SMALL ANIMAL IMAGING RESOURCE PROGRAMS
Release Date: July 31, 2000 (see reissuance RFA-CA-04-011)
RFA: CA-01-012
National Cancer Institute
Letter of Intent Receipt Date: October 19, 2000
Application Receipt Date: November 28, 2000
This Request for Applications (RFA) is a reissue of RFA-CA-98-023 "Small
Animal Imaging Resource Programs" which was released in the NIH Guide on
August 20, 1998.
PURPOSE
The National Cancer Institute (NCI) invites applications from extramural and
intramural investigators for Small Animal Imaging Resource Programs (SAIRPs).
These grants will support (a) shared imaging research resources to be used by
cancer investigators, (b) research related to small animal imaging
technology, and (c) training of both professional and technical support
personnel interested in the science and techniques of small animal imaging.
SAIRPs will enhance capabilities for conducting basic, clinical, and
translational cancer research relevant to the mission of the NCI. Major goals
of this initiative are to increase efficiency, synergy, and innovation of
such research and to foster research interactions that cross disciplines,
approaches and levels of analysis. Building and strengthening such links
holds great potential for better understanding cancer, and ultimately, for
better treatment and prevention.
For this RFA, teams composed of NIH intramural investigators are encouraged
to submit intramural project applications to become components of the
network, but they may not request or receive funds from this program
(Potential intramural applicants please see
http://cancer.gov/bip/NCI-DIPini.htm).
RESEARCH OBJECTIVES
Background
Small animal models, particularly genetically engineered mice, are
increasingly recognized as powerful discovery tools in cancer research. The
potential that could be realized by the use of animal models has not yet
fully been realized. One of the limitations is the need to sacrifice the
animals to perform tissue or molecular analysis. This prevents researchers
from observing in vivo the natural or perturbed evolution of the processes
under study. Functional, molecular, and morphologic quantitative imaging
techniques are an important tool for providing data about biochemical,
genetic or pharmacological processes in vivo, and repetitively in the same
animal.
Neoplasms have an intrinsic spatially distributed nature. That is, tumors
develop in different sites, metastasize to other sites and are internally
heterogeneous. To study tumors one must make spatially distributed
measurements. Imaging is a means of making and displaying spatially coherent
measurements and is therefore a key resource for studying the development,
growth and therapeutic response of neoplasms. One of the important research
directions for imaging research is to provide quantitative information in the
setting of cancer diagnosis and therapy. Quantitation of image data for
small animals will lead the way to application of quantitative methods in
human beings.
A major limitation to studying tumors in model systems with current imaging
techniques is the limited availability of small animal imaging systems. Most
biomedical imaging devices have been optimized for human studies and have
suboptimal spatial resolution for small animals and their tumors. However,
imaging techniques can be scaled down to yield very high resolution and
signal sensitivity for in vivo images of mouse-sized organs. Furthermore,
there are some applications of imaging techniques that could provide valuable
knowledge from small animal models, but are not feasible for human subjects.
Therefore, in order to take full advantage of the small animal tumor models
being developed, it has been recommended that dedicated small animal imaging
laboratories be developed.
The NCI recognizes the importance, synergy and innovation that often evolve
from research crossing disciplines, approaches, and levels of analysis. The
SAIRP award is envisioned as enhancing such multidisciplinary activities by
supporting coordinated shared research resources for NIH-funded investigators
performing cancer research. The use of such shared resources can increase
efficiency in an area of research by eliminating unnecessary duplication of
effort and/or the support of research resources (e.g., costly equipment) that
might be needed in, but not fully utilized by, the activities of any one
research grant. Shared-resource laboratories can stimulate new research
directions by providing access to equipment, services, and other resources
that might not otherwise be available. Finally, shared research resources
which are properly coordinated will promote research interactions and
collaborations that cross disciplines, technical and theoretical approaches,
and levels of analysis, including interactions across basic and clinical
cancer research. Such interactions often have results that exceed the sum of
the contributing activities. For this reason, participation of
scientifically diverse base grants are strongly encouraged and, all else
being equal, applications for SAIRPs with such scientific diversity will be
given higher priority for funding consideration.
Objectives and Scope
SAIRPs will offer a unique opportunity for multidisciplinary teams within the
cancer research community to address critical cancer research questions.
Small Animal Imaging Resource Programs (SAIRP) will provide:
Multiple imaging technologies for small animals, emphasizing, but not limited
to, those technologies which can provide biochemical, genetic or
pharmacological information in vivo.
Technology research and development on innovative new imaging technologies
appropriate for small animals, as well as refinement and development of
technologies already established.
Capabilities and personnel to assist in the development and/or production of
necessary probes for the imaging technologies provided.
Capabilities and personnel to aid in small animal anesthesia and care, as
well as to consult on the optimal use of animals in connection with the
imaging experiments.
Training for both professional and technical personnel in the techniques and
methodologies of small animal imaging.
Structure
The structure of the SAIRP must reflect the need to ensure that the small
animal imaging technologies available for access or under development through
this mechanism are pushing the state of the art. In addition, the SAIRP
should explore the broadest range of cancer research related applications
appropriate.
The primary purpose of each SAIRP is to support coordinated shared research
resources and related research to enhance the capabilities of NIH-supported
investigators to pursue cancer research relevant to the mission of the NCI.
A SAIRP is characterized as follows:
SAIRPs and SAIRP-related research represent shared research resources and
activities that can include services (e.g., software development,
histological processing, bio-statistical support), equipment (e.g., image
analysis systems, multi-channel recording equipment), and other resources
(e.g., use of animal handling facilities, access to supercomputing centers,
time on scanners, other clinical research resources).
SAIRPs must benefit the base grants that they serve and are expected to
increase efficiency, promote new research directions and foster interactions
and synergy among investigators.
SAIRPs may also be used by those not in base grants, particularly to the
extent that they provide opportunities for young investigators, women and
minorities. If this is planned, rationale for such usage and for selection
of such investigators should be provided.
SAIRPs must address the training of professional and technical individuals
within the institution as well as from outside in the techniques of small
animal imaging.
Resource
The SAIRP should use approximately one half to two thirds of its resources
and time to provide imaging services and collaboration to cancer-related
research projects. As part of the initial application, there must be
commitments from at least three cancer-related research projects [R01, FIRST
(R29), program project (P01), relevant consortia (U01) and/or MERIT (R37)
grants],or R01-equivalent cancer-related awards from other agencies, that
will use the small animal imaging resource at the beginning of year 2. After
implementation, the applicants would be expected to form similar
collaborations with at least three additional cancer-related research
projects by the beginning of the third year of the SAIRP award. At the time
of application, applicants must give evidence of potential to form these
additional collaborations. Collaboration with at least six other research
projects using small animals within 2 years after the award is a MINIMUM
requirement. Collaboration with more than six research projects is strongly
encouraged.
Applicants must demonstrate that at the time of application they have
available at least one state-of-the-art imaging technology optimized for
small animals. In addition, they must show evidence of experience with in
vivo imaging of small animals using the available technology.
Applicants must provide plans for providing at least one additional imaging
technology for small animals within the first year of the award. This could
be acquired commercially or developed in-house. Funds to acquire or develop
this additional imaging technology may be included in the budget of year 1 of
the application.
Imaging Technology Research
The SAIRP should use approximately one third to one half of its resources and
time for research and development of small animal imaging technology. This
could be further development and optimization of existing technologies or
exploration of novel technologies. Methods to produce valid quantitative
results would be particularly encouraged. Funds for small animal imaging
technology research may be included in the application budget for all years
of the award.
Training
A plan for training of individuals including basic scientists, clinicians,
technologists and support personnel interested in learning the techniques and
science of small animal imaging must be included. Some of the trainees must
come from institutions other than the awardee institution. The training
should include both didactic and hands-on instruction.
Governance
The Director of the SAIRP must have a demonstrated capability to organize,
administer and direct the shared resource. Applicants must describe their
plan for governance, and methods to be used to evaluate and select protocols
to support with the SAIRP. It is suggested that a scientific advisory board
of collaborators and other cancer investigators would be established for this
purpose. The expertise of the scientific advisors and the structure of the
board should be discussed, but the advisors do not need to named in the
application.
Two years after the award there will be a review by NCI program staff to
confirm that: two or more small animal imaging technologies have been
implemented and are operational, collaboration with a minimum of six cancer-
related research projects requiring imaging data from small animals is in
progress, developmental research on small animal imaging systems is in
progress.
If these components do not exist or are insufficient, the award will be
phased out.
Research Support
The following are examples of ancillary research capabilities for which
funding could be requested in SAIRP application. This list of examples is
not meant to be comprehensive or exclusive of other possibilities.
Contrast agent support: synthesize agents that can be used by investigators
to differentially label normal or abnormal structures, or make evident
specific processes in tumor imaging studies.
Supercomputer support: fund access to high performance platforms and
technical assistance in optimizing algorithms used in analyzing very large
data sets resulting from high resolution imaging, 3D and 4D imaging, etc.
Informatics support: funds to support the purchase as well as research and
development of tools and approaches for data storage, retrieval, analysis,
visualization and manipulation.
Imaging instrument support: purchase equipment, supplies, and service
contracts needed for small animal imaging.
Research animal support: support of laboratory facilities to provide the
animal imaging operations.
Biostatistics support: support for statistical consultation in experimental
design and data analysis for small animal imaging.
Activities Supported
An overall budget for the SAIRP should be provided, as well as budgets for
each of the proposed imaging instruments, including instrument-related
research. Direct costs may be requested that are essential for the support of
the SAIRPs and must be fully documented and justified, salary support for
administrative costs should be kept at a minimum.
The SAIRP investigators will organize a public meeting in year 3, open to all
interested researchers. Attendance at this meeting should be budgeted for.
SPECIAL REQUIREMENT
A budget item to support travel of two persons to an annual meeting of
individuals from all the funded SAIRPs should be included.
MECHANISM OF SUPPORT
Small Animal Imaging Resource Programs will be supported by the resource-
related research projects (R24) mechanism. This mechanism is used to support
projects that enhance capabilities of resources to contribute to extramural
research of the Public Health Service. Responsibility for the planning,
direction, and execution of the proposed project will be solely that of the
applicant. Funding for NIH intramural applicants will be derived from
existing intramural resources.
This RFA is a one-time solicitation. Amended or competing continuation
applications will be accepted only through future RFAs, the publication of
which will be contingent upon program priorities and availability of funds.
Because the nature and scope of the research proposed may vary, it is
anticipated that the size of each award will also vary.
FUNDS AVAILABLE
Approximately $20 million total cost will be available for the 5-year period
of the award for all the SAIRPs. Approximately $5.9 million total cost will
be available for the first year of this RFA, which should fund five resource
related grants, including funds for adding small animal imaging equipment as
described below, subsequent year funding would be less, because it would not
fund equipment acquisition. Approximately $3.5 million total cost for all
the SAIRPs will be available each year for years 2 through 5 of the award.
It is anticipated that five awards will be supported through this RFA.
Purchase or assembling of imaging equipment will be allowed in the first year
only. The funds requested should be based on the requirements of the project
and the requested costs must be fully justified. Each SAIRP will provide
services, equipment and/or other research resources to the base grants,
imaging technology research related to the SAIRP, in turn, will enhance the
capabilities of the SAIRP. The coordinated use of shared resources increases
the efficiency of cancer research, facilitates the use of new technologies
and the pursuit of new lines of research, and promotes interdisciplinary and
collaborative research.
Although the financial plans of the NCI provide support for this program,
awards pursuant to this RFA are contingent upon the availability of funds and
the receipt of a sufficient number of meritorious applications. At this
time, it is not known if competing renewal applications will be accepted
and/or if this RFA will be reissued.
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic, for-profit and non-profit
organizations, public and private, such as universities, colleges, hospitals,
laboratories, units of State and local governments, and eligible agencies of
the Federal government. For this RFA, teams composed of NIH intramural
investigators are encouraged to submit intramural project applications to
become components of the Consortium, but they may not request or receive
funds from this program (Potential intramural applicants please see
http://cancer.gov/bip/NCI-DIPini.htm). Foreign institutions are not eligible
for resource-related research project (R24) grants. Racial/ethnic minority
individuals, women, and persons with disabilities are encouraged to apply as
SAIRP Directors and heads of laboratories. Applicants for SAIRPs may request
support for a period of up to 5 years. By the beginning of the third year of
the SAIRP award, each application for a SAIRP must serve a minimum of 6
cancer-related research projects (R01), FIRST (R29), program projects (P01),
relevant consortia (U01) and/or MERIT (R37) grants (known as the base
grants). Training grants (T32) and individual and institutional fellowship
grants are not eligible for inclusion as base grants. R01-equivalent cancer-
related awards from other agencies may be included as base grants. Only one
SAIRP will be awarded to any single applicant organization, but base grants
may be housed in multiple institutions. In general, each cancer-related
research project grant should only serve as a base grant for one SAIRP. If
well justified, activities and research may be located at sites and
institutions other than that/those of the base grants and the SAIRP. For
example, research related to a program might exist at a transgenic facility,
supercomputer center, imaging facility, etc., which is neither at nor part of
the institution applying for the SAIRP, nor at or part of any of the
institutions housing the base grants.
One intention of this initiative is to promote regional distribution of small
animal imaging facilities.
INQUIRIES
Inquiries concerning this RFA are encouraged. The opportunity to clarify any
issues or questions from potential applicants is welcome.
Direct inquiries regarding programmatic issues to:
Barbara Y. Croft, Ph.D.
Diagnostic Imaging Program
National Cancer Institute
6130 Executive Boulevard, Room 800
Rockville, MD 20892-7440
Telephone: (301) 496-9531
FAX: (301) 480-5785
Email: bc129b@nih.gov
Direct inquiries regarding review issues to:
Ms. Toby Friedberg
Referral Officer
Division of Extramural Activities
National Cancer Institute
6116 Executive Blvd., Room 8062, MSC-8329
Rockville, MD 20852 (express courier)
Bethesda, MD 20892-8329
Telephone (301) 496-3428
Fax: (301) 402-0275
Email: tf12w@nih.gov
Direct inquiries regarding fiscal matters to:
Kathleen J. Shino, M.B.A.
Grants Administration Branch
National Cancer Institute
6120 Executive Boulevard, Room 243, MSC 7150
Bethesda, MD 20892-7150
Telephone: (301) 496-7800 ext. 248
FAX: (301) 496-8601
Email: shinok@gab.nci.nih.gov
LETTER OF INTENT
Prospective applicants are asked to submit, by October 19, 2000, a letter of
intent that includes a descriptive title of the proposed research, the name,
address, telephone number, and e-mail address of the Principal Investigator,
the identities of other key personnel and participating institutions, and the
number and title of the RFA in response to which the application may be
submitted. Although a letter of intent is not required, is not binding, and
does not enter into the review of a subsequent application, the information
that it contains allows IC staff to estimate the potential review workload
and plan the review.
The letter of intent is to be sent to Dr. Barbara Croft by the letter of
intent receipt date listed.
SCHEDULE
Letter of Intent Receipt: October 19, 2000
Application Receipt: November 28, 2000
Peer Review Date: March 2001
Review by NCAB Advisory Board: May 2001
Earliest Anticipated Start Date: July 1, 2001
APPLICATION PROCEDURES
The research grant application form PHS 398 (rev. 4/98) is to be used in
applying for these grants. Applications kits are available at most
institutional offices of sponsored research and may be obtained from the
Division of Extramural Outreach and Information Resources, National
Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-
7910, telephone 301/710-0267, email: grantsinfo@nih.gov. For those
applicants with internet access, the 398 kit may be found at
http://grants.nih.gov/grants/forms.htm.
The SAIRPs are intended to enhance the capabilities of scientists to pursue
cancer research relevant to the mission of this Institute. The manner in
which the proposed SAIRP will do this must be made clear in the application.
The following sections should replace the Specific Aims, Background and
Significance, Preliminary Studies/Progress Report, and the Research Design
and Methods sections of the traditional Research Plan in form PHS 398 (Rev.
4/98) (adhering to the 25-page limit):
General Description of the SAIRP:
Describe the SAIRP, existing small animal imaging instrument(s), proposed
small animal imaging instrument(s), and ancillary capabilities existing and
proposed. Describe the provision of imaging services and the small animal
imaging research and development proposed. Describe the plans for training
of professionals and technical support personnel.
General Description of the Base Grants of the SAIRP (Not to exceed 1 page for
each base grant participating in the SAIRP):
Provide an overview of the research goals and approaches used in each of the
base grants and the manner in which the SAIRP award will benefit the research
activities of the base grants. In addition, describe the specific ways in
which the SAIRP will increase efficiency, promote new research directions and
foster research interactions and synergy of cancer-related research.
Finally, for each of the base grants, the following must be provided: the
grant number, title, name of the PI, grantee organization, the project period
end date, and the direct cost budget for the year on which the budget of the
SAIRP application is based.
Operational Plan:
Describe arrangements required to implement the SAIRP, including the manner
in which priority for imaging facility access and use is decided, the
operational and administrative role of the director of the imaging facility,
etc. This section is especially important for those applications proposing
an offsite facility.
Imaging Equipment Descriptions:
Describe the purpose of each component, describe imaging technology-related
research including the manner in which it is expected to enhance the
capabilities of the imaging instruments, and clearly indicate the space,
facilities, resources, services, technical and professional expertise and
support that the applicant institution will provide.
Describe the specific manner in which each component will relate to the base
grants. For each component, describe the level of use by the base grants,
starting in year 3 of the award, each imaging technology must be used by at
least three of the base grants.
Ancillary Capabilities
Describe the specific ancillary capabilities requested and how they will
enhance the SAIRP.
Training Program
Describe a dedicated plan for the training of individuals in the science of
small animal imaging. A plan for training of individuals such as basic
scientists, clinicians, technologists, and support personnel interested in
learning the techniques and science of small animal imaging is required.
Examples of training for research scientists or clinicians might be in the
form of, but not limited to, full-time or part-time post-doctoral
fellowships. Examples of training for support personnel might be in the form
of, but not limited to, short-term courses. Some of the trainees must come
from institutions other than the awardee institution. The training should be
comprehensive and include both didactic and hands-on instruction.
Table of Contents
The table of contents should reflect the actual contents of the application
and should not copy the categories of PHS 398 Form Page 3.
Budget and Financial Information
Break out the budget contribution for each proposed small animal imaging
instrument. The budget and the proposed research and resource provision
should be aligned.
Appendix: All instructions in the Form 398 application kit apply.
The RFA label available in the PHS 398 (rev. 4/98) application form must be
affixed to the bottom of the face page of the application. Type the RFA
number on the label. Failure to use this label could result in delayed
processing of the application such that it may not reach the review committee
in time for review. In addition, the RFA title and number must be typed on
line 2 of the face page of the application form and the YES box must be
marked.
The sample RFA label available at:
http://grants.nih.gov/grants/funding/phs398/label-bk.pdf has been modified to
allow for this change. Please note this is in pdf format.
Submit a signed, typewritten original of the application, including the
Checklist, and three signed, photocopies, in one package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive
Room 1040 - MSC 7710
Bethesda, MD 20892-7710
(20817 for express service)
At the time of submission, two additional copies of the application must be
sent to:
Ms. Toby Friedberg
Referral Officer
Division of Extramural Activities
National Cancer Institute
6116 Executive Boulevard, Room 8062, MSC 8329
Bethesda, MD 20892-8329
Rockville, MD 20852 (for express/courier service)
Applications must be received by November 28, 2000. If an application is
received after that date, it will be returned to the applicant without
review. The Center for Scientific Review (CSR) will not accept any
application in response to this RFA that is essentially the same as one
currently pending initial review, unless the applicant withdraws the pending
application. The CSR will not accept any application that is essentially the
same as one already reviewed. This does not preclude the submission of
substantial revisions of applications already reviewed, but such applications
must include an introduction addressing the previous critique.
REVIEW CONSIDERATIONS
Upon receipt, applications will be reviewed for completeness by CSR and
responsiveness by the NCI. Incomplete and/or non-responsive applications
will be returned to the applicant without further consideration.
Applications that are complete and responsive to the RFA will be evaluated
for scientific and technical merit by an appropriate peer review group
convened by the NCI in accordance with the review criteria stated below. As
part of the initial merit review, all applications will receive a written
critique and undergo a process in which only those applications deemed to
have the highest scientific merit, generally the top half of the applications
under review, will be discussed assigned a priority score, and receive a
second level review by the National Cancer Advisory Board.
The goals of NIH-supported research are to advance our understanding of
biological systems, improve the control of disease, and enhance health. The
reviewers will comment on the following aspects of the application in their
written critiques in order to judge the likelihood that the proposed research
will have a substantial impact on the pursuit of these goals. Each of these
criteria will be addressed and considered by the reviewers in assigning the
overall score weighting them as appropriate for each application. Note that
the application does not need to be strong in all categories to be judged
likely to have a major scientific impact and thus deserve a high priority
score. For example, an investigator may propose to carry out important work
that by its nature is not innovative but is essential to move a field
forward.
1. Significance. Does the application address an important problem? If the
aims of the application are achieved, how will scientific knowledge be
advanced? What will be the effect of this resource program on the concepts
or methods that drive this field? What is the likelihood that the proposed
SAIRP will increase efficiency, promote new research directions, facilitate
interactions across disciplines and levels of analysis, and/or across
theoretical and technological approaches?
2. Approach. Are the conceptual framework, design, methods, and analyses
adequately developed, well-integrated, and appropriate to the aims of the
SAIRP? Does the applicant acknowledge potential problem areas and consider
alternative tactics? How will the effectiveness of the SAIRP in achieving
its goals be judged?
3. Innovation. Does the imaging research project employ novel concepts,
approaches or methods? Are the aims original and innovative? Does the imaging
research project challenge existing paradigms or develop new methodologies or
technologies?
4. Investigator. Is the investigator appropriately trained and well suited
to manage the SAIRP and carry out the research? Is the work proposed
appropriate to the experience level of the principal investigator and other
researchers (if any)? Has the principal investigator assembled the
appropriate team to manage the SAIRP and conduct the proposed research?
5. Environment. Does the scientific environment in which the work will be
done contribute to the probability of success? Do the proposed experiments
take advantage of unique features of the scientific environment or employ
useful collaborative arrangements? Is there evidence of institutional
support?
6. Relationship to base grants: Will the SAIRP significantly enhance the
capabilities of the base grants to pursue cancer research relevant to the
NCI? Is there participation of scientifically diverse base grants?
7. Training: The application will also be reviewed on the merit of a
plan to provide a comprehensive and balanced didactic and hands-on training
experience. This should include a plan for the training of individuals from
the awardee institution as well as from other institutions throughout the
country in the science of small animal imaging.
The initial review group will also examine: the appropriateness of proposed
project budget and duration, the provisions for the protection of animal
subjects, and the safety of the research environment.
AWARD CRITERIA
Applications will compete with other applications received in response to
this RFA. The following will be considered in making funding decisions:
Quality of the proposed project as determined by peer review, availability of
funds, and program balance.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups and
their subpopulations must be included in all NIH supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification is provided that inclusion is
inappropriate with respect to the health of the subjects or the purpose of
the research. This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103-43).
All investigators proposing research involving human subjects should read the
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical
Research," which have been published in the Federal Register of March 28,
1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts,
Volume 23, Number 11, March 18, 1994, available on the web at the following
URL address: http://grants.nih.gov/grants/guide/notice-files/not94-100.html.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS.
It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by
the NIH, unless there are scientific and ethical reasons not to include them.
This policy applies to all initial (Type 1) applications submitted for
receipt dates after October 1, 1998.
All investigators proposing research involving human subjects should read the
NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects that was published in the NIH Guide for
Grants and Contracts, March 6, 1998, and is available at the following URL
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html.
Investigators may also obtain copies of the policy from the program staff
listed under INQUIRIES. Program staff may also provide additional relevant
information concerning the policy.
URLS IN NIH GRANT APPLICATIONS OR APPENDICES
All applications and proposals for NIH funding must be self-contained within
specified page limitations. Unless otherwise specified in an NIH
solicitation, internet addresses (URLs) should not be used to provide
information necessary to the review because reviewers are under no obligation
to view the Internet sites. Reviewers are cautioned that their anonymity may
be compromised when they directly access an Internet site.
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2010," a
PHS-led national activity for setting priority areas. This RFA, Small Animal
Imaging Resource Programs, is related to priority area of cancer. Potential
applicants may obtain a copy of "Healthy People 2010" at
http://www.health.gov/healthypeople/.
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance No.
93.394. Awards are made under authorization of Sections 301 and 405 of the
Public Health Service Act as amended (42 USC 241 and 284) and administered
under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts
74 and 92. This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant recipients to provide a smoke-free
workplace and promote the non-use of all tobacco products. In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in
certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care, or early
childhood development services are provided to children. This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.
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