Department of Health
and Human Services (HHS)
and Human Services (HHS)
NOT-DK-20-028: Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium – Field Site (U01 - Clinical Trial Not Allowed)
NOT-DK 20-030: Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium - Scientific Data Coordinating Center (SDCC) (U24 - Clinical Trial Not Allowed)
National Institute of Environmental Health Sciences (NIEHS)
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Environmental Health Sciences (NIEHS) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite applications for research on Chronic Kidney Disease of Uncertain Etiology (CKDu) in Agricultural Communities.
Included in this initiative will be a Renal Analytic Core to provide leadership in discovery science and support the analytic needs ofthe new consortium to study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE). The Renal Analytic Core will analyze blood and urine to assess renal function, analyze kidney biopsies, devise and carry out a scientific approach to understanding the cause or causes of CKDu, including planning a biological sampling strategy to be implemented at Field Sites.
This collaborative research consortium will bring together a broad range of expertise and enable discovery science to understand the cause or causes of CKDu. The consortium will also work to identify potential therapeutic targets and public health interventions. The consortium will consist of a Scientific Data Coordinating Center, Field Sites, a Renal Analytic Core and the NIEHS Human Health Exposure Analysis Resource (HHEAR). The consortium will work together to develop common protocols for evaluation of participants who are currently affected with early manifestations of CKDu and controls, to define common strategies for biological sampling and environmental assessment, and to determine analytic strategies to best use the samples collected by the consortium.
This FOA will not support intervention trials to prevent or treat CKDu. This FOA is intended to support only human studies and applications that include animal or model systems are not responsive.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The FOA is expected to be published in Summer 2020with an expected application due date in Fall 2020.
This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.
This Notice encourages investigators with expertise and insights into state-of-the-art methods that can be used or adapted to interrogate human biological samples (blood, urine, and kidney tissue) to examine mechanisms that underlie the cause or causes of CKDu to begin to consider applying for this new FOA.
The participating ICs expected to commit up to $4,000,000 in FY 2021 for the entire consortium.
NIDDK and NIEHS anticipate funding one award in FY 2021.
The direct costs may be up to $400,000 in per year in FY 2021 for the Renal Analytic Core.
93.847 and 93.113
Applications are not being solicited at this time.
Inquiries
Susan R. Mendley, MD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
301-827-1861
susan.mendley@nih.gov
Bonnie R. Joubert, MPH, PhD
National Institute of Environmental Health Sciences (NIEHS)
Telephone: 984-287-3276
Email: bonnie.joubert@nih.gov