Release Date:  February 27, 2001

RFA:  RFA-TW-01-004 (NOT-TW-06-003 updates and supersedes this RFA)

Fogarty International Center
National Institute of Environmental Health Sciences
National Institute of General Medical Sciences
National Science Foundation
U.S. Geological Survey

Letter of Intent Receipt Date:  April 2, 2001
Application Receipt Date:       May 17, 2001


The National Institutes of Health (NIH), the National Science Foundation (NSF) 
and the U.S. Geological Survey (USGS) (hereafter "the Government" or "the 
Participating Agencies") invite applications for the establishment of research 
programs to elucidate the underlying mechanisms that govern the relationships 
between anthropogenic environmental changes and the transmission dynamics of 
infectious diseases.

This Request for Applications (RFA) calls for the development of 
interdisciplinary research programs on the ecology of infectious diseases in 
the context of anthropogenic environmental changes such as biodiversity loss, 
habitat transformation, environmental contamination, climate change and other 
influences.  The focus of this RFA is on discovery of basic ecological and 
biological mechanisms and development of predictive models for the emergence 
and transmission of diseases in humans and other animals, and ultimately the 
development of strategies to prevent or control them.  This is the second RFA 
issued for this program.  The most significant change from the previous RFA is 
a more inclusive definition of relevant climate change-disease projects. 


The Public Health Service (PHS) is committed to achieving the health promotion 
and disease prevention objectives of "Healthy People 2010," a PHS-led national 
activity for setting priority areas.  This RFA, Ecology of Infectious Diseases 
(EID), is related to one or more of the priority areas.  Potential applicants 
may obtain a copy of "Healthy People 2010" at


Applications may be submitted by domestic and foreign for-profit and non-
profit organizations, both public and private (including domestic institutions 
with foreign collaborators), such as universities, colleges, hospitals, 
laboratories, units of State and local governments, and eligible agencies of 
the Federal Government.  Racial/ethnic minority individuals, women, and 
persons with disabilities are encouraged to apply as Principal Investigators 


The participating agencies will jointly administer the program from receipt of 
proposals and throughout the duration of awards.  Following the initial 
review, the institutes and agencies involved will choose from the top scoring 
applications those that they will support.  Each award will be made by NSF or 
NIH.  In some cases, the awards will include support from the other agency.  
For awards that will be made by the NSF, the PIs will be asked to resubmit the 
same application on NSF forms through the FastLane Internet system 
( prior to making the award.  Grant 
awards by the NIH will use the R01 research project grant award mechanism.  

Participating NIH components are the Fogarty International Center (FIC), the 
National Institute of Environmental Health Sciences (NIEHS), and the National 
Institute of General Medical Sciences (NIGMS).  NSF participation is 
principally through the Directorate for Biological Sciences.  If collaborative 
support from the USGS, as described below, is of interest, applicants should 
prearrange this collaboration with the appropriate agency representatives and 
document this support in their applications.  Individual agency and institute 
contacts are listed later in this announcement.  

Responsibility for the planning, direction, and execution of the proposed 
project will be solely that of the applicant.  The total project period for an 
application submitted in response to this RFA may not exceed five years.  We 
do not know at this time if or when this RFA will be issued again.  Future 
unsolicited competing continuation applications will compete with all 
investigator-initiated applications and be reviewed according to the customary 
peer review procedures of the receiving agency or institute.  The anticipated 
award date is approximately February 1, 2002 for NSF awards and March 1, 2002 
for NIH awards.

USGS will provide, by agreement among investigators, support through 
collaboration with USGS laboratories for research addressing needs related to 
the ecology of infectious diseases.  These needs include, but are not limited 
to:  access to databases for water quality, the chemical and physical 
characteristics of earth materials, land (both natural and man-made 
attributes), and satellite and airborne remotely sensed data; laboratory 
analysis of wildlife diseases, including wildlife and environmental 
toxicology; and chemical analysis of water, plants, soils, rocks, and 
sediments.  The USGS studies, assesses, and develops and maintains National 
Data Bases on the Nation's water (quantity and quality) resources, flora, 
fauna, land characteristics, natural hazards including earthquakes, volcanic 
eruptions, landslides, floods, coastal erosion, and mineral and energy 
resources; and determines past ecological and climate histories.  Grant funds 
to support research or post-doctoral associates will not be available through 
USGS National Programs.  Post-doctoral support may, however, be available 
through individual USGS laboratories.  If such support is of interest, 
applicants must arrange it with the appropriate USGS laboratory, describe it, 
and provide supporting letters in their application.  Information on potential 
collaborators and resources within the USGS can be found on the World Wide Web 

Note that unconfirmed support from USGS or any other collaborator cannot be 
considered during initial peer review of an application.  While such 
collaborations could be added to a project after it has been funded, 
investigators are encouraged to develop these for the initial application.


An applicant may request a project period of up to five years, with a budget 
of up to $350,000 per year direct costs.  We anticipate that the nature and 
scope of projects will vary, and accordingly, the budget and duration of 
funded projects will also vary.  Contingent upon the availability of funds, 
the Government anticipates a total from all collaborating agencies of 
approximately $3 million will be awarded for the first year, providing for an 
estimated six to eight grants.  Additional funding may become available to 
support more awards if Congressional budget allocations and/or potential 
interest from other institutes allow for it.  Because the anticipated award 
size is greater than $250,000 per year, the NIH modular approach will not be 
used for any application submitted for this RFA.



For the purpose of this RFA, some relevant terms are defined below.

o  Anthropogenic Environmental Change - A sustained change in the natural 
environment resulting from human activity such as deforestation, exotic 
species introduction, chemical effluent release, carbon dioxide release, etc.
o  Biocomplexity - A property of systems structured or influenced by living 
organisms, their components, or biological processes.  This RFA focuses on 
biocomplexity that arises from the interactions of living organisms with all 
facets of their external environment, particularly those interactions 
involving multiple levels of biological organization and/or multiple spatial 
and temporal scales.
o  Biodiversity - The structural and functional variety of life forms at 
genetic, population, species, and ecosystems levels.
o  Biological Invasion - The mass movement or encroachment of organisms from 
one area into another, generally, non-native area.
o  Climate Change – Sustained directional change in atmospheric temperature, 
seasonality, or other feature of climate that may be considered a result of 
human activities such as release of carbon dioxide.
o  Ecology - The study of the abundance and distribution of organisms and of 
the relationships between organisms and their biotic and abiotic environments, 
including climate. 
o  Habitat Fragmentation - The disruption of extensive habitats into isolated 
and smaller patches, typically by agriculture, human settlement or development 
o  Infection - The process of invasion and establishment by a microorganism or 
helminth within host tissues.
o  Infectious Diseases - Diseases resulting from presence of an infectious 
o  Species Richness - The absolute number of species in an assemblage or 


Over the past 20 years, unprecedented rates of change in diversity of non-
human biota have coincided with the emergence and reemergence of numerous 
infectious diseases around the world.  Virtually all of the world's 
terrestrial and aquatic communities and ecosystems have undergone dramatic 
changes in biodiversity and biocomplexity due primarily to habitat 
transformation (deforestation, reforestation, agricultural intensification, 
fragmentation), invasions of exotic species, chemical contamination, and 
climate change events.  The coincidence of broad-scale environmental changes 
and emergence of infectious diseases may point to underlying predictable 
ecological relationships. 

For example, habitat fragmentation may reduce populations of mammalian 
predators of animals that are natural reservoirs of disease agents, resulting 
in increased transmission to humans.  Similarly, runoff from urban and rural 
sewage systems may carry pathogenic microorganisms and helminths that 
proliferate in shellfish and fish and eventually infect humans via consumption 
as food.  While a descriptive understanding of some cases exists, there is 
little mechanistic understanding of basic ecological principles that may 
regulate such complex systems.

The role of biological diversity and habitat structure in stabilizing 
communities of plants, animals and micro-organisms has received a great deal 
of attention from ecologists in recent years.  As a result, our capacity to 
analyze and model biocomplexity and ecological dynamics, and to evaluate 
spatial and temporal aspects of environmental change has become increasingly 
sophisticated.  However, few of these advances in ecological science have yet 
contributed to biomedical research or to public health.  

Similarly, we have improved our ability to define the molecular identity of 
pathogens or infectious agents and their vectors, and our understanding of the 
defense systems of their hosts.  These improvements have contributed 
significantly to our understanding of epidemiology and transmission patterns 
of diseases.  However, the relationship of these factors to population 
dynamics of disease reservoirs, or the biotic and structural complexity of 
ecological systems in which transmission occurs, remains a poorly understood 

At present, basic and applied research in infectious disease ecology is 
largely piecemeal, due in part to the differentiated missions of federal 
science agencies that support research.  The potential benefits of an 
interdisciplinary research program in this area include:  development of 
disease transmission theory, improved understanding of unintended health 
effects of development projects, increased capacity to forecast outbreaks, and 
improved understanding of how diseases (re)emerge.  An interdisciplinary 
program will also solidify long-term collaborative relationships among federal 
agencies that have been independently supporting research in ecological and 
health sciences.  These opportunities led the participating agencies to 
announce the first RFA for EID last year (NIH Guide November 16, 1999: seeking to 
bring together advances in methods and understanding from these and other 
fields in an interdisciplinary program of research aimed at the interface of 
ecology and human health.  Brief descriptions of the funded projects from that 
competition can be found at:  This 
RFA represents a second competition of that program in recognition of the very 
large number of applications and inquiries we received in response to the 
first announcement.  

Scientific Objectives

Fundamentally, the goal of this effort is to encourage development of 
predictive models and discovery of principles for relationships between 
anthropogenic environmental change and transmission of infectious agents.  To 
that end, research should focus on understanding the ecological determinants 
of transmission by vectors or abiotic agents, the population dynamics of 
reservoir species, and transmission to humans or other hosts.  These 
anthropogenic environmental changes include, but are not limited to, 
deforestation, habitat destruction or fragmentation, biological invasion, 
agricultural practices, and environmental pollution, climate change and 
resulting climate events.  

A variety of topics, questions and approaches are appropriate.  Research could 
focus on particular infectious agents, individual diseases or groups of 
diseases, and might involve one or more regions, habitats or groups of 
organisms.  Depending on the hypotheses being addressed, investigations might 
entail laboratory experiments, field observations or manipulations, novel 
analyses of existing data, theoretical investigations of ecological dynamics 
or all of the above.  Field investigations that elucidate extensive temporal 
and/or spatial patterns from nature are among those most likely to yield 
important insights.  Such insights are likely to be gained through integrating 
work among several scales of observation, including molecular, individual, 
population, and regional levels of analysis.  Use of remote sensing, 
geographic information systems, and other information technologies may be 
useful in such efforts. 

Investigations may also consider dynamic processes using model biological 
systems, even in a laboratory setting.  New insights gained from the study of 
biological interactions involving organisms or ecological settings other than 
those of ultimate concern may very well improve our understanding of complex 
interactions in natural ecological systems.

The primary focus should be on ecological dynamics related to disease agent 
transmission and infection.  Analysis of environmental influences on the 
susceptibility of individuals or populations to infection by particular agents 
is appropriate.  However, research that does not include a substantial focus 
on the underlying ecological parameters of environmental change that influence 
transmission and infection is outside the scope of this RFA.  Infectious 
disease researchers with a different focus are directed to the National 
Institute on Allergy and Infectious Diseases (NIAID) 
or other opportunities at the NIH or the NSF.  Similarly, while the evolution 
of pathogens and hosts may be inseparable from many ecological questions, 
investigations focused primarily on genetic change in diseases or hosts are 
outside the scope of this RFA.  Investigators interested in this area are 
encouraged to examine the NIH Program Announcement PA-99-147 Evolutionary 
Mechanisms in Infectious Diseases 
This RFA is intended to support research related to 
anthropogenic environmental changes.  In contrast to the previous EID RFA, 
research on the effects of “normal” climate phenomena, such as El Nino 
Southern Oscillation (ENSO) cycles and extreme climatic events, will be 
considered responsive to this RFA.  However, they are only responsive to the 
extent that the research proposed serves explicitly as a model for the effects 
of global climate change on infectious disease transmission.

Examples of the kinds of ecological relationships that may be studied include, 
but are not limited to, the following:
o  effect of changes in species richness on the persistence and relative 
abundance of pathogenic and non-pathogenic microorganisms, and their 
transmission to hosts,
o  identification and evaluation of habitats favorable to the emergence of new 
o  influences of global climate change and associated extreme events on 
transmission or risk of disease,
o  impact of chemical or physical pollutants on abundance of pathogens and 
rates of transmission,
o  consequences of newly-introduced species on competitive interactions among 
o  impact of deforestation on human population density and the incidence of 
zoonotic and vector-borne disease,
o  habitat fragmentation and changes in the geographic range of disease 
o  effects of pollution-related algal blooms on abundance of associated 
infectious organisms and their transmission to humans,
o  meta-analyses of historical patterns of transmission and the underlying 
environmental determinants,
o  factors affecting reservoir abundance and risk of zoonotic disease,
o  role of habitat-specific diseases in shaping the community structure of 
non-human hosts,
o  ecology of migration and population structure on emergence or regional 
maintenance of disease.

Funded research under this RFA will aim beyond description to achieve 
mechanistic insights into such phenomena.  

These kinds of problems are fundamentally interdisciplinary, and teams of 
investigators with expertise in a wide range of scientific training and skills 
from diverse disciplines are likely to be most effective.  Integrated, 
collaborative efforts might involve infectious disease epidemiologists, 
population ecologists, statisticians, immunologists, parasitologists, 
taxonomists, molecular biologists, environmental health scientists, 
climatologists, and mathematical modelers, for example.  A team approach is 
encouraged to answer questions that normally cannot be addressed within a 
single discipline.  Work under this RFA can involve the collection or 
development of new data, the reanalysis of existing data, or a combination of 


Each application should budget for travel by one or more investigators to the 
Washington, D.C. area every year for a network meeting of all funded projects 
under this RFA.  

Research projects proposed for execution in a developing country should, as 
part of the research process, make an express effort to build sustainable 
research capacity in collaborating institutions in the host country through 
transferring skills, information and equipment, as relevant to the proposed 

Protection of Research Subjects

Applicants should be aware that provisions for the protection of human 
research subjects and laboratory animals must be met in research done in both 
domestic and foreign institutions, including obtaining any necessary 
assurances.  Applicants should see Title 45 CFR, Part 46 for information 
concerning the Department of Health and Human Services regulations for the 
protection of human subjects and the PHS Policy on Humane Care and Use of 
Laboratory Animals.  These are available from:  

The Office for Human Research Protections (OHRP)
Department of Health and Human Services
6100 Executive Boulevard, Suite 3B01, MSC 7507
Rockville, MD  20892-7507

Office of Laboratory Animal Welfare (OLAW)
National Institutes of Health
RKL1, Suite 1050, MSC 7982
6705 Rockledge Drive
Bethesda, MD  20892-7982

Applicants should refer to NIH Guide Notice OD-00-039, dated June 5, 2000, and 
revised August 25, 2000 
for information on required education on the protection of 
human research participants.


It is the policy of the NIH that women and members of minority groups and 
their sub-populations must be included in all NIH-supported biomedical and 
behavioral research projects involving human subjects, unless a clear and 
compelling rationale and justification are provided indicating that inclusion 
is inappropriate with respect to the health of the subjects or the purpose of 
the research.  This policy results from the NIH Revitalization Act of 1993 
(Section 492B of Public Law 103-43).

All investigators proposing research involving human subjects should read the 
updated "NIH Guidelines for Inclusion of Women and Minorities as Subjects in 
Clinical Research," published in the NIH Guide for Grants and Contracts on 
August 2, 2000 
a complete copy of the updated Guidelines is available at  The 
revisions relate to NIH defined Phase III clinical trials and require:  a) all 
applications or proposals and/or protocols to provide a description of plans 
to conduct analyses, as appropriate, to address differences by sex/gender 
and/or racial/ethnic groups, including subgroups if applicable; and b) all 
investigators to report accrual, and to conduct and report analyses, as 
appropriate, by sex/gender and/or racial/ethnic group differences.


It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research conducted or supported by the 
NIH, unless there are scientific and ethical reasons not to include them.  
This policy applies to all initial (Type 1) applications submitted for receipt 
dates after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines" on the Inclusion of Children as Participants in 
Research Involving Human Subjects that was published in the NIH Guide for 
Grants and Contracts, March 6, 1998, and is available at the following URL 

Investigators also may obtain copies of these policies from the program staff 
listed under INQUIRIES.  Program staff may also provide additional relevant 
information concerning the policy.


All applications and proposals for NIH funding must be self-contained within 
specified page limitations.  Unless otherwise specified in an NIH 
solicitation, Internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no obligation 
to view the Internet sites.  Reviewers are cautioned that their anonymity may 
be compromised when they directly access an Internet site.


Prospective applicants are asked to submit a letter of intent by March 23, 
2001, that includes a descriptive title of the proposed research, the name, 
address, and telephone number of the PI, the identities of other key personnel 
and participating institutions, and the number and title of the RFA in 
response to which the application may be submitted.  Although a letter of 
intent is not required, is not binding, and does not enter into the review of 
a subsequent application, the information that it contains allows staff to 
estimate the potential review workload and plan the review.  The letter of 
intent should be sent to:

Dr. Joshua Rosenthal
Fogarty International Center
National Institutes of Health
BETHESDA  MD  20892-2220
FAX: 301-402-2056


The regular research grant application Form PHS-398 (Rev. 4/98) must be used 
in applying.  General instructions for completing the Form PHS-398 are 
contained in the application package.  Apply additional instructions as 
outlined in this RFA.  The Form PHS-398 is available through the NIH pages on 
the World Wide Web (  
These forms are available at most institutional offices of sponsored research 
and from the Division of Extramural Outreach and Information Resources, 
National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD, 
20892-7910, telephone 301/710-0267, email:

The RFA label available in the PHS 398 (rev. 4/98) application form must be 
affixed to the bottom of the face page of the application and must indicate 
the RFA number.  Failure to use this label could result in delayed processing 
of the application such that it may not reach the review committee in time for 
review.  In addition, the RFA title and number must be typed on line 2 of the 
face page of the application form and the YES box must be marked.

The sample RFA label available at:  Please note this is 
in pdf format.

Submit a signed, typewritten original of the application, including a single 
Checklist, and three signed, single-sided photocopies in one package to:

6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, to ensure that your application receives 
appropriate consideration, two additional copies of the application with all 
appendices must be sent to:

Dr. Joshua Rosenthal
Fogarty International Center
National Institutes of Health
BETHESDA  MD  20892-2220

Applications must be received by the application receipt date listed in the 
heading of this RFA.  If an application is received after that date, it will 
be returned to the applicant without review.

The Center for Scientific Review (CSR) will not accept any application in 
response to this RFA that is essentially the same as one currently pending 
initial review, unless the applicant withdraws the pending application.  The 
CSR will not accept any application that is essentially the same as one 
already reviewed.  This does not preclude the submission of substantial 
revisions of applications already reviewed, but such applications must include 
an introduction addressing the previous critique. 


Review Procedures

Upon receipt, applications will be reviewed for completeness by CSR and for 
responsiveness by staff from the participating agencies.  Incomplete 
applications will be returned to the applicant without further consideration.  
Applications that are judged to be non-responsive will be administratively 
withdrawn and the proposed PI will be notified.  

Applications that are both complete and responsive to the RFA will be further 
evaluated, using the review criteria below, for scientific and technical merit 
by an appropriate interdisciplinary peer review group convened by the NIAID.  
The composition of the initial review group, as well as the review procedures 
and criteria they employ will satisfy both NIH and NSF regulations.  For NIH 
awards, a second level review will be provided by the Advisory Board or 
Council of the awarding Institute or Center.  Based on recommendations from 
the peer review process, the Participating Agencies will recommend funding 
levels and priorities.  Final funding decisions will be made considering the 
outcome of the above process.  

Review Criteria

The goals of research supported under this RFA are to advance our 
understanding of biological systems, improve the control of disease, and 
enhance health.  In the written comments, reviewers will be asked to discuss 
the following aspects of the application in order to judge the likelihood that 
the proposed research will have a substantial impact on the pursuit of these 
goals.  Each of these criteria will be addressed and considered in assigning 
the overall rank, weighting them as appropriate for each application.  Note 
that the application does not need to be strong in all categories to be judged 
likely to have major scientific impact and thus deserve a high priority score.  
For example, an investigator may propose to carry out important work that, by 
its nature, is not innovative but is essential to move a field forward.

(1) Significance:  Does this study address an important problem?  If the aims 
of the application are achieved, how will scientific knowledge be advanced?  
What will be the effect of these studies on the concepts or methods that drive 
this field?
(2) Approach:  Are the conceptual framework, design, methods, and analyses 
adequately developed, well-integrated and appropriate, and to the aims of the 
project?  Does the applicant acknowledge potential problem areas and consider 
alternative tactics?  
(3) Innovation:  Does the project employ novel concepts, approaches or 
methods?  Are the aims original and innovative?  Does the project challenge 
existing paradigms or develop new methodologies or technologies?
(4) Investigator:  Are the investigators appropriately trained and well-suited 
to carry out this work?  Is the work proposed appropriate to the experience 
level of the PI and other researchers (if any)?  Are the nature and quality of 
the collaborations appropriate for the proposed research?
(5) Environment:  Does the scientific environment in which the work will be 
done contribute to the probability of success?  Do the proposed experiments 
take advantage of unique features of the scientific environment or employ 
useful collaborative arrangements?  Is there evidence of institutional 
(6) Integration:  Will the proposed research team and program function as a 
truly interdisciplinary unit that integrates models, methods, and expertise 
from both ecological and biomedical sciences?

In addition, reviewers will be asked to comment on other issues including:

a) How well does the activity advance discovery and understanding while 
promoting teaching, training, and learning?  To what extent will it enhance 
the infrastructure for research and education, such as facilities, 
instrumentation, networks, and partnerships?  Will the results be disseminated 
broadly to enhance scientific and technological understanding?
b) The adequacy of plans to include participation by underrepresented groups 
(e.g. gender, ethnicity, geographic, and children), as appropriate, for the 
scientific goals of the research.  Plans for the recruitment and retention of 
subjects will also be evaluated.
c) The reasonableness of the proposed budget and duration in relation to the 
proposed research.
d) The adequacy of the proposed protection for humans, animals or the 
environment, to the extent they may be adversely affected by the project 
proposed in the application.
e) Lastly, if working in a developing country context, are investigators from 
the host country participating substantially in the design and implementation 
of the program?  Are these investigators and their institution likely to learn 
new techniques or have other significant enhancements to their research 
capacity as an outcome of the project?


Letter of Intent Receipt Date:    April 2, 2001
Application Receipt Date:         May 17, 2001
Peer Review Date:                 Approximately October 15, 2001
Council Review:                   February 15, 2002
Earliest Anticipated Start Date:  February 1, 2002 (NSF awards); March 1, 2002
(NIH awards)


Award criteria that will be used to make award decisions include:
o  scientific merit (as determined by peer review)
o  availability of funds
o  programmatic priorities of the funding organizations, including scientific 
and geographic balance.


It is strongly advised that prospective applicants contact program 
representatives early in their planning process to discuss their applications 
and to obtain any clarifying information or instructions that may be 
developed.  Applicants are encouraged to contact the agency representative 
below that is closest to your interest, background or affiliation.

Dr. Joshua Rosenthal
Program Director
Fogarty International Center
National Institutes of Health
BETHESDA  MD  20892-2220
Telephone:  301-496-1653
FAX:  301-402-2056

Dr. Allen Dearry
Chief, Chemical Exposures and Molecular Biology Branch
National Institute of Environmental Health Sciences (NIEHS)
MD EC-21
P.O. Box 12233
Research Triangle Park  NC 27709
Telephone:  919-541-4943
FAX:  919-541-2843

Dr. Irene Eckstrand
Program Director
Division of Genetics and Developmental Biology
National Institute of General Medical Sciences (NIGMS)
45 Center Drive
Bethesda  MD  20892
Telephone:  301-594-0943
FAX:  301-480-2753

Dr. Samuel M. Scheiner
Program Director
Division of Environmental Biology
National Science Foundation (NSF)
4201 Wilson Blvd., Rm. 635
Arlington  VA  22230
Telephone:  703-306-1481
FAX:  703-306-0817

Janet Hren 
Science Advisor for Environment 
U.S. Geological Survey 
107 National Center 
Reston  VA 20192 
Telephone: 703-648-4480 
Fax: 703-648-5470 

Direct inquiries regarding fiscal matters to:

Bruce R. Butrum
Grants Management Officer
Fogarty International Center
Building 31. Room B2C29
Bethesda, MD  20892-2220
Phone  301-496-1653
Fax      301-594-1211


NSF awards made as a result of this document are administered in accordance 
with the terms and conditions of NSF GC-1, "Grant General Conditions."  FDP-
III "Federal Demonstration Partnership General Terms and Conditions," 
depending on the grantee organization.  Copies of these documents are 
available at no cost from the Clearinghouse, P.O. Box 218, Jessup, MD 20794-
0218, phone (301) 947-2722, or via e-mail to  More comprehensive 
information is contained in the NSF Grant Policy Manual, GPM (NSF 95-26), for 
sale through the Superintendent of Documents, Government Printing Office 
(GPO), Washington, DC 20402.  The telephone number at GPO is (202) 783-3238 
for subscription information.  The GPM is also be available on the NSF OnLine 
Document System located at

Awards are made under authorization of Sections 301 and 405 of the Public 
Health Service Act, as amended (42 USC 241 and 284) and administered under NIH 
grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92.  
This program is not subject to the intergovernmental review requirements of 
Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant recipients to provide a smoke-free 
workplace and promote the non-use of all tobacco products.  In addition, 
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain 
facilities (or in some cases, any portion of a facility) in which regular or 
routine education, library, day care, health care, or early childhood 
development services are provided to children.  This is consistent with the 
PHS mission to protect and advance the physical and mental health of the 
American people.

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