Section 2.4.4 Disposition of Applications.
If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement. This request is not a Notice of Award nor should it be construed to be an indicator of possible funding.
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the recipient's business official.
Recipients must comply with any funding restrictions described in Section IV.6. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this NOFO will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.
Institutional Review Board or Independent Ethics Committee Approval: Recipient institutions must ensure that protocols are reviewed by their IRB or IEC. To help ensure the safety of participants enrolled in NIH-funded studies, the recipient must provide NIH copies of documents related to all major changes in the status of ongoing protocols.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: Generaland Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities, including of note, but not limited to:
If a recipient is successful and receives a Notice of Award, in accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.
If a recipient receives an award, the recipient must follow all applicable nondiscrimination laws. The recipient agrees to this when registering in SAM.gov. The recipient must also submit an Assurance of Compliance (HHS-690). To learn more, see the Laws and Regulations Enforced by the HHS Office for Civil Rights website.
HHS recognizes that NIH research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigators scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO.
In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to System for Award Management (SAM.gov) requirements. SAM.gov requires Federal agencies to review and consider information about an applicant in the designated integrity and performance system (currently SAM.gov) prior to making an award. An applicant can review and comment on any information in the responsibility/qualification records available in SAM.gov. NIH will consider any comments by the applicant, in addition to the information available in the responsibility/qualification records in SAM.gov, in making a judgement about the applicants integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 2 CFR Part 200.206 Federal awarding agency review of risk posed by applicants. This provision will apply to all NIH grants and cooperative agreements except fellowships.
The following special terms of award are in addition to, and not in lieu of, otherwise applicable U.S. Office of Management and Budget (OMB) administrative guidelines, U.S. Department of Health and Human Services (HHS) grant administration regulations at 2 CFR Part 200, and other HHS, PHS, and NIH grant administration policies.
The administrative and funding instrument used for this program will be the cooperative agreement, an "assistance" mechanism (rather than an "acquisition" mechanism), in which substantial NIH programmatic involvement with the recipients is anticipated during the performance of the activities. Under the cooperative agreement, the NIH purpose is to support and stimulate the recipients' activities by involvement in and otherwise working jointly with the recipients in a partnership role; it is not to assume direction, prime responsibility, or a dominant role in the activities. Consistent with this concept, the dominant role and prime responsibility resides with the recipients for the project as a whole, although specific tasks and activities may be shared among the recipients and NIH as defined below.
The PD(s)/PI(s) will have the primary responsibility for:
Recipients will retain custody of and have primary rights to the data and software developed under these awards, subject to Government rights of access consistent with current HHS, PHS, and NIH policies.
NIH staff have substantial programmatic involvement that is above and beyond the normal stewardship role in awards, as described below:
Areas of Joint Responsibility include:
All responsibilities are divided between recipients and NIH staff as described above.
Dispute Resolution:
Any disagreements that may arise in scientific or programmatic matters (within the scope of the award) between recipients and NIH may be brought to Dispute Resolution. A Dispute Resolution Panel composed of three members will be convened. It will have three members: a designee of the Steering Committee chosen without NIH staff voting, one NIH designee, and a third designee with expertise in the relevant area who is chosen by the other two; in the case of individual disagreement, the first member may be chosen by the individual recipient. This special Dispute Resolution procedure does not alter the recipient's right to appeal an adverse action that is otherwise appealable in accordance with PHS regulation 42 CFR Part 50, Subpart D and HHS regulation 45 CFR Part 16.
Consistent with the 2023 NIH Policy for Data Management and Sharing, when data management and sharing is applicable to the award, recipients will be required to adhere to the Data Management and Sharing requirements as outlined in the NIH Grants Policy Statement. Upon the approval of a Data Management and Sharing Plan, it is required for recipients to implement the plan as described.
When multiple years are involved, recipients will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement.
Recipients will provide updates at least annually on implementation of the PEDP.
A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement. NIH NOFOs outline intended research goals and objectives. Post award, NIH will review and measure performance based on the details and outcomes that are shared within the RPPR, as described at 2 CFR Part 200.301.
The Federal Funding Accountability and Transparency Act of 2006 as amended (FFATA), includes a requirement for recipients of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All recipients of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over the threshold. See the NIH Grants Policy Statement for additional information on this reporting requirement.
In accordance with the regulatory requirements provided at 2 CFR Part 200.113 and Appendix XII to 2 CFR Part 200, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period. The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (Responsibility/Qualification in SAM.gov, formerly FAPIIS). This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Full reporting requirements and procedures are found in Appendix XII to 2 CFR Part 200 – Award Term and Condition for Recipient Integrity and Performance Matters.
We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten submission by the due date, and post-submission issues)
Finding Help Online: https://www.era.nih.gov/need-help (preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
General Grants Information (Questions regarding application instructions, application processes, and NIH grant resources)
Email: GrantsInfo@nih.gov (preferred method of contact)
Telephone: 301-637-3015
Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace)
Contact Center Telephone: 800-518-4726
Email: support@grants.gov
Lanay M. Mudd, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Phone: 301-594-9346
Email: lanay.mudd@nih.gov
Jessica McKlveen, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-594-8018
Email: jessica.mcklveen@nih.gov
Debbie Chen
National Center for Complementary and Integrative Health (NCCIH)
Phone: 301-594-3788
Email: debbie.chen@nih.gov
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.