NOT-DK-20-029: Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium – Renal Analytic Core (U01 - Clinical Trial Not Allowed)
NOT-DK 20-030: Notice of Intent to Publish a Funding Opportunity Announcement for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium - Scientific Data Coordinating Center (SDCC) (U24 - Clinical Trial Not Allowed)
National Institute of Environmental Health Sciences (NIEHS)
Fogarty International Center (FIC)
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Environmental Health Sciences (NIEHS), and the Fogarty International Center (FIC) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite applications for research on Chronic Kidney Disease of Uncertain Etiology (CKDu) in Agricultural Communities. Included in this initiative will be Field Sites to enroll research participants in the consortium to study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE). The Field Sites will identify, recruit and study participants with evidence of CKDu and appropriate controls, and collect biological and environmental samples at multiple visits over time.
This collaborative research consortium will bring together a broad range of expertise and enable discovery science to understand the cause or causes of CKDu. The consortium will also work to identify potential therapeutic targets and public health interventions. The consortium will consist of a Scientific Data Coordinating Center, Field Sites, a Renal Analytic Core and the NIEHS Human Health Exposure Analysis Resource (HHEAR). The consortium will work together to develop common protocols for evaluation of participants who are currently affected with early manifestations of CKDu and controls, to define common strategies for biological sampling and environmental assessment, and to determine analytic strategies to best use the samples collected by the consortium.
This FOA will not support intervention trials to prevent or treat CKDu. This FOA is intended to support only human studies and applications that include animal or model systems are not responsive.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The FOA is expected to be published in Summer 2020 with an expected application due date in Fall 2020.
This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.
This Notice encourages collaborative investigations combining expertise in epidemiologic research in low resource settings, kidney disease, project management, assessment of work practices and collection of biological samples. These investigators should begin considering applying for this application. Field Sites will conduct study activities in CKDu-endemic areas and applications may be submitted by local investigators or by a collaborative effort involving US and foreign investigators.
The participating ICs expected to commit $4,000,000 during FY 2021 for the entire consortium.
NIDDK,NIEHS and FIC expect to fund three awards for Field Sites during FY 2021.
The anticipated award for each Field Site is expected to be $400,000 in direct costs per year.
93.847, 93.113 and 93.989
Applications are not being solicited at this time.
Susan R. Mendley, MD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)