Department of Health
and Human Services (HHS)
and Human Services (HHS)
NOT-DK-20-028: Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium – Field Site (U01 - Clinical Trial Not Allowed)
NOT-DK-20-029: Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium – Renal Analytic Core (U01 - Clinical Trial Not Allowed)
National Institute of Environmental Health Sciences (NIEHS)
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Environmental Health Sciences (NIEHS) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite applications for research on Chronic Kidney Disease of Uncertain Etiology (CKDu) in Agricultural Communities. Included in this initiative will be a Scientific Data Coordinating Center (SDCC) to support and provide scientific guidance as part of the new consortium to study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE). The SDCC will guide the consortium as it develops protocols for epidemiologic studies. It will provide data management and analysis, as well as overall project management for the consortium.
This collaborative research consortium will bring together a broad range of expertise and enable discovery science to understand the cause or causes of CKDu. The consortium will also work to identify potential therapeutic targets and public health interventions. The consortium will consist of a Scientific Data Coordinating Center, Field Sites, a Renal Analytic Core and the NIEHS Human Health Exposure Analysis Resource (HHEAR). The consortium will work together to develop common protocols for evaluation of participants who are currently affected with early manifestations of CKDu and controls, to define common strategies for biological sampling and environmental assessment, and to determine analytic strategies to best use the samples collected by the consortium.
This FOA will not support intervention trials to prevent or treat CKDu. This FOA is intended to support only human studies and applications that include animal or model systems are not responsive.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The FOA is expected to be published in Summer 2020 with an expected application due date in Fall 2020.
This FOA will utilize the U24 activity code. Details of the planned FOA are provided below.
This Notice encourages investigators with expertise and insights into this area of epidemiology to begin to consider applying for this new FOA. Multi-PI applications are required to encompass the range of expertise needed, including experience in managing multi-center, multi-institutional and international research projects, expertise in data science, biostatistics, kidney research, environmental health, epidemiology, project management, and ethical conduct of international research in resource-limited settings.
The participating ICs intend to commit up to $4,000,000 in FY 2021 for the entire consortium.
NIDDK and NIEHS expect to fund one award for the Scientific Data Coordinating Center.
The direct costs may be up to $600,000 per year for the Scientific Data Coordinating Center.
93.847 and 93.113
Applications are not being solicited at this time.
Inquiries
Susan R. Mendley, MD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
301-827-1861
susan.mendley@nih.gov
Bonnie R. Joubert, MPH, PhD
National Institute of Environmental Health Sciences (NIEHS)
Telephone: 984-287-3276
Email: bonnie.joubert@nih.gov