ECOLOGY OF INFECTIOUS DISEASES
Release Date: February 27, 2001
RFA: RFA-TW-01-004 (NOT-TW-06-003 updates and supersedes this RFA)
Fogarty International Center
(http://www.nih.gov/fic/)
National Institute of Environmental Health Sciences
(http://www.niehs.nih.gov)
National Institute of General Medical Sciences
(http://www.nigms.nih.gov/)
National Science Foundation
(http://www.nsf.gov)
U.S. Geological Survey
(http://www.usgs.gov)
Letter of Intent Receipt Date: April 2, 2001
Application Receipt Date: May 17, 2001
PURPOSE
The National Institutes of Health (NIH), the National Science Foundation (NSF)
and the U.S. Geological Survey (USGS) (hereafter "the Government" or "the
Participating Agencies") invite applications for the establishment of research
programs to elucidate the underlying mechanisms that govern the relationships
between anthropogenic environmental changes and the transmission dynamics of
infectious diseases.
This Request for Applications (RFA) calls for the development of
interdisciplinary research programs on the ecology of infectious diseases in
the context of anthropogenic environmental changes such as biodiversity loss,
habitat transformation, environmental contamination, climate change and other
influences. The focus of this RFA is on discovery of basic ecological and
biological mechanisms and development of predictive models for the emergence
and transmission of diseases in humans and other animals, and ultimately the
development of strategies to prevent or control them. This is the second RFA
issued for this program. The most significant change from the previous RFA is
a more inclusive definition of relevant climate change-disease projects.
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2010," a PHS-led national
activity for setting priority areas. This RFA, Ecology of Infectious Diseases
(EID), is related to one or more of the priority areas. Potential applicants
may obtain a copy of "Healthy People 2010" at
http://www.health.gov/healthypeople/.
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic and foreign for-profit and non-
profit organizations, both public and private (including domestic institutions
with foreign collaborators), such as universities, colleges, hospitals,
laboratories, units of State and local governments, and eligible agencies of
the Federal Government. Racial/ethnic minority individuals, women, and
persons with disabilities are encouraged to apply as Principal Investigators
(PIs).
MECHANISM OF SUPPORT
The participating agencies will jointly administer the program from receipt of
proposals and throughout the duration of awards. Following the initial
review, the institutes and agencies involved will choose from the top scoring
applications those that they will support. Each award will be made by NSF or
NIH. In some cases, the awards will include support from the other agency.
For awards that will be made by the NSF, the PIs will be asked to resubmit the
same application on NSF forms through the FastLane Internet system
(https://www.fastlane.nsf.gov/fastlane.htm) prior to making the award. Grant
awards by the NIH will use the R01 research project grant award mechanism.
Participating NIH components are the Fogarty International Center (FIC), the
National Institute of Environmental Health Sciences (NIEHS), and the National
Institute of General Medical Sciences (NIGMS). NSF participation is
principally through the Directorate for Biological Sciences. If collaborative
support from the USGS, as described below, is of interest, applicants should
prearrange this collaboration with the appropriate agency representatives and
document this support in their applications. Individual agency and institute
contacts are listed later in this announcement.
Responsibility for the planning, direction, and execution of the proposed
project will be solely that of the applicant. The total project period for an
application submitted in response to this RFA may not exceed five years. We
do not know at this time if or when this RFA will be issued again. Future
unsolicited competing continuation applications will compete with all
investigator-initiated applications and be reviewed according to the customary
peer review procedures of the receiving agency or institute. The anticipated
award date is approximately February 1, 2002 for NSF awards and March 1, 2002
for NIH awards.
USGS will provide, by agreement among investigators, support through
collaboration with USGS laboratories for research addressing needs related to
the ecology of infectious diseases. These needs include, but are not limited
to: access to databases for water quality, the chemical and physical
characteristics of earth materials, land (both natural and man-made
attributes), and satellite and airborne remotely sensed data; laboratory
analysis of wildlife diseases, including wildlife and environmental
toxicology; and chemical analysis of water, plants, soils, rocks, and
sediments. The USGS studies, assesses, and develops and maintains National
Data Bases on the Nation's water (quantity and quality) resources, flora,
fauna, land characteristics, natural hazards including earthquakes, volcanic
eruptions, landslides, floods, coastal erosion, and mineral and energy
resources; and determines past ecological and climate histories. Grant funds
to support research or post-doctoral associates will not be available through
USGS National Programs. Post-doctoral support may, however, be available
through individual USGS laboratories. If such support is of interest,
applicants must arrange it with the appropriate USGS laboratory, describe it,
and provide supporting letters in their application. Information on potential
collaborators and resources within the USGS can be found on the World Wide Web
at http://www.usgs.gov.
Note that unconfirmed support from USGS or any other collaborator cannot be
considered during initial peer review of an application. While such
collaborations could be added to a project after it has been funded,
investigators are encouraged to develop these for the initial application.
FUNDS AVAILABLE
An applicant may request a project period of up to five years, with a budget
of up to $350,000 per year direct costs. We anticipate that the nature and
scope of projects will vary, and accordingly, the budget and duration of
funded projects will also vary. Contingent upon the availability of funds,
the Government anticipates a total from all collaborating agencies of
approximately $3 million will be awarded for the first year, providing for an
estimated six to eight grants. Additional funding may become available to
support more awards if Congressional budget allocations and/or potential
interest from other institutes allow for it. Because the anticipated award
size is greater than $250,000 per year, the NIH modular approach will not be
used for any application submitted for this RFA.
RESEARCH OBJECTIVES
Definitions
For the purpose of this RFA, some relevant terms are defined below.
o Anthropogenic Environmental Change - A sustained change in the natural
environment resulting from human activity such as deforestation, exotic
species introduction, chemical effluent release, carbon dioxide release, etc.
o Biocomplexity - A property of systems structured or influenced by living
organisms, their components, or biological processes. This RFA focuses on
biocomplexity that arises from the interactions of living organisms with all
facets of their external environment, particularly those interactions
involving multiple levels of biological organization and/or multiple spatial
and temporal scales.
o Biodiversity - The structural and functional variety of life forms at
genetic, population, species, and ecosystems levels.
o Biological Invasion - The mass movement or encroachment of organisms from
one area into another, generally, non-native area.
o Climate Change Sustained directional change in atmospheric temperature,
seasonality, or other feature of climate that may be considered a result of
human activities such as release of carbon dioxide.
o Ecology - The study of the abundance and distribution of organisms and of
the relationships between organisms and their biotic and abiotic environments,
including climate.
o Habitat Fragmentation - The disruption of extensive habitats into isolated
and smaller patches, typically by agriculture, human settlement or development
projects.
o Infection - The process of invasion and establishment by a microorganism or
helminth within host tissues.
o Infectious Diseases - Diseases resulting from presence of an infectious
agent.
o Species Richness - The absolute number of species in an assemblage or
community.
Background
Over the past 20 years, unprecedented rates of change in diversity of non-
human biota have coincided with the emergence and reemergence of numerous
infectious diseases around the world. Virtually all of the world's
terrestrial and aquatic communities and ecosystems have undergone dramatic
changes in biodiversity and biocomplexity due primarily to habitat
transformation (deforestation, reforestation, agricultural intensification,
fragmentation), invasions of exotic species, chemical contamination, and
climate change events. The coincidence of broad-scale environmental changes
and emergence of infectious diseases may point to underlying predictable
ecological relationships.
For example, habitat fragmentation may reduce populations of mammalian
predators of animals that are natural reservoirs of disease agents, resulting
in increased transmission to humans. Similarly, runoff from urban and rural
sewage systems may carry pathogenic microorganisms and helminths that
proliferate in shellfish and fish and eventually infect humans via consumption
as food. While a descriptive understanding of some cases exists, there is
little mechanistic understanding of basic ecological principles that may
regulate such complex systems.
The role of biological diversity and habitat structure in stabilizing
communities of plants, animals and micro-organisms has received a great deal
of attention from ecologists in recent years. As a result, our capacity to
analyze and model biocomplexity and ecological dynamics, and to evaluate
spatial and temporal aspects of environmental change has become increasingly
sophisticated. However, few of these advances in ecological science have yet
contributed to biomedical research or to public health.
Similarly, we have improved our ability to define the molecular identity of
pathogens or infectious agents and their vectors, and our understanding of the
defense systems of their hosts. These improvements have contributed
significantly to our understanding of epidemiology and transmission patterns
of diseases. However, the relationship of these factors to population
dynamics of disease reservoirs, or the biotic and structural complexity of
ecological systems in which transmission occurs, remains a poorly understood
area.
At present, basic and applied research in infectious disease ecology is
largely piecemeal, due in part to the differentiated missions of federal
science agencies that support research. The potential benefits of an
interdisciplinary research program in this area include: development of
disease transmission theory, improved understanding of unintended health
effects of development projects, increased capacity to forecast outbreaks, and
improved understanding of how diseases (re)emerge. An interdisciplinary
program will also solidify long-term collaborative relationships among federal
agencies that have been independently supporting research in ecological and
health sciences. These opportunities led the participating agencies to
announce the first RFA for EID last year (NIH Guide November 16, 1999:
http://grants.nih.gov/grants/guide/rfa-files/RFA-TW-00-002.html) seeking to
bring together advances in methods and understanding from these and other
fields in an interdisciplinary program of research aimed at the interface of
ecology and human health. Brief descriptions of the funded projects from that
competition can be found at: http://www.nih.gov/fic/news/ecology.html. This
RFA represents a second competition of that program in recognition of the very
large number of applications and inquiries we received in response to the
first announcement.
Scientific Objectives
Fundamentally, the goal of this effort is to encourage development of
predictive models and discovery of principles for relationships between
anthropogenic environmental change and transmission of infectious agents. To
that end, research should focus on understanding the ecological determinants
of transmission by vectors or abiotic agents, the population dynamics of
reservoir species, and transmission to humans or other hosts. These
anthropogenic environmental changes include, but are not limited to,
deforestation, habitat destruction or fragmentation, biological invasion,
agricultural practices, and environmental pollution, climate change and
resulting climate events.
A variety of topics, questions and approaches are appropriate. Research could
focus on particular infectious agents, individual diseases or groups of
diseases, and might involve one or more regions, habitats or groups of
organisms. Depending on the hypotheses being addressed, investigations might
entail laboratory experiments, field observations or manipulations, novel
analyses of existing data, theoretical investigations of ecological dynamics
or all of the above. Field investigations that elucidate extensive temporal
and/or spatial patterns from nature are among those most likely to yield
important insights. Such insights are likely to be gained through integrating
work among several scales of observation, including molecular, individual,
population, and regional levels of analysis. Use of remote sensing,
geographic information systems, and other information technologies may be
useful in such efforts.
Investigations may also consider dynamic processes using model biological
systems, even in a laboratory setting. New insights gained from the study of
biological interactions involving organisms or ecological settings other than
those of ultimate concern may very well improve our understanding of complex
interactions in natural ecological systems.
The primary focus should be on ecological dynamics related to disease agent
transmission and infection. Analysis of environmental influences on the
susceptibility of individuals or populations to infection by particular agents
is appropriate. However, research that does not include a substantial focus
on the underlying ecological parameters of environmental change that influence
transmission and infection is outside the scope of this RFA. Infectious
disease researchers with a different focus are directed to the National
Institute on Allergy and Infectious Diseases (NIAID) http://www.niaid.nih.gov/
or other opportunities at the NIH or the NSF. Similarly, while the evolution
of pathogens and hosts may be inseparable from many ecological questions,
investigations focused primarily on genetic change in diseases or hosts are
outside the scope of this RFA. Investigators interested in this area are
encouraged to examine the NIH Program Announcement PA-99-147 Evolutionary
Mechanisms in Infectious Diseases
(http://grants.nih.gov/grants/guide/pa-files/PA-99-147.html).
This RFA is intended to support research related to
anthropogenic environmental changes. In contrast to the previous EID RFA,
research on the effects of normal climate phenomena, such as El Nino
Southern Oscillation (ENSO) cycles and extreme climatic events, will be
considered responsive to this RFA. However, they are only responsive to the
extent that the research proposed serves explicitly as a model for the effects
of global climate change on infectious disease transmission.
Examples of the kinds of ecological relationships that may be studied include,
but are not limited to, the following:
o effect of changes in species richness on the persistence and relative
abundance of pathogenic and non-pathogenic microorganisms, and their
transmission to hosts,
o identification and evaluation of habitats favorable to the emergence of new
infections,
o influences of global climate change and associated extreme events on
transmission or risk of disease,
o impact of chemical or physical pollutants on abundance of pathogens and
rates of transmission,
o consequences of newly-introduced species on competitive interactions among
hosts,
o impact of deforestation on human population density and the incidence of
zoonotic and vector-borne disease,
o habitat fragmentation and changes in the geographic range of disease
transmission,
o effects of pollution-related algal blooms on abundance of associated
infectious organisms and their transmission to humans,
o meta-analyses of historical patterns of transmission and the underlying
environmental determinants,
o factors affecting reservoir abundance and risk of zoonotic disease,
o role of habitat-specific diseases in shaping the community structure of
non-human hosts,
o ecology of migration and population structure on emergence or regional
maintenance of disease.
Funded research under this RFA will aim beyond description to achieve
mechanistic insights into such phenomena.
These kinds of problems are fundamentally interdisciplinary, and teams of
investigators with expertise in a wide range of scientific training and skills
from diverse disciplines are likely to be most effective. Integrated,
collaborative efforts might involve infectious disease epidemiologists,
population ecologists, statisticians, immunologists, parasitologists,
taxonomists, molecular biologists, environmental health scientists,
climatologists, and mathematical modelers, for example. A team approach is
encouraged to answer questions that normally cannot be addressed within a
single discipline. Work under this RFA can involve the collection or
development of new data, the reanalysis of existing data, or a combination of
both.
SPECIAL REQUIREMENTS
Each application should budget for travel by one or more investigators to the
Washington, D.C. area every year for a network meeting of all funded projects
under this RFA.
Research projects proposed for execution in a developing country should, as
part of the research process, make an express effort to build sustainable
research capacity in collaborating institutions in the host country through
transferring skills, information and equipment, as relevant to the proposed
project.
Protection of Research Subjects
Applicants should be aware that provisions for the protection of human
research subjects and laboratory animals must be met in research done in both
domestic and foreign institutions, including obtaining any necessary
assurances. Applicants should see Title 45 CFR, Part 46 for information
concerning the Department of Health and Human Services regulations for the
protection of human subjects and the PHS Policy on Humane Care and Use of
Laboratory Animals. These are available from:
The Office for Human Research Protections (OHRP)
Department of Health and Human Services
6100 Executive Boulevard, Suite 3B01, MSC 7507
Rockville, MD 20892-7507
http://www.hhs.gov/ohrp
ohrp@osophs.dhhs.gov
Office of Laboratory Animal Welfare (OLAW)
National Institutes of Health
RKL1, Suite 1050, MSC 7982
6705 Rockledge Drive
Bethesda, MD 20892-7982
http://grants.nih.gov/grants/olaw/olaw.htm
olaw@od.nih.gov
Applicants should refer to NIH Guide Notice OD-00-039, dated June 5, 2000, and
revised August 25, 2000
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html)
for information on required education on the protection of
human research participants.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups and
their sub-populations must be included in all NIH-supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification are provided indicating that inclusion
is inappropriate with respect to the health of the subjects or the purpose of
the research. This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103-43).
All investigators proposing research involving human subjects should read the
updated "NIH Guidelines for Inclusion of Women and Minorities as Subjects in
Clinical Research," published in the NIH Guide for Grants and Contracts on
August 2, 2000
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html);
a complete copy of the updated Guidelines is available at
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm. The
revisions relate to NIH defined Phase III clinical trials and require: a) all
applications or proposals and/or protocols to provide a description of plans
to conduct analyses, as appropriate, to address differences by sex/gender
and/or racial/ethnic groups, including subgroups if applicable; and b) all
investigators to report accrual, and to conduct and report analyses, as
appropriate, by sex/gender and/or racial/ethnic group differences.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them.
This policy applies to all initial (Type 1) applications submitted for receipt
dates after October 1, 1998.
All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines" on the Inclusion of Children as Participants in
Research Involving Human Subjects that was published in the NIH Guide for
Grants and Contracts, March 6, 1998, and is available at the following URL
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html.
Investigators also may obtain copies of these policies from the program staff
listed under INQUIRIES. Program staff may also provide additional relevant
information concerning the policy.
URLS IN NIH GRANT APPLICATIONS OR APPENDICES
All applications and proposals for NIH funding must be self-contained within
specified page limitations. Unless otherwise specified in an NIH
solicitation, Internet addresses (URLs) should not be used to provide
information necessary to the review because reviewers are under no obligation
to view the Internet sites. Reviewers are cautioned that their anonymity may
be compromised when they directly access an Internet site.
LETTER OF INTENT
Prospective applicants are asked to submit a letter of intent by March 23,
2001, that includes a descriptive title of the proposed research, the name,
address, and telephone number of the PI, the identities of other key personnel
and participating institutions, and the number and title of the RFA in
response to which the application may be submitted. Although a letter of
intent is not required, is not binding, and does not enter into the review of
a subsequent application, the information that it contains allows staff to
estimate the potential review workload and plan the review. The letter of
intent should be sent to:
Dr. Joshua Rosenthal
Fogarty International Center
National Institutes of Health
31 CENTER DRIVE MSC 2220
BETHESDA MD 20892-2220
FAX: 301-402-2056
Email: joshua_rosenthal@nih.gov
APPLICATION PROCEDURES
The regular research grant application Form PHS-398 (Rev. 4/98) must be used
in applying. General instructions for completing the Form PHS-398 are
contained in the application package. Apply additional instructions as
outlined in this RFA. The Form PHS-398 is available through the NIH pages on
the World Wide Web (http://grants.nih.gov/grants/funding/phs398/phs398.html).
These forms are available at most institutional offices of sponsored research
and from the Division of Extramural Outreach and Information Resources,
National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD,
20892-7910, telephone 301/710-0267, email: GrantsInfo@nih.gov.
The RFA label available in the PHS 398 (rev. 4/98) application form must be
affixed to the bottom of the face page of the application and must indicate
the RFA number. Failure to use this label could result in delayed processing
of the application such that it may not reach the review committee in time for
review. In addition, the RFA title and number must be typed on line 2 of the
face page of the application form and the YES box must be marked.
The sample RFA label available at:
http://grants.nih.gov/grants/funding/phs398/label-bk.pdf. Please note this is
in pdf format.
Submit a signed, typewritten original of the application, including a single
Checklist, and three signed, single-sided photocopies in one package to:
CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)
At the time of submission, to ensure that your application receives
appropriate consideration, two additional copies of the application with all
appendices must be sent to:
Dr. Joshua Rosenthal
Fogarty International Center
National Institutes of Health
31 CENTER DRIVE MSC 2220
BETHESDA MD 20892-2220
Applications must be received by the application receipt date listed in the
heading of this RFA. If an application is received after that date, it will
be returned to the applicant without review.
The Center for Scientific Review (CSR) will not accept any application in
response to this RFA that is essentially the same as one currently pending
initial review, unless the applicant withdraws the pending application. The
CSR will not accept any application that is essentially the same as one
already reviewed. This does not preclude the submission of substantial
revisions of applications already reviewed, but such applications must include
an introduction addressing the previous critique.
revisions.
REVIEW CONSIDERATIONS
Review Procedures
Upon receipt, applications will be reviewed for completeness by CSR and for
responsiveness by staff from the participating agencies. Incomplete
applications will be returned to the applicant without further consideration.
Applications that are judged to be non-responsive will be administratively
withdrawn and the proposed PI will be notified.
Applications that are both complete and responsive to the RFA will be further
evaluated, using the review criteria below, for scientific and technical merit
by an appropriate interdisciplinary peer review group convened by the NIAID.
The composition of the initial review group, as well as the review procedures
and criteria they employ will satisfy both NIH and NSF regulations. For NIH
awards, a second level review will be provided by the Advisory Board or
Council of the awarding Institute or Center. Based on recommendations from
the peer review process, the Participating Agencies will recommend funding
levels and priorities. Final funding decisions will be made considering the
outcome of the above process.
Review Criteria
The goals of research supported under this RFA are to advance our
understanding of biological systems, improve the control of disease, and
enhance health. In the written comments, reviewers will be asked to discuss
the following aspects of the application in order to judge the likelihood that
the proposed research will have a substantial impact on the pursuit of these
goals. Each of these criteria will be addressed and considered in assigning
the overall rank, weighting them as appropriate for each application. Note
that the application does not need to be strong in all categories to be judged
likely to have major scientific impact and thus deserve a high priority score.
For example, an investigator may propose to carry out important work that, by
its nature, is not innovative but is essential to move a field forward.
(1) Significance: Does this study address an important problem? If the aims
of the application are achieved, how will scientific knowledge be advanced?
What will be the effect of these studies on the concepts or methods that drive
this field?
(2) Approach: Are the conceptual framework, design, methods, and analyses
adequately developed, well-integrated and appropriate, and to the aims of the
project? Does the applicant acknowledge potential problem areas and consider
alternative tactics?
(3) Innovation: Does the project employ novel concepts, approaches or
methods? Are the aims original and innovative? Does the project challenge
existing paradigms or develop new methodologies or technologies?
(4) Investigator: Are the investigators appropriately trained and well-suited
to carry out this work? Is the work proposed appropriate to the experience
level of the PI and other researchers (if any)? Are the nature and quality of
the collaborations appropriate for the proposed research?
(5) Environment: Does the scientific environment in which the work will be
done contribute to the probability of success? Do the proposed experiments
take advantage of unique features of the scientific environment or employ
useful collaborative arrangements? Is there evidence of institutional
support?
(6) Integration: Will the proposed research team and program function as a
truly interdisciplinary unit that integrates models, methods, and expertise
from both ecological and biomedical sciences?
In addition, reviewers will be asked to comment on other issues including:
a) How well does the activity advance discovery and understanding while
promoting teaching, training, and learning? To what extent will it enhance
the infrastructure for research and education, such as facilities,
instrumentation, networks, and partnerships? Will the results be disseminated
broadly to enhance scientific and technological understanding?
b) The adequacy of plans to include participation by underrepresented groups
(e.g. gender, ethnicity, geographic, and children), as appropriate, for the
scientific goals of the research. Plans for the recruitment and retention of
subjects will also be evaluated.
c) The reasonableness of the proposed budget and duration in relation to the
proposed research.
d) The adequacy of the proposed protection for humans, animals or the
environment, to the extent they may be adversely affected by the project
proposed in the application.
e) Lastly, if working in a developing country context, are investigators from
the host country participating substantially in the design and implementation
of the program? Are these investigators and their institution likely to learn
new techniques or have other significant enhancements to their research
capacity as an outcome of the project?
Schedule
Letter of Intent Receipt Date: April 2, 2001
Application Receipt Date: May 17, 2001
Peer Review Date: Approximately October 15, 2001
Council Review: February 15, 2002
Earliest Anticipated Start Date: February 1, 2002 (NSF awards); March 1, 2002
(NIH awards)
AWARD CRITERIA
Award criteria that will be used to make award decisions include:
o scientific merit (as determined by peer review)
o availability of funds
o programmatic priorities of the funding organizations, including scientific
and geographic balance.
INQUIRIES
It is strongly advised that prospective applicants contact program
representatives early in their planning process to discuss their applications
and to obtain any clarifying information or instructions that may be
developed. Applicants are encouraged to contact the agency representative
below that is closest to your interest, background or affiliation.
Dr. Joshua Rosenthal
Program Director
Fogarty International Center
National Institutes of Health
31 CENTER DRIVE MSC 2220
BETHESDA MD 20892-2220
Telephone: 301-496-1653
FAX: 301-402-2056
Email: joshua_rosenthal@nih.gov
Dr. Allen Dearry
Chief, Chemical Exposures and Molecular Biology Branch
National Institute of Environmental Health Sciences (NIEHS)
MD EC-21
P.O. Box 12233
Research Triangle Park NC 27709
Telephone: 919-541-4943
FAX: 919-541-2843
e-mail: ad29x@nih.gov
Dr. Irene Eckstrand
Program Director
Division of Genetics and Developmental Biology
National Institute of General Medical Sciences (NIGMS)
45 Center Drive
Bethesda MD 20892
Telephone: 301-594-0943
FAX: 301-480-2753
e-mail: eckstrai@gml.nigms.nih.gov
Dr. Samuel M. Scheiner
Program Director
Division of Environmental Biology
National Science Foundation (NSF)
4201 Wilson Blvd., Rm. 635
Arlington VA 22230
Telephone: 703-306-1481
FAX: 703-306-0817
e-mail: sscheine@nsf.gov
Janet Hren
Science Advisor for Environment
U.S. Geological Survey
107 National Center
Reston VA 20192
Telephone: 703-648-4480
Fax: 703-648-5470
Email: jhren@usgs.gov
Direct inquiries regarding fiscal matters to:
Bruce R. Butrum
Grants Management Officer
Fogarty International Center
Building 31. Room B2C29
Bethesda, MD 20892-2220
Phone 301-496-1653
Fax 301-594-1211
Email: butrumb@mail.nih.gov
AUTHORITY AND REGULATIONS
NSF awards made as a result of this document are administered in accordance
with the terms and conditions of NSF GC-1, "Grant General Conditions." FDP-
III "Federal Demonstration Partnership General Terms and Conditions,"
depending on the grantee organization. Copies of these documents are
available at no cost from the Clearinghouse, P.O. Box 218, Jessup, MD 20794-
0218, phone (301) 947-2722, or via e-mail to pubs@nsf.gov. More comprehensive
information is contained in the NSF Grant Policy Manual, GPM (NSF 95-26), for
sale through the Superintendent of Documents, Government Printing Office
(GPO), Washington, DC 20402. The telephone number at GPO is (202) 783-3238
for subscription information. The GPM is also be available on the NSF OnLine
Document System located at http://www.nsf.gov/.
Awards are made under authorization of Sections 301 and 405 of the Public
Health Service Act, as amended (42 USC 241 and 284) and administered under NIH
grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92.
This program is not subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant recipients to provide a smoke-free
workplace and promote the non-use of all tobacco products. In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or in some cases, any portion of a facility) in which regular or
routine education, library, day care, health care, or early childhood
development services are provided to children. This is consistent with the
PHS mission to protect and advance the physical and mental health of the
American people.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
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Department of Health and Human Services (HHS)
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NIH... Turning Discovery Into Health®
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